EA200400658A1 - Способ лечения опухолей, экспрессирующих рецептор для ил-13 (варианты) - Google Patents

Способ лечения опухолей, экспрессирующих рецептор для ил-13 (варианты)

Info

Publication number
EA200400658A1
EA200400658A1 EA200400658A EA200400658A EA200400658A1 EA 200400658 A1 EA200400658 A1 EA 200400658A1 EA 200400658 A EA200400658 A EA 200400658A EA 200400658 A EA200400658 A EA 200400658A EA 200400658 A1 EA200400658 A1 EA 200400658A1
Authority
EA
Eurasian Patent Office
Prior art keywords
catheter
receptor
tumor
options
treatment
Prior art date
Application number
EA200400658A
Other languages
English (en)
Inventor
Льюис Стросс
Радж Пьюри
Original Assignee
Неофарм, Инк.
Правительство Соединенных Штатов Америки В Лице Министра Здравоохранения И Социального Обеспечения
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Неофарм, Инк., Правительство Соединенных Штатов Америки В Лице Министра Здравоохранения И Социального Обеспечения filed Critical Неофарм, Инк.
Publication of EA200400658A1 publication Critical patent/EA200400658A1/ru

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложен способ лечения опухолей, которые экспрессируют рецептор для ИЛ-13. Способ предусматривает непосредственное введение в опухоль цитотоксина, который направлен на рецептор ИЛ-13. Цитотоксический агент может быть введен посредством доставки, усиленной конвекцией, через подходящий катетер или с помощью других средств. При использовании катетера с усиленной конвекцией способ включает помещение конца катетера, по меньшей мере, в непосредственной близости от опухоли. После того, как катетер помещен, его соединяют с насосом, который доставляет активный агент через конец катетера в опухоль. Во время инфузии поддерживают градиент давления на конце катетера.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400658A 2001-11-09 2002-11-08 Способ лечения опухолей, экспрессирующих рецептор для ил-13 (варианты) EA200400658A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33247701P 2001-11-09 2001-11-09
PCT/US2002/036112 WO2003039600A1 (en) 2001-11-09 2002-11-08 Selective treatment of il-13 expressing tumors

Publications (1)

Publication Number Publication Date
EA200400658A1 true EA200400658A1 (ru) 2004-10-28

Family

ID=23298400

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400658A EA200400658A1 (ru) 2001-11-09 2002-11-08 Способ лечения опухолей, экспрессирующих рецептор для ил-13 (варианты)

Country Status (7)

Country Link
US (1) US20050002918A1 (ru)
EP (1) EP1448237A1 (ru)
JP (1) JP2005508375A (ru)
CA (1) CA2466443A1 (ru)
EA (1) EA200400658A1 (ru)
IL (1) IL161863A0 (ru)
WO (1) WO2003039600A1 (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7262173B2 (en) * 1997-03-21 2007-08-28 Georgetown University Chemosensitizing with liposomes containing oligonucleotides
ATE413164T1 (de) * 2000-11-09 2008-11-15 Neopharm Inc Sn-38-lipidkomplexe und verfahren zu ihrer verwendung
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
US7138512B2 (en) * 2002-04-10 2006-11-21 Georgetown University Gene SHINC-2 and diagnostic and therapeutic uses thereof
WO2003102011A1 (en) * 2002-05-29 2003-12-11 Neopharm, Inc. Method for determining oligonucleotide concentration
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
EP1613284A2 (en) * 2003-02-11 2006-01-11 Neopharm, Inc. Manufacturing process for liposomal preparations
WO2004087758A2 (en) * 2003-03-26 2004-10-14 Neopharm, Inc. Il 13 receptor alpha 2 antibody and methods of use
WO2005000266A2 (en) * 2003-05-22 2005-01-06 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
US20060078560A1 (en) * 2003-06-23 2006-04-13 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
JP4813364B2 (ja) 2003-11-25 2011-11-09 アメリカ合衆国 突然変異型抗ｃｄ２２抗体および免疫複合体
PL3006458T3 (pl) 2005-07-29 2018-05-30 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services Zmutowane egzotoksyny Pseudomonas o zmniejszonej antygenowości
WO2007075912A2 (en) * 2005-12-22 2007-07-05 Neopharm, Inc. A system and method of administering a therapeutic material to brain tissue
US8112292B2 (en) 2006-04-21 2012-02-07 Medtronic Navigation, Inc. Method and apparatus for optimizing a therapy
EP2068975A4 (en) * 2006-08-08 2013-10-30 Peak Biosciences Inc CATHETER AND ARRAY FOR ANTIQUE THERAPY
US8660635B2 (en) * 2006-09-29 2014-02-25 Medtronic, Inc. Method and apparatus for optimizing a computer assisted surgical procedure
US20080206139A1 (en) * 2006-11-03 2008-08-28 The Penn State Research Foundation Delivery system for diagnostic and therapeutic agents
WO2008115511A1 (en) * 2007-03-20 2008-09-25 Peak Biosciences, Inc. Method for therapeutic administration of radionucleosides
US8165658B2 (en) * 2008-09-26 2012-04-24 Medtronic, Inc. Method and apparatus for positioning a guide relative to a base
CN102655882B (zh) 2009-09-11 2014-11-19 美国政府健康及人类服务部 具有降低的免疫原性的改进的假单胞菌外毒素a
CA2886064A1 (en) * 2012-10-19 2014-04-24 The Regents Of The University Of California Treating tumors of the central nervous system
WO2015070210A1 (en) 2013-11-11 2015-05-14 Wake Forest University Health Sciences Epha3 and multi-valent targeting of tumors

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4596792A (en) * 1981-09-04 1986-06-24 The Regents Of The University Of California Safe vaccine for hepatitis containing polymerized serum albumin
FR2523976B1 (fr) * 1982-03-26 1985-08-30 Pasteur Institut Nouveau produit proteique, obtention et application comme medicament, en particulier immunoregulateur et antiallergique
US4661913A (en) * 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
US4608251A (en) * 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) * 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4892827A (en) * 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0814159B1 (en) * 1990-08-29 2005-07-27 GenPharm International, Inc. Transgenic mice capable of producing heterologous antibodies
US5328984A (en) * 1991-03-04 1994-07-12 The United States As Represented By The Department Of Health & Human Services Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells
US5776457A (en) * 1991-03-29 1998-07-07 Genentech, Inc. Antibodies to human PF4A receptor and compositions thereof
US5366859A (en) * 1991-10-31 1994-11-22 Mitsubishi Petrochemical Co., Ltd. Radioimmunoassay method
CA2099883A1 (en) * 1991-11-07 1993-05-08 John A. Kink Epitope mapping of the c33c region of hcv
US5639641A (en) * 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
WO1995005864A1 (en) * 1993-08-27 1995-03-02 Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Convection-enhanced drug delivery
US5491096A (en) * 1993-12-27 1996-02-13 Eli Lilly And Company Antigen detection with affinity chromatography and parallel processing a control
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands
US20020031492A1 (en) * 1995-03-15 2002-03-14 Waldemar Debinski Characterizing a brain tumor
US6428788B1 (en) * 1995-03-15 2002-08-06 Penn State University Compositions and methods for specifically targeting tumors
US6518061B1 (en) * 1995-03-15 2003-02-11 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
US5614191A (en) * 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
US20010053371A1 (en) * 1999-01-07 2001-12-20 Waldemar Debinski Method for diagnosing, imaging, and treating tumors using restrictive receptor for interleukin 13
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
GB9512994D0 (en) * 1995-06-26 1995-08-30 Brf International Method for quantitative measurement of an enzyme linked immunosorbent assay
US5714352A (en) * 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US20030229040A1 (en) * 1997-03-21 2003-12-11 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
US6559129B1 (en) * 1997-03-21 2003-05-06 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
US6126965A (en) * 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
US7262173B2 (en) * 1997-03-21 2007-08-28 Georgetown University Chemosensitizing with liposomes containing oligonucleotides
US6090407A (en) * 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US20030129132A1 (en) * 1998-02-17 2003-07-10 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services IL-13 receptor specific chimeric proteins & uses thereof
US6296843B1 (en) * 1998-04-03 2001-10-02 The Penn State Research Foundation Mutagenized IL 13-based chimeric molecules
US6884603B2 (en) * 1998-04-03 2005-04-26 The Penn State Research Foundation Nucleic acids encoding IL13 mutants
US6576232B1 (en) * 1998-04-03 2003-06-10 The Penn State Research Foundation IL13 mutants
US6630576B2 (en) * 1998-04-03 2003-10-07 Pennsylvania State Research Foundation Amino acid substitution mutants of interleukin 13
US6461637B1 (en) * 2000-09-01 2002-10-08 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6146659A (en) * 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
EP1222212A4 (en) * 1999-10-06 2005-05-04 Penn State Res Found MUTANTS OF IL-13
EP1257289A1 (en) * 2000-02-08 2002-11-20 The Penn State Research Foundation Immunotherapy using interleukin 13 receptor subunit alpha 2
FR2809898B1 (fr) * 2000-06-05 2002-11-29 Cit Alcatel Procede de gestion d'un reseau de telecommunications et unite de gestion de reseau pour la mise en oeuvre du procede
JP2004511510A (ja) * 2000-10-16 2004-04-15 ネオファーム、インコーポレイティッド ミトキサントロンのリポソーム製剤
ATE413164T1 (de) * 2000-11-09 2008-11-15 Neopharm Inc Sn-38-lipidkomplexe und verfahren zu ihrer verwendung
WO2002059337A1 (en) * 2001-01-26 2002-08-01 Georgetown University School Of Medicine Anti-apoptopic gene scc-s2 and diagnostic and therapeutic uses thereof
US20020164624A1 (en) * 2001-02-12 2002-11-07 Waldemar Debinski VEGF-D expression in brain cancer
US20050260649A1 (en) * 2001-02-12 2005-11-24 The Penn State Research Foundation Fra-1 expression in brain cancer
AU2002258728A1 (en) * 2001-04-06 2002-10-21 Georgetown University Gene brcc-3 and diagnostic and therapeutic uses thereof
AU2002305151A1 (en) * 2001-04-06 2002-10-21 Georgetown University Gene scc-112 and diagnostic and therapeutic uses thereof
WO2002081639A2 (en) * 2001-04-06 2002-10-17 Georgetown University Gene brcc2 and diagnostic and therapeutic uses thereof
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
US20040136959A1 (en) * 2001-08-15 2004-07-15 Puri Raj K. Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il -13 receptor alpha chain
EP1455833A1 (en) * 2001-12-04 2004-09-15 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Chimeric molecule for the treatment of th2-like cytokine mediated disorders
CA2479306A1 (en) * 2002-03-19 2003-10-02 The Penn State Research Foundation Egfr ligands and methods of use
US7244565B2 (en) * 2002-04-10 2007-07-17 Georgetown University Gene shinc-3 and diagnostic and therapeutic uses thereof
US7138512B2 (en) * 2002-04-10 2006-11-21 Georgetown University Gene SHINC-2 and diagnostic and therapeutic uses thereof
US20050148528A1 (en) * 2002-05-20 2005-07-07 Neopharm, Inc Method for reducing platelet count
US20030228317A1 (en) * 2002-05-22 2003-12-11 Prafulla Gokhale Gene BRCC-1 and diagnostic and therapeutic uses thereof
CA2486967A1 (en) * 2002-05-24 2003-12-04 Neopharm, Inc. Cardiolipin compositions their methods of preparation and use
EA200401565A1 (ru) * 2002-05-24 2005-04-28 Неофарм, Инк. Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
WO2003102011A1 (en) * 2002-05-29 2003-12-11 Neopharm, Inc. Method for determining oligonucleotide concentration
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
US20050277611A1 (en) * 2002-10-16 2005-12-15 Neopharm, Inc. Cationic cardiolipin analoges and its use thereof

Also Published As

Publication number Publication date
WO2003039600A1 (en) 2003-05-15
EP1448237A1 (en) 2004-08-25
IL161863A0 (en) 2005-11-20
JP2005508375A (ja) 2005-03-31
CA2466443A1 (en) 2003-05-15
US20050002918A1 (en) 2005-01-06

Similar Documents

Publication Publication Date Title
EA200400658A1 (ru) Способ лечения опухолей, экспрессирующих рецептор для ил-13 (варианты)
DE602005011105D1 (de) Implantierbare arzneiabgabevorrichtung mit drahtfäden
MX2009010000A (es) Dispositivo para el suministro de farmaco.
CA2902713C (en) Method and apparatus for drug delivery to a target site
EP1389121A4 (en) METHODS AND COMPOSITIONS FOR TREATING MAMMARY NERVOUS TISSUE DAMAGE
SG161307A1 (en) Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
CY1112403T1 (el) Συσκευη, συστημα και μεθοδος για την χορηγηση σκληρυνομενου υλικου εντος οστου
WO2007127176A3 (en) Ultrasound therapy system
WO2000032267A3 (en) Device for locally delivering a drug in a body cavity
MXPA04003437A (es) Dispositivo para suministro de medicamento por medio de iontoforesis o electroporacion intraocular.
IL212777A0 (en) Baloon catheter
GB2435211B (en) Drug delivery system
SI1913947T1 (sl) Kombinirana terapija za zdravljenje raka
PH12020551715A1 (en) Methods of treating cancer
EP1108426A3 (en) Use of prostaglandin agonists to treat erectile dysfunction or impotence
MXPA02009984A (es) Metodo y composicion para el tratamiento del cancer mediante la administracion de agentes quimioterapeuticos que inducen la apoptosis.
WO2006031390A3 (en) Apparatus and methods for treating undesired veins
MX2019010651A (es) Aparato y métodos para administración de un compuesto nauseogénico desde un dispositivo de administración de fármacos.
DE602005026510D1 (en) Anthracyclinderivate
EP4233932A3 (en) Apparatus for extracorporeal treatment of blood and method of priming an extracorporeal blood circuit
CN208525122U (zh) 一种畜牧兽医注射器
HK1050853A1 (en) se of methoxymorpholino doxorubicin in the preparation of a medicament for the treatment of a liver tumor.
MY151447A (en) Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
Brastianos Dabrafenib/trametinib
JP1725969S (ja) 医療用マイクロシリンジユニット