ATE236655T1 - Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden - Google Patents

Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden

Info

Publication number
ATE236655T1
ATE236655T1 AT94906037T AT94906037T ATE236655T1 AT E236655 T1 ATE236655 T1 AT E236655T1 AT 94906037 T AT94906037 T AT 94906037T AT 94906037 T AT94906037 T AT 94906037T AT E236655 T1 ATE236655 T1 AT E236655T1
Authority
AT
Austria
Prior art keywords
biodegradable polyesters
molecular conjugates
bioactive polypeptides
ionic molecular
composition
Prior art date
Application number
AT94906037T
Other languages
English (en)
Inventor
Shalaby W Shalaby
Steven A Jackson
Jacques-Pierre Moreau
Original Assignee
Kinerton Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinerton Ltd filed Critical Kinerton Ltd
Application granted granted Critical
Publication of ATE236655T1 publication Critical patent/ATE236655T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT94906037T 1993-01-06 1994-01-05 Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden ATE236655T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE930005 1993-01-06
PCT/US1994/000148 WO1994015587A2 (en) 1993-01-06 1994-01-05 Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
CNB941085236A CN1163260C (zh) 1993-01-06 1994-07-20 可生物降解聚酯和生物活性多肽的离子性分子轭合物

Publications (1)

Publication Number Publication Date
ATE236655T1 true ATE236655T1 (de) 2003-04-15

Family

ID=37075859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94906037T ATE236655T1 (de) 1993-01-06 1994-01-05 Ionische molekularkonjugate von bioabbaubaren polyestern und bioaktiven polypeptiden

Country Status (20)

Country Link
EP (1) EP0678018B1 (de)
JP (1) JPH08505395A (de)
CN (1) CN1163260C (de)
AT (1) ATE236655T1 (de)
AU (1) AU680650B2 (de)
CA (1) CA2150574A1 (de)
CZ (2) CZ293425B6 (de)
DE (1) DE69432459T2 (de)
DK (1) DK0678018T3 (de)
ES (1) ES2196023T3 (de)
FI (1) FI114898B (de)
HU (1) HU220137B (de)
NZ (1) NZ261250A (de)
PL (1) PL174772B1 (de)
PT (1) PT678018E (de)
RU (2) RU2185393C2 (de)
SG (1) SG47043A1 (de)
SK (1) SK74495A3 (de)
WO (1) WO1994015587A2 (de)
ZA (1) ZA9477B (de)

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Also Published As

Publication number Publication date
HU220137B (hu) 2001-11-28
FI953314A0 (fi) 1995-07-05
RU2185393C2 (ru) 2002-07-20
DE69432459D1 (de) 2003-05-15
WO1994015587A3 (en) 1994-09-01
AU680650B2 (en) 1997-08-07
ES2196023T3 (es) 2003-12-16
PL309776A1 (en) 1995-11-13
AU5992194A (en) 1994-08-15
CN1115252A (zh) 1996-01-24
FI953314A (fi) 1995-07-05
HU9502029D0 (en) 1995-09-28
SG47043A1 (en) 1998-03-20
WO1994015587A2 (en) 1994-07-21
HUT73188A (en) 1996-06-28
CA2150574A1 (en) 1994-07-21
ZA9477B (en) 1994-08-11
PT678018E (pt) 2003-08-29
CZ293425B6 (cs) 2004-04-14
CN1163260C (zh) 2004-08-25
PL174772B1 (pl) 1998-09-30
CZ173495A3 (en) 1996-01-17
JPH08505395A (ja) 1996-06-11
CZ293378B6 (cs) 2004-04-14
SK74495A3 (en) 1997-01-08
EP0678018B1 (de) 2003-04-09
DE69432459T2 (de) 2003-11-27
DK0678018T3 (da) 2003-04-28
EP0678018A4 (de) 1998-09-09
FI114898B (fi) 2005-01-31
NZ261250A (en) 1997-08-22
RU2146128C1 (ru) 2000-03-10
EP0678018A1 (de) 1995-10-25

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