MX9702809A - Formulaciones orales de ciclosporina. - Google Patents

Formulaciones orales de ciclosporina.

Info

Publication number
MX9702809A
MX9702809A MX9702809A MX9702809A MX9702809A MX 9702809 A MX9702809 A MX 9702809A MX 9702809 A MX9702809 A MX 9702809A MX 9702809 A MX9702809 A MX 9702809A MX 9702809 A MX9702809 A MX 9702809A
Authority
MX
Mexico
Prior art keywords
formulations
subject formulations
oral cyclosporin
cyclosporin
cyclosporin formulations
Prior art date
Application number
MX9702809A
Other languages
English (en)
Other versions
MXPA97002809A (es
Inventor
Moo J Cho
Ralph E Levy
Philippe J Pouletty
Floc H Robert
Christian Merle
Original Assignee
Sangstat Medical Corp
Univ North Carolina At
Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/519,689 external-priority patent/US5834017A/en
Priority claimed from US08/620,021 external-priority patent/US5766629A/en
Priority claimed from US08/622,516 external-priority patent/US5827822A/en
Application filed by Sangstat Medical Corp, Univ North Carolina At, Chapel Hill filed Critical Sangstat Medical Corp
Publication of MXPA97002809A publication Critical patent/MXPA97002809A/es
Publication of MX9702809A publication Critical patent/MX9702809A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se dan a conocer formulaciones orales mejoradas de la ciclosporina, las cuales tienen alta biodisponibilidad y son capaces de su administracion en cápsulas duras o en nanopartículas. En las presente formulaciones, la ciclosporina se entrega en un vehículo aceptable oralmente, que comprende al menos un solvente de alcanol, con 2 o 3 átomos de carbono, en combinacion con al menos un agente tensoactivo no ionico. Las presente formulaciones además pueden comprender cuando menos un cosolvente, donde cosolventes de interés incluyen los ácidos grasos y los dioles. Las presentes formulaciones encuentran uso en la terapia inmuno-supresora.
MX9702809A 1995-08-25 1996-07-31 Formulaciones orales de ciclosporina. MX9702809A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08519689 1995-08-25
US08/519,689 US5834017A (en) 1995-08-25 1995-08-25 Oral cyclopsporin formulations
US08/620,021 US5766629A (en) 1995-08-25 1996-03-21 Oral cyclosporin formulations
US08620021 1996-03-21
US08622516 1996-03-25
US08/622,516 US5827822A (en) 1996-03-25 1996-03-25 Cyclosporin a formulations as nanoparticles
PCT/US1996/012569 WO1997007787A1 (en) 1995-08-25 1996-07-31 Oral cyclosporin formulations

Publications (2)

Publication Number Publication Date
MXPA97002809A MXPA97002809A (es) 1998-02-01
MX9702809A true MX9702809A (es) 1998-02-28

Family

ID=27414735

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702809A MX9702809A (es) 1995-08-25 1996-07-31 Formulaciones orales de ciclosporina.

Country Status (27)

Country Link
EP (1) EP0789561B1 (es)
JP (1) JP3009742B2 (es)
KR (1) KR100294935B1 (es)
CN (1) CN1164828A (es)
AR (1) AR001985A1 (es)
AT (1) ATE263550T1 (es)
AU (1) AU709548B2 (es)
BG (1) BG62875B1 (es)
BR (1) BR9606603A (es)
CA (1) CA2202887A1 (es)
CZ (1) CZ124897A3 (es)
DE (2) DE69632125T2 (es)
ES (1) ES2129381T1 (es)
GE (1) GEP20012547B (es)
HK (1) HK1001956A1 (es)
HU (1) HUP9801052A3 (es)
IL (1) IL120673A0 (es)
IS (1) IS4460A (es)
MX (1) MX9702809A (es)
NO (1) NO971890D0 (es)
NZ (1) NZ313899A (es)
PL (1) PL319898A1 (es)
RO (1) RO119815B1 (es)
SI (1) SI9620014A (es)
SK (1) SK53697A3 (es)
TW (1) TW460287B (es)
WO (1) WO1997007787A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
IL131609A0 (en) * 1997-03-12 2001-01-28 Abbott Lab Hydrophilic binary systems for the administration of cyclosporine
JP2001520170A (ja) 1997-10-16 2001-10-30 ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム Ｎｆ−ａｔ３機能に関連した心肥大動物モデルと治療法
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
MY145753A (en) * 2001-10-19 2012-03-30 Isotechnika Inc Novel cyclosporin analog formulations
ES2393814T3 (es) 2007-04-04 2012-12-28 Sigmoid Pharma Limited Una composición farmacéutica oral
WO2008132707A1 (en) 2007-04-26 2008-11-06 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
DK2471518T3 (en) 2009-05-18 2017-12-04 Sigmoid Pharma Ltd COMPOSITION INCLUDING OIL DROPS
IN2012DN00781A (es) 2009-08-12 2015-06-26 Sigmoid Pharma Ltd
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP3881829A1 (en) 2014-11-07 2021-09-22 Sublimity Therapeutics Limited Compositions comprising cyclosporin
CN104940132B (zh) * 2015-06-05 2018-02-27 河南牧翔动物药业有限公司 一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
EP1142568A1 (en) * 1992-09-25 2001-10-10 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
RU2158601C2 (ru) * 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения

Also Published As

Publication number Publication date
KR100294935B1 (ko) 2001-07-12
IL120673A0 (en) 1997-08-14
SK53697A3 (en) 1997-10-08
NO971890L (no) 1997-04-24
BG62875B1 (bg) 2000-10-31
HUP9801052A3 (en) 1998-12-28
CA2202887A1 (en) 1997-03-06
PL319898A1 (en) 1997-09-01
EP0789561A4 (en) 1998-12-02
WO1997007787A1 (en) 1997-03-06
DE69632125T2 (de) 2004-09-16
NZ313899A (en) 2000-03-27
JPH10509462A (ja) 1998-09-14
DE69632125D1 (de) 2004-05-13
SI9620014A (sl) 1998-04-30
HUP9801052A2 (hu) 1998-09-28
EP0789561A1 (en) 1997-08-20
HK1001956A1 (en) 1998-07-24
IS4460A (is) 1997-04-08
CN1164828A (zh) 1997-11-12
AU6644196A (en) 1997-03-19
DE789561T1 (de) 1999-06-10
NO971890D0 (no) 1997-04-24
ES2129381T1 (es) 1999-06-16
JP3009742B2 (ja) 2000-02-14
BR9606603A (pt) 1997-09-30
EP0789561B1 (en) 2004-04-07
GEP20012547B (en) 2001-10-25
ATE263550T1 (de) 2004-04-15
AU709548B2 (en) 1999-09-02
BG101443A (en) 1998-03-31
KR970706803A (ko) 1997-12-01
AR001985A1 (es) 1998-01-07
CZ124897A3 (en) 1997-09-17
TW460287B (en) 2001-10-21
RO119815B1 (ro) 2005-04-29

Similar Documents

Publication Publication Date Title
MX9702809A (es) Formulaciones orales de ciclosporina.
AR013710A1 (es) Formulaciones orales de ciclosporina
EP1039893B1 (en) Pharmaceutical compositions containing an omega-3 fatty acid oil
ES2020738A6 (es) Composiciones farmaceuticas comprendiendo ciclosporinas.
CA2185347A1 (en) A carrier for hydrophobic drugs and a pharmaceutical composition based thereon
CA2106827A1 (en) Pharmaceutical compositions containing cyclosporins
NZ504076A (en) A topical formulation which induces a minimal systemic effect when applied to the skin, the topical formulation comprising an immunosuppressive macrolide selected from sirolimus, FK506 and SDZ ASM 981 and a permeation modulator for the treatment of a dermatological condition
EP0954278B8 (en) Pharmaceutical compositions containing kukui nut oil
CA2072509A1 (en) Cyclosporin emulsion compositions for oral administration
AP2000001943A0 (en) Orally administrable immediate-release and prolonged-release galenic form comprising an absorption-promoting agent and use of this absorption-promoting agent.
AR015729A1 (es) Una composicion en la forma de un preconcentrado en emulsion o en microemulsion para la administracion oral, el uso de la misma para la fabricacion de unmedicamento y un metodo para reducir la variabilidad de los niveles de biodisponibilidad de una ciclosporina o un macrolido.
CA2264718A1 (en) Solid coprecipitates for enhanced bioavailability of lipophilic substances
EP1075252A2 (en) Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
CA2175472A1 (en) Propylene glycol stearate vesicles
CA2077647A1 (en) Topical formulation of cyclosporine
AU3924895A (en) Pharmaceutical compositions
CA2186750A1 (en) Use of fatty acid esters as bioadhesive substances
ZA966067B (en) New pharmaceutical dosage formulations of fenofibrate and their applications
NZ335685A (en) Antiherpetic pharmaceutical compositions containing acyclovir for topical applicators
JP2003503441A (ja) シリビンを含有する経口用マイクロエマルジョン組成物
ATE152613T1 (de) Zusammensetzung, die bei peroraler verabreichung eine mikroemulsion bildet
KR100352088B1 (ko) 미녹시딜 함유 외용 에멀젼 조성물
EP0542930B1 (en) Oral pharmaceutical compositions containing melatonin
MY120521A (en) Pharmaceutical microspheres of valproic acid for oral administration.
GR3035613T3 (en) Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids