HU186904B

HU186904B - Process for producing retarde pharmaceutical compositions

Process for producing retarde pharmaceutical compositions Download PDF

Info

Publication number: HU186904B
Authority: HU; Hungary
Prior art keywords: weight; polylactide; polypeptide; viscosity; process according
Prior art date: 1981-02-16

Application number

HU82449A

Other languages

English (en)

Hungarian (hu)

Inventor

Francis G Hutchinson

Original Assignee

Ici Plc

Priority date

1981-02-16

Filing date

1982-02-15

Publication date

1985-10-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10519727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HU186904(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1982-02-15 Application filed by Ici Plc filed Critical Ici Plc

1985-10-28 Publication of HU186904B publication Critical patent/HU186904B/hu

Links

238000000034 method Methods 0.000 title claims abstract description 48
230000008569 process Effects 0.000 title claims description 29
239000008194 pharmaceutical composition Substances 0.000 title abstract description 16
239000000203 mixture Substances 0.000 claims abstract description 143
229920001184 polypeptide Polymers 0.000 claims abstract description 125
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 125
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 124
229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 121
238000004519 manufacturing process Methods 0.000 claims abstract description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 48
239000000243 solution Substances 0.000 claims description 48
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
239000011159 matrix material Substances 0.000 claims description 35
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 34
239000003814 drug Substances 0.000 claims description 31
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 30
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229940079593 drug Drugs 0.000 claims description 28
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JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical group CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 27
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BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims description 18
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