EA200501285A1 - Способ получения липосомальных препаратов - Google Patents

Способ получения липосомальных препаратов

Info

Publication number
EA200501285A1
EA200501285A1 EA200501285A EA200501285A EA200501285A1 EA 200501285 A1 EA200501285 A1 EA 200501285A1 EA 200501285 A EA200501285 A EA 200501285A EA 200501285 A EA200501285 A EA 200501285A EA 200501285 A1 EA200501285 A1 EA 200501285A1
Authority
EA
Eurasian Patent Office
Prior art keywords
liposomal
methods
organic solvent
main
water
Prior art date
Application number
EA200501285A
Other languages
English (en)
Inventor
Зафир Ахмад
Имран Ахмад
Шастри Бхамидипати
Original Assignee
Неофарм, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Неофарм, Инк. filed Critical Неофарм, Инк.
Publication of EA200501285A1 publication Critical patent/EA200501285A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Данное изобретение представляет способы получения липосомальных препаратов. Согласно способам липидную фракцию растворяют в смешивающемся с водой органическом растворителе. Данный раствор, содержащий липидную фракцию, может быть добавлен и смешан с водным раствором в условиях формирования основного липосомального препарата. Желательно, когда препарат может включать один или более активных элементов. Основной липосомальный препарат может быть далее обработан, как требуется, например, путем фракционирования или уменьшения размера, удаления смешивающегося с водой органического растворителя, сублимационной сушки или другой обработки. Способы обеспечивают получение липосомальных препаратов на высоком или коммерческом уровне.Отчет о международном поиске был опубликован 2004.12.02.
EA200501285A 2003-02-11 2004-02-11 Способ получения липосомальных препаратов EA200501285A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44689503P 2003-02-11 2003-02-11
PCT/US2004/004555 WO2004071466A2 (en) 2003-02-11 2004-02-11 Manufacturing process for liposomal preparations

Publications (1)

Publication Number Publication Date
EA200501285A1 true EA200501285A1 (ru) 2006-02-24

Family

ID=32869567

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501285A EA200501285A1 (ru) 2003-02-11 2004-02-11 Способ получения липосомальных препаратов

Country Status (9)

Country Link
US (1) US20060034908A1 (ru)
EP (1) EP1613284A2 (ru)
JP (1) JP2006517594A (ru)
KR (1) KR20050105455A (ru)
CN (1) CN1753657A (ru)
BR (1) BRPI0407415A (ru)
EA (1) EA200501285A1 (ru)
MX (1) MXPA05008489A (ru)
WO (1) WO2004071466A2 (ru)

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US20080121733A1 (en) * 2006-11-29 2008-05-29 Donald Ackley Droplet generating device and method
US7824708B2 (en) * 2006-12-11 2010-11-02 Access Business Group International Llc Liposome containing cardiolipin for improvement of mitochondrial function
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CN101827613A (zh) 2007-09-27 2010-09-08 免疫疫苗技术有限公司 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
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US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
EP2368627A4 (en) * 2008-12-24 2015-01-14 Biomedcore Inc METHOD FOR MANUFACTURING LIPOSOME AND METHOD FOR DISSOLVING CHOLESTEROL
WO2010118200A2 (en) * 2009-04-08 2010-10-14 Brian Salvatore Liposomal formulations of tocopheryl amides
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
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CN103619325A (zh) * 2011-07-04 2014-03-05 国立血清研究所 用于生产脂质体的方法
CN103181898B (zh) * 2012-11-23 2016-03-09 杭州师范大学 一种奥沙利铂脂质体及其应用
JP2015193580A (ja) * 2014-03-31 2015-11-05 テルモ株式会社 アムホテリシンｂリポソームの製造方法
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US20180280300A1 (en) * 2015-10-07 2018-10-04 Ensuiko Sugar Refining Co., Ltd. Liposome including taxane compound
WO2017097197A1 (zh) * 2015-12-08 2017-06-15 正大天晴药业集团股份有限公司 美西替康的药物组合物
EP3388055B1 (en) * 2015-12-08 2021-11-17 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Method for preparing liposome
KR20200050982A (ko) 2017-09-04 2020-05-12 이치마루 화루코스 가부시키가이샤 pH 감수성 리포솜 및 그 제조 방법
WO2019191627A1 (en) * 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
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Also Published As

Publication number Publication date
WO2004071466A3 (en) 2004-12-02
WO2004071466A2 (en) 2004-08-26
EP1613284A2 (en) 2006-01-11
US20060034908A1 (en) 2006-02-16
JP2006517594A (ja) 2006-07-27
BRPI0407415A (pt) 2006-01-10
MXPA05008489A (es) 2005-10-18
CN1753657A (zh) 2006-03-29
KR20050105455A (ko) 2005-11-04

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