JPS57150609A - Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture - Google Patents

Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture

Info

Publication number
JPS57150609A
JPS57150609A JP57023497A JP2349782A JPS57150609A JP S57150609 A JPS57150609 A JP S57150609A JP 57023497 A JP57023497 A JP 57023497A JP 2349782 A JP2349782 A JP 2349782A JP S57150609 A JPS57150609 A JP S57150609A
Authority
JP
Japan
Prior art keywords
manufacture
pharmaceutical composition
lactic acid
heterogeneous copolymer
glycolic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57023497A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0157098B2 (enExample
Inventor
Gourando Hatsuchi Furanshisuko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10519727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS57150609(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of JPS57150609A publication Critical patent/JPS57150609A/ja
Publication of JPH0157098B2 publication Critical patent/JPH0157098B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biological Depolymerization Polymers (AREA)
JP57023497A 1981-02-16 1982-02-16 Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture Granted JPS57150609A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8104734 1981-02-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP3098688A Division JPH0774143B2 (ja) 1981-02-16 1991-04-30 ポリ（ラクチド−共−グリコリド）ポリマーの製造法
JP3098686A Division JPH0686390B2 (ja) 1981-02-16 1991-04-30 薬理学上活性で酸に安定なポリペプチドの製剤

Publications (2)

Publication Number Publication Date
JPS57150609A true JPS57150609A (en) 1982-09-17
JPH0157098B2 JPH0157098B2 (enExample) 1989-12-04

Family

ID=10519727

Family Applications (4)

Application Number Title Priority Date Filing Date
JP57023497A Granted JPS57150609A (en) 1981-02-16 1982-02-16 Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture
JP61162196A Granted JPS6264824A (ja) 1981-02-16 1986-07-11 乳酸単位とグリコ−ル酸単位との不均一なコ−ポリマ−及びその製造法
JP3098686A Expired - Lifetime JPH0686390B2 (ja) 1981-02-16 1991-04-30 薬理学上活性で酸に安定なポリペプチドの製剤
JP3098688A Expired - Lifetime JPH0774143B2 (ja) 1981-02-16 1991-04-30 ポリ（ラクチド−共−グリコリド）ポリマーの製造法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP61162196A Granted JPS6264824A (ja) 1981-02-16 1986-07-11 乳酸単位とグリコ−ル酸単位との不均一なコ−ポリマ−及びその製造法
JP3098686A Expired - Lifetime JPH0686390B2 (ja) 1981-02-16 1991-04-30 薬理学上活性で酸に安定なポリペプチドの製剤
JP3098688A Expired - Lifetime JPH0774143B2 (ja) 1981-02-16 1991-04-30 ポリ（ラクチド−共−グリコリド）ポリマーの製造法

Country Status (20)

Country Link
US (2) US5004602A (enExample)
EP (1) EP0058481B2 (enExample)
JP (4) JPS57150609A (enExample)
AT (1) ATE22535T1 (enExample)
AU (3) AU560829B2 (enExample)
CA (1) CA1169090A (enExample)
DE (1) DE3273501D1 (enExample)
DK (1) DK164845B (enExample)
ES (1) ES8307845A1 (enExample)
FI (1) FI80594B (enExample)
GR (1) GR76791B (enExample)
HK (1) HK107890A (enExample)
HU (2) HU186904B (enExample)
IE (1) IE52535B1 (enExample)
MY (1) MY101545A (enExample)
NO (1) NO162103C (enExample)
NZ (1) NZ199732A (enExample)
PT (1) PT74434B (enExample)
YU (1) YU44066B (enExample)
ZA (1) ZA82565B (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6097918A (ja) * 1983-11-01 1985-05-31 Sumitomo Chem Co Ltd インタ−フエロン持続性製剤
JPS60181029A (ja) * 1984-02-29 1985-09-14 Toyo Jozo Co Ltd 徐放性製剤の製法
JPS62230729A (ja) * 1986-03-31 1987-10-09 Sumitomo Pharmaceut Co Ltd Ｃｓｆ徐放性製剤
JPS6391325A (ja) * 1986-10-07 1988-04-22 Chugai Pharmaceut Co Ltd 顆粒球コロニ−刺激因子を含有する徐放性製剤
JPH01121222A (ja) * 1987-09-21 1989-05-12 Bpd Biopharma Dev Ltd 長時間にわたって薬剤の放出を維持・調節するための薬剤組成物
JPH0269553A (ja) * 1988-07-29 1990-03-08 Rhone Poulenc Chim 沃素を含有する被浸食性ポリマー組成物
JPH0366625A (ja) * 1989-07-28 1991-03-22 Debiopharm Sa 微粒子状の薬剤組成物、その調製方法およびこの薬剤組成物より調製した懸濁剤
JPH0368511A (ja) * 1989-07-07 1991-03-25 Sandoz Ag 水溶性ペプチドの徐放性製剤
EP0781548A2 (en) 1995-12-15 1997-07-02 Takeda Chemical Industries, Ltd. Production of sustained-release preparation for injection
JP2007517042A (ja) * 2003-12-30 2007-06-28 デュレクト コーポレーション 活性物質、好ましくはｇｎｒｈの制御放出のための、好ましくはｐｅｇおよびｐｌｇの混合物を含有するポリマーインプラント
US7342048B2 (en) 2005-04-28 2008-03-11 Nipro Corporation Bioabsorbable pharmaceutical formulation
JP2009530332A (ja) * 2006-03-21 2009-08-27 ヘキサル アーゲー 分解耐性ポリラクタイド重合体を含む皮下インプラント

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* Cited by examiner, † Cited by third party
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US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
FR2537980B1 (fr) * 1982-12-17 1986-12-19 Sandoz Sa Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation
US4652443A (en) * 1983-06-07 1987-03-24 Japan Atomic Energy Research Institute Slow-release composite and process for producing the same
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
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CA1236641A (en) * 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
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JPH05271051A (ja) 1993-10-19
AU7998682A (en) 1982-08-26
AU602623B2 (en) 1990-10-18
US5004602A (en) 1991-04-02
US4767628B1 (enExample) 1990-07-17
YU44066B (en) 1990-02-28
FI820467L (fi) 1982-08-17
EP0058481B2 (en) 2003-05-21
FI80594B (fi) 1990-03-30
DE3273501D1 (en) 1986-11-06
JPH05221871A (ja) 1993-08-31
NO162103B (no) 1989-07-31
GR76791B (enExample) 1984-09-04
JPH0774143B2 (ja) 1995-08-09
JPH0686390B2 (ja) 1994-11-02
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EP0058481B1 (en) 1986-10-01
ATE22535T1 (de) 1986-10-15
CA1169090A (en) 1984-06-12
DK59182A (da) 1982-08-17
AU582920B2 (en) 1989-04-13
AU2840789A (en) 1989-05-04
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HU186904B (en) 1985-10-28
NZ199732A (en) 1985-08-30
PT74434B (en) 1983-07-14
JPS6264824A (ja) 1987-03-23
EP0058481A1 (en) 1982-08-25
AU560829B2 (en) 1987-04-16
IE820165L (en) 1982-08-16
JPH031330B2 (enExample) 1991-01-10
PT74434A (en) 1982-03-01
MY101545A (en) 1991-12-17
US4767628A (en) 1988-08-30
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HU199695B (en) 1990-03-28
JPH0157098B2 (enExample) 1989-12-04

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