KR960700690A - 리포좀 조성물의 제조방법(Process for producing liposome composition) - Google Patents

리포좀 조성물의 제조방법(Process for producing liposome composition) Download PDF

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Publication number
KR960700690A
KR960700690A KR1019950703318A KR19950703318A KR960700690A KR 960700690 A KR960700690 A KR 960700690A KR 1019950703318 A KR1019950703318 A KR 1019950703318A KR 19950703318 A KR19950703318 A KR 19950703318A KR 960700690 A KR960700690 A KR 960700690A
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KR
South Korea
Prior art keywords
organic solvent
drug
emulsion
lipid
lipids
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KR1019950703318A
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English (en)
Inventor
고지 무네치카
도모요 세키
노리히데 기시
히로시 마쓰다
야스오 우에다
Original Assignee
가와노 다케히코
가부시키가이샤 미도리쥬지
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Application filed by 가와노 다케히코, 가부시키가이샤 미도리쥬지 filed Critical 가와노 다케히코
Publication of KR960700690A publication Critical patent/KR960700690A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 리포좀내로 봉입되는 약물, 특히 분자량이 500 내지 100,000인 생리학적으로 활성 단백질인 약물이 분해되는 것을 억제할 수 있고, 약물 함유율이 높으면, 피하로 또는 근육내로 투여될 수 있고 약물이 지속적으로 방출되도록 하는 리포좀 조성물을 제조하는 방법에 관한 것이다. 상기 방법은 제1유기 용매에 지질을 용해시키는 단계, 약물 수용액을 지질 용액에 첨가시킨 후 유화시켜 유액을 수득하는 단계, 유액을 저온에서 지질이 난용성인 제2유기 용매와 혼합하는 단계, 침전된 분획을 수집하는 단계, 및 수성 용매 중에서 침전된 분획을 현탁시키는 단계를 포함한다.

Description

리포좀 조성물의 제조방법(Process for producing liposome composition)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. (1) 제1유기 용매에 지질을 용해시켜 지질 용액을 형성하는 단계; (2) 약물-함유 수용액을 지질 용액에 가한 후, 유화시켜 유액을 수득하는 단계; (3) 유액을 저온에서 지질이 난용성인 제2유기 용매와 혼합하는 단계; (4) 단계(3)에서 형성된 침전물을 수집하는 단계; 및 (5) 수성 용매에 침전물을 현탁시키는 단계를 포함하는, 약물-함유 리포좀 조성물의 제조방법.
  2. 제1항에 있어서, 제1유기 용매가 지질은 용해시키고 물과는 비혼화성인 방법.
  3. 제1항에 있어서, 제1유기 용매가 클로로포름, 디클로로메탄 및 헥산으로부터 선택되는 방법.
  4. 제1항에 있어서, 제2유기 용매가 에틸 아세테이트 또는 아세톤으로부터 선택되는 방법.
  5. 제1항에 있어서, 제2유기 용매가 지질이 난용성이고 제2유기 용매가 물과 비혼화성인 방법.
  6. 제1항에 있어서, 약물이 분자량이 500 내지 100,000인 생리학적 활성 단백질인 방법.
  7. 제1항에 있어서, 단계(3)이 10℃ 이하의 온도에서 수행되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950703318A 1993-02-23 1994-01-20 리포좀 조성물의 제조방법(Process for producing liposome composition) KR960700690A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5056378A JPH06247842A (ja) 1993-02-23 1993-02-23 リポソーム組成物の製造方法
JP93-056378 1993-02-23
PCT/JP1994/000075 WO1994018948A1 (en) 1993-02-23 1994-01-20 Process for producing liposome composition

Publications (1)

Publication Number Publication Date
KR960700690A true KR960700690A (ko) 1996-02-24

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ID=13025604

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950703318A KR960700690A (ko) 1993-02-23 1994-01-20 리포좀 조성물의 제조방법(Process for producing liposome composition)

Country Status (7)

Country Link
US (1) US5662931A (ko)
EP (1) EP0688563A4 (ko)
JP (1) JPH06247842A (ko)
KR (1) KR960700690A (ko)
CA (1) CA2155958A1 (ko)
TW (1) TW247274B (ko)
WO (1) WO1994018948A1 (ko)

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JP4467789B2 (ja) 1997-09-18 2010-05-26 パシラ ファーマシューティカルズ インコーポレーテッド 持続放出性リポソーム麻酔組成物
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FR2771636B1 (fr) * 1997-12-01 2001-06-15 Capsulis Procede perfectionne pour eviter la degradation d'un principe actif
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
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US7223406B2 (en) 2000-07-21 2007-05-29 The Regents Of The University Of California Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder
AU2001278981A1 (en) * 2000-07-21 2002-02-05 Tom F Lue Prevention and treatment of sexual arousal disorders
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JP3742602B2 (ja) * 2001-05-09 2006-02-08 株式会社カネカ 還元型補酵素ｑの安定な溶液
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
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JP5715051B2 (ja) 2008-06-05 2015-05-07 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． リポソーム、抗原、ポリヌクレオチド及び疎水性物質の連続相を含む担体を含む組成物
WO2010148352A1 (en) 2009-06-19 2010-12-23 Altos Vision Limited Time-release and micro-dose formulations for topical application of estrogen and estrogen analogs or other estrogen receptor modulators in the treatment of dry eye syndrome, and methods of preparation and application
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JPWO2012105485A1 (ja) 2011-01-31 2014-07-03 マルホ株式会社 高分子逆ミセルを含む皮膚用組成物およびその製造方法
JP6240077B2 (ja) 2011-10-06 2017-11-29 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用
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Also Published As

Publication number Publication date
TW247274B (ko) 1995-05-11
JPH06247842A (ja) 1994-09-06
CA2155958A1 (en) 1994-09-01
EP0688563A4 (en) 1998-02-04
US5662931A (en) 1997-09-02
WO1994018948A1 (en) 1994-09-01
EP0688563A1 (en) 1995-12-27

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