AR012627A1 - Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado - Google Patents

Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado

Info

Publication number
AR012627A1
AR012627A1 ARP980102004A ARP980102004A AR012627A1 AR 012627 A1 AR012627 A1 AR 012627A1 AR P980102004 A ARP980102004 A AR P980102004A AR P980102004 A ARP980102004 A AR P980102004A AR 012627 A1 AR012627 A1 AR 012627A1
Authority
AR
Argentina
Prior art keywords
concentrate
emulsion
solvent
cyclosporine
lipophilic
Prior art date
Application number
ARP980102004A
Other languages
English (en)
Original Assignee
Sherman Bernard Charles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NZ314702A external-priority patent/NZ314702A/en
Application filed by Sherman Bernard Charles filed Critical Sherman Bernard Charles
Publication of AR012627A1 publication Critical patent/AR012627A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones farmacéuticas con la forma de un pre-concentrado de emulsion o preconcentrado de microemulsion que comprenden a una ciclosporina comoingrediente activo, un monoglicérido acetilado como solvente lipofílico, un surfactante y opcionalmente, un solvente hidrofílico. Se ha descubiertoinesperadamente que estas ventajas pueden lograrse y que pueden solucionar los inconvenientes de la técnica anterior usando como solvente lipofílico a losmonoglicéridos acetilados. Los monoglicéridos acetilados no son caros y exhiben propiedades ideales para usar como solvente lipofílico (hidrofobico) en lospre-concentrados de emulsion de ciclosporina.
ARP980102004A 1997-04-29 1998-04-29 Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado AR012627A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ314702A NZ314702A (en) 1997-04-29 1997-04-29 Pharmaceutical composition comprising a cyclosporin in a solvent system of acetylated monoglycerides and a surfactant and optionally a hydrophilic solvent

Publications (1)

Publication Number Publication Date
AR012627A1 true AR012627A1 (es) 2000-11-08

Family

ID=19926224

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102004A AR012627A1 (es) 1997-04-29 1998-04-29 Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado

Country Status (3)

Country Link
US (2) US6258783B1 (es)
AR (1) AR012627A1 (es)
CA (1) CA2285983A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145753A (en) * 2001-10-19 2012-03-30 Isotechnika Inc Novel cyclosporin analog formulations
JP2005513096A (ja) * 2001-12-20 2005-05-12 チャールズ シャーマン，バーナード シクロスポリン、親水性界面活性剤及び親油性界面活性剤を含んで成る医薬組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB9113872D0 (en) 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
EP1142568A1 (en) 1992-09-25 2001-10-10 Novartis AG Pharmaceutical compositions containing cyclosporins
IT1256386B (it) 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
NZ247516A (en) 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
KR0167613B1 (ko) * 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
GB9514878D0 (en) 1995-07-20 1995-09-20 Danbiosyst Uk Vitamin E as a solubilizer for drugs contained in lipid vehicles
NZ280689A (en) 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
KR980008239A (ko) * 1996-07-26 1998-04-30 김충환 사이클로스포린-함유 약학적 조성물
PT946145E (pt) * 1996-12-20 2008-10-17 Mcneil Ppc Inc Fármacos antitússicos libertados por resinas de troca iónica

Also Published As

Publication number Publication date
US6258783B1 (en) 2001-07-10
US20010027178A1 (en) 2001-10-04
CA2285983A1 (en) 1998-11-05

Similar Documents

Publication Publication Date Title
MXPA05013278A (es) Composiciones farmaceuticas que comprenden compuestos activos de vitamina d.
DK0597007T3 (da) V/O mikroemulsioner
BR9808656A (pt) Sistemas binários hidrofìlicos para a administração de ciclosporina
PE20080141A1 (es) Sistemas estables de nanocapsulas para la administracion de moleculas activas
DK1289502T3 (da) Mikroemulsionsprækoncentrat, mikroemulsion og anvendelse af en sammensætning
ATE554750T1 (de) Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
AU7912598A (en) Biphasic multicomponent pharmaceutical dosage forms containing substanc es able to modify the partitioning of drugs
WO2007018943A3 (en) Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
ECSP083351A (es) Composiciones farmacéuticas
DE19581805T1 (de) Pharmazeutische Zusammensetzungen
DE69823663D1 (de) Selbstemulgierbare formulierung enthaltend lipophile verbindungen
MX9204382A (es) Composiciones
NO20024737D0 (no) Farmasöytiske preparater og fremstilling derav
BRPI0510694A (pt) composições farmacêuticas compreendendo ingredientes ativos concentrados encapsuladas em gelatina mole
BR9809708A (pt) Composições farmacêuticas de peptìdeos tendo solubilidade baixa em meio fisiológico
BR9713811A (pt) Preparações de cápsula macia contendo ciclosporina
DE60131432D1 (de) Hiv-peptide aus tat-, rev- und wef-konservierten regionen und deren anwendung z.b. als impfstoffkomponenten
AR012627A1 (es) Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado
AR011682A1 (es) UN MÉTODO PARA LA PREPARACIoN DE UNA COMPOSICIoN FARMACÉUTICA ACUOSA CON UN INGREDIENTE ACTIVO QUE TIENE UNA SOLUBILIDAD EN AGUA NO MAYOR QUE 0,01% (P/V) QUE ESTÁ DISPERSO EN LIPOSOMAS
DE69933671D1 (de) Adenosin a1 antagonisten gegen männliche sterilität
FR2806624B1 (fr) Systeme huile silicone/co-solvant concentre en matiere(s) active(s) cosmetique(s) liposoluble(s), emulsion et formulation cosmetiques correspondantes
ECSP951565A (es) Composiciones farmaceuticas
UY25945A1 (es) Composiciones farmacéuticas conteniendo ciclosporinas
UY25958A1 (es) Procedimiento para preparar hidrosoles con ciclosporinas y composiciones farmaceuticas que la contienen