BR0316685A - Composições e métodos para a administração aperfeiçoada por via mucosal de peptìdeos fixadores ao receptor de y2 e métodos para tratar e prevenir a obesidade - Google Patents

Composições e métodos para a administração aperfeiçoada por via mucosal de peptìdeos fixadores ao receptor de y2 e métodos para tratar e prevenir a obesidade

Info

Publication number
BR0316685A
BR0316685A BR0316685A BR0316685A BR0316685A BR 0316685 A BR0316685 A BR 0316685A BR 0316685 A BR0316685 A BR 0316685A BR 0316685 A BR0316685 A BR 0316685A BR 0316685 A BR0316685 A BR 0316685A
Authority
BR
Brazil
Prior art keywords
methods
peptide
administration
compositions
tissue
Prior art date
Application number
BR0316685A
Other languages
English (en)
Inventor
Steven C Quay
Gordon Brandt
Mary S Kleppe
Conor J Macevilly
Original Assignee
Nastech Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/322,266 external-priority patent/US7166575B2/en
Application filed by Nastech Pharm Co filed Critical Nastech Pharm Co
Publication of BR0316685A publication Critical patent/BR0316685A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2271—Neuropeptide Y
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"COMPOSIçõES E MéTODOS PARA A ADMINISTRAçãO APERFEIçOADA POR VIA MUCOSAL DE PEPTìDEOS FIXADORES AO RECEPTOR DE Y2 E MéTODOS PARA TRATAR E PREVENIR A OBESIDADE". São descritos composições farmacêuticas e métodos que abrangem ao menos um composto de peptídeo YY e nenhum ou mais agentes promotores da administração intranasal para uma administração do peptídeo YY por via mucosal nasal aprimorada, para ot ratamento de uma variedade de enfermidades e condições que incluem a obesidade em sujeitos mamíferos. Em um aspecto, as formulações para a administração itnranasal e os métodos provêem uma administração aprimorada do peptídeo YY no plasma sanguíneo o0u no tecido ou fluido do sistema nervoso central (SNC), por exemplo, produzindo um pico de concentração (C~ max~) do péptideo YY no plasma sanguíneo ou no fluido ou tecido do SNC do sujeito que é de 20% ou superior, comparado com o pico de concentração do peptídeo YY no plasma sanguíneo ou no fluido ou tecido do SNC do sujeito após a adminsitração de uma mesma concenetração ou dose de peptídeo YY por injeção subcutânea.
BR0316685A 2002-12-17 2003-12-17 Composições e métodos para a administração aperfeiçoada por via mucosal de peptìdeos fixadores ao receptor de y2 e métodos para tratar e prevenir a obesidade BR0316685A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10/322,266 US7166575B2 (en) 2002-12-17 2002-12-17 Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
US49322603P 2003-08-07 2003-08-07
US50117003P 2003-09-08 2003-09-08
US51078503P 2003-10-10 2003-10-10
US51729003P 2003-11-04 2003-11-04
US51881203P 2003-11-10 2003-11-10
PCT/US2003/040538 WO2004056314A2 (en) 2002-12-17 2003-12-17 Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity

Publications (1)

Publication Number Publication Date
BR0316685A true BR0316685A (pt) 2005-11-01

Family

ID=32686401

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316685A BR0316685A (pt) 2002-12-17 2003-12-17 Composições e métodos para a administração aperfeiçoada por via mucosal de peptìdeos fixadores ao receptor de y2 e métodos para tratar e prevenir a obesidade

Country Status (13)

Country Link
US (4) US7186691B2 (pt)
EP (1) EP1581245A2 (pt)
JP (1) JP2006516262A (pt)
AU (1) AU2003299722A1 (pt)
BR (1) BR0316685A (pt)
CA (1) CA2510199A1 (pt)
CO (1) CO5700705A2 (pt)
EA (1) EA008829B1 (pt)
EC (1) ECSP055839A (pt)
MA (1) MA27535A1 (pt)
MX (1) MXPA05006572A (pt)
NO (1) NO20053430L (pt)
WO (1) WO2004056314A2 (pt)

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CO5700705A2 (es) 2006-11-30
US20070129299A1 (en) 2007-06-07
US20040209807A1 (en) 2004-10-21
US20070197437A1 (en) 2007-08-23
WO2004056314A2 (en) 2004-07-08
EA008829B1 (ru) 2007-08-31
WO2004056314B1 (en) 2005-09-29
MA27535A1 (fr) 2005-09-01
NO20053430L (no) 2005-09-15
US7157426B2 (en) 2007-01-02
MXPA05006572A (es) 2005-12-14
ECSP055839A (es) 2006-03-01
US7186691B2 (en) 2007-03-06
US20040157777A1 (en) 2004-08-12
AU2003299722A1 (en) 2004-07-14
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EP1581245A2 (en) 2005-10-05
JP2006516262A (ja) 2006-06-29

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