BRPI0413957A - processo para preparar diterpenos solúveis em água, solução aquosa e suas aplicações - Google Patents

processo para preparar diterpenos solúveis em água, solução aquosa e suas aplicações

Info

Publication number
BRPI0413957A
BRPI0413957A BRPI0413957-7A BRPI0413957A BRPI0413957A BR PI0413957 A BRPI0413957 A BR PI0413957A BR PI0413957 A BRPI0413957 A BR PI0413957A BR PI0413957 A BRPI0413957 A BR PI0413957A
Authority
BR
Brazil
Prior art keywords
water soluble
diterpenes
applications
aqueous solution
preparing water
Prior art date
Application number
BRPI0413957-7A
Other languages
English (en)
Inventor
Muhammed Majeed
Arvind Kumar
Kalyanam Nagabhushanam
Subbalakshmi Prakash
Original Assignee
Muhammed Majeed
Arvind Kumar
Kalyanam Nagabhushanam
Subbalakshmi Prakash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Muhammed Majeed, Arvind Kumar, Kalyanam Nagabhushanam, Subbalakshmi Prakash filed Critical Muhammed Majeed
Publication of BRPI0413957A publication Critical patent/BRPI0413957A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"PROCESSO PARA PREPARAR DITERPENOS SOLúVEIS EM áGUA, SOLUçãO AQUOSA E SUAS APLICAçõES". Soluções aquosas de diterpenos tais como a Forscolina, seus congêneres, análogos e derivados, com concentração de até aproximadamente 6% são preparadas utilizando-se satisfatoriamente substitutos de ciclodextrina como agente solubilizante. Na ausência de ciclodextrina, alguns diterpenos tais como a forscolina, são solúveis em água somente para concentrações de cerca de 0,01%. Tais soluções aquosas encontram aplicações em uso tópico e sistêmico, tais como preparações farmacêuticas, cosméticas, nutracêuticas, contendo diterpenos como a Forscolina e congêneres.
BRPI0413957-7A 2003-09-08 2004-09-02 processo para preparar diterpenos solúveis em água, solução aquosa e suas aplicações BRPI0413957A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/605,086 US6960300B2 (en) 2003-09-08 2003-09-08 Process for preparing water soluble diterpenes and their applications
PCT/US2004/028644 WO2005025500A2 (en) 2003-09-08 2004-09-02 Process for preparing water soluble diterpenes and their applications

Publications (1)

Publication Number Publication Date
BRPI0413957A true BRPI0413957A (pt) 2006-10-31

Family

ID=34225859

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413957-7A BRPI0413957A (pt) 2003-09-08 2004-09-02 processo para preparar diterpenos solúveis em água, solução aquosa e suas aplicações

Country Status (14)

Country Link
US (2) US6960300B2 (pt)
EP (1) EP1718568B1 (pt)
JP (1) JP5021305B2 (pt)
CN (1) CN1882508B (pt)
AU (1) AU2004272005B2 (pt)
BR (1) BRPI0413957A (pt)
CA (1) CA2537820C (pt)
EA (1) EA012836B1 (pt)
HK (1) HK1098450A1 (pt)
MX (1) MXPA06002684A (pt)
NZ (1) NZ545765A (pt)
RS (1) RS20060169A (pt)
WO (1) WO2005025500A2 (pt)
ZA (1) ZA200601898B (pt)

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US20110077292A1 (en) * 2004-07-01 2011-03-31 Biotest Laboratories, Llc. Forskolin carbonates and uses thereof
JP2007210988A (ja) * 2006-02-07 2007-08-23 Sabinsa Corp ジテルペンフォルスコリン及びその誘導体で男性ホルモン及び女性ホルモンを生理学的に増大するための組成物
US20080181877A1 (en) * 2006-03-22 2008-07-31 Leangene Ab, C/O Cit Ekonomiservice Ab Method For Monitoring the Effect of Compounds on Foxc2 Expression
US20080226571A1 (en) * 2007-03-16 2008-09-18 Muhammed Majeed Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin
US20080241285A1 (en) * 2007-04-01 2008-10-02 Muhammed Majeed Compositions and Methods to Treat Alopecia
WO2009110009A2 (en) * 2008-03-07 2009-09-11 Sun Pharma Advanced Research Company Ltd., Opthalmic composition
US20100076069A1 (en) * 2008-09-22 2010-03-25 Muhammed Majeed Forskolin dosing regimen in open angle glaucoma and patient compliance methods thereof
WO2011043630A2 (ko) * 2009-10-08 2011-04-14 (주)송호바이오메드 고 수용성 ２-하이드록시프로필-베타사이클로덱스트린을 유효성분으로 함유하는 비만 질환 예방 및 치료용 조성물
WO2011053979A1 (en) * 2009-11-02 2011-05-05 Nupathe, Inc. Methods for treating parkinson's disease
CA2820984C (en) * 2010-12-09 2016-10-11 Indus Biotech Private Limited A complex of garcinol, cyclodextrin and method thereof
CN103588745B (zh) * 2013-11-26 2015-10-28 陕西嘉禾植物化工有限责任公司 一种从毛喉鞘蕊花中提取和分离弗斯可林的方法
WO2017103840A1 (en) * 2015-12-16 2017-06-22 MOHAMED ABDULLA ANZAR, Cheppattu A water soluble 10% w/w forskolin composition and a method of synthesizing the same
WO2018000093A1 (en) 2016-06-30 2018-01-04 Plume Cosmetics Inc. Composition and method for promoting eyelash and eyebrow growth exclusively containing naturally sourced ingredients
HUE054617T2 (hu) * 2017-01-09 2021-09-28 Scipharm S A R L Új eljárás vízoldható forskolin elõállítására
WO2018235939A1 (ja) * 2017-06-23 2018-12-27 Ｔｋヘルスリサーチ株式会社 包接化された抗酸化物質を含む眼科用組成物ならびにその使用
JP7004968B2 (ja) 2017-10-06 2022-01-21 青葉化成株式会社 食用の徐放性機能材の製造方法
CN108651819A (zh) * 2018-05-18 2018-10-16 南昌大学 一种稳定态全谷物超微粉速食粉的制备方法
WO2020179503A1 (ja) * 2019-03-01 2020-09-10 長谷川香料株式会社 セスキテルペン酸素付加体の製造方法、化合物および組成物
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HUE065181T2 (hu) 2020-01-23 2024-05-28 Scipharm S A R L 7-deacetilforskolin és PVP komplexe
KR20220149987A (ko) * 2021-05-03 2022-11-10 연세대학교 산학협력단 안구건조증 또는 안구건조증 연관 안과 질환의 예방, 개선 또는 치료용 조성물
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Also Published As

Publication number Publication date
US6960300B2 (en) 2005-11-01
HK1098450A1 (en) 2007-07-20
JP5021305B2 (ja) 2012-09-05
AU2004272005B2 (en) 2011-03-10
RS20060169A (en) 2008-08-07
EA200600528A1 (ru) 2006-08-25
EP1718568A4 (en) 2009-01-07
EA012836B1 (ru) 2009-12-30
CA2537820C (en) 2013-03-26
US20050284812A1 (en) 2005-12-29
WO2005025500A3 (en) 2005-06-09
JP2007505040A (ja) 2007-03-08
MXPA06002684A (es) 2007-03-15
EP1718568A2 (en) 2006-11-08
NZ545765A (en) 2009-11-27
CA2537820A1 (en) 2005-03-24
CN1882508A (zh) 2006-12-20
CN1882508B (zh) 2010-07-14
US20050051483A1 (en) 2005-03-10
EP1718568B1 (en) 2012-12-26
ZA200601898B (en) 2008-09-25
WO2005025500A2 (en) 2005-03-24
AU2004272005A1 (en) 2005-03-24

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 9/00 (2006.01), A23L 33/105 (2016.01), A61K 3