EA200300294A1 - Способы лечения связанного с bcl-2 нарушения с использованием bcl-2-антисмысловых олигомеров - Google Patents

Способы лечения связанного с bcl-2 нарушения с использованием bcl-2-антисмысловых олигомеров

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Publication number
EA200300294A1
EA200300294A1 EA200300294A EA200300294A EA200300294A1 EA 200300294 A1 EA200300294 A1 EA 200300294A1 EA 200300294 A EA200300294 A EA 200300294A EA 200300294 A EA200300294 A EA 200300294A EA 200300294 A1 EA200300294 A1 EA 200300294A1
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Eurasian Patent Office
Prior art keywords
bcl
present
disorders
relates
oligomers
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EA200300294A
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English (en)
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EA005424B1 (ru
Inventor
Рэймонд П. мл. Уоррел
Роберт Э. Клем
Ховард Фингерт
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Джента Инкорпорейтед
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27397795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200300294(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джента Инкорпорейтед filed Critical Джента Инкорпорейтед
Publication of EA200300294A1 publication Critical patent/EA200300294A1/ru
Publication of EA005424B1 publication Critical patent/EA005424B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к применению bcl-2-антисмысловых олигомеров для лечения и профилактики нарушений, связанных с bcl-2. Данные нарушения включают рак, опухоли, карциномы и нарушения, связанные с клеточной пролиферацией. В одном из вариантов осуществления изобретения bcl-2 -антисмысловой олигомер вводят в больших дозах. Настоящее изобретение также относится к способу профилактики или лечения нарушения, связанного с bcl-2, в частности рака, включающему введение bcl-2-антисмыслового олигомера в течение кратких периодов времени. Настоящее изобретение, кроме того, относится к применению bcl-2-антисмысловых олигомеров для повышения чувствительности субъекта к противоопухолевой терапии. Настоящее изобретение также относится к фармацевтическим композициям, включающим один или более bcl-2-антисмысловых олигомеров, которые могут включать одно или более противоопухолевых терапевтических средств.Отчет о международном поиске был опубликован 2003.04.03.
EA200300294A 2000-08-25 2001-08-23 СПОСОБЫ ЛЕЧЕНИЯ СВЯЗАННОГО С bcl-2 НАРУШЕНИЯ С ИСПОЛЬЗОВАНИЕМ bcl-2-АНТИСМЫСЛОВЫХ ОЛИГОМЕРОВ EA005424B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22797000P 2000-08-25 2000-08-25
US23700900P 2000-09-29 2000-09-29
US09/709,170 US7795232B1 (en) 2000-08-25 2000-11-10 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
PCT/US2001/026414 WO2002017852A2 (en) 2000-08-25 2001-08-23 Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers

Publications (2)

Publication Number Publication Date
EA200300294A1 true EA200300294A1 (ru) 2003-08-28
EA005424B1 EA005424B1 (ru) 2005-02-24

Family

ID=27397795

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300294A EA005424B1 (ru) 2000-08-25 2001-08-23 СПОСОБЫ ЛЕЧЕНИЯ СВЯЗАННОГО С bcl-2 НАРУШЕНИЯ С ИСПОЛЬЗОВАНИЕМ bcl-2-АНТИСМЫСЛОВЫХ ОЛИГОМЕРОВ

Country Status (33)

Country Link
US (2) US7795232B1 (ru)
EP (2) EP1313514B1 (ru)
JP (1) JP2004507480A (ru)
KR (1) KR20030034153A (ru)
CN (1) CN1471408A (ru)
AP (1) AP2003002761A0 (ru)
AT (1) ATE432717T1 (ru)
AU (2) AU8837301A (ru)
BG (1) BG107641A (ru)
BR (1) BR0113447A (ru)
CA (1) CA2419480A1 (ru)
CY (1) CY1109340T1 (ru)
CZ (1) CZ301582B6 (ru)
DE (1) DE60138892D1 (ru)
DK (1) DK1313514T3 (ru)
DZ (1) DZ3471A1 (ru)
EA (1) EA005424B1 (ru)
EE (1) EE200300074A (ru)
ES (1) ES2327904T3 (ru)
GE (1) GEP20063934B (ru)
HK (1) HK1056505A1 (ru)
HR (1) HRP20030102A2 (ru)
HU (1) HUP0303125A2 (ru)
IL (1) IL154409A0 (ru)
MX (1) MXPA03001575A (ru)
NO (1) NO20030858L (ru)
OA (1) OA12586A (ru)
PL (1) PL363050A1 (ru)
PT (1) PT1313514E (ru)
SK (1) SK3652003A3 (ru)
UA (1) UA77945C2 (ru)
WO (1) WO2002017852A2 (ru)
YU (1) YU13603A (ru)

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US6977244B2 (en) 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
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Also Published As

Publication number Publication date
AP2003002761A0 (en) 2003-06-30
SK3652003A3 (en) 2003-08-05
BR0113447A (pt) 2003-07-08
EE200300074A (et) 2004-12-15
KR20030034153A (ko) 2003-05-01
HUP0303125A2 (hu) 2003-12-29
HRP20030102A2 (en) 2005-04-30
PT1313514E (pt) 2009-09-01
AU8837301A (en) 2002-03-13
CA2419480A1 (en) 2002-03-07
EP1313514B1 (en) 2009-06-03
WO2002017852A2 (en) 2002-03-07
US20100216867A1 (en) 2010-08-26
CZ2003848A3 (cs) 2003-11-12
UA77945C2 (en) 2007-02-15
NO20030858D0 (no) 2003-02-24
ES2327904T3 (es) 2009-11-05
GEP20063934B (en) 2006-10-10
NO20030858L (no) 2003-04-24
JP2004507480A (ja) 2004-03-11
DE60138892D1 (de) 2009-07-16
EP1313514A4 (en) 2005-07-13
ATE432717T1 (de) 2009-06-15
BG107641A (bg) 2004-01-30
CZ301582B6 (cs) 2010-04-21
DZ3471A1 (fr) 2002-03-07
EP1313514A2 (en) 2003-05-28
IL154409A0 (en) 2003-09-17
US7795232B1 (en) 2010-09-14
PL363050A1 (en) 2004-11-15
CY1109340T1 (el) 2014-07-02
OA12586A (en) 2006-06-07
CN1471408A (zh) 2004-01-28
YU13603A (sh) 2006-05-25
WO2002017852A3 (en) 2003-04-03
AU2001288373B2 (en) 2006-05-11
EA005424B1 (ru) 2005-02-24
EP2135623A1 (en) 2009-12-23
HK1056505A1 (en) 2004-02-20
MXPA03001575A (es) 2004-11-01
DK1313514T3 (da) 2009-10-12

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