CY1108026T1 - Φαρμακευτικη τυποποιηση iressa που περιλαμβανει ενα υδατοδιαλυτο παραγωγο κυτταρινης - Google Patents

Φαρμακευτικη τυποποιηση iressa που περιλαμβανει ενα υδατοδιαλυτο παραγωγο κυτταρινης

Info

Publication number
CY1108026T1
CY1108026T1 CY20071100974T CY071100974T CY1108026T1 CY 1108026 T1 CY1108026 T1 CY 1108026T1 CY 20071100974 T CY20071100974 T CY 20071100974T CY 071100974 T CY071100974 T CY 071100974T CY 1108026 T1 CY1108026 T1 CY 1108026T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical
iressa
producer
water solution
water
Prior art date
Application number
CY20071100974T
Other languages
English (en)
Inventor
Paul Richard Gellert
Michael Davis Parker
Matas Marcel De
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27767732&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108026(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0204392A external-priority patent/GB0204392D0/en
Priority claimed from GB0212462A external-priority patent/GB0212462D0/en
Priority claimed from GB0213267A external-priority patent/GB0213267D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1108026T1 publication Critical patent/CY1108026T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Μία φαρμακευτική σύνθεση που περιλαμβάνει 4-(3'-χλωρο-4'-φθοροανιλινο)-7-μεθοξυ-6-(3-μορφολινοπροποξυ)κουιναζολίνη ή ένα φαρμακευτικώς ανεκτό άλας αυτής (τον Παράγοντα) κι έναν υδατο-διαλυτό αιθέρα κυτταρίνης ή έναν εστέρα ενός υδατοδιαλυτού αιθέρα κυτταρίνης. Ο υδατοδιαλυτός αιθέρας κυτταρίνης ή ο εστέρας ενός υδατοδιαλυτού αιθέρα κυτταρίνης που είναι παρών στη σύνθεση αναστέλλει το ρυθμό της καθίζησης του Παράγοντα από το διάλυμα.
CY20071100974T 2002-02-26 2007-07-20 Φαρμακευτικη τυποποιηση iressa που περιλαμβανει ενα υδατοδιαλυτο παραγωγο κυτταρινης CY1108026T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0204392A GB0204392D0 (en) 2002-02-26 2002-02-26 Pharmaceutical compound
GB0212462A GB0212462D0 (en) 2002-05-30 2002-05-30 Pharmaceutical compound
GB0213267A GB0213267D0 (en) 2002-06-11 2002-06-11 Pharmaceutical composition
EP03706732A EP1480679B1 (en) 2002-02-26 2003-02-24 Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative

Publications (1)

Publication Number Publication Date
CY1108026T1 true CY1108026T1 (el) 2013-09-04

Family

ID=27767732

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100974T CY1108026T1 (el) 2002-02-26 2007-07-20 Φαρμακευτικη τυποποιηση iressa που περιλαμβανει ενα υδατοδιαλυτο παραγωγο κυτταρινης

Country Status (30)

Country Link
US (2) US20050163835A1 (el)
EP (1) EP1480679B1 (el)
JP (1) JP4544863B2 (el)
KR (2) KR20100090726A (el)
CN (1) CN1326569C (el)
AR (1) AR038848A1 (el)
AT (1) ATE362771T1 (el)
AU (1) AU2003208444B2 (el)
BR (1) BRPI0307786B8 (el)
CA (1) CA2476587C (el)
CO (1) CO5601038A2 (el)
CY (1) CY1108026T1 (el)
DE (1) DE60313956T2 (el)
DK (1) DK1480679T3 (el)
ES (1) ES2286406T3 (el)
HK (1) HK1070585A1 (el)
IL (2) IL163642A0 (el)
IS (1) IS2462B (el)
MX (1) MXPA04008307A (el)
MY (1) MY135609A (el)
NO (1) NO328658B1 (el)
NZ (1) NZ534513A (el)
PL (1) PL208114B1 (el)
PT (1) PT1480679E (el)
RU (1) RU2318518C2 (el)
SA (1) SA03240043B1 (el)
TW (1) TWI271193B (el)
UA (1) UA76325C2 (el)
UY (1) UY27682A1 (el)
WO (1) WO2003072139A1 (el)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL163689A0 (en) 2002-02-26 2005-12-18 Astrazeneca Ab Novel crystalline forms of the anti-cancer compound zd1839
GB0317663D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Pharmaceutical composition
GEP20084551B (en) 2004-05-06 2008-11-25 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amides
MY151003A (en) 2005-09-12 2014-03-31 Actelion Pharmaceuticals Ltd Stable pharmaceutical composition comprising a pyrimidine-sulfamide
EP3594248B1 (en) 2006-10-27 2021-08-04 Capsugel Belgium NV Hydroxypropyl methyl cellulose hard capsules and process of manufacture
CA2686964A1 (en) * 2007-06-06 2008-12-11 Basf Se Pharmaceutical formulation for the production of rapidly disintegrating tablets
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
CN102470109A (zh) * 2009-07-02 2012-05-23 惠氏有限责任公司 3-氰基喹啉片剂制剂及其应用
JP5779591B2 (ja) * 2009-12-22 2015-09-16 アッヴィ・インコーポレイテッド Ａｂｔ−２６３カプセル剤
JP4574742B1 (ja) * 2010-04-08 2010-11-04 有限会社ミールジャパン プロポリス組成物
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2632436B1 (en) 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
WO2012071340A1 (en) 2010-11-23 2012-05-31 Metamagnetics Inc. Antenna module having reduced size, high gain, and increased power efficiency
US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
WO2012071374A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Methods of treatment using selective bcl-2 inhibitors
CN102631347B (zh) * 2012-05-03 2014-06-25 石药集团中奇制药技术（石家庄）有限公司 一种吉非替尼药物组合物及其制备方法
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
KR101332829B1 (ko) * 2013-05-31 2013-11-27 재단법인 통합의료진흥원 보중익기탕을 포함하는 폐암 치료용 조성물
GB201400034D0 (en) 2014-01-02 2014-02-19 Astrazeneca Ab Pharmaceutical Compositions comprising AZD9291
KR101721831B1 (ko) * 2014-11-06 2017-03-31 주식회사 종근당 로베글리타존을 함유하는 경구 투여용 약제학적 조성물
WO2016096999A1 (en) 2014-12-19 2016-06-23 Synthon B.V. Pharmaceutical composition comprising gefifinib
DK3263110T3 (da) * 2015-02-26 2023-07-31 Takeda Pharmaceuticals Co Tablet, som omfatter et methoxyurinstofderivat og mannitolpartikler
KR101739731B1 (ko) * 2015-12-31 2017-05-25 환인제약 주식회사 유당불내성 환자에게 투여가 가능하며, 복용편의성이 향상된 게피티니브를 함유하는 약제학적 조성물
CN108096251B (zh) * 2016-11-24 2021-11-16 江苏恒瑞医药股份有限公司 一种吉非替尼药物组合物及其制备方法
CN107007562B (zh) * 2017-02-16 2020-10-27 南京优科制药有限公司 一种吉非替尼片剂及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608063A (en) * 1969-08-15 1971-09-21 Gilbert S Banker Molecular drug entrapment process and compositions
US4178376A (en) * 1977-01-21 1979-12-11 Interx Research Corporation Method for inducing rapid therapeutically effective antimalarial levels of certain selected conventional antimalarials
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4704284A (en) * 1982-08-12 1987-11-03 Pfizer Inc. Long-acting matrix tablet formulations
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
GB9207988D0 (en) * 1992-04-10 1992-05-27 Smithkline Beecham Plc Topical composition
EP0716597A1 (en) * 1993-08-30 1996-06-19 Warner-Lambert Company Tablet coating based on a melt-spun mixture of a saccharide and apolymer
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB2306885B (en) * 1995-11-08 1999-07-14 Reckitt & Colmann Prod Ltd Supersaturated Pharmaceutical Compositions
CO4940469A1 (es) * 1997-03-05 2000-07-24 Sugen Inc Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol
DK0901786T3 (da) * 1997-08-11 2007-10-08 Pfizer Prod Inc Faste farmaceutiske dispersioner med foröget biotilgængelighed
UA74141C2 (uk) * 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
DE19911509A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
EP1175205B1 (en) * 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
US6287599B1 (en) * 2000-12-20 2001-09-11 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
KR100397792B1 (ko) * 2001-06-28 2003-09-13 한국과학기술연구원 4-(페닐아미노)-[1,4]디옥사노[2,3-ｇ]퀴나졸린 유도체 및그의 제조방법
IL163689A0 (en) * 2002-02-26 2005-12-18 Astrazeneca Ab Novel crystalline forms of the anti-cancer compound zd1839
KR20050104152A (ko) 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물

Also Published As

Publication number Publication date
CN1326569C (zh) 2007-07-18
NO20043866L (no) 2004-09-15
CN1638805A (zh) 2005-07-13
PL208114B1 (pl) 2011-03-31
BR0307786A (pt) 2004-12-07
JP2005523293A (ja) 2005-08-04
UY27682A1 (es) 2003-10-31
CA2476587A1 (en) 2003-09-04
TWI271193B (en) 2007-01-21
ES2286406T3 (es) 2007-12-01
US20090186890A1 (en) 2009-07-23
DE60313956D1 (de) 2007-07-05
HK1070585A1 (en) 2005-06-24
IL163642A (en) 2007-07-24
TW200304379A (en) 2003-10-01
JP4544863B2 (ja) 2010-09-15
KR20100090726A (ko) 2010-08-16
DK1480679T3 (da) 2007-09-03
BRPI0307786B1 (pt) 2018-03-13
RU2318518C2 (ru) 2008-03-10
PL372215A1 (en) 2005-07-11
KR20040088524A (ko) 2004-10-16
SA03240043B1 (ar) 2007-05-06
US20050163835A1 (en) 2005-07-28
IS7420A (is) 2004-08-24
CA2476587C (en) 2010-05-04
RU2004129280A (ru) 2005-06-10
IS2462B (is) 2008-11-15
BRPI0307786B8 (pt) 2021-05-25
ATE362771T1 (de) 2007-06-15
AU2003208444B2 (en) 2006-10-26
AU2003208444A1 (en) 2003-09-09
EP1480679B1 (en) 2007-05-23
MY135609A (en) 2008-05-30
NZ534513A (en) 2007-04-27
AR038848A1 (es) 2005-01-26
CO5601038A2 (es) 2006-01-31
EP1480679A1 (en) 2004-12-01
WO2003072139A1 (en) 2003-09-04
MXPA04008307A (es) 2004-11-26
PT1480679E (pt) 2007-07-18
UA76325C2 (uk) 2006-07-17
KR101002374B1 (ko) 2010-12-17
IL163642A0 (en) 2005-12-18
NO328658B1 (no) 2010-04-19
DE60313956T2 (de) 2008-05-15

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