HUP9801052A2 - Orális ciklosporin készítmények - Google Patents

Orális ciklosporin készítmények

Info

Publication number
HUP9801052A2
HUP9801052A2 HU9801052A HUP9801052A HUP9801052A2 HU P9801052 A2 HUP9801052 A2 HU P9801052A2 HU 9801052 A HU9801052 A HU 9801052A HU P9801052 A HUP9801052 A HU P9801052A HU P9801052 A2 HUP9801052 A2 HU P9801052A2
Authority
HU
Hungary
Prior art keywords
solvent
compositions according
preparations
oral cyclosporin
cyclosporin formulations
Prior art date
Application number
HU9801052A
Other languages
English (en)
Inventor
Moo J. Cho
Robert Floc'h
Ralph E. Levy
Christian Merle
Philippe J. Pouletty
Original Assignee
Sangstat Medical Corporation
University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/519,689 external-priority patent/US5834017A/en
Priority claimed from US08/620,021 external-priority patent/US5766629A/en
Priority claimed from US08/622,516 external-priority patent/US5827822A/en
Application filed by Sangstat Medical Corporation, University Of North Carolina At Chapel Hill filed Critical Sangstat Medical Corporation
Publication of HUP9801052A2 publication Critical patent/HUP9801052A2/hu
Publication of HUP9801052A3 publication Critical patent/HUP9801052A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány javítőtt tűlajdőnságú őrális ciklőspőrin készítményekrevőnatkőzik, melyek magas biőlógiai hasznősűlással rendelkeznek,alkalmasak kemény zselatin kapszűlában való adagőlásra, vagynanőrészecskék főrmájában állíthatók elő és alkalmazhatók. A találmányszerinti készítmények a ciklőspőrin mellett őrálisan alkalmazhatósegédanyagként legalább egy 2-3 szénatőmős alkanőlt mint őldószert, éslegalább egy nemiőnős felületaktív anyagőt tartalmaznak. A találmányszerinti készítmények tartalmazhatnak tővábbá legalább egytársőldószert, amely zsírsavészter és diől lehet. A találmány szerintikészítmények az imműszűppresszív terápiában alkalmazhatók. ŕ
HU9801052A 1995-08-25 1996-07-31 Oral cyclosporin formulations HUP9801052A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/519,689 US5834017A (en) 1995-08-25 1995-08-25 Oral cyclopsporin formulations
US08/620,021 US5766629A (en) 1995-08-25 1996-03-21 Oral cyclosporin formulations
US08/622,516 US5827822A (en) 1996-03-25 1996-03-25 Cyclosporin a formulations as nanoparticles

Publications (2)

Publication Number Publication Date
HUP9801052A2 true HUP9801052A2 (hu) 1998-09-28
HUP9801052A3 HUP9801052A3 (en) 1998-12-28

Family

ID=27414735

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801052A HUP9801052A3 (en) 1995-08-25 1996-07-31 Oral cyclosporin formulations

Country Status (27)

Country Link
EP (1) EP0789561B1 (hu)
JP (1) JP3009742B2 (hu)
KR (1) KR100294935B1 (hu)
CN (1) CN1164828A (hu)
AR (1) AR001985A1 (hu)
AT (1) ATE263550T1 (hu)
AU (1) AU709548B2 (hu)
BG (1) BG62875B1 (hu)
BR (1) BR9606603A (hu)
CA (1) CA2202887A1 (hu)
CZ (1) CZ124897A3 (hu)
DE (2) DE69632125T2 (hu)
ES (1) ES2129381T1 (hu)
GE (1) GEP20012547B (hu)
HK (1) HK1001956A1 (hu)
HU (1) HUP9801052A3 (hu)
IL (1) IL120673A0 (hu)
IS (1) IS4460A (hu)
MX (1) MX9702809A (hu)
NO (1) NO971890L (hu)
NZ (1) NZ313899A (hu)
PL (1) PL319898A1 (hu)
RO (1) RO119815B1 (hu)
SI (1) SI9620014A (hu)
SK (1) SK53697A3 (hu)
TW (1) TW460287B (hu)
WO (1) WO1997007787A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
HU228855B1 (en) * 1997-03-12 2013-06-28 Abbott Lab Hydrophilic binary systems for the administration of cyclosporine
AU748334B2 (en) 1997-10-16 2002-05-30 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with NF-AT3 function
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
AR036852A1 (es) * 2001-10-19 2004-10-06 Isotechnika Inc Preconcentrado de una microemulsion de analogos de ciclosporina, su metodo de preparacion y metodos para producir inmunosupresion
JP2010523554A (ja) 2007-04-04 2010-07-15 シグモイド・ファーマ・リミテッド タクロリムスの医薬組成物
ES2963291T3 (es) 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
CA2762179A1 (en) 2009-05-18 2010-11-25 Sigmoid Pharma Limited Composition comprising oil drops
IN2012DN00781A (hu) 2009-08-12 2015-06-26 Sigmoid Pharma Ltd
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
ES2858517T3 (es) 2014-11-07 2021-09-30 Sublimity Therapeutics Ltd Composiciones que comprenden ciclosporina
CN104940132B (zh) * 2015-06-05 2018-02-27 河南牧翔动物药业有限公司 一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
EP0589843B1 (en) * 1992-09-25 2001-11-28 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
RU2158601C2 (ru) * 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения

Also Published As

Publication number Publication date
BG62875B1 (bg) 2000-10-31
CA2202887A1 (en) 1997-03-06
DE69632125D1 (de) 2004-05-13
NO971890D0 (no) 1997-04-24
KR970706803A (ko) 1997-12-01
JP3009742B2 (ja) 2000-02-14
HK1001956A1 (en) 1998-07-24
EP0789561A1 (en) 1997-08-20
EP0789561B1 (en) 2004-04-07
DE789561T1 (de) 1999-06-10
HUP9801052A3 (en) 1998-12-28
EP0789561A4 (en) 1998-12-02
NO971890L (no) 1997-04-24
DE69632125T2 (de) 2004-09-16
BG101443A (en) 1998-03-31
IS4460A (is) 1997-04-08
AR001985A1 (es) 1998-01-07
TW460287B (en) 2001-10-21
MX9702809A (es) 1998-02-28
BR9606603A (pt) 1997-09-30
CZ124897A3 (en) 1997-09-17
RO119815B1 (ro) 2005-04-29
PL319898A1 (en) 1997-09-01
SI9620014A (sl) 1998-04-30
ATE263550T1 (de) 2004-04-15
AU709548B2 (en) 1999-09-02
SK53697A3 (en) 1997-10-08
IL120673A0 (en) 1997-08-14
JPH10509462A (ja) 1998-09-14
ES2129381T1 (es) 1999-06-16
NZ313899A (en) 2000-03-27
CN1164828A (zh) 1997-11-12
KR100294935B1 (ko) 2001-07-12
GEP20012547B (en) 2001-10-25
WO1997007787A1 (en) 1997-03-06
AU6644196A (en) 1997-03-19

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