AR013710A1 - Formulaciones orales de ciclosporina - Google Patents
Formulaciones orales de ciclosporinaInfo
- Publication number
- AR013710A1 AR013710A1 ARP980105274A ARP980105274A AR013710A1 AR 013710 A1 AR013710 A1 AR 013710A1 AR P980105274 A ARP980105274 A AR P980105274A AR P980105274 A ARP980105274 A AR P980105274A AR 013710 A1 AR013710 A1 AR 013710A1
- Authority
- AR
- Argentina
- Prior art keywords
- formulations
- cyclosporine
- administered
- oral administration
- oral cyclosporine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/42—Nature of the water, waste water, sewage or sludge to be treated from bathing facilities, e.g. swimming pools
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2201/00—Apparatus for treatment of water, waste water or sewage
- C02F2201/008—Mobile apparatus and plants, e.g. mounted on a vehicle
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2301/00—General aspects of water treatment
- C02F2301/04—Flow arrangements
- C02F2301/046—Recirculation with an external loop
Abstract
Se proveen formulaciones mejoradas para administracion oral de ciclosporina que tienen una gran biodisponibilidad y pueden ser administradas tanto en formalíquida como en cápsulas. En las formulaciones de la invencion, se administra ciclosporina enun vehículo aceptable para administracion oral que comprende almenos un solvente de alcanol de entre 2 y 3 átomos de carbono, combinado al menos con un agente tensoactivo no ionico. Las formulaciones de la invencionpueden comprender además al menos un cosolvente, y los cosolventes de interés incluyen ácidos grasos y dioles. Las formulaciones de la invencion se utilizanen una terapia inmunosupresora.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/956,841 US5962019A (en) | 1995-08-25 | 1997-10-23 | Oral cyclosporin formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
AR013710A1 true AR013710A1 (es) | 2001-01-10 |
Family
ID=25498759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980105274A AR013710A1 (es) | 1997-10-23 | 1998-10-22 | Formulaciones orales de ciclosporina |
Country Status (20)
Country | Link |
---|---|
US (1) | US5962019A (es) |
EP (1) | EP0956035A1 (es) |
JP (1) | JP2000516267A (es) |
KR (1) | KR20000069688A (es) |
CN (1) | CN1246057A (es) |
AR (1) | AR013710A1 (es) |
AU (1) | AU9810698A (es) |
BR (1) | BR9806271A (es) |
CA (1) | CA2275773A1 (es) |
HU (1) | HUP0004733A3 (es) |
IL (1) | IL130631A0 (es) |
NO (1) | NO993096L (es) |
NZ (1) | NZ336253A (es) |
PL (1) | PL334100A1 (es) |
RU (1) | RU2174405C2 (es) |
SK (1) | SK97199A3 (es) |
TR (1) | TR199901448T1 (es) |
TW (1) | TW592707B (es) |
WO (1) | WO1999020296A1 (es) |
ZA (1) | ZA989684B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
RU2211047C2 (ru) | 1997-01-30 | 2003-08-27 | Новартис Аг | Желатиновые капсулы с твердым покрытием, включающие фармацевтические композиции, практически не содержащие масел |
ATE404172T1 (de) | 1998-12-30 | 2008-08-15 | Dexcel Ltd | Dispergierbares konzentrat zur verabreichung von cyclosporin |
US6057289A (en) * | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
ES2241663T3 (es) * | 1999-09-21 | 2005-11-01 | Skyepharma Canada Inc. | Composiciones particuladas modificadas superficialmente de substancias biologicamente activas. |
ATE470447T1 (de) | 1999-12-08 | 2010-06-15 | Cyclacel Pharmaceuticals Inc | Depsipetid und kongenere davon für den einsatz als immunsuppressiva zur vorbeugung und behandlung von abstossreaktionen infolge einer transplantation und zur induktion des apoptosis in aktivierten cd4 oder cd8 t-zellen |
US6828302B1 (en) | 1999-12-08 | 2004-12-07 | Xcyte Therapies, Inc. | Therapeutic uses of depsipeptides and congeners thereof |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6960563B2 (en) * | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
EP1435910B9 (en) * | 2001-10-19 | 2010-02-03 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
US7282194B2 (en) * | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
CN101171000A (zh) * | 2005-04-12 | 2008-04-30 | 依兰药物国际有限公司 | 包含环孢菌素的毫微粒和控制释放组合物 |
US20070015693A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
US7297679B2 (en) | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
US7202209B2 (en) | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
US7288520B2 (en) | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
US7276476B2 (en) * | 2005-07-13 | 2007-10-02 | Allergan, Inc. | Cyclosporin compositions |
US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
US7745400B2 (en) * | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
ES2530637T3 (es) * | 2006-03-02 | 2015-03-04 | Alexion Pharma Inc | Prolongación de la supervivencia de un aloinjerto por inhibición de la actividad del complemento |
CN101032620B (zh) * | 2007-03-08 | 2010-05-19 | 上海凯昭医药科技有限公司 | 一种环孢素自乳化制剂及其制备方法 |
JP2010522774A (ja) * | 2007-03-30 | 2010-07-08 | フォベア、ファルマスティカル、ソシエテ、アノニム | 血管新生眼疾患を治療するための方法 |
AU2008309923B2 (en) * | 2007-10-08 | 2014-04-03 | Fovea Pharmaceuticals | Aqueous ophthalmic formulations |
US20180177879A1 (en) * | 2015-06-05 | 2018-06-28 | Maruho Co., Ltd | External preparation for transdermal administration |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US506219A (en) * | 1893-10-10 | Steam-cooker | ||
US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
FI65914C (fi) * | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
GB8305693D0 (en) * | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5118493A (en) * | 1986-05-02 | 1992-06-02 | Brigham And Women's Hospital | Composition having reduced nephrotoxocity comprising a fatty acid containing component and cyclosporine |
NL194638C (nl) * | 1986-12-19 | 2002-10-04 | Novartis Ag | Hydrosol die vaste deeltjes van een farmaceutisch actieve stof bevat en farmaceutisch preparaat dat deze hydrosol bevat. |
US4792449A (en) * | 1987-01-28 | 1988-12-20 | Baxter Travenol Laboratories, Inc. | Method for drug administration |
US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
KR880012221A (ko) * | 1987-04-13 | 1988-11-26 | 사노 가즈오 | 에스테르 또는 아미드를 활성성분으로 함유하는 약제 조성물 |
JP2577049B2 (ja) * | 1987-06-04 | 1997-01-29 | 三共株式会社 | シクロスポリン製剤 |
HU205010B (en) * | 1987-09-15 | 1992-03-30 | Sandoz Ag | Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity |
GB8729153D0 (en) * | 1987-12-14 | 1988-01-27 | Efamol Ltd | Fatty acid compositions |
HU203564B (en) * | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
AU609242B2 (en) * | 1988-01-29 | 1991-04-26 | Novartis Ag | Cyclosporin compositions |
HU201567B (en) * | 1988-07-21 | 1990-11-28 | Gyogyszerkutato Intezet | Process for production of intravenous medical compositions containing cyclosphorin |
US5350741A (en) * | 1988-07-30 | 1994-09-27 | Kanji Takada | Enteric formulations of physiologically active peptides and proteins |
US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
FR2638089A1 (fr) * | 1988-10-26 | 1990-04-27 | Sandoz Sa | Nouvelles compositions ophtalmiques a base d'une cyclosporine |
CH679277A5 (es) * | 1989-02-09 | 1992-01-31 | Sandoz Ag | |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
AU654483B2 (en) * | 1990-04-18 | 1994-11-10 | University Of Utah Research Foundation | Crosslinked hydrogels containing azobonds |
JPH04253907A (ja) * | 1990-05-23 | 1992-09-09 | Green Cross Corp:The | 静脈注射用免疫抑制剤 |
US5393791A (en) * | 1990-07-19 | 1995-02-28 | Helena Chemical Company | Homogeneous, essentially nonaqueous adjuvant compositions with buffering capability |
HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
US5122383A (en) * | 1991-05-17 | 1992-06-16 | Theratech, Inc. | Sorbitan esters as skin permeation enhancers |
MX9201782A (es) * | 1991-04-19 | 1992-10-01 | Sandoz Ag | Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene. |
IL102236A0 (en) * | 1991-06-27 | 1993-01-14 | Ltt Inst Co Ltd | Topical preparations containing cyclosporin |
JPH0558906A (ja) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | シクロスポリン点眼製剤 |
GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
IT1260505B (it) * | 1992-06-01 | 1996-04-09 | Poli Ind Chimica Spa | Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon |
PT589843E (pt) * | 1992-09-25 | 2002-04-29 | Novartis Ag | Composicoes farmaceuticas contendo ciclosporinas |
PT697881E (pt) * | 1993-04-20 | 2002-10-31 | Novartis Ag | Novas composicoes farmaceuticas contendo ciclosporina para administracao oral |
CN1077800C (zh) * | 1993-07-01 | 2002-01-16 | 韩美药品工业株式会社 | 环孢菌素软胶囊组合物 |
DE4329503A1 (de) * | 1993-09-01 | 1995-03-02 | Galenik Labor Freiburg Gmbh | Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa |
DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
KR0146671B1 (ko) * | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
PT789580E (pt) * | 1994-11-03 | 2002-09-30 | Novartis Ag | Formulacoes de ciclosporina para administracao oral com composicao simples e alta biodisponibilidade e processo para a sua producao |
HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
KR0167613B1 (ko) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
AU709548B2 (en) * | 1995-08-25 | 1999-09-02 | Sangstat Medical Corporation | Oral cyclosporin formulations |
NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
HU228855B1 (en) * | 1997-03-12 | 2013-06-28 | Abbott Lab | Hydrophilic binary systems for the administration of cyclosporine |
-
1997
- 1997-10-23 US US08/956,841 patent/US5962019A/en not_active Expired - Fee Related
-
1998
- 1998-10-21 KR KR1019997005738A patent/KR20000069688A/ko active IP Right Grant
- 1998-10-21 HU HU0004733A patent/HUP0004733A3/hu unknown
- 1998-10-21 WO PCT/US1998/022330 patent/WO1999020296A1/en not_active Application Discontinuation
- 1998-10-21 CN CN98801568A patent/CN1246057A/zh active Pending
- 1998-10-21 EP EP98952393A patent/EP0956035A1/en not_active Withdrawn
- 1998-10-21 RU RU99113343/14A patent/RU2174405C2/ru active
- 1998-10-21 JP JP11524568A patent/JP2000516267A/ja active Pending
- 1998-10-21 BR BR9806271-9A patent/BR9806271A/pt not_active IP Right Cessation
- 1998-10-21 TR TR1999/01448T patent/TR199901448T1/xx unknown
- 1998-10-21 NZ NZ336253A patent/NZ336253A/en unknown
- 1998-10-21 AU AU98106/98A patent/AU9810698A/en not_active Abandoned
- 1998-10-21 SK SK97199A patent/SK97199A3/sk unknown
- 1998-10-21 PL PL98334100A patent/PL334100A1/xx unknown
- 1998-10-21 CA CA002275773A patent/CA2275773A1/en not_active Abandoned
- 1998-10-21 IL IL13063198A patent/IL130631A0/xx unknown
- 1998-10-21 TW TW087117445A patent/TW592707B/zh active
- 1998-10-22 AR ARP980105274A patent/AR013710A1/es not_active Application Discontinuation
- 1998-10-23 ZA ZA989684A patent/ZA989684B/xx unknown
-
1999
- 1999-06-22 NO NO993096A patent/NO993096L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1246057A (zh) | 2000-03-01 |
US5962019A (en) | 1999-10-05 |
RU2174405C2 (ru) | 2001-10-10 |
SK97199A3 (en) | 2004-10-05 |
NZ336253A (en) | 2001-06-29 |
HUP0004733A3 (en) | 2001-12-28 |
JP2000516267A (ja) | 2000-12-05 |
ZA989684B (en) | 1999-04-25 |
NO993096D0 (no) | 1999-06-22 |
WO1999020296A1 (en) | 1999-04-29 |
HUP0004733A2 (hu) | 2001-05-28 |
TR199901448T1 (xx) | 1999-12-21 |
PL334100A1 (en) | 2000-01-31 |
TW592707B (en) | 2004-06-21 |
CA2275773A1 (en) | 1999-04-29 |
AU9810698A (en) | 1999-05-10 |
EP0956035A1 (en) | 1999-11-17 |
NO993096L (no) | 1999-08-17 |
IL130631A0 (en) | 2000-06-01 |
KR20000069688A (ko) | 2000-11-25 |
BR9806271A (pt) | 2000-04-04 |
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