TWI784957B - 免疫細胞介素 - Google Patents

免疫細胞介素 Download PDF

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Publication number
TWI784957B
TWI784957B TW106120562A TW106120562A TWI784957B TW I784957 B TWI784957 B TW I784957B TW 106120562 A TW106120562 A TW 106120562A TW 106120562 A TW106120562 A TW 106120562A TW I784957 B TWI784957 B TW I784957B
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TW
Taiwan
Prior art keywords
seq
amino acid
attached
acid sequence
concept
Prior art date
Application number
TW106120562A
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English (en)
Chinese (zh)
Other versions
TW201811820A (zh
Inventor
傑米 伊恩 坎佩貝爾
妮可 珊蒂
克瑞恩克斯 卡珊德拉 凡
史蒂芬 約翰 阿奇恩斯塔爾
唯克爾 格曼史切奇
伊恩 可畢
米哈 寇馬克
湯瑪斯 格拉赫
西西里亞 狄恩提尼歐
史蒂芬 道格拉斯 吉爾斯
Original Assignee
英商克馬伯有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/211,504 external-priority patent/US9567399B1/en
Priority claimed from GBGB1615224.1A external-priority patent/GB201615224D0/en
Priority claimed from GBGB1615335.5A external-priority patent/GB201615335D0/en
Priority claimed from GBGB1620414.1A external-priority patent/GB201620414D0/en
Priority claimed from GBGB1621782.0A external-priority patent/GB201621782D0/en
Priority claimed from GBGB1702338.3A external-priority patent/GB201702338D0/en
Priority claimed from GBGB1702339.1A external-priority patent/GB201702339D0/en
Priority claimed from GBGB1703071.9A external-priority patent/GB201703071D0/en
Application filed by 英商克馬伯有限公司 filed Critical 英商克馬伯有限公司
Priority to JP2019529699A priority Critical patent/JP7198752B2/ja
Priority to KR1020267003693A priority patent/KR20260030924A/ko
Priority to BR112019002529-4A priority patent/BR112019002529A2/pt
Priority to KR1020237009918A priority patent/KR20230044038A/ko
Priority to PCT/GB2017/052352 priority patent/WO2018029474A2/en
Priority to US16/323,980 priority patent/US11858996B2/en
Priority to EP17752162.2A priority patent/EP3497128A2/en
Priority to RU2019104980A priority patent/RU2764548C2/ru
Priority to CA3032897A priority patent/CA3032897A1/en
Priority to KR1020197006706A priority patent/KR102604433B1/ko
Priority to US15/698,600 priority patent/US9957323B2/en
Priority to US16/471,161 priority patent/US20200190191A1/en
Priority to EP17840565.0A priority patent/EP3559041A1/en
Priority to PCT/GB2017/053826 priority patent/WO2018115859A1/en
Priority to JP2019533195A priority patent/JP7290568B2/ja
Publication of TW201811820A publication Critical patent/TW201811820A/zh
Priority to US17/727,288 priority patent/US20220380467A1/en
Priority to US17/727,309 priority patent/US20220403029A1/en
Priority to JP2022089801A priority patent/JP7448586B2/ja
Application granted granted Critical
Publication of TWI784957B publication Critical patent/TWI784957B/zh
Priority to JP2023016174A priority patent/JP7750887B2/ja
Priority to US18/499,431 priority patent/US20240158502A1/en
Priority to JP2023205810A priority patent/JP7781129B2/ja
Priority to US19/282,256 priority patent/US20260049143A1/en
Priority to JP2025157613A priority patent/JP2026001069A/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/46—Hybrid immunoglobulins
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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TW106120562A 2016-06-20 2017-06-20 免疫細胞介素 TWI784957B (zh)

Priority Applications (23)

Application Number Priority Date Filing Date Title
KR1020197006706A KR102604433B1 (ko) 2016-08-09 2017-08-09 항-icos 항체
CA3032897A CA3032897A1 (en) 2016-08-09 2017-08-09 Anti-icos antibodies
RU2019104980A RU2764548C2 (ru) 2016-08-09 2017-08-09 Анти-icos антитела
JP2019529699A JP7198752B2 (ja) 2016-08-09 2017-08-09 抗ｉｃｏｓ抗体
EP17752162.2A EP3497128A2 (en) 2016-08-09 2017-08-09 Anti-icos antibodies
US16/323,980 US11858996B2 (en) 2016-08-09 2017-08-09 Anti-ICOS antibodies
PCT/GB2017/052352 WO2018029474A2 (en) 2016-08-09 2017-08-09 Anti-icos antibodies
KR1020237009918A KR20230044038A (ko) 2016-08-09 2017-08-09 항-icos 항체
KR1020267003693A KR20260030924A (ko) 2016-08-09 2017-08-09 항-icos 항체
BR112019002529-4A BR112019002529A2 (pt) 2016-08-09 2017-08-09 anticorpo isolado, composição, método para modular o equilíbrio de células t, método para tratar uma doença ou afecção tratável com terapia, método para tratar câncer, combinação de anticorpo igg1, anticorpo anti-icos, mamífero não humano transgênico, e método para produzir um anticorpo
US15/698,600 US9957323B2 (en) 2016-06-20 2017-09-07 Anti-ICOS antibodies
EP17840565.0A EP3559041A1 (en) 2016-12-20 2017-12-19 Multispecific antibody with combination therapy for immuno-oncology
PCT/GB2017/053826 WO2018115859A1 (en) 2016-12-20 2017-12-19 Multispecific antibody with combination therapy for immuno-oncology
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JP2022089801A JP7448586B2 (ja) 2016-08-09 2022-06-01 抗ｉｃｏｓ抗体
JP2023016174A JP7750887B2 (ja) 2016-12-20 2023-02-06 癌免疫療法のための併用療法での多重特異性抗体
US18/499,431 US20240158502A1 (en) 2016-08-09 2023-11-01 Anti-icos antibodies
JP2023205810A JP7781129B2 (ja) 2016-08-09 2023-12-06 抗ｉｃｏｓ抗体
US19/282,256 US20260049143A1 (en) 2016-12-20 2025-07-28 Multispecific antibody with combination therapy for immuno-oncology
JP2025157613A JP2026001069A (ja) 2016-12-20 2025-09-24 癌免疫療法のための併用療法での多重特異性抗体

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