EA200600528A1 - Способ получения водорастворимых дитерпенов и их применение - Google Patents

Способ получения водорастворимых дитерпенов и их применение

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Publication number
EA200600528A1
EA200600528A1 EA200600528A EA200600528A EA200600528A1 EA 200600528 A1 EA200600528 A1 EA 200600528A1 EA 200600528 A EA200600528 A EA 200600528A EA 200600528 A EA200600528 A EA 200600528A EA 200600528 A1 EA200600528 A1 EA 200600528A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diterpenes
application
water soluble
obtaining water
forskolin
Prior art date
Application number
EA200600528A
Other languages
English (en)
Other versions
EA012836B1 (ru
Inventor
Мухаммед Маджид
Арвинд Кумар
Кальяннам Нагабхушанам
Суббалакшми Пракаш
Original Assignee
Мухаммед Маджид
Арвинд Кумар
Кальяннам Нагабхушанам
Суббалакшми Пракаш
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мухаммед Маджид, Арвинд Кумар, Кальяннам Нагабхушанам, Суббалакшми Пракаш filed Critical Мухаммед Маджид
Publication of EA200600528A1 publication Critical patent/EA200600528A1/ru
Publication of EA012836B1 publication Critical patent/EA012836B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Водные растворы дитерпенов, таких как форсколин, родственные ему соединения, аналоги и производные, с концентрацией приблизительно до 6 % получают, используя в качестве солюбилизирующего агента соответствующим образом замещенный циклодекстрин. В отсутствие циклодекстрина некоторые дитерпены, например форсколин, растворяются в воде только до концентраций приблизительно 0,001%. Такие водные растворы находят применение при локальном и системном использовании в виде фармацевтических, косметических, нутрицевтических препаратов, содержащих дитерпены, такие как форсколин и родственные ему соединения.
EA200600528A 2003-09-08 2004-09-02 Способ получения водорастворимых дитерпенов и их применение EA012836B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/605,086 US6960300B2 (en) 2003-09-08 2003-09-08 Process for preparing water soluble diterpenes and their applications
PCT/US2004/028644 WO2005025500A2 (en) 2003-09-08 2004-09-02 Process for preparing water soluble diterpenes and their applications

Publications (2)

Publication Number Publication Date
EA200600528A1 true EA200600528A1 (ru) 2006-08-25
EA012836B1 EA012836B1 (ru) 2009-12-30

Family

ID=34225859

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600528A EA012836B1 (ru) 2003-09-08 2004-09-02 Способ получения водорастворимых дитерпенов и их применение

Country Status (14)

Country Link
US (2) US6960300B2 (ru)
EP (1) EP1718568B1 (ru)
JP (1) JP5021305B2 (ru)
CN (1) CN1882508B (ru)
AU (1) AU2004272005B2 (ru)
BR (1) BRPI0413957A (ru)
CA (1) CA2537820C (ru)
EA (1) EA012836B1 (ru)
HK (1) HK1098450A1 (ru)
MX (1) MXPA06002684A (ru)
NZ (1) NZ545765A (ru)
RS (1) RS20060169A (ru)
WO (1) WO2005025500A2 (ru)
ZA (1) ZA200601898B (ru)

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US20110077292A1 (en) * 2004-07-01 2011-03-31 Biotest Laboratories, Llc. Forskolin carbonates and uses thereof
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WO2007108727A1 (en) * 2006-03-22 2007-09-27 Leangene Ab Method for monitoring the effect of compounds on foxc2 expression
US20080226571A1 (en) * 2007-03-16 2008-09-18 Muhammed Majeed Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin
US20080241285A1 (en) * 2007-04-01 2008-10-02 Muhammed Majeed Compositions and Methods to Treat Alopecia
US20110003816A1 (en) * 2008-03-07 2011-01-06 Sun Pharma Advanced Research Company Limited Ophthalmic composition
US20100076069A1 (en) * 2008-09-22 2010-03-25 Muhammed Majeed Forskolin dosing regimen in open angle glaucoma and patient compliance methods thereof
US8975241B2 (en) * 2009-10-08 2015-03-10 Song Ho Biomed Co., Ltd. Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component
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CN103588745B (zh) * 2013-11-26 2015-10-28 陕西嘉禾植物化工有限责任公司 一种从毛喉鞘蕊花中提取和分离弗斯可林的方法
WO2017103840A1 (en) * 2015-12-16 2017-06-22 MOHAMED ABDULLA ANZAR, Cheppattu A water soluble 10% w/w forskolin composition and a method of synthesizing the same
WO2018000093A1 (en) 2016-06-30 2018-01-04 Plume Cosmetics Inc. Composition and method for promoting eyelash and eyebrow growth exclusively containing naturally sourced ingredients
KR102583356B1 (ko) 2017-01-09 2023-09-26 에스씨아이팜 에스에이알엘 수용성 포스콜린의 신규 제조 방법
JPWO2018235939A1 (ja) * 2017-06-23 2020-04-23 Ｔｋヘルスリサーチ株式会社 包接化された抗酸化物質を含む眼科用組成物ならびにその使用
JP7004968B2 (ja) * 2017-10-06 2022-01-21 青葉化成株式会社 食用の徐放性機能材の製造方法
CN108651819A (zh) * 2018-05-18 2018-10-16 南昌大学 一种稳定态全谷物超微粉速食粉的制备方法
WO2020179503A1 (ja) * 2019-03-01 2020-09-10 長谷川香料株式会社 セスキテルペン酸素付加体の製造方法、化合物および組成物
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KR20220149987A (ko) * 2021-05-03 2022-11-10 연세대학교 산학협력단 안구건조증 또는 안구건조증 연관 안과 질환의 예방, 개선 또는 치료용 조성물
CN117586217B (zh) * 2024-01-17 2024-03-19 云南省药物研究所 一种基于国产毛喉鞘蕊花的佛司可林制备方法

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Also Published As

Publication number Publication date
CN1882508A (zh) 2006-12-20
HK1098450A1 (en) 2007-07-20
US20050051483A1 (en) 2005-03-10
WO2005025500A2 (en) 2005-03-24
EP1718568B1 (en) 2012-12-26
BRPI0413957A (pt) 2006-10-31
AU2004272005A1 (en) 2005-03-24
NZ545765A (en) 2009-11-27
CA2537820C (en) 2013-03-26
CA2537820A1 (en) 2005-03-24
CN1882508B (zh) 2010-07-14
ZA200601898B (en) 2008-09-25
US6960300B2 (en) 2005-11-01
MXPA06002684A (es) 2007-03-15
JP2007505040A (ja) 2007-03-08
EA012836B1 (ru) 2009-12-30
AU2004272005B2 (en) 2011-03-10
EP1718568A2 (en) 2006-11-08
US20050284812A1 (en) 2005-12-29
WO2005025500A3 (en) 2005-06-09
JP5021305B2 (ja) 2012-09-05
RS20060169A (en) 2008-08-07
EP1718568A4 (en) 2009-01-07

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