CN103588745B - 一种从毛喉鞘蕊花中提取和分离弗斯可林的方法 - Google Patents
一种从毛喉鞘蕊花中提取和分离弗斯可林的方法 Download PDFInfo
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- CN103588745B CN103588745B CN201310617281.0A CN201310617281A CN103588745B CN 103588745 B CN103588745 B CN 103588745B CN 201310617281 A CN201310617281 A CN 201310617281A CN 103588745 B CN103588745 B CN 103588745B
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- Prior art keywords
- extraction
- kelin
- crystallization
- coleus forskohlii
- separation
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- 241000131459 Plectranthus barbatus Species 0.000 title claims abstract description 35
- 235000005320 Coleus barbatus Nutrition 0.000 title claims abstract description 34
- 238000000605 extraction Methods 0.000 title claims abstract description 26
- 238000000926 separation method Methods 0.000 title claims abstract description 20
- 238000002425 crystallisation Methods 0.000 claims abstract description 30
- 230000008025 crystallization Effects 0.000 claims abstract description 30
- 239000000284 extract Substances 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 22
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 52
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000741 silica gel Substances 0.000 claims description 18
- 229910002027 silica gel Inorganic materials 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 7
- 230000008719 thickening Effects 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000012046 mixed solvent Substances 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 239000013078 crystal Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 229960001866 silicon dioxide Drugs 0.000 description 14
- 239000003814 drug Substances 0.000 description 4
- 235000020242 coleus extract Nutrition 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
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- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- CLOQVZCSBYBUPB-KGGHGJDLSA-N [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-6-yl] acetate Chemical compound O[C@H]([C@@]12C)CCC(C)(C)[C@@H]1[C@H](OC(=O)C)[C@H](O)[C@]1(C)[C@]2(O)C(=O)C[C@](C)(C=C)O1 CLOQVZCSBYBUPB-KGGHGJDLSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- SBMKZIAQTQIEHN-NRADYMPXSA-N Coleonol C Natural products [H][C@@]12[C@H](OC(C)=O)[C@@H](O)[C@@]3(C)O[C@@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](C)CCC2(C)C)C=C SBMKZIAQTQIEHN-NRADYMPXSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 241000134253 Lanka Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
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- 239000012141 concentrate Substances 0.000 description 1
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- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000002222 matrix solid-phase dispersion Methods 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
Abstract
Description
Claims (6)
Priority Applications (1)
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CN201310617281.0A CN103588745B (zh) | 2013-11-26 | 2013-11-26 | 一种从毛喉鞘蕊花中提取和分离弗斯可林的方法 |
Applications Claiming Priority (1)
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CN201310617281.0A CN103588745B (zh) | 2013-11-26 | 2013-11-26 | 一种从毛喉鞘蕊花中提取和分离弗斯可林的方法 |
Publications (2)
Publication Number | Publication Date |
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CN103588745A CN103588745A (zh) | 2014-02-19 |
CN103588745B true CN103588745B (zh) | 2015-10-28 |
Family
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CN201310617281.0A Active CN103588745B (zh) | 2013-11-26 | 2013-11-26 | 一种从毛喉鞘蕊花中提取和分离弗斯可林的方法 |
Country Status (1)
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107302997A (zh) * | 2016-04-19 | 2017-10-31 | 林秀霞 | 一种抑制脂肪蓄积的组合物及其用途 |
CN117586217B (zh) * | 2024-01-17 | 2024-03-19 | 云南省药物研究所 | 一种基于国产毛喉鞘蕊花的佛司可林制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1882508A (zh) * | 2003-09-08 | 2006-12-20 | 萨米实验室有限公司 | 水溶性二萜的制备方法及其应用 |
CN1944384A (zh) * | 2006-10-31 | 2007-04-11 | 湖北中医学院 | 毛喉鞘蕊花提取物主要成分及提取方法 |
WO2008138095A1 (en) * | 2007-05-10 | 2008-11-20 | Multi Formulations Ltd. | Composition for maintaining androgen and androgen-like uptake potential by cells |
CN102127049A (zh) * | 2010-12-20 | 2011-07-20 | 大兴安岭林格贝有机食品有限责任公司 | 一种富集纯化刺玫果花中弗斯可林的方法 |
CN103183658A (zh) * | 2011-12-29 | 2013-07-03 | 复旦大学 | 一种提取毛喉鞘蕊花有效成分的方法 |
-
2013
- 2013-11-26 CN CN201310617281.0A patent/CN103588745B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1882508A (zh) * | 2003-09-08 | 2006-12-20 | 萨米实验室有限公司 | 水溶性二萜的制备方法及其应用 |
CN1944384A (zh) * | 2006-10-31 | 2007-04-11 | 湖北中医学院 | 毛喉鞘蕊花提取物主要成分及提取方法 |
WO2008138095A1 (en) * | 2007-05-10 | 2008-11-20 | Multi Formulations Ltd. | Composition for maintaining androgen and androgen-like uptake potential by cells |
CN102127049A (zh) * | 2010-12-20 | 2011-07-20 | 大兴安岭林格贝有机食品有限责任公司 | 一种富集纯化刺玫果花中弗斯可林的方法 |
CN103183658A (zh) * | 2011-12-29 | 2013-07-03 | 复旦大学 | 一种提取毛喉鞘蕊花有效成分的方法 |
Non-Patent Citations (2)
Title |
---|
Extraction of forskolin from Coleus forskohlii roots using three phase partitioning;Shirish M. Harde,等;《Separation and Purification Technology》;20120518;第96卷;20-25 * |
通城移植毛喉鞘蕊花的化学成分研究;李水清 等;《中草药》;20060630;第37卷(第6期);824-826 * |
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CN103588745A (zh) | 2014-02-19 |
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Address after: 710075 Xi'an high tech Zone, Shaanxi hi tech Road, No. 25 Maple Leaf Garden District, block C, No. 157 Patentee after: SHAANXI JIAHE PHYTOCHEM CO., LTD. Address before: 710075 Xi'an high tech Zone, Shaanxi hi tech Road, No. 25 Maple Leaf Garden District, block C, No. 157 Patentee before: Shanxi Jiahe Plant Chemical Co., Ltd. |
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Denomination of invention: Method for extracting and separating forskolin in coleus forskohlii Effective date of registration: 20180206 Granted publication date: 20151028 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2018990000131 |
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Date of cancellation: 20190326 Granted publication date: 20151028 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2018990000131 |
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Denomination of invention: Method for extracting and separating forskolin in coleus forskohlii Effective date of registration: 20190411 Granted publication date: 20151028 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2019610000066 |
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Date of cancellation: 20200616 Granted publication date: 20151028 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: 2019610000066 |
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Denomination of invention: A method for the extraction and separation of forskolin from Coleus tomentosa Effective date of registration: 20200910 Granted publication date: 20151028 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: Y2020610000141 |
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Date of cancellation: 20210602 Granted publication date: 20151028 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: Y2020610000141 |