MXPA05008489A - Procedimiento de fabricacion para preparaciones liposomicas. - Google Patents
Procedimiento de fabricacion para preparaciones liposomicas.Info
- Publication number
- MXPA05008489A MXPA05008489A MXPA05008489A MXPA05008489A MXPA05008489A MX PA05008489 A MXPA05008489 A MX PA05008489A MX PA05008489 A MXPA05008489 A MX PA05008489A MX PA05008489 A MXPA05008489 A MX PA05008489A MX PA05008489 A MXPA05008489 A MX PA05008489A
- Authority
- MX
- Mexico
- Prior art keywords
- liposomal
- preparation
- organic solvent
- water
- miscible organic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
La presente invencion provee procedimientos de fabricacion para preparaciones liposomicas. De conformidad con los metodos, se disuelve una fraccion lipida en un solvente organico miscible en agua. Esta solucion que comprende la fraccion lipida se puede agregar a, y mezclar con una solucion acuosa bajo condiciones para formar una preparacion liposomica a granel. De manera deseable, la preparacion puede incluir uno o mas principios activos. La preparacion liposomica a granel se puede procesar tambien segun se desee, por ejemplo, mediante fraccionamiento o reduccion de tamano, remocion del solvente organico miscible en agua, secado por congelamiento, u otro tratamiento. Los metodos permiten la produccion de formulaciones liposomicas a gran escala o a escala comercial.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44689503P | 2003-02-11 | 2003-02-11 | |
PCT/US2004/004555 WO2004071466A2 (en) | 2003-02-11 | 2004-02-11 | Manufacturing process for liposomal preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05008489A true MXPA05008489A (es) | 2005-10-18 |
Family
ID=32869567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05008489A MXPA05008489A (es) | 2003-02-11 | 2004-02-11 | Procedimiento de fabricacion para preparaciones liposomicas. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060034908A1 (es) |
EP (1) | EP1613284A2 (es) |
JP (1) | JP2006517594A (es) |
KR (1) | KR20050105455A (es) |
CN (1) | CN1753657A (es) |
BR (1) | BRPI0407415A (es) |
EA (1) | EA200501285A1 (es) |
MX (1) | MXPA05008489A (es) |
WO (1) | WO2004071466A2 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2584583A1 (en) * | 2004-10-28 | 2006-05-11 | Alza Corporation | Lyophilized liposome formulations and method |
EP1811962A2 (en) * | 2004-10-29 | 2007-08-01 | Neopharm, Inc. | Manufacturing process for liposomal preparations |
US20080121733A1 (en) * | 2006-11-29 | 2008-05-29 | Donald Ackley | Droplet generating device and method |
US7824708B2 (en) * | 2006-12-11 | 2010-11-02 | Access Business Group International Llc | Liposome containing cardiolipin for improvement of mitochondrial function |
EP2146692A1 (en) * | 2007-03-19 | 2010-01-27 | Fresenius Kabi Oncology Limited | Proliposomal and liposomal compositions |
KR20080101056A (ko) * | 2007-05-15 | 2008-11-21 | 한국화학연구원 | 지질나노입자를 포함하는 디테르페노이드 알칼로이드계약물 용액 및 이의 제조방법 |
CN101827613A (zh) | 2007-09-27 | 2010-09-08 | 免疫疫苗技术有限公司 | 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 |
US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
EP2296696B1 (en) | 2008-06-05 | 2014-08-27 | ImmunoVaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
US20110250262A1 (en) * | 2008-12-24 | 2011-10-13 | Biomedcore, Inc. | Method for producing liposome and method for dissolving cholesterol |
WO2010118200A2 (en) * | 2009-04-08 | 2010-10-14 | Brian Salvatore | Liposomal formulations of tocopheryl amides |
JP5771366B2 (ja) | 2009-09-02 | 2015-08-26 | 株式会社バイオメッドコア | リポソーム製造装置及び方法 |
WO2011038068A1 (en) * | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
EP2813220A3 (en) | 2010-04-09 | 2015-06-17 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
DK2729127T3 (en) * | 2011-07-04 | 2018-08-06 | Statens Seruminstitut | METHODS FOR LIPOSOMES PREPARATION |
CN103181898B (zh) * | 2012-11-23 | 2016-03-09 | 杭州师范大学 | 一种奥沙利铂脂质体及其应用 |
JP2015193580A (ja) * | 2014-03-31 | 2015-11-05 | テルモ株式会社 | アムホテリシンbリポソームの製造方法 |
US9931298B2 (en) | 2015-05-26 | 2018-04-03 | Comfort Care For Animals Llc | Liposome loading |
EP3360577A4 (en) * | 2015-10-07 | 2019-06-12 | Ensuiko Sugar Refining Co., Ltd. | LIPOSOME COMPRISING A TAXANE COMPOUND |
WO2017097196A1 (zh) * | 2015-12-08 | 2017-06-15 | 正大天晴药业集团股份有限公司 | 脂质体的制备方法 |
WO2017097197A1 (zh) * | 2015-12-08 | 2017-06-15 | 正大天晴药业集团股份有限公司 | 美西替康的药物组合物 |
KR20200050982A (ko) | 2017-09-04 | 2020-05-12 | 이치마루 화루코스 가부시키가이샤 | pH 감수성 리포솜 및 그 제조 방법 |
WO2019191627A1 (en) * | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
CN109925956A (zh) * | 2019-04-29 | 2019-06-25 | 苏州艾特森制药设备有限公司 | 一种实验室脂质体制备系统 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665710A (en) * | 1990-04-30 | 1997-09-09 | Georgetown University | Method of making liposomal oligodeoxynucleotide compositions |
AU3922193A (en) * | 1992-03-23 | 1993-10-21 | Georgetown University | Liposome encapsulated taxol and a method of using the same |
JPH08512056A (ja) * | 1993-06-30 | 1996-12-17 | ジェネンテク・インコーポレイテッド | リポソームの製造法 |
WO1995024201A1 (fr) * | 1994-03-11 | 1995-09-14 | Yoshitomi Pharmaceutical Industries, Ltd. | Preparation de liposomes |
US6156337A (en) * | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
US6066331A (en) * | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
WO1996006112A1 (en) * | 1994-08-25 | 1996-02-29 | Instituut Voor Veehouderij En Diergezondheid (Id-Dlo) | Antigenic peptides derived from the g protein of rsv for type- and subtype-specific diagnosis of respiratory syncytial virus (rsv) infection |
WO1997035559A2 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation |
US7262173B2 (en) * | 1997-03-21 | 2007-08-28 | Georgetown University | Chemosensitizing with liposomes containing oligonucleotides |
US6126965A (en) * | 1997-03-21 | 2000-10-03 | Georgetown University School Of Medicine | Liposomes containing oligonucleotides |
US20030229040A1 (en) * | 1997-03-21 | 2003-12-11 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
US6559129B1 (en) * | 1997-03-21 | 2003-05-06 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
DE69841002D1 (de) * | 1997-05-14 | 2009-09-03 | Univ British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
US6461637B1 (en) * | 2000-09-01 | 2002-10-08 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
US6146659A (en) * | 1998-07-01 | 2000-11-14 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
US7025988B2 (en) * | 2000-02-04 | 2006-04-11 | Lipoxen Technologies Limited | Liposomes |
WO2001070220A1 (en) * | 2000-03-22 | 2001-09-27 | Neopharm, Inc. | A method of administering liposomal encapsulated taxane |
MXPA03003401A (es) * | 2000-10-16 | 2004-06-30 | Neopharm Inc | Formulacion liposomica de mitoxantrona. |
PL363618A1 (en) * | 2000-11-09 | 2004-11-29 | Neopharm, Inc. | Sn-38 lipid complexes and methods of use |
WO2002059337A1 (en) * | 2001-01-26 | 2002-08-01 | Georgetown University School Of Medicine | Anti-apoptopic gene scc-s2 and diagnostic and therapeutic uses thereof |
WO2002081642A2 (en) * | 2001-04-06 | 2002-10-17 | Georgetown University | Gene brcc-3 and diagnostic and therapeutic uses thereof |
WO2002081641A2 (en) * | 2001-04-06 | 2002-10-17 | Georgetown University | Gene scc-112 and diagnostic and therapeutic uses thereof |
AU2002303261A1 (en) * | 2001-04-06 | 2002-10-21 | Georgetown University | Gene brcc2 and diagnostic and therapeutic uses thereof |
WO2003030864A1 (en) * | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
JP2005508375A (ja) * | 2001-11-09 | 2005-03-31 | ネオファーム、インコーポレイティッド | Il−13を発現する腫瘍の選択的治療 |
US7244565B2 (en) * | 2002-04-10 | 2007-07-17 | Georgetown University | Gene shinc-3 and diagnostic and therapeutic uses thereof |
US7138512B2 (en) * | 2002-04-10 | 2006-11-21 | Georgetown University | Gene SHINC-2 and diagnostic and therapeutic uses thereof |
US20050148528A1 (en) * | 2002-05-20 | 2005-07-07 | Neopharm, Inc | Method for reducing platelet count |
US20030228317A1 (en) * | 2002-05-22 | 2003-12-11 | Prafulla Gokhale | Gene BRCC-1 and diagnostic and therapeutic uses thereof |
WO2003099830A2 (en) * | 2002-05-24 | 2003-12-04 | Neopharm, Inc. | Cardiolipin compositions, methods of preparation and use |
EA200401565A1 (ru) * | 2002-05-24 | 2005-04-28 | Неофарм, Инк. | Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты) |
AU2003240934A1 (en) * | 2002-05-29 | 2003-12-19 | Neopharm, Inc. | Method for determining oligonucleotide concentration |
AU2003296897A1 (en) * | 2002-08-20 | 2004-05-04 | Neopharm, Inc. | Pharmaceutical formulations of camptothecine derivatives |
WO2004017944A1 (en) * | 2002-08-23 | 2004-03-04 | Neopharm, Inc. | Liposomal gemcitabine compositions for better drug delivery |
US20050277611A1 (en) * | 2002-10-16 | 2005-12-15 | Neopharm, Inc. | Cationic cardiolipin analoges and its use thereof |
-
2004
- 2004-02-11 EA EA200501285A patent/EA200501285A1/ru unknown
- 2004-02-11 BR BR0407415-7A patent/BRPI0407415A/pt not_active Application Discontinuation
- 2004-02-11 JP JP2006503621A patent/JP2006517594A/ja active Pending
- 2004-02-11 CN CNA2004800011941A patent/CN1753657A/zh active Pending
- 2004-02-11 WO PCT/US2004/004555 patent/WO2004071466A2/en active Application Filing
- 2004-02-11 EP EP04710304A patent/EP1613284A2/en not_active Withdrawn
- 2004-02-11 MX MXPA05008489A patent/MXPA05008489A/es not_active Application Discontinuation
- 2004-02-11 KR KR1020057014387A patent/KR20050105455A/ko not_active Application Discontinuation
-
2005
- 2005-08-11 US US11/201,810 patent/US20060034908A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006517594A (ja) | 2006-07-27 |
BRPI0407415A (pt) | 2006-01-10 |
WO2004071466A3 (en) | 2004-12-02 |
CN1753657A (zh) | 2006-03-29 |
EA200501285A1 (ru) | 2006-02-24 |
US20060034908A1 (en) | 2006-02-16 |
EP1613284A2 (en) | 2006-01-11 |
WO2004071466A2 (en) | 2004-08-26 |
KR20050105455A (ko) | 2005-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |