DZ3471A1 - Methodes de traitement d'une pathologie en rapport avec le gene bcl-2 au moyen d'oligomeres antisens de bcl-2 - Google Patents

Methodes de traitement d'une pathologie en rapport avec le gene bcl-2 au moyen d'oligomeres antisens de bcl-2

Info

Publication number
DZ3471A1
DZ3471A1 DZ013471A DZ013471A DZ3471A1 DZ 3471 A1 DZ3471 A1 DZ 3471A1 DZ 013471 A DZ013471 A DZ 013471A DZ 013471 A DZ013471 A DZ 013471A DZ 3471 A1 DZ3471 A1 DZ 3471A1
Authority
DZ
Algeria
Prior art keywords
bcl
gene
treating
methods
condition related
Prior art date
Application number
DZ013471A
Other languages
English (en)
Inventor
Raymond P Warrel Jr
Robert E Klem
Howard Fingert
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27397795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DZ3471(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genta Inc filed Critical Genta Inc
Application granted granted Critical
Publication of DZ3471A1 publication Critical patent/DZ3471A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DZ013471A 2000-08-25 2001-08-23 Methodes de traitement d'une pathologie en rapport avec le gene bcl-2 au moyen d'oligomeres antisens de bcl-2 DZ3471A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22797000P 2000-08-25 2000-08-25
US23700900P 2000-09-29 2000-09-29
US09/709,170 US7795232B1 (en) 2000-08-25 2000-11-10 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
PCT/US2001/026414 WO2002017852A2 (fr) 2000-08-25 2001-08-23 Methodes de traitement d'une pathologie en rapport avec le gene bcl-2 au moyen d'oligomeres antisens de bcl-2

Publications (1)

Publication Number Publication Date
DZ3471A1 true DZ3471A1 (fr) 2002-03-07

Family

ID=27397795

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ013471A DZ3471A1 (fr) 2000-08-25 2001-08-23 Methodes de traitement d'une pathologie en rapport avec le gene bcl-2 au moyen d'oligomeres antisens de bcl-2

Country Status (33)

Country Link
US (2) US7795232B1 (fr)
EP (2) EP2135623A1 (fr)
JP (1) JP2004507480A (fr)
KR (1) KR20030034153A (fr)
CN (1) CN1471408A (fr)
AP (1) AP2003002761A0 (fr)
AT (1) ATE432717T1 (fr)
AU (2) AU2001288373B2 (fr)
BG (1) BG107641A (fr)
BR (1) BR0113447A (fr)
CA (1) CA2419480A1 (fr)
CY (1) CY1109340T1 (fr)
CZ (1) CZ301582B6 (fr)
DE (1) DE60138892D1 (fr)
DK (1) DK1313514T3 (fr)
DZ (1) DZ3471A1 (fr)
EA (1) EA005424B1 (fr)
EE (1) EE200300074A (fr)
ES (1) ES2327904T3 (fr)
GE (1) GEP20063934B (fr)
HK (1) HK1056505A1 (fr)
HR (1) HRP20030102A2 (fr)
HU (1) HUP0303125A2 (fr)
IL (1) IL154409A0 (fr)
MX (1) MXPA03001575A (fr)
NO (1) NO20030858L (fr)
OA (1) OA12586A (fr)
PL (1) PL363050A1 (fr)
PT (1) PT1313514E (fr)
SK (1) SK3652003A3 (fr)
UA (1) UA77945C2 (fr)
WO (1) WO2002017852A2 (fr)
YU (1) YU13603A (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855911A (en) 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US7309692B1 (en) 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6977244B2 (en) 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
WO2003078662A1 (fr) 2002-03-13 2003-09-25 Genomic Health Profilage d'expression genique dans des tissus tumoraux ponctionnes
CA2505680A1 (fr) 2002-11-14 2004-06-03 Genta Salus Llc Oliogonucleotides inhibiteurs diriges sur bcl-2
AU2003295598B2 (en) 2002-11-15 2009-12-24 Genomic Health, Inc. Gene expression profiling of EGFR positive cancer
DE10258677A1 (de) * 2002-12-13 2004-06-24 Elez, Vera, Dr. Kombinations-antisense-Oligonukleotid-Krebstherapie
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
ATE412779T1 (de) 2003-02-20 2008-11-15 Genomic Health Inc Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression
US20080020990A1 (en) 2003-05-30 2008-01-24 Nippon Shinyaku Co., Ltd. Oligo Double-Stranded Rna Inhibiting the Expression of Bcl-2 and Pharmaceutical Composition Containing the Same
ES2787475T3 (es) 2003-06-24 2020-10-16 Genomic Health Inc Predicción de probabilidad de recurrencia del cáncer
ES2905579T3 (es) 2003-07-10 2022-04-11 Genomic Health Inc Algoritmo del perfil de expresión y prueba para el pronóstico de la recaída del cáncer de mama
US20050196782A1 (en) 2003-12-23 2005-09-08 Kiefer Michael C. Universal amplification of fragmented RNA
GB0406415D0 (en) * 2004-03-22 2004-04-21 Inst Of Cancer Res The Materials and methods for treatment of cancer
EP2947160B1 (fr) 2004-04-09 2017-07-12 Genomic Health, Inc. Marqueurs d'expression de genes permettant de predire une reponse a la chimiotherapie
US8815599B2 (en) 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US8691963B2 (en) 2004-08-26 2014-04-08 Engeneic Molecular Delivery Pty. Ltd. Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
AU2013203202B2 (en) * 2004-08-26 2017-02-16 Engeneic Molecular Delivery Pty Ltd Delivering functional nucleic acids to mammalian cells via bacterially derived intact minicells
AU2005304824B2 (en) 2004-11-05 2011-12-22 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
ATE550440T1 (de) 2004-11-05 2012-04-15 Genomic Health Inc Molekulare indikatoren für brustkrebsprognose und vorhersage des ansprechens auf eine behandlung
WO2007064857A2 (fr) * 2005-12-01 2007-06-07 Pronai Therapeutics, Inc. Formulation de liposomes amphoteres
TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
CN100368424C (zh) * 2006-07-21 2008-02-13 福建金山生物制药股份有限公司 抑制肿瘤的反义核苷酸
US20080171718A1 (en) * 2006-11-08 2008-07-17 Brown Bob D Methods and Compositions for Treating Cancer Using BCL-2 Antisense Oligomers, Tyrosine Kinase Inhibitors, and Chemotherapeutic Agents
DE102007020554A1 (de) * 2007-04-27 2008-10-30 Henkel Ag & Co. Kgaa Nukleinsäurehaltige kosmetische und/oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
WO2009071681A2 (fr) * 2007-12-07 2009-06-11 Santaris Pharma A/S Composés d'antagoniste d'arn utiles pour moduler bcl-2
AU2009316773A1 (en) * 2008-11-21 2010-05-27 Isis Pharmaceuticals, Inc. Anticancer combination comprising docetaxel and an antisense oligonucleotide
CN102712924A (zh) 2009-07-30 2012-10-03 安提森斯制药有限公司 化疗药剂和TGF-β系统抑制剂的组合
KR101853509B1 (ko) * 2010-01-06 2018-04-30 큐알엔에이, 인크. 췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
RS58823B1 (sr) 2015-07-07 2019-07-31 Hoffmann La Roche Kombinovana terapija konjugatom anti-her2 antitelo-lek i bcl-2 inhibitorom
US20180221393A1 (en) 2015-08-03 2018-08-09 Biokine Therapeutics Ltd. Cxcr4 binding agents for treatment of diseases
WO2021231486A1 (fr) * 2020-05-13 2021-11-18 Unity Biotechnology, Inc. Traitement du cancer par l'induction de sénescence suivie d'un sénolytique

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US5276019A (en) 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US5098890A (en) 1988-11-07 1992-03-24 Temple University-Of The Commonwealth System Of Higher Education Antisence oligonucleotides to c-myb proto-oncogene and uses thereof
US5831066A (en) 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
US5734033A (en) 1988-12-22 1998-03-31 The Trustees Of The University Of Pennsylvania Antisense oligonucleotides inhibiting human bcl-2 gene expression
WO1991004014A1 (fr) 1989-09-21 1991-04-04 Synergen, Inc. Procede de transport de compositions a travers la barriere hemato-encephalique
WO1993020200A1 (fr) 1992-04-02 1993-10-14 Imperial Cancer Research Technology Limited Cellules modifiees et procede de traitement
WO1994008625A1 (fr) 1992-10-21 1994-04-28 Temple University - Of The Commonwealth System Of Higher Education Combinaison d'un agent anti-neoplasique et d'oligonucleotides non codants dans le traitement du cancer
US5550019A (en) 1993-05-26 1996-08-27 La Jolla Cancer Research Foundation Methods of identifying compounds which alter apoptosis
US5783683A (en) * 1995-01-10 1998-07-21 Genta Inc. Antisense oligonucleotides which reduce expression of the FGFRI gene
US6214986B1 (en) * 1998-10-07 2001-04-10 Isis Pharmaceuticals, Inc. Antisense modulation of bcl-x expression

Also Published As

Publication number Publication date
CA2419480A1 (fr) 2002-03-07
NO20030858D0 (no) 2003-02-24
EP1313514A2 (fr) 2003-05-28
EA200300294A1 (ru) 2003-08-28
AP2003002761A0 (en) 2003-06-30
IL154409A0 (en) 2003-09-17
OA12586A (en) 2006-06-07
EP1313514B1 (fr) 2009-06-03
CY1109340T1 (el) 2014-07-02
EP1313514A4 (fr) 2005-07-13
MXPA03001575A (es) 2004-11-01
WO2002017852A3 (fr) 2003-04-03
US20100216867A1 (en) 2010-08-26
US7795232B1 (en) 2010-09-14
BG107641A (bg) 2004-01-30
UA77945C2 (en) 2007-02-15
CN1471408A (zh) 2004-01-28
PT1313514E (pt) 2009-09-01
PL363050A1 (en) 2004-11-15
AU2001288373B2 (en) 2006-05-11
NO20030858L (no) 2003-04-24
BR0113447A (pt) 2003-07-08
CZ2003848A3 (cs) 2003-11-12
CZ301582B6 (cs) 2010-04-21
WO2002017852A2 (fr) 2002-03-07
YU13603A (sh) 2006-05-25
DK1313514T3 (da) 2009-10-12
KR20030034153A (ko) 2003-05-01
JP2004507480A (ja) 2004-03-11
EP2135623A1 (fr) 2009-12-23
HK1056505A1 (en) 2004-02-20
GEP20063934B (en) 2006-10-10
DE60138892D1 (de) 2009-07-16
ATE432717T1 (de) 2009-06-15
EE200300074A (et) 2004-12-15
AU8837301A (en) 2002-03-13
ES2327904T3 (es) 2009-11-05
SK3652003A3 (en) 2003-08-05
HRP20030102A2 (en) 2005-04-30
EA005424B1 (ru) 2005-02-24
HUP0303125A2 (hu) 2003-12-29

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