BR0113447A - Método de tratamento ou prevenção do câncer em um ser humano, e, composição farmacêutica - Google Patents

Método de tratamento ou prevenção do câncer em um ser humano, e, composição farmacêutica

Info

Publication number
BR0113447A
BR0113447A BR0113447-7A BR0113447A BR0113447A BR 0113447 A BR0113447 A BR 0113447A BR 0113447 A BR0113447 A BR 0113447A BR 0113447 A BR0113447 A BR 0113447A
Authority
BR
Brazil
Prior art keywords
cancer
present
treating
human
pharmaceutical composition
Prior art date
Application number
BR0113447-7A
Other languages
English (en)
Inventor
Raymond P Warrel Jr
Robert E Klem
Howard Fingert
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27397795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0113447(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genta Inc filed Critical Genta Inc
Publication of BR0113447A publication Critical patent/BR0113447A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Abstract

"MéTODO DE TRATAMENTO OU PREVENçãO DO CâNCER EM UM SER HUMANO, E, COMPOSIçãO FARMACêUTICA". A presente invenção está direcionada ao uso de oligómeros anti-sentido bc1-2 para tratar e prevenir distúrbios relacionados com bc1-2. Esses distúrbios incluem câncer, tumores, carcinomas e distúrbios relacionados a proliferação de células. Em uma modalidade da invenção, oligómero anti-sentido bc1-2 é administrado em doses altas. A presente invenção está também direcionada ao método para prevenir ou tratar distúrbios relacionados com bc1-2, em particular câncer, compreendendo administrar oligómero anti-sentido bc1-2 para períodos de tempo curtos. A presente invenção é ainda descrita para usar os oligómeros anti-sentido bc1-2 para aumentar a sensitividade de um paciente para terapêuticos de câncer. A presente invenção também refere-se a composições farmacêuticas compreendendo um ou mais oligómeros anti-sentido bc1-2, que podem compreender um ou mais agentes terapêuticos de câncer.
BR0113447-7A 2000-08-25 2001-08-23 Método de tratamento ou prevenção do câncer em um ser humano, e, composição farmacêutica BR0113447A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22797000P 2000-08-25 2000-08-25
US23700900P 2000-09-29 2000-09-29
US09/709,170 US7795232B1 (en) 2000-08-25 2000-11-10 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
PCT/US2001/026414 WO2002017852A2 (en) 2000-08-25 2001-08-23 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers

Publications (1)

Publication Number Publication Date
BR0113447A true BR0113447A (pt) 2003-07-08

Family

ID=27397795

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113447-7A BR0113447A (pt) 2000-08-25 2001-08-23 Método de tratamento ou prevenção do câncer em um ser humano, e, composição farmacêutica

Country Status (33)

Country Link
US (2) US7795232B1 (pt)
EP (2) EP1313514B1 (pt)
JP (1) JP2004507480A (pt)
KR (1) KR20030034153A (pt)
CN (1) CN1471408A (pt)
AP (1) AP2003002761A0 (pt)
AT (1) ATE432717T1 (pt)
AU (2) AU2001288373B2 (pt)
BG (1) BG107641A (pt)
BR (1) BR0113447A (pt)
CA (1) CA2419480A1 (pt)
CY (1) CY1109340T1 (pt)
CZ (1) CZ301582B6 (pt)
DE (1) DE60138892D1 (pt)
DK (1) DK1313514T3 (pt)
DZ (1) DZ3471A1 (pt)
EA (1) EA005424B1 (pt)
EE (1) EE200300074A (pt)
ES (1) ES2327904T3 (pt)
GE (1) GEP20063934B (pt)
HK (1) HK1056505A1 (pt)
HR (1) HRP20030102A2 (pt)
HU (1) HUP0303125A2 (pt)
IL (1) IL154409A0 (pt)
MX (1) MXPA03001575A (pt)
NO (1) NO20030858L (pt)
OA (1) OA12586A (pt)
PL (1) PL363050A1 (pt)
PT (1) PT1313514E (pt)
SK (1) SK3652003A3 (pt)
UA (1) UA77945C2 (pt)
WO (1) WO2002017852A2 (pt)
YU (1) YU13603A (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855911A (en) 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US7309692B1 (en) 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6977244B2 (en) 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
EP2258872B1 (en) 2002-03-13 2013-08-14 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US7256284B2 (en) 2002-11-14 2007-08-14 Genta Incorporated Inhibitory oligonucleotides targeted to Bcl-2
CA2506066A1 (en) 2002-11-15 2004-06-03 Genomic Health, Inc. Gene expression profiling of egfr positive cancer
DE10258677A1 (de) * 2002-12-13 2004-06-24 Elez, Vera, Dr. Kombinations-antisense-Oligonukleotid-Krebstherapie
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
PT1597391E (pt) 2003-02-20 2008-12-19 Genomic Health Inc Utilização de arn intrónico para medir a expressão genética
JP4505749B2 (ja) 2003-05-30 2010-07-21 日本新薬株式会社 Ｂｃｌ−２の発現抑制をするオリゴ二本鎖ＲＮＡとそれを含有する医薬組成物
CA3061769C (en) 2003-06-24 2021-10-26 Genomic Health, Inc. Methods of predicting the likelihood of long-term survival of a human patient with node-negative, estrogen receptor (er) positive, invasive ductal breast cancer without the recurrence of breast cancer
WO2005008213A2 (en) 2003-07-10 2005-01-27 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
KR20070000438A (ko) 2003-12-23 2007-01-02 게노믹 헬쓰, 인코포레이티드 단편화 ｒｎａ의 범용적 증폭
GB0406415D0 (en) * 2004-03-22 2004-04-21 Inst Of Cancer Res The Materials and methods for treatment of cancer
EP1737980A2 (en) 2004-04-09 2007-01-03 Fondazione IRCCS Istituto Nazionale dei Tumori Gene expression markers for predicting response to chemotherapy
US8815599B2 (en) 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
AU2013203202B2 (en) * 2004-08-26 2017-02-16 Engeneic Molecular Delivery Pty Ltd Delivering functional nucleic acids to mammalian cells via bacterially derived intact minicells
JP4965447B2 (ja) 2004-08-26 2012-07-04 エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド 細菌由来のインタクトなミニセルを介した哺乳動物細胞への機能性核酸の送達
DK1815014T3 (da) 2004-11-05 2012-06-18 Genomic Health Inc Molekylære indikatorer for brystcancerprognose og forudsigelse af behandlingsrespons
JP5020088B2 (ja) 2004-11-05 2012-09-05 ジェノミック ヘルス， インコーポレイテッド 遺伝子発現マーカーを使用する、化学療法に対する反応の予測
JP5122474B2 (ja) * 2005-12-01 2013-01-16 プロネイ・セラピューティクス・インコーポレイテッド 両性リポソーム製剤
TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
CN100368424C (zh) * 2006-07-21 2008-02-13 福建金山生物制药股份有限公司 抑制肿瘤的反义核苷酸
US20080171718A1 (en) * 2006-11-08 2008-07-17 Brown Bob D Methods and Compositions for Treating Cancer Using BCL-2 Antisense Oligomers, Tyrosine Kinase Inhibitors, and Chemotherapeutic Agents
DE102007020554A1 (de) * 2007-04-27 2008-10-30 Henkel Ag & Co. Kgaa Nukleinsäurehaltige kosmetische und/oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
WO2009071681A2 (en) * 2007-12-07 2009-06-11 Santaris Pharma A/S Rna antagonist compounds for the modulation of bcl-2
JP2012509878A (ja) * 2008-11-21 2012-04-26 アイシス ファーマシューティカルズ， インコーポレーテッド ドセタキセルおよびアンチセンスオリゴヌクレオチドを含む、抗腫瘍併用療法
IN2012DN00969A (pt) 2009-07-30 2015-04-10 Antisense Pharma Gmbh
EP2521785B1 (en) * 2010-01-06 2022-03-09 CuRNA, Inc. Inhibition of natural antisense transcript to a pancreatic developmental gene for use in a treatment of pancreatic developmental gene related diseases
ES2731377T3 (es) 2015-07-07 2019-11-15 Hoffmann La Roche Politerapia con un conjugado anticuerpo anti-HER2-fármaco y un inhibidor de bcl-2
US20180221393A1 (en) 2015-08-03 2018-08-09 Biokine Therapeutics Ltd. Cxcr4 binding agents for treatment of diseases
WO2021231486A1 (en) * 2020-05-13 2021-11-18 Unity Biotechnology, Inc. Cancer treatment by senescence induction followed by a senolytic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US5276019A (en) 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US5098890A (en) 1988-11-07 1992-03-24 Temple University-Of The Commonwealth System Of Higher Education Antisence oligonucleotides to c-myb proto-oncogene and uses thereof
US5831066A (en) 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5734033A (en) 1988-12-22 1998-03-31 The Trustees Of The University Of Pennsylvania Antisense oligonucleotides inhibiting human bcl-2 gene expression
CA2025907A1 (en) 1989-09-21 1991-03-22 Franklin D. Collins Method of transporting compositions across the blood brain barrier
EP0633934A1 (en) 1992-04-02 1995-01-18 Imperial Cancer Research Technology Limited Modified cells and method of treatment
CA2147663A1 (en) 1992-10-21 1994-04-28 Bruno Calabretta Combination of antineoplastic agent and antisense oligonucleotides for treatment of cancer
US5550019A (en) 1993-05-26 1996-08-27 La Jolla Cancer Research Foundation Methods of identifying compounds which alter apoptosis
US5783683A (en) * 1995-01-10 1998-07-21 Genta Inc. Antisense oligonucleotides which reduce expression of the FGFRI gene
US6214986B1 (en) * 1998-10-07 2001-04-10 Isis Pharmaceuticals, Inc. Antisense modulation of bcl-x expression

Also Published As

Publication number Publication date
AU8837301A (en) 2002-03-13
DE60138892D1 (de) 2009-07-16
CN1471408A (zh) 2004-01-28
US20100216867A1 (en) 2010-08-26
PT1313514E (pt) 2009-09-01
YU13603A (sh) 2006-05-25
EE200300074A (et) 2004-12-15
EP1313514B1 (en) 2009-06-03
HRP20030102A2 (en) 2005-04-30
EP1313514A2 (en) 2003-05-28
WO2002017852A3 (en) 2003-04-03
BG107641A (bg) 2004-01-30
NO20030858D0 (no) 2003-02-24
PL363050A1 (en) 2004-11-15
UA77945C2 (en) 2007-02-15
KR20030034153A (ko) 2003-05-01
OA12586A (en) 2006-06-07
EA200300294A1 (ru) 2003-08-28
DZ3471A1 (fr) 2002-03-07
NO20030858L (no) 2003-04-24
WO2002017852A2 (en) 2002-03-07
AU2001288373B2 (en) 2006-05-11
ES2327904T3 (es) 2009-11-05
ATE432717T1 (de) 2009-06-15
HUP0303125A2 (hu) 2003-12-29
CZ301582B6 (cs) 2010-04-21
IL154409A0 (en) 2003-09-17
SK3652003A3 (en) 2003-08-05
EP2135623A1 (en) 2009-12-23
HK1056505A1 (en) 2004-02-20
CZ2003848A3 (cs) 2003-11-12
CY1109340T1 (el) 2014-07-02
GEP20063934B (en) 2006-10-10
DK1313514T3 (da) 2009-10-12
MXPA03001575A (es) 2004-11-01
JP2004507480A (ja) 2004-03-11
EP1313514A4 (en) 2005-07-13
US7795232B1 (en) 2010-09-14
CA2419480A1 (en) 2002-03-07
AP2003002761A0 (en) 2003-06-30
EA005424B1 (ru) 2005-02-24

Similar Documents

Publication Publication Date Title
BR0113447A (pt) Método de tratamento ou prevenção do câncer em um ser humano, e, composição farmacêutica
BR0012136A (pt) Inibidores de reabsorção de norepinefrina altamente seletivos e métodos de uso dos mesmos
BR0009647A (pt) Docetaxel em combinação com rhumab her2 para o tratamento de cânceres
BR0115109A (pt) Agentes terapêuticos e métodos de uso dos mesmos para a modulação da angiogênese
BR9908030A (pt) Composição farmacêutica compreendendo uma ou mais unidades de dose oralmente ministráveis, e, processos para prepará-la, para uso da mesma, e para tratar uma condição ou distúrbio médico em um indivìduo em que tratamento com um inibidor da ciclooxigenase-2 é indicado
BR9715022A (pt) Método para tratar de doenças prostáticas usando formulações de vitamina d por liberação sistemática e/ou prolongada
BR0015974A (pt) Uso de levetiracetam, composição farmacêutica, uso de uma composição farmacêutica e métodos para tratar um paciente admintstrado com uma quantidade de pelo menos um composto e uma doença e para potenciar seletivamente o efeito terapêutico de um composto
BR0316685A (pt) Composições e métodos para a administração aperfeiçoada por via mucosal de peptìdeos fixadores ao receptor de y2 e métodos para tratar e prevenir a obesidade
BR0309280A (pt) Terapia de combinação para o tratamento de câncer
KR960703009A (ko) 중추유래의 수면성 무호흡증 및 호흡곤란증의 치료를 위한 모다피닐의 사용
ES2162615T3 (es) Metodo para tratar o prevenir diabetes de tipo 1 mediante la administracion oral de insulina.
BR0209147A (pt) Terapia combinada que usa anticorpos anti-egfr e agentes anti-hormonais
ES2172654T3 (es) Uso de nsaid para el tratamiento de carcinomas de celulas escamosas de la cavidad oral u orofaringe.
IL107109A0 (en) Compounds for modifying drug resistance and pharmaceutical compositions containing the same
BR0109336A (pt) Medicamento para a prevenção, melhora e/ou tratamento de uma complicação diabética, droga medicinal adequada ou utilizável como o mesmo, método para prevenir, melhorar e/ou tratar a complicação diabética, e a neuropatia, e, usos de um agente redutor do açúcar no sangue pós-prandial e pelo menos um agente selecionado de um agente anti-hipertensivo, um agente vasodilatador e um agente anti-hiperlipidêmico
BR0111207A (pt) Combinações de um antagonista receptor de endotelina e um composto antiepiléptico tendo propriedades de alìvio da dor ou analgésicos
BR0207316A (pt) Derivados de epotilona para o tratamento de tumores refratários
BR0315573A (pt) Método para tratar, prevenir, controlar e/ou modificar dor em um paciente e composição farmacêutica
MX9708800A (es) Compuestos biciclicos aromaticos.
BR9813318A (pt) Processo de tratamento de tumores e degeneração macular em paciente humano ou veterinário, composição farmacêutica para tratamento de tumores e degeneração macular em um paciente humano ou veterinário
DE69400353T2 (de) Schlankmachende Zusammensetzung
NZ328874A (en) Heterocyclic biaryl compounds and their use in pharmaceutical compositions for treatment of dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders
MX9708803A (es) Compuestos biaromaticos de propinilo o dienilo.
BR9809694A (pt) Processo e composição para administração de taxanos oralmente a pacientes humanos
BR0201974A (pt) Composição farmacêutica para tratamento de alterações do sono

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2164 DE 26/06/2012.