DK0678018T3 - Ion molekylærkonjugater af bionedbrydelige polyestere og bioaktive polypeptider - Google Patents
Ion molekylærkonjugater af bionedbrydelige polyestere og bioaktive polypeptiderInfo
- Publication number
- DK0678018T3 DK0678018T3 DK94906037T DK94906037T DK0678018T3 DK 0678018 T3 DK0678018 T3 DK 0678018T3 DK 94906037 T DK94906037 T DK 94906037T DK 94906037 T DK94906037 T DK 94906037T DK 0678018 T3 DK0678018 T3 DK 0678018T3
- Authority
- DK
- Denmark
- Prior art keywords
- biodegradable polyesters
- molecular conjugates
- bioactive polypeptides
- ion molecular
- composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE930005 | 1993-01-06 | ||
| PCT/US1994/000148 WO1994015587A2 (en) | 1993-01-06 | 1994-01-05 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| CNB941085236A CN1163260C (zh) | 1993-01-06 | 1994-07-20 | 可生物降解聚酯和生物活性多肽的离子性分子轭合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0678018T3 true DK0678018T3 (da) | 2003-04-28 |
Family
ID=37075859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94906037T DK0678018T3 (da) | 1993-01-06 | 1994-01-05 | Ion molekylærkonjugater af bionedbrydelige polyestere og bioaktive polypeptider |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0678018B1 (da) |
| JP (1) | JPH08505395A (da) |
| CN (1) | CN1163260C (da) |
| AT (1) | ATE236655T1 (da) |
| AU (1) | AU680650B2 (da) |
| CA (1) | CA2150574A1 (da) |
| CZ (2) | CZ293425B6 (da) |
| DE (1) | DE69432459T2 (da) |
| DK (1) | DK0678018T3 (da) |
| ES (1) | ES2196023T3 (da) |
| FI (1) | FI114898B (da) |
| HU (1) | HU220137B (da) |
| NZ (1) | NZ261250A (da) |
| PL (1) | PL174772B1 (da) |
| PT (1) | PT678018E (da) |
| RU (2) | RU2146128C1 (da) |
| SG (1) | SG47043A1 (da) |
| SK (1) | SK74495A3 (da) |
| WO (1) | WO1994015587A2 (da) |
| ZA (1) | ZA9477B (da) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221958B1 (en) | 1993-01-06 | 2001-04-24 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US6413536B1 (en) * | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5955574A (en) | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
| CA2250981C (en) * | 1996-04-23 | 2002-07-02 | Kinerton Limited | Acidic polylactic polymers |
| AU750739B2 (en) * | 1996-04-23 | 2002-07-25 | Ipsen Manufacturing Ireland Limited | Methods for preparing biodegradable polyesters and derivatives thereof |
| IE960308A1 (en) * | 1996-04-23 | 1997-11-05 | Kinerton Ltd | Sustained release ionic conjugate |
| US6264970B1 (en) * | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| AU779930B2 (en) * | 1996-12-11 | 2005-02-17 | Praecis Pharmaceuticals Incorporated | Pharmaceutical formulations for sustained drug delivery |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| TW577759B (en) * | 1997-04-18 | 2004-03-01 | Ipsen Pharma Biotech | Sustained release compositions in the form of microcapsules or implants and the process for their preparation |
| US6867181B1 (en) | 1997-06-02 | 2005-03-15 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| WO2001012233A2 (en) * | 1999-08-18 | 2001-02-22 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Sustained release formulation of a peptide |
| EP1348444B1 (en) * | 1999-08-18 | 2006-04-12 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Sustained release formulation of a peptide complexed with a polymer |
| IES990700A2 (en) * | 1999-08-18 | 2001-08-22 | Kinerton Ltd | Process to make a sustained release formulation |
| US7109166B1 (en) | 1999-08-18 | 2006-09-19 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Sustained release formulation of a peptide |
| BR0109725A (pt) | 2000-03-31 | 2003-02-04 | Tufts College | Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo |
| KR100452752B1 (ko) * | 2000-04-18 | 2004-10-12 | 주식회사 펩트론 | 단백질 함유 서방성 제제를 제조하는 방법 및 그 제제 |
| EP1383376A4 (en) * | 2001-03-19 | 2006-03-08 | Praecis Pharm Inc | PHARMACEUTICAL FORMULATIONS WITH PROLONGED RELEASE |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP1556086A2 (en) * | 2002-10-31 | 2005-07-27 | Pfizer Products Inc. | Solid and semi-solid polymeric ionic conjugates |
| DK1575569T3 (da) | 2002-12-13 | 2011-01-10 | Durect Corp | Oralt indgivelsessystem omfattende flydende bærematerialer med høj viskositet |
| EA008829B1 (ru) | 2002-12-17 | 2007-08-31 | Нэстек Фармасьютикал Кампани Инк. | Композиции и способы для усовершенствованной доставки пептидов, связывающихся с y-рецепторами, которую осуществляют через слизистые оболочки, и способы лечения и предотвращения ожирения |
| US7229966B2 (en) | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| US7186692B2 (en) | 2002-12-17 | 2007-03-06 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| MXPA05008097A (es) | 2003-01-28 | 2006-02-08 | Microbia Inc | Metodos y composiciones para el tratamiento de desordenes gastrointestinales. |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CN102174102A (zh) | 2003-05-15 | 2011-09-07 | 塔夫茨大学信托人 | 肽和多肽药物的稳定类似物 |
| EP1682537B1 (en) | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulators of cellular adhesion |
| EA014852B1 (ru) | 2004-09-17 | 2011-02-28 | Дьюрект Корпорейшн | Система контролируемой доставки |
| US20090054320A1 (en) | 2005-04-20 | 2009-02-26 | Protemix Discovery Limited | Vesiculins |
| PL2444079T3 (pl) | 2005-05-17 | 2017-07-31 | Sarcode Bioscience Inc. | Kompozycje i sposoby leczenia chorób oczu |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US8318668B2 (en) | 2005-09-08 | 2012-11-27 | Trustees Of Tufts College | Stabilized GLP-1 analogs |
| PT1937262T (pt) | 2005-09-29 | 2019-08-21 | Ipsen Pharma Sas | Composição para utilização no tratamento de dismotilidade gastrointestinal |
| US20100022457A1 (en) | 2006-05-26 | 2010-01-28 | Bristol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
| PT2117521E (pt) | 2006-11-03 | 2012-09-10 | Durect Corp | Sistemas de administração transdérmica que compreendem bupivacaína |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CN103977404A (zh) | 2007-06-14 | 2014-08-13 | 比奥根艾迪克Ma公司 | 抗体制剂 |
| TW200916113A (en) | 2007-08-08 | 2009-04-16 | Sod Conseils Rech Applic | Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue |
| US20090155176A1 (en) | 2007-10-19 | 2009-06-18 | Sarcode Corporation | Compositions and methods for treatment of diabetic retinopathy |
| AU2008347158B8 (en) | 2007-12-06 | 2013-08-22 | Durect Corporation | Oral pharmaceutical dosage forms |
| WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| KR101581986B1 (ko) | 2008-10-29 | 2016-01-04 | 아블린쓰 엔.브이. | 단일 도메인 항원 결합 분자의 제형 |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| KR101224004B1 (ko) * | 2009-12-29 | 2013-01-22 | 주식회사 삼양바이오팜 | 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법 |
| WO2012007880A2 (en) | 2010-07-16 | 2012-01-19 | Ablynx Nv | Modified single domain antigen binding molecules and uses thereof |
| WO2012028496A1 (de) * | 2010-08-31 | 2012-03-08 | Basf Se | Verzweigte polyester auf basis von zitronensäure sowie deren herstellung und verwendung |
| BRPI1003424A2 (pt) * | 2010-09-08 | 2013-01-08 | Univ Rio De Janeiro | sistema polimÉtrico de confinamento de amilina humana e anÁlogos agonistas, processo e uso; processo de avaliaÇço funcional de amilina liberada |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| NZ608630A (en) | 2010-10-01 | 2015-03-27 | Biogen Idec Inc | Interferon-beta for use as monotherapy or in combination with other cancer therapies |
| WO2012151343A1 (en) | 2011-05-04 | 2012-11-08 | Balance Therapeutics, Inc. | Pentylenetetrazole derivatives |
| EP2734573B1 (en) * | 2011-07-22 | 2021-09-08 | InnoCore Technologies Holding B.V. | Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds |
| EP3715345B1 (en) | 2012-07-25 | 2024-04-10 | Novartis AG | Preparation of lfa-1 inhibitor |
| WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CN105120659A (zh) | 2013-03-15 | 2015-12-02 | 度瑞公司 | 用于降低溶解可变性的具有流变改性剂的组合物 |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CA2918787A1 (en) | 2013-06-13 | 2014-12-18 | George Tachas | Combination therapy |
| EP3054969B1 (en) | 2013-10-10 | 2021-03-10 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions |
| US9181427B2 (en) * | 2013-12-11 | 2015-11-10 | Ethicon, Inc. | Absorbable bimodal polymeric blend compositions, processing methods, and medical devices |
| KR102468902B1 (ko) * | 2014-11-14 | 2022-11-18 | 에보닉 오퍼레이션스 게엠베하 | 미립자 형태의 생체재흡수성 폴리에스테르를 제조하는 방법 |
| CN108884130B (zh) | 2016-01-11 | 2022-09-13 | 博士医疗爱尔兰有限公司 | 用于治疗溃疡性结肠炎的制剂和方法 |
| TR201702016A2 (tr) * | 2017-02-10 | 2018-08-27 | Tuerkiye Bilimsel Ve Teknolojik Arastirma Kurumu Tuebitak | Düşük mali̇yetli̇ yüksek moleküler ağirlikli ve yüksek çözünürlüğe sahi̇p poli̇gli̇koli̇k asi̇t sentezi̇ |
| CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4609707A (en) * | 1983-11-10 | 1986-09-02 | Genetic Systems Corporation | Synthesis of polymers containing integral antibodies |
| US5071909A (en) * | 1989-07-26 | 1991-12-10 | Millipore Corporation | Immobilization of proteins and peptides on insoluble supports |
| US5162505A (en) * | 1989-09-19 | 1992-11-10 | Centocor | Proteins modified with positively charged carriers and compositions prepared therefrom |
| CA2046830C (en) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
| GB9310030D0 (en) * | 1993-05-15 | 1993-06-30 | Scras | Dry processed particles and process for the preparation of the same |
-
1994
- 1994-01-05 PL PL94309776A patent/PL174772B1/pl not_active IP Right Cessation
- 1994-01-05 SG SG1996004005A patent/SG47043A1/en unknown
- 1994-01-05 RU RU95118395/14A patent/RU2146128C1/ru not_active IP Right Cessation
- 1994-01-05 NZ NZ261250A patent/NZ261250A/xx unknown
- 1994-01-05 CZ CZ20002050A patent/CZ293425B6/cs not_active IP Right Cessation
- 1994-01-05 AT AT94906037T patent/ATE236655T1/de not_active IP Right Cessation
- 1994-01-05 CA CA002150574A patent/CA2150574A1/en not_active Abandoned
- 1994-01-05 HU HU9502029A patent/HU220137B/hu not_active IP Right Cessation
- 1994-01-05 JP JP6516182A patent/JPH08505395A/ja active Pending
- 1994-01-05 SK SK744-95A patent/SK74495A3/sk unknown
- 1994-01-05 AU AU59921/94A patent/AU680650B2/en not_active Ceased
- 1994-01-05 RU RU99122608/04A patent/RU2185393C2/ru not_active IP Right Cessation
- 1994-01-05 DE DE69432459T patent/DE69432459T2/de not_active Expired - Fee Related
- 1994-01-05 PT PT94906037T patent/PT678018E/pt unknown
- 1994-01-05 DK DK94906037T patent/DK0678018T3/da active
- 1994-01-05 EP EP94906037A patent/EP0678018B1/en not_active Expired - Lifetime
- 1994-01-05 CZ CZ19951734A patent/CZ293378B6/cs not_active IP Right Cessation
- 1994-01-05 ES ES94906037T patent/ES2196023T3/es not_active Expired - Lifetime
- 1994-01-05 WO PCT/US1994/000148 patent/WO1994015587A2/en active IP Right Grant
- 1994-01-06 ZA ZA9477A patent/ZA9477B/xx unknown
- 1994-07-20 CN CNB941085236A patent/CN1163260C/zh not_active Expired - Fee Related
-
1995
- 1995-07-05 FI FI953314A patent/FI114898B/fi active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT678018E (pt) | 2003-08-29 |
| PL174772B1 (pl) | 1998-09-30 |
| CN1163260C (zh) | 2004-08-25 |
| FI114898B (fi) | 2005-01-31 |
| SG47043A1 (en) | 1998-03-20 |
| AU5992194A (en) | 1994-08-15 |
| HU9502029D0 (en) | 1995-09-28 |
| HUT73188A (en) | 1996-06-28 |
| CZ293425B6 (cs) | 2004-04-14 |
| JPH08505395A (ja) | 1996-06-11 |
| AU680650B2 (en) | 1997-08-07 |
| EP0678018A1 (en) | 1995-10-25 |
| SK74495A3 (en) | 1997-01-08 |
| ATE236655T1 (de) | 2003-04-15 |
| FI953314A0 (fi) | 1995-07-05 |
| RU2185393C2 (ru) | 2002-07-20 |
| WO1994015587A3 (en) | 1994-09-01 |
| ES2196023T3 (es) | 2003-12-16 |
| HU220137B (hu) | 2001-11-28 |
| CZ173495A3 (en) | 1996-01-17 |
| DE69432459D1 (de) | 2003-05-15 |
| NZ261250A (en) | 1997-08-22 |
| RU2146128C1 (ru) | 2000-03-10 |
| FI953314A (fi) | 1995-07-05 |
| CA2150574A1 (en) | 1994-07-21 |
| DE69432459T2 (de) | 2003-11-27 |
| WO1994015587A2 (en) | 1994-07-21 |
| CN1115252A (zh) | 1996-01-24 |
| ZA9477B (en) | 1994-08-11 |
| CZ293378B6 (cs) | 2004-04-14 |
| EP0678018A4 (en) | 1998-09-09 |
| PL309776A1 (en) | 1995-11-13 |
| EP0678018B1 (en) | 2003-04-09 |
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