CY1109340T1 - Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη - Google Patents

Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη

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Publication number
CY1109340T1
CY1109340T1 CY20091100919T CY091100919T CY1109340T1 CY 1109340 T1 CY1109340 T1 CY 1109340T1 CY 20091100919 T CY20091100919 T CY 20091100919T CY 091100919 T CY091100919 T CY 091100919T CY 1109340 T1 CY1109340 T1 CY 1109340T1
Authority
CY
Cyprus
Prior art keywords
bcl
present
oligomer
disorder
treatment
Prior art date
Application number
CY20091100919T
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English (en)
Inventor
Raymond P Warrel Jr
Robert E Klem
Howard Dr Fingert
Original Assignee
Genta Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27397795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109340(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genta Incorporated filed Critical Genta Incorporated
Publication of CY1109340T1 publication Critical patent/CY1109340T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση κατευθύνεται στην χρήση bcl-2 αντιπληροφοριακού ολιγομερών για την θεραπεία και πρόληψη σχετικών με bcl-2 διαταραχών. Αυτές οι διαταραχές περιλαμβάνουν καρκίνους, όγκους, καρκινώματα και σχετικές κυτταροπολλαπλασιαστικές διαταραχές. Σε εφαρμογή της εφεύρεσης, bcl-2 αντιπληροφοριακό ολιγομερές χορηγείται σε υψηλές δόσεις. Η παρούσα εφεύρεση κατευθύνεται επίσης σε μέθοδο πρόληψης ή θεραπείας σχετικής με bcl-2 διαταραχής, συγκεκριμένα καρκίνου, που περιλαμβάνει χορήγηση bcl-2 αντιπληροφοριακού ολιγομερούς για σύντομες χρονικές περιόδους. Η παρούσα εφεύρεση κατευθύνεται περαιτέρω στην χρήση bcl-2 αντιπληροφοριακού ολιγομερών για να αυξηθεί η ευαισθησία υποκειμένου στην θεραπευτική του καρκίνου. Η παρούσα εφεύρεση επίσης αφορά φαρμακευτικές συνθέσεις που περιλαμβάνουν ένα ή περισσότερα bcl-2 αντιπληροφοριακά ολιγομερών, που μπορεί να περιλαμβάνουν έναν ή περισσότερους θεραπευτικούς παράγοντες του καρκίνου.
CY20091100919T 2000-08-25 2009-09-02 Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη CY1109340T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22797000P 2000-08-25 2000-08-25
US23700900P 2000-09-29 2000-09-29
US09/709,170 US7795232B1 (en) 2000-08-25 2000-11-10 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
EP01968097A EP1313514B1 (en) 2000-08-25 2001-08-23 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers

Publications (1)

Publication Number Publication Date
CY1109340T1 true CY1109340T1 (el) 2014-07-02

Family

ID=27397795

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100919T CY1109340T1 (el) 2000-08-25 2009-09-02 Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη

Country Status (33)

Country Link
US (2) US7795232B1 (el)
EP (2) EP1313514B1 (el)
JP (1) JP2004507480A (el)
KR (1) KR20030034153A (el)
CN (1) CN1471408A (el)
AP (1) AP2003002761A0 (el)
AT (1) ATE432717T1 (el)
AU (2) AU8837301A (el)
BG (1) BG107641A (el)
BR (1) BR0113447A (el)
CA (1) CA2419480A1 (el)
CY (1) CY1109340T1 (el)
CZ (1) CZ301582B6 (el)
DE (1) DE60138892D1 (el)
DK (1) DK1313514T3 (el)
DZ (1) DZ3471A1 (el)
EA (1) EA005424B1 (el)
EE (1) EE200300074A (el)
ES (1) ES2327904T3 (el)
GE (1) GEP20063934B (el)
HK (1) HK1056505A1 (el)
HR (1) HRP20030102A2 (el)
HU (1) HUP0303125A2 (el)
IL (1) IL154409A0 (el)
MX (1) MXPA03001575A (el)
NO (1) NO20030858L (el)
OA (1) OA12586A (el)
PL (1) PL363050A1 (el)
PT (1) PT1313514E (el)
SK (1) SK3652003A3 (el)
UA (1) UA77945C2 (el)
WO (1) WO2002017852A2 (el)
YU (1) YU13603A (el)

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US6977244B2 (en) 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
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DE10258677A1 (de) * 2002-12-13 2004-06-24 Elez, Vera, Dr. Kombinations-antisense-Oligonukleotid-Krebstherapie
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Also Published As

Publication number Publication date
AP2003002761A0 (en) 2003-06-30
EA200300294A1 (ru) 2003-08-28
SK3652003A3 (en) 2003-08-05
BR0113447A (pt) 2003-07-08
EE200300074A (et) 2004-12-15
KR20030034153A (ko) 2003-05-01
HUP0303125A2 (hu) 2003-12-29
HRP20030102A2 (en) 2005-04-30
PT1313514E (pt) 2009-09-01
AU8837301A (en) 2002-03-13
CA2419480A1 (en) 2002-03-07
EP1313514B1 (en) 2009-06-03
WO2002017852A2 (en) 2002-03-07
US20100216867A1 (en) 2010-08-26
CZ2003848A3 (cs) 2003-11-12
UA77945C2 (en) 2007-02-15
NO20030858D0 (no) 2003-02-24
ES2327904T3 (es) 2009-11-05
GEP20063934B (en) 2006-10-10
NO20030858L (no) 2003-04-24
JP2004507480A (ja) 2004-03-11
DE60138892D1 (de) 2009-07-16
EP1313514A4 (en) 2005-07-13
ATE432717T1 (de) 2009-06-15
BG107641A (bg) 2004-01-30
CZ301582B6 (cs) 2010-04-21
DZ3471A1 (fr) 2002-03-07
EP1313514A2 (en) 2003-05-28
IL154409A0 (en) 2003-09-17
US7795232B1 (en) 2010-09-14
PL363050A1 (en) 2004-11-15
OA12586A (en) 2006-06-07
CN1471408A (zh) 2004-01-28
YU13603A (sh) 2006-05-25
WO2002017852A3 (en) 2003-04-03
AU2001288373B2 (en) 2006-05-11
EA005424B1 (ru) 2005-02-24
EP2135623A1 (en) 2009-12-23
HK1056505A1 (en) 2004-02-20
MXPA03001575A (es) 2004-11-01
DK1313514T3 (da) 2009-10-12

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