FI953314A - Biohajoavien polyesterien ja bioaktiivisten polypeptidien ionisia molekyylijonjugaatteja - Google Patents

Biohajoavien polyesterien ja bioaktiivisten polypeptidien ionisia molekyylijonjugaatteja Download PDF

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Publication number
FI953314A
FI953314A FI953314A FI953314A FI953314A FI 953314 A FI953314 A FI 953314A FI 953314 A FI953314 A FI 953314A FI 953314 A FI953314 A FI 953314A FI 953314 A FI953314 A FI 953314A
Authority
FI
Finland
Prior art keywords
biodegradable polyesters
molecular conjugates
bioactive polypeptides
ionic molecular
composition
Prior art date
Application number
FI953314A
Other languages
English (en)
Swedish (sv)
Other versions
FI953314A0 (fi
FI114898B (fi
Inventor
Shalaby W Shalaby
Steven A Jackson
Jacques-Pierre Moreau
Original Assignee
Kinerton Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinerton Ltd filed Critical Kinerton Ltd
Publication of FI953314A0 publication Critical patent/FI953314A0/fi
Publication of FI953314A publication Critical patent/FI953314A/fi
Application granted granted Critical
Publication of FI114898B publication Critical patent/FI114898B/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/23Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593Polyesters, e.g. PLGA or polylactide-co-glycolide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI953314A 1993-01-06 1995-07-05 Menetelmä biohajoavien polyesterien ja bioaktiivisten polypeptidien ionisien molekyylikonjugaattien valmistamiseksi FI114898B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IE930005 1993-01-06
IE930005 1993-01-06
PCT/US1994/000148 WO1994015587A2 (en) 1993-01-06 1994-01-05 Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US9400148 1994-01-05
CN94108523 1994-07-20
CNB941085236A CN1163260C (zh) 1993-01-06 1994-07-20 可生物降解聚酯和生物活性多肽的离子性分子轭合物

Publications (3)

Publication Number Publication Date
FI953314A0 FI953314A0 (fi) 1995-07-05
FI953314A true FI953314A (fi) 1995-07-05
FI114898B FI114898B (fi) 2005-01-31

Family

ID=37075859

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953314A FI114898B (fi) 1993-01-06 1995-07-05 Menetelmä biohajoavien polyesterien ja bioaktiivisten polypeptidien ionisien molekyylikonjugaattien valmistamiseksi

Country Status (20)

Country Link
EP (1) EP0678018B1 (fi)
JP (1) JPH08505395A (fi)
CN (1) CN1163260C (fi)
AT (1) ATE236655T1 (fi)
AU (1) AU680650B2 (fi)
CA (1) CA2150574A1 (fi)
CZ (2) CZ293425B6 (fi)
DE (1) DE69432459T2 (fi)
DK (1) DK0678018T3 (fi)
ES (1) ES2196023T3 (fi)
FI (1) FI114898B (fi)
HU (1) HU220137B (fi)
NZ (1) NZ261250A (fi)
PL (1) PL174772B1 (fi)
PT (1) PT678018E (fi)
RU (2) RU2146128C1 (fi)
SG (1) SG47043A1 (fi)
SK (1) SK74495A3 (fi)
WO (1) WO1994015587A2 (fi)
ZA (1) ZA9477B (fi)

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US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
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KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

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Also Published As

Publication number Publication date
FI953314A0 (fi) 1995-07-05
WO1994015587A2 (en) 1994-07-21
EP0678018A1 (en) 1995-10-25
FI114898B (fi) 2005-01-31
DE69432459D1 (de) 2003-05-15
HU9502029D0 (en) 1995-09-28
AU680650B2 (en) 1997-08-07
ES2196023T3 (es) 2003-12-16
RU2185393C2 (ru) 2002-07-20
PT678018E (pt) 2003-08-29
JPH08505395A (ja) 1996-06-11
SG47043A1 (en) 1998-03-20
NZ261250A (en) 1997-08-22
PL174772B1 (pl) 1998-09-30
ATE236655T1 (de) 2003-04-15
PL309776A1 (en) 1995-11-13
RU2146128C1 (ru) 2000-03-10
HU220137B (hu) 2001-11-28
AU5992194A (en) 1994-08-15
EP0678018A4 (en) 1998-09-09
DK0678018T3 (da) 2003-04-28
SK74495A3 (en) 1997-01-08
HUT73188A (en) 1996-06-28
CN1115252A (zh) 1996-01-24
WO1994015587A3 (en) 1994-09-01
CA2150574A1 (en) 1994-07-21
CZ293425B6 (cs) 2004-04-14
ZA9477B (en) 1994-08-11
CZ293378B6 (cs) 2004-04-14
CN1163260C (zh) 2004-08-25
EP0678018B1 (en) 2003-04-09
CZ173495A3 (en) 1996-01-17
DE69432459T2 (de) 2003-11-27

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