HUP0101026A2 - Parenterálisan alkalmazható, liposzóma alapú diszperziós eritropoietin készítmények - Google Patents

Parenterálisan alkalmazható, liposzóma alapú diszperziós eritropoietin készítmények

Info

Publication number
HUP0101026A2
HUP0101026A2 HU0101026A HUP0101026A HUP0101026A2 HU P0101026 A2 HUP0101026 A2 HU P0101026A2 HU 0101026 A HU0101026 A HU 0101026A HU P0101026 A HUP0101026 A HU P0101026A HU P0101026 A2 HUP0101026 A2 HU P0101026A2
Authority
HU
Hungary
Prior art keywords
erythropoietin
cholesterol
liposome
lecithin
derivatives
Prior art date
Application number
HU0101026A
Other languages
English (en)
Inventor
Sandro Delmenico
Frank-Ulrich Flöther
Rainer Näff
André Wetter
Original Assignee
Cilag Ag International
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Ag International filed Critical Cilag Ag International
Publication of HUP0101026A2 publication Critical patent/HUP0101026A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Abstract

A találmány etanolbefecskendezéses eljárással készült, kiválóstabilitású, parenterális adagolási formájú, liposzóma alapúdiszperziós eritropoietin készítményekre vonatkozik. A találmányszerinti, liposzóma alapú parenterális készítmények magukban foglalnak(a) hatásos mennyiségű, eritropoietinből vagy annak farmakológiaiszempontból elfogadható származékaiból álló hatóanyagot, amely olyanbiológiai tulajdonságokkal rendelkezik, hogy képes a csontvelősejtjeit a retikulociták és a vörösvérsejtek termelésének fokozásáraserkenteni; (b) egy olyan lipidfázist, amely (i) lecitinből vagyhidrogénezett lecitinből; (ii) adott esetben alkalmazott, pozitív vagynegatív elektromos töltésű lipidvegyületből; (iii) koleszterinből vagya koleszterin-észterek és a koleszterin polietilénglikollal képzettszármazékai közül kiválasztott vegyületből és (iv) 1-6 szénatomosrövid szénláncú alkoholt tartalmazó alkohol komponensből áll, valamint(c) egy foszfátos puffert. Ó
HU0101026A 1998-02-23 1999-02-12 Parenterálisan alkalmazható, liposzóma alapú diszperziós eritropoietin készítmények HUP0101026A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98103111A EP0937456B1 (en) 1998-02-23 1998-02-23 Erythropoietin liposomal dispersion
PCT/IB1999/000249 WO1999042085A1 (en) 1998-02-23 1999-02-12 Erythropoietin liposomal dispersion

Publications (1)

Publication Number Publication Date
HUP0101026A2 true HUP0101026A2 (hu) 2001-08-28

Family

ID=8231466

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101026A HUP0101026A2 (hu) 1998-02-23 1999-02-12 Parenterálisan alkalmazható, liposzóma alapú diszperziós eritropoietin készítmények

Country Status (23)

Country Link
US (2) US6645522B2 (hu)
EP (1) EP0937456B1 (hu)
JP (1) JP4613294B2 (hu)
KR (1) KR100591871B1 (hu)
CN (1) CN1184958C (hu)
AT (1) ATE271376T1 (hu)
AU (1) AU750481B2 (hu)
BR (1) BR9908202A (hu)
CA (1) CA2320072C (hu)
CZ (1) CZ296415B6 (hu)
DE (1) DE69825137T2 (hu)
DK (1) DK0937456T3 (hu)
ES (1) ES2224299T3 (hu)
HU (1) HUP0101026A2 (hu)
IL (2) IL137808A0 (hu)
NO (1) NO20004186L (hu)
NZ (1) NZ506429A (hu)
PL (1) PL194502B1 (hu)
PT (1) PT937456E (hu)
RU (1) RU2218914C2 (hu)
SI (1) SI0937456T1 (hu)
SK (1) SK284036B6 (hu)
WO (1) WO1999042085A1 (hu)

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SI0937456T1 (en) * 1998-02-23 2004-12-31 Cilag Ag International Erythropoietin liposomal dispersion
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
ES2280170T3 (es) * 1999-12-22 2007-09-16 Dade Behring Marburg Gmbh Soluciones de procalcitonina humana.
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
DE10219545A1 (de) * 2002-04-26 2003-11-06 Lang Florian Regulation der Apoptose
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
JP2004115397A (ja) * 2002-09-25 2004-04-15 Fuji Photo Film Co Ltd 血管疾患治療薬を含むリポソーム
PT1592416E (pt) * 2003-02-07 2009-04-03 Prometic Biosciences Inc Ácidos gordos, glicéridos e análogos com cadeia de comprimento médio como estimulantes da eritropoiese
US7465753B2 (en) 2003-07-17 2008-12-16 Otsuka Pharmaceutical Co., Ltd. Glycoside-containing liposome
AU2004277954A1 (en) * 2003-09-29 2005-04-14 The Kenneth S Warren Institute, Inc. Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
EP1537876A1 (en) * 2003-12-01 2005-06-08 BioGeneriX AG Erythropoietin solution formulation
WO2005115337A1 (en) * 2004-05-24 2005-12-08 Polymun Scientific Immunbiologische Forschung Gmbh Superloaded liposomes for drug delivery
KR100684380B1 (ko) 2005-05-24 2007-02-20 한국화학연구원 빗살형 폴리에틸렌글리콜을 결합한 리포솜 및 이의 제조방법
US9119782B2 (en) 2006-03-20 2015-09-01 Mary P. McCourt Drug delivery means
EP2120998B1 (en) 2006-11-28 2013-08-07 HanAll Biopharma Co., Ltd. Modified erythropoietin polypeptides and uses thereof for treatment
US20100310636A1 (en) * 2007-05-09 2010-12-09 Gita Sharma Stearically stabilized unilamilar vesicles, process for preparation thereof and use thereof
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
KR20130028967A (ko) * 2010-06-23 2013-03-20 브라잇사이드 이노베이션스 인크. 레시틴 캐리어 베시클 및 이의 제조 방법
EA018472B1 (ru) * 2010-09-15 2013-08-30 Открытое Акционерное Общество "Протек" Частицы, содержащие эритропоэтин, для лечения и профилактики неврологических и гематологических заболеваний и нарушений
MX2015011462A (es) 2013-03-14 2016-05-31 Jerome J Schentag Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones.
CN108066288A (zh) * 2014-01-03 2018-05-25 广州市鼍龙生物技术开发有限公司 一种鳄鱼油纳米脂质体及其制备方法
WO2015166988A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソームの製造方法
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
AU598002B2 (en) * 1986-07-15 1990-06-14 Cilag Ltd. Method of preparing single bilayered liposomes
JPH087219B2 (ja) 1992-04-27 1996-01-29 雪印乳業株式会社 リポソーム封入生理活性蛋白質の定量方法
JPH06228012A (ja) 1993-01-29 1994-08-16 Dai Ichi Seiyaku Co Ltd リポソーム製剤
CA2120197A1 (en) * 1993-04-02 1994-10-03 Kenji Endo Stable aqueous dispersions containing liposomes
US5874075A (en) * 1993-10-06 1999-02-23 Amgen Inc. Stable protein: phospholipid compositions and methods
US6214388B1 (en) * 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
JP3850468B2 (ja) * 1994-12-28 2006-11-29 中外製薬株式会社 エリスロポエチンのリポソーム製剤
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
SI0937456T1 (en) * 1998-02-23 2004-12-31 Cilag Ag International Erythropoietin liposomal dispersion

Also Published As

Publication number Publication date
US20020028236A1 (en) 2002-03-07
US6645522B2 (en) 2003-11-11
ES2224299T3 (es) 2005-03-01
CN1184958C (zh) 2005-01-19
BR9908202A (pt) 2000-10-24
CZ296415B6 (cs) 2006-03-15
PL342514A1 (en) 2001-06-18
AU2180899A (en) 1999-09-06
PL194502B1 (pl) 2007-06-29
EP0937456A1 (en) 1999-08-25
US20040052838A1 (en) 2004-03-18
CZ20002959A3 (cs) 2001-10-17
SK284036B6 (sk) 2004-08-03
DE69825137D1 (de) 2004-08-26
CN1298296A (zh) 2001-06-06
IL137808A0 (en) 2001-10-31
DK0937456T3 (da) 2004-11-08
JP2002503685A (ja) 2002-02-05
NO20004186D0 (no) 2000-08-22
ATE271376T1 (de) 2004-08-15
CA2320072C (en) 2009-04-07
AU750481B2 (en) 2002-07-18
SI0937456T1 (en) 2004-12-31
KR20010041152A (ko) 2001-05-15
SK12222000A3 (sk) 2001-11-06
NZ506429A (en) 2003-03-28
KR100591871B1 (ko) 2006-06-23
NO20004186L (no) 2000-08-22
WO1999042085A1 (en) 1999-08-26
CA2320072A1 (en) 1999-08-26
JP4613294B2 (ja) 2011-01-12
RU2218914C2 (ru) 2003-12-20
IL137808A (en) 2007-07-24
EP0937456B1 (en) 2004-07-21
DE69825137T2 (de) 2005-07-21
PT937456E (pt) 2004-10-29

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Legal Events

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished