AR001985A1 - Formulaciones de ciclosporina oral - Google Patents

Formulaciones de ciclosporina oral

Info

Publication number
AR001985A1
AR001985A1 ARP960104092A AR10409296A AR001985A1 AR 001985 A1 AR001985 A1 AR 001985A1 AR P960104092 A ARP960104092 A AR P960104092A AR 10409296 A AR10409296 A AR 10409296A AR 001985 A1 AR001985 A1 AR 001985A1
Authority
AR
Argentina
Prior art keywords
formulations
present formulations
oral cyclosporine
administered
cyclosporine formulations
Prior art date
Application number
ARP960104092A
Other languages
English (en)
Original Assignee
Sangstat Medical Corp
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/519,689 external-priority patent/US5834017A/en
Priority claimed from US08/620,021 external-priority patent/US5766629A/en
Priority claimed from US08/622,516 external-priority patent/US5827822A/en
Application filed by Sangstat Medical Corp, Univ North Carolina filed Critical Sangstat Medical Corp
Publication of AR001985A1 publication Critical patent/AR001985A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se presentan formulaciones orales de ciclosporina mejoradas que tienen alta biodisponibilidad y pueden ser administradas en cápsulas duras o ennanopartículas. En las presente formulaciones, se administra ciclosporina en un vehículo oralmente aceptable que comprende por lo menos un disolvente dealcanol de entre 2 y 3 átomos de carbono en combinación con por lo menos un surfactante no iónico. Las presentes formulaciones pueden comprender además porlo menos un codisolvente, incluyéndose entre los codisolventes de interés los ácidos grasos y dioles. Las presentes formulaciones se utilizan en terapia deinmunosupresión.
ARP960104092A 1995-08-25 1996-08-23 Formulaciones de ciclosporina oral AR001985A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/519,689 US5834017A (en) 1995-08-25 1995-08-25 Oral cyclopsporin formulations
US08/620,021 US5766629A (en) 1995-08-25 1996-03-21 Oral cyclosporin formulations
US08/622,516 US5827822A (en) 1996-03-25 1996-03-25 Cyclosporin a formulations as nanoparticles

Publications (1)

Publication Number Publication Date
AR001985A1 true AR001985A1 (es) 1998-01-07

Family

ID=27414735

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104092A AR001985A1 (es) 1995-08-25 1996-08-23 Formulaciones de ciclosporina oral

Country Status (27)

Country Link
EP (1) EP0789561B1 (es)
JP (1) JP3009742B2 (es)
KR (1) KR100294935B1 (es)
CN (1) CN1164828A (es)
AR (1) AR001985A1 (es)
AT (1) ATE263550T1 (es)
AU (1) AU709548B2 (es)
BG (1) BG62875B1 (es)
BR (1) BR9606603A (es)
CA (1) CA2202887A1 (es)
CZ (1) CZ124897A3 (es)
DE (2) DE69632125T2 (es)
ES (1) ES2129381T1 (es)
GE (1) GEP20012547B (es)
HK (1) HK1001956A1 (es)
HU (1) HUP9801052A3 (es)
IL (1) IL120673A0 (es)
IS (1) IS4460A (es)
MX (1) MX9702809A (es)
NO (1) NO971890D0 (es)
NZ (1) NZ313899A (es)
PL (1) PL319898A1 (es)
RO (1) RO119815B1 (es)
SI (1) SI9620014A (es)
SK (1) SK53697A3 (es)
TW (1) TW460287B (es)
WO (1) WO1997007787A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
IL131609A0 (en) * 1997-03-12 2001-01-28 Abbott Lab Hydrophilic binary systems for the administration of cyclosporine
JP2001520170A (ja) 1997-10-16 2001-10-30 ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム Ｎｆ−ａｔ３機能に関連した心肥大動物モデルと治療法
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
MY145753A (en) * 2001-10-19 2012-03-30 Isotechnika Inc Novel cyclosporin analog formulations
ES2393814T3 (es) 2007-04-04 2012-12-28 Sigmoid Pharma Limited Una composición farmacéutica oral
WO2008132707A1 (en) 2007-04-26 2008-11-06 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
DK2471518T3 (en) 2009-05-18 2017-12-04 Sigmoid Pharma Ltd COMPOSITION INCLUDING OIL DROPS
IN2012DN00781A (es) 2009-08-12 2015-06-26 Sigmoid Pharma Ltd
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP3881829A1 (en) 2014-11-07 2021-09-22 Sublimity Therapeutics Limited Compositions comprising cyclosporin
CN104940132B (zh) * 2015-06-05 2018-02-27 河南牧翔动物药业有限公司 一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
EP1142568A1 (en) * 1992-09-25 2001-10-10 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
RU2158601C2 (ru) * 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения

Also Published As

Publication number Publication date
KR100294935B1 (ko) 2001-07-12
IL120673A0 (en) 1997-08-14
SK53697A3 (en) 1997-10-08
NO971890L (no) 1997-04-24
BG62875B1 (bg) 2000-10-31
HUP9801052A3 (en) 1998-12-28
CA2202887A1 (en) 1997-03-06
PL319898A1 (en) 1997-09-01
EP0789561A4 (en) 1998-12-02
WO1997007787A1 (en) 1997-03-06
DE69632125T2 (de) 2004-09-16
NZ313899A (en) 2000-03-27
JPH10509462A (ja) 1998-09-14
DE69632125D1 (de) 2004-05-13
SI9620014A (sl) 1998-04-30
HUP9801052A2 (hu) 1998-09-28
EP0789561A1 (en) 1997-08-20
HK1001956A1 (en) 1998-07-24
IS4460A (is) 1997-04-08
CN1164828A (zh) 1997-11-12
AU6644196A (en) 1997-03-19
DE789561T1 (de) 1999-06-10
NO971890D0 (no) 1997-04-24
ES2129381T1 (es) 1999-06-16
JP3009742B2 (ja) 2000-02-14
BR9606603A (pt) 1997-09-30
EP0789561B1 (en) 2004-04-07
GEP20012547B (en) 2001-10-25
MX9702809A (es) 1998-02-28
ATE263550T1 (de) 2004-04-15
AU709548B2 (en) 1999-09-02
BG101443A (en) 1998-03-31
KR970706803A (ko) 1997-12-01
CZ124897A3 (en) 1997-09-17
TW460287B (en) 2001-10-21
RO119815B1 (ro) 2005-04-29

Similar Documents

Publication Publication Date Title
AR001985A1 (es) Formulaciones de ciclosporina oral
AR013710A1 (es) Formulaciones orales de ciclosporina
US10456474B2 (en) Cyclosporin compositions
JP4086501B2 (ja) シリビンを含有する経口用マイクロエマルジョン組成物
HUP0101080A2 (hu) Ciklosporint vagy egy makrolidet tartalmazó emulzió előkoncentrátumok
ES2154661T3 (es) Preparados liquidos que contienen cyclosporin y procedimiento para su obtencion.
EE03425B1 (et) Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod
HUP0400566A2 (hu) Mátrixon diszpergált hatóanyagot tartalmazó gyógyászati készítmény
CA2166204A1 (en) Pharmaceutical compositions for sparingly soluble therapeutic agents
ES2020738A6 (es) Composiciones farmaceuticas comprendiendo ciclosporinas.
DE69804624D1 (de) Selbstemulgierende formulierung enthaltend lipophile verbindungen
NO328722B1 (no) Farmasoytiske sammensetninger, i form av selvemulgerende prekonsentrater, som inneholder en omega-3-fettsyreolje, mikroemulsjon eller farmasoytisk sammensetning i form av mikroemulsjon samt hard- eller blotgelkapselformulering.
CA2294031A1 (en) SELF-EMULSIFYING FORMULATION FOR LIPOPHILIC COMPOUNDS
RU99113343A (ru) Лекарственные формы циклоспорина для перорального введения
DE60132103T2 (de) Perorale, selbst-emulgierende darreichungsformen von pyranon-proteaseinhibitoren
EA200200415A1 (ru) Композиция фармацевтического носителя
EP0372527B1 (en) Topical compositions containing diclofenac
DE69732109D1 (de) Pharmazeutische zusammensetzungen die ein alkylaryl polyether alkohol polymer enthalten
HUP0004362A2 (hu) Karbamazepint vagy származékait tartalmazó parenterális készítmények
JPS5679626A (en) Semi-solid medicine
ES2141049A1 (es) Formulaciones farmaceuticas en aerosol que contienen trigliceridos de cadena media como surfactantes.
GR900100076A (en) Preparation method of novel pharmaceutical forms of cyclosporine