HUP0101080A2 - Ciklosporint vagy egy makrolidet tartalmazó emulzió előkoncentrátumok - Google Patents
Ciklosporint vagy egy makrolidet tartalmazó emulzió előkoncentrátumokInfo
- Publication number
- HUP0101080A2 HUP0101080A2 HU0101080A HUP0101080A HUP0101080A2 HU P0101080 A2 HUP0101080 A2 HU P0101080A2 HU 0101080 A HU0101080 A HU 0101080A HU P0101080 A HUP0101080 A HU P0101080A HU P0101080 A2 HUP0101080 A2 HU P0101080A2
- Authority
- HU
- Hungary
- Prior art keywords
- ester
- mono
- fatty acid
- fatty acids
- carbon
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108010036949 Cyclosporine Proteins 0.000 title abstract 2
- 229960001265 ciclosporin Drugs 0.000 title abstract 2
- 239000000839 emulsion Substances 0.000 title abstract 2
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 6
- 239000000194 fatty acid Substances 0.000 abstract 6
- 229930195729 fatty acid Natural products 0.000 abstract 6
- 150000002148 esters Chemical class 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- -1 carbon fatty acid Chemical class 0.000 abstract 3
- 150000004665 fatty acids Chemical class 0.000 abstract 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 abstract 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 2
- 235000010935 mono and diglycerides of fatty acids Nutrition 0.000 abstract 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 abstract 2
- 239000001069 triethyl citrate Substances 0.000 abstract 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 abstract 2
- 235000013769 triethyl citrate Nutrition 0.000 abstract 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 235000013773 glyceryl triacetate Nutrition 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229960002622 triacetin Drugs 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány olyan, orális beadásra szolgáló, emulzió előkoncentrátumformájában lévő antirivális kompozíciókra vonatkozik, amelyek akövetkező összetevőket tartalmazzák: 1.) egy ciklosporin vagymakrolid, és a következő komponenseket tartalmazó hordozóközeg: 2.)egy második komponens a következő csoportból kiválasztva: (i) trietil-citrát vagy acetil-trietil-citrát, (ii) polietilénglikol-gliceril-(6-10 szénatomos zsírsav)-észter, (iii) gliceril-di(6-16 szénatomoszsírsav)-észter, (iv) gliceril-mono(6-14 szénatomos zsírsav)-észter,(v) 6-16 szénatomos zsírsavak mono-, digliceridjeinek keveréke, (vi)propilénglikol-mono(6-12 szénatomos zsírsav)-észter, (vii) zsírsavakés zsíralkoholok, (viii) N-metil-pirrolidon, (ix) glicerin-triacetát,(x) benzil-alkohol, és (xi) alkilén-poliol-éter vagy -észter, 3.) egylipofil komponens, és 4.) egy felületaktív anyag, azzal a megkötéssel,hogy ha a 2.) komponens (a) trietil-citrátból áll, akkor a kompozícióetanoltól mentes vagy lényegében mentes, és/vagy (b) 8-10 szénatomoszsírsavak mono-, digliceridjeinek a keverékéből áll, akkor akompozíció (6-12 szénatomos zsírsav)-trigliceridtől mentes vagylényegében mentes. Ó
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9804742.6A GB9804742D0 (en) | 1998-03-06 | 1998-03-06 | Organic compounds |
GBGB9805104.8A GB9805104D0 (en) | 1998-03-10 | 1998-03-10 | Organic compounds |
GBGB9805199.8A GB9805199D0 (en) | 1998-03-11 | 1998-03-11 | Organic compounds |
PCT/EP1999/001415 WO1999044584A1 (en) | 1998-03-06 | 1999-03-04 | Emulsion preconcentrates containing cyclosporin or a macrolide |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101080A2 true HUP0101080A2 (hu) | 2001-08-28 |
HUP0101080A3 HUP0101080A3 (en) | 2001-12-28 |
Family
ID=27269231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101080A HUP0101080A3 (en) | 1998-03-06 | 1999-03-04 | Emulsion preconcentrates containing cyclosporin or a macrolide |
Country Status (30)
Country | Link |
---|---|
EP (2) | EP1059913B1 (hu) |
JP (2) | JP2002505271A (hu) |
KR (1) | KR100443306B1 (hu) |
CN (1) | CN1195495C (hu) |
AR (1) | AR015729A1 (hu) |
AT (1) | ATE277599T1 (hu) |
AU (1) | AU749217B2 (hu) |
BE (3) | BE1012400A5 (hu) |
BR (1) | BR9908597A (hu) |
CA (1) | CA2322845C (hu) |
CO (1) | CO4930289A1 (hu) |
CZ (1) | CZ301967B6 (hu) |
DE (2) | DE69920668T2 (hu) |
ES (1) | ES2228014T3 (hu) |
FR (4) | FR2775596B1 (hu) |
GB (1) | GB2350791B (hu) |
HK (2) | HK1034038A1 (hu) |
HU (1) | HUP0101080A3 (hu) |
ID (1) | ID25908A (hu) |
IL (2) | IL138248A0 (hu) |
IT (1) | IT1313550B1 (hu) |
MY (1) | MY129274A (hu) |
NO (1) | NO331800B1 (hu) |
NZ (1) | NZ506644A (hu) |
PE (1) | PE20000324A1 (hu) |
PT (1) | PT1059913E (hu) |
SK (1) | SK285139B6 (hu) |
TR (1) | TR200002586T2 (hu) |
TW (3) | TWI248368B (hu) |
WO (1) | WO1999044584A1 (hu) |
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PT1154759E (pt) * | 1998-12-30 | 2008-11-20 | Dexcel Ltd | Concentrado dispersível para administração de ciclosporina |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
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WO2001032143A1 (en) * | 1999-11-02 | 2001-05-10 | Cipla Ltd. | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and a process for preparation thereof |
GB2362573A (en) * | 2000-05-25 | 2001-11-28 | Cipla Ltd | Cyclosporin formulation |
EP1227793A1 (en) * | 1999-11-02 | 2002-08-07 | Cipla Ltd. | Cyclosporin formulation |
GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
WO2003002095A1 (fr) * | 2001-06-28 | 2003-01-09 | Chugai Seiyaku Kabushiki Kaisha | Preparation d'une micro-emulsion de type huile-eau |
US6960563B2 (en) | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
GB2391471B (en) * | 2002-08-02 | 2005-05-04 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
KR20040047056A (ko) * | 2002-11-29 | 2004-06-05 | 한미약품 주식회사 | 비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물 |
US8802116B2 (en) | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
KR20040084240A (ko) * | 2003-03-27 | 2004-10-06 | (주) 코스메디 | 고형지질나노입자, 이를 함유하는 활성성분 전달용약학조성물 및 이의 제조방법 |
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MX2007005124A (es) * | 2004-10-29 | 2007-06-22 | Novartis Ag | Composiciones farmaceuticas espontaneamente dispersables. |
CN101141953A (zh) | 2005-03-21 | 2008-03-12 | 伊瓦克斯制药有限公司 | 结晶抑制剂及其在明胶胶囊中的用途 |
CN101032620B (zh) * | 2007-03-08 | 2010-05-19 | 上海凯昭医药科技有限公司 | 一种环孢素自乳化制剂及其制备方法 |
US20090130198A1 (en) * | 2007-11-21 | 2009-05-21 | Innopharmax Inc. | Pharmaceutical composition with enhanced bioavailability |
EP2268274B1 (en) | 2008-03-20 | 2012-05-16 | Virun, Inc. | Vitamin e derivatives and their uses |
US8282977B2 (en) | 2008-03-20 | 2012-10-09 | Virun, Inc. | Compositions containing non-polar compounds |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
JP5567909B2 (ja) * | 2010-06-17 | 2014-08-06 | 東洋カプセル株式会社 | タクロリムス含有カプセル剤 |
US8741373B2 (en) | 2010-06-21 | 2014-06-03 | Virun, Inc. | Compositions containing non-polar compounds |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
JO3337B1 (ar) | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
JP5717034B2 (ja) * | 2012-08-27 | 2015-05-13 | 丸和バイオケミカル株式会社 | マクロライド系化合物を含有する土壌線虫防除用薬剤 |
KR101458466B1 (ko) * | 2013-06-24 | 2014-11-07 | 한국화학연구원 | 면역억제제가 봉입된 마이셀을 함유하는 경구제 |
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US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
WO2017048807A1 (en) | 2015-09-17 | 2017-03-23 | Jrx Biotechnology, Inc. | Approaches for improving skin hydration or moisturization |
WO2018098501A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
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HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
KR970064620A (ko) * | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
KR980008239A (ko) * | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
EP1039893B1 (en) * | 1997-12-10 | 2011-02-02 | Cyclosporine Therapeutics Limited | Pharmaceutical compositions containing an omega-3 fatty acid oil |
-
1998
- 1998-10-16 ID IDW20001708A patent/ID25908A/id unknown
-
1999
- 1999-03-04 BR BR9908597-6A patent/BR9908597A/pt not_active IP Right Cessation
- 1999-03-04 FR FR9902748A patent/FR2775596B1/fr not_active Expired - Fee Related
- 1999-03-04 WO PCT/EP1999/001415 patent/WO1999044584A1/en active Application Filing
- 1999-03-04 KR KR10-2000-7009861A patent/KR100443306B1/ko not_active IP Right Cessation
- 1999-03-04 PT PT99908952T patent/PT1059913E/pt unknown
- 1999-03-04 AU AU28361/99A patent/AU749217B2/en not_active Ceased
- 1999-03-04 CZ CZ20003222A patent/CZ301967B6/cs not_active IP Right Cessation
- 1999-03-04 IL IL13824899A patent/IL138248A0/xx active IP Right Grant
- 1999-03-04 JP JP2000534187A patent/JP2002505271A/ja not_active Withdrawn
- 1999-03-04 CN CNB99803746XA patent/CN1195495C/zh not_active Expired - Fee Related
- 1999-03-04 EP EP99908952A patent/EP1059913B1/en not_active Revoked
- 1999-03-04 BE BE9900153A patent/BE1012400A5/fr not_active IP Right Cessation
- 1999-03-04 CA CA002322845A patent/CA2322845C/en not_active Expired - Fee Related
- 1999-03-04 DE DE69920668T patent/DE69920668T2/de not_active Expired - Lifetime
- 1999-03-04 AR ARP990100910A patent/AR015729A1/es not_active Application Discontinuation
- 1999-03-04 DE DE19983012T patent/DE19983012T1/de not_active Withdrawn
- 1999-03-04 ES ES99908952T patent/ES2228014T3/es not_active Expired - Lifetime
- 1999-03-04 SK SK1319-2000A patent/SK285139B6/sk not_active IP Right Cessation
- 1999-03-04 PE PE1999000178A patent/PE20000324A1/es not_active Application Discontinuation
- 1999-03-04 EP EP03013016A patent/EP1354582A3/en not_active Withdrawn
- 1999-03-04 AT AT99908952T patent/ATE277599T1/de active
- 1999-03-04 NZ NZ506644A patent/NZ506644A/xx not_active IP Right Cessation
- 1999-03-04 TR TR2000/02586T patent/TR200002586T2/xx unknown
- 1999-03-04 HU HU0101080A patent/HUP0101080A3/hu unknown
- 1999-03-04 GB GB0021495A patent/GB2350791B/en not_active Expired - Fee Related
- 1999-03-05 MY MYPI99000807A patent/MY129274A/en unknown
- 1999-03-05 IT IT1999MI000452A patent/IT1313550B1/it active
- 1999-03-05 CO CO99013726A patent/CO4930289A1/es unknown
- 1999-05-21 TW TW093120909A patent/TWI248368B/zh not_active IP Right Cessation
- 1999-05-21 TW TW088107417A patent/TWI236912B/zh not_active IP Right Cessation
- 1999-05-21 TW TW094129536A patent/TWI257870B/zh not_active IP Right Cessation
- 1999-11-09 BE BE9900732A patent/BE1013423A5/fr not_active IP Right Cessation
-
2000
- 2000-08-18 BE BE2000/0520A patent/BE1013648A5/fr not_active IP Right Cessation
- 2000-08-29 NO NO20004299A patent/NO331800B1/no not_active IP Right Cessation
- 2000-09-05 IL IL138248A patent/IL138248A/en not_active IP Right Cessation
- 2000-10-25 FR FR0013782A patent/FR2800277B1/fr not_active Expired - Fee Related
-
2001
- 2001-04-27 HK HK01103061A patent/HK1034038A1/xx not_active IP Right Cessation
- 2001-06-13 HK HK01104070A patent/HK1033277A1/xx not_active IP Right Cessation
-
2004
- 2004-03-05 JP JP2004062679A patent/JP2004189753A/ja active Pending
- 2004-03-26 FR FR0403163A patent/FR2853546B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-05 FR FR0600097A patent/FR2881956A1/fr not_active Withdrawn
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