JPS5229888B2
(he)
|
1972-02-01 |
1977-08-04 |
|
|
US4769320A
(en)
|
1982-07-27 |
1988-09-06 |
New England Medical Center Hospitals, Inc. |
Immunoassay means and methods useful in human native prothrombin and human abnormal prothorombin determinations
|
ES521371A0
(es)
*
|
1982-04-12 |
1984-05-16 |
Hybritech Inc |
Un procedimiento para la purificacion de un anticuerpo.
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
US4689299A
(en)
*
|
1982-09-30 |
1987-08-25 |
University Of Rochester |
Human monoclonal antibodies against bacterial toxins
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
JPS6088703A
(ja)
|
1983-10-18 |
1985-05-18 |
新日本製鐵株式会社 |
耐重荷重性舗装体
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
US4801687A
(en)
*
|
1986-10-27 |
1989-01-31 |
Bioprobe International, Inc. |
Monoclonal antibody purification process using protein A
|
JPS63149900A
(ja)
|
1986-12-15 |
1988-06-22 |
Toshiba Corp |
半導体メモリ
|
US4851341A
(en)
|
1986-12-19 |
1989-07-25 |
Immunex Corporation |
Immunoaffinity purification system
|
JPH01144991A
(ja)
|
1987-12-02 |
1989-06-07 |
Kagaku Oyobi Ketsusei Riyouhou Kenkyusho |
血液凝固第8因子の精製方法
|
US5670373A
(en)
*
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
US5322678A
(en)
*
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
BG60017A3
(en)
|
1988-09-28 |
1993-06-15 |
Lilly Co Eli |
Method for reducing the heterogeneity of monoclonal antibodies
|
US5126250A
(en)
*
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5202253A
(en)
|
1988-12-30 |
1993-04-13 |
Oklahoma Medical Research Foundation |
Monoclonal antibody specific for protein C and antibody purification method
|
CA2006684C
(en)
|
1988-12-30 |
1996-12-17 |
Charles T. Esmon |
Monoclonal antibody against protein c
|
JPH0636741B2
(ja)
|
1989-11-08 |
1994-05-18 |
帝人株式会社 |
ヒト・プロテインcの分離方法
|
CA2075927A1
(en)
|
1990-02-16 |
1991-08-17 |
Victor A. Raso |
Hybrid reagents capable of selectively releasing molecules into cells
|
US5130129A
(en)
|
1990-03-06 |
1992-07-14 |
The Regents Of The University Of California |
Method for enhancing antibody transport through capillary barriers
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
DK0546073T3
(da)
|
1990-08-29 |
1998-02-02 |
Genpharm Int |
Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
|
GB9022547D0
(en)
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Purified immunoglobulin
|
RU2139351C1
(ru)
|
1991-04-25 |
1999-10-10 |
Чугаи Сейяку Кабусики Кайся |
Н- и l-цепи моноклонального антитела рм1 (монат) к рецептору il-6r человека и их v-области, модифицированная монат, его н- и l-цепи и их v-области, cdr- последовательности, днк-последовательности
|
US5468634A
(en)
*
|
1991-06-24 |
1995-11-21 |
The University Of North Carolina At Chapel Hill |
Axl oncogene
|
JP3087857B2
(ja)
|
1991-07-04 |
2000-09-11 |
東洋紡績株式会社 |
交編編地の染色処理方法
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
EP0656941B1
(en)
|
1992-03-24 |
2005-06-01 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
WO1994002602A1
(en)
|
1992-07-24 |
1994-02-03 |
Cell Genesys, Inc. |
Generation of xenogeneic antibodies
|
BR9204244A
(pt)
|
1992-10-26 |
1994-05-03 |
Cofap |
Ferro fundido cinzento
|
WO1994012215A1
(en)
|
1992-12-01 |
1994-06-09 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with l-selectin
|
CA2157577C
(en)
|
1993-03-19 |
2009-11-17 |
Se-Jin Lee |
Growth differentiation factor-8
|
US7393682B1
(en)
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
JPH08511423A
(ja)
*
|
1993-06-10 |
1996-12-03 |
ジェネティック セラピー,インコーポレイテッド |
血友病治療のためのアデノウイルスベクター
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
FR2707189B1
(fr)
|
1993-07-09 |
1995-10-13 |
Gradient Ass |
Procédé de traitement de résidus de combustion et installation de mise en Óoeuvre dudit procédé.
|
GB9314271D0
(en)
|
1993-07-09 |
1993-08-18 |
Inst Of Cancer The Research |
Cell growth factor receptors
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
US6214613B1
(en)
|
1993-12-03 |
2001-04-10 |
Ashai Kasei Kogyo Kabushiki Kaisha |
Expression screening vector
|
EP0731842A1
(en)
|
1993-12-03 |
1996-09-18 |
Medical Research Council |
Recombinant binding proteins and peptides
|
JPH07177572A
(ja)
|
1993-12-20 |
1995-07-14 |
Matsushita Electric Ind Co Ltd |
コードレス電話の留守番方法
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
DE122009000068I2
(de)
|
1994-06-03 |
2011-06-16 |
Ascenion Gmbh |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
US5945311A
(en)
*
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
US8017121B2
(en)
*
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
EP0771216B9
(en)
|
1994-07-11 |
2003-01-02 |
The Board Of Regents, The University Of Texas System |
Methods and compositions for the specific coagulation of tumoral vasculature
|
CN1156460A
(zh)
|
1994-07-13 |
1997-08-06 |
中外制药株式会社 |
抗人白细胞介素-8的重构人抗体
|
TW416960B
(en)
|
1994-07-13 |
2001-01-01 |
Chugai Pharmaceutical Co Ltd |
Reshaped human antibody to human interleukin-8
|
US6048972A
(en)
|
1994-07-13 |
2000-04-11 |
Chugai Pharmaceutical Co., Ltd. |
Recombinant materials for producing humanized anti-IL-8 antibodies
|
JP3865418B2
(ja)
|
1994-07-13 |
2007-01-10 |
中外製薬株式会社 |
ヒトインターロイキン−8に対する再構成ヒト抗体
|
WO1996002576A1
(fr)
|
1994-07-13 |
1996-02-01 |
Chugai Seiyaku Kabushiki Kaisha |
Anticorps humain reconstitue contre l'interleukine-8 humaine
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
DK0783893T3
(da)
|
1994-10-07 |
2012-05-29 |
Chugai Pharmaceutical Co Ltd |
Inhibering af unormal vækst af synovial-celler under anvendelse af il-6-antagonist som aktiv bestanddel
|
EP0791359A4
(en)
|
1994-10-21 |
2002-09-11 |
Chugai Pharmaceutical Co Ltd |
MEDICINE AGAINST IL-6 PRODUCTION IN DISEASES
|
US5876950A
(en)
|
1995-01-26 |
1999-03-02 |
Bristol-Myers Squibb Company |
Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5830478A
(en)
|
1995-06-07 |
1998-11-03 |
Boston Biomedical Research Institute |
Method for delivering functional domains of diphtheria toxin to a cellular target
|
CA2205007C
(en)
|
1995-09-11 |
2010-12-14 |
Masamichi Koike |
Antibody against human interleukin-5 receptor .alpha. chain
|
US5783186A
(en)
|
1995-12-05 |
1998-07-21 |
Amgen Inc. |
Antibody-induced apoptosis
|
WO1997034631A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
ZA976326B
(en)
|
1996-07-19 |
1998-02-03 |
Amgen Inc |
Analogs of cationic proteins.
|
US7247302B1
(en)
|
1996-08-02 |
2007-07-24 |
Bristol-Myers Squibb Company |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
ES2300113T3
(es)
|
1996-08-02 |
2008-06-01 |
Bristol-Myers Squibb Company |
Un procedimiento para inhibir toxicidad inducida por inmunoglobulinas que resulta del uso de inmunoglobulinas en terapia y diagnostico in vivo.
|
CZ106299A3
(cs)
|
1996-09-26 |
1999-08-11 |
Chugai Seiyaku Kabushiki Kaisha |
Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
|
US6025158A
(en)
|
1997-02-21 |
2000-02-15 |
Genentech, Inc. |
Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
DE69839992D1
(de)
|
1997-03-21 |
2008-10-23 |
Chugai Pharmaceutical Co Ltd |
Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
CA2286098C
(en)
|
1997-04-17 |
2009-07-07 |
Amgen Inc. |
Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods
|
ES2246069T3
(es)
|
1997-05-02 |
2006-02-01 |
Genentech, Inc. |
Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos.
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
DK1004315T3
(da)
|
1997-08-15 |
2008-07-21 |
Chugai Pharmaceutical Co Ltd |
Forebyggende midler og/eller lægemidler indeholdende anti-IL6-receptorneutraliserende antistoffer til reduktion af urinproteinudskillelsen ved systemisk lupus erythematosus
|
EP1020522B1
(en)
|
1997-10-03 |
2007-09-19 |
Chugai Seiyaku Kabushiki Kaisha |
Natural human antibody
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
PL201461B1
(pl)
|
1998-03-17 |
2009-04-30 |
Chugai Pharmaceutical Co Ltd |
Czynnik zapobiegający lub terapeutyczny do leczenia zapalenia jelita, zawierający antagonistę IL-6 jako składnik aktywny
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
WO1999054342A1
(en)
|
1998-04-20 |
1999-10-28 |
Pablo Umana |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
CA2341029A1
(en)
*
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
US6475718B2
(en)
|
1998-09-08 |
2002-11-05 |
Schering Aktiengesellschaft |
Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
|
JP2002531466A
(ja)
*
|
1998-12-01 |
2002-09-24 |
プロテイン デザイン ラブス, インコーポレイテッド |
γ−インターフェロンに対するヒト化抗体
|
ES2278463T3
(es)
|
1998-12-08 |
2007-08-01 |
Biovation Limited |
Metodo para reducir la inmunogenicidad de proteinas.
|
PL209786B1
(pl)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
AU2006225302B2
(en)
|
1999-03-25 |
2010-08-12 |
AbbVie Deutschland GmbH & Co. KG |
Human antibodies that bind human IL-12 and methods for producing
|
ES2420835T3
(es)
|
1999-04-09 |
2013-08-27 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de las moléculas inmunofuncionales
|
AU4952400A
(en)
*
|
1999-06-02 |
2000-12-28 |
Chugai Research Institute For Molecular Medicine, Inc. |
Novel hemopoietin receptor protein nr10
|
US6331642B1
(en)
|
1999-07-12 |
2001-12-18 |
Hoffmann-La Roche Inc. |
Vitamin D3 analogs
|
SK782002A3
(en)
*
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
US20040058393A1
(en)
|
2000-04-17 |
2004-03-25 |
Naoshi Fukishima |
Agonist antibodies
|
HUP0301835A2
(hu)
|
2000-05-03 |
2003-09-29 |
Mbt Munich Biotechnology Ag |
Kationos diagnosztikai, képalkotó és terápiás ágensek, aktivált vaszkuláris helyekkel asszociálódva
|
KR101287395B1
(ko)
*
|
2000-06-16 |
2014-11-04 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
면역특이적으로 BLyS에 결합하는 항체
|
AU2011244851A1
(en)
|
2000-07-27 |
2011-11-24 |
The John Hopkins University School Of Medicine |
Promyostatin peptides and methods of using same
|
AU2002218166A1
(en)
|
2000-09-08 |
2002-03-22 |
Universitat Zurich |
Collections of repeat proteins comprising repeat modules
|
CN103333860B
(zh)
|
2000-10-06 |
2015-07-08 |
协和发酵麒麟株式会社 |
产生抗体组合物的细胞
|
PT1325033E
(pt)
|
2000-10-10 |
2010-04-15 |
Genentech Inc |
Inibição da activação do complemento c5 para o tratamento e a prevenção da rejeição diferida de um xenoenxertos ou de uma rejeição vascular aguda
|
AU1325102A
(en)
|
2000-10-16 |
2002-04-29 |
Phylos Inc |
Protein scaffolds for antibody mimics and other binding proteins
|
EP1334731B1
(en)
|
2000-10-25 |
2008-02-27 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist
|
JP4889187B2
(ja)
*
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
JP2005500018A
(ja)
|
2001-04-02 |
2005-01-06 |
アイデック ファーマスーティカルズ コーポレイション |
GnTIIIと同時発現する組換え抗体
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
US7358054B2
(en)
*
|
2001-04-13 |
2008-04-15 |
Biogen Idec Ma Inc. |
Antibodies to VLA-1
|
US7667004B2
(en)
*
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
DE60228721D1
(en)
*
|
2001-06-22 |
2008-10-16 |
Chugai Pharmaceutical Co Ltd |
Zellproliferationsinhibitoren mit anti-glypican-3-antikörper
|
DE60237282D1
(de)
|
2001-06-28 |
2010-09-23 |
Domantis Ltd |
Doppelspezifischer ligand und dessen verwendung
|
US20040161741A1
(en)
|
2001-06-30 |
2004-08-19 |
Elazar Rabani |
Novel compositions and processes for analyte detection, quantification and amplification
|
BRPI0211953B8
(pt)
|
2001-08-17 |
2021-05-25 |
Genentech Inc |
anticorpo monoclonal ou fragmento de ligação a antígeno que se liga a c5 e c5a sem a prevenção da formação de c5b, linhagem celular, composição farmacêutica, bem como método in vitro para inibir a atividade de c5a e método de diagnóstico in vitro
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
KR20100120246A
(ko)
|
2001-11-14 |
2010-11-12 |
센토코 오르토 바이오테크 인코포레이티드 |
항 il-6 항체, 조성물, 방법 및 용도
|
AU2002357060A1
(en)
|
2001-12-03 |
2003-06-17 |
Abgenix, Inc. |
Antibody categorization based on binding characteristics
|
EP3960855A1
(en)
|
2001-12-28 |
2022-03-02 |
Chugai Seiyaku Kabushiki Kaisha |
Method for stabilizing proteins
|
EP1476541B1
(en)
|
2002-01-18 |
2008-07-16 |
ZymoGenetics, Inc. |
Cytokine (zcytor17 ligand)
|
CA2473733C
(en)
*
|
2002-01-18 |
2014-09-09 |
Zymogenetics, Inc. |
Cytokine receptor zcytor17 multimers
|
MXPA04007583A
(es)
|
2002-02-11 |
2005-04-25 |
Genentech Inc |
Variantes de anticuerpo con tasas mas rapidas de asociacion a antigeno.
|
AR038568A1
(es)
|
2002-02-20 |
2005-01-19 |
Hoffmann La Roche |
Anticuerpos anti-a beta y su uso
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
US20040110226A1
(en)
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
EP1509770B1
(en)
|
2002-05-31 |
2014-07-09 |
GE Healthcare Bio-Sciences AB |
Method of coupling binding agents to a substrate surface
|
EP1510943A4
(en)
|
2002-05-31 |
2007-05-09 |
Celestar Lexico Sciences Inc |
INTERACTION PREDICTION DEVICE
|
US20060088838A1
(en)
*
|
2002-06-12 |
2006-04-27 |
Murray Christopher J |
Methods for improving a binding characteristic of a molecule
|
EP1511861A4
(en)
|
2002-06-12 |
2007-12-05 |
Genencor Int |
METHODS AND BINDING COMPOSITIONS DEPENDENT FROM THE MEDIUM OF A TARGET AGENT TO A TARGET
|
ITMI20021527A1
(it)
|
2002-07-11 |
2004-01-12 |
Consiglio Nazionale Ricerche |
Anticorpi anti componente c5 del complemento e loro uso
|
EP1382969A1
(en)
|
2002-07-17 |
2004-01-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Diagnosis and prevention of cancer cell invasion
|
US20040138118A1
(en)
|
2002-09-16 |
2004-07-15 |
Neil Wolfman |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
EP1562972B1
(en)
|
2002-10-15 |
2010-09-08 |
Facet Biotech Corporation |
ALTERATION OF FcRn BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7217798B2
(en)
|
2003-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of Fc-fusion protein serum half-lives by mutagenesis
|
AU2003285874A1
(en)
*
|
2002-10-16 |
2004-05-04 |
Amgen Inc. |
HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS
|
US7261893B2
(en)
|
2002-10-22 |
2007-08-28 |
Wyeth |
Neutralizing antibodies against GDF-8 and uses therefor
|
NZ541050A
(en)
|
2002-12-16 |
2010-06-25 |
Genmab As |
Human monoclonal antibodies against interleukin 8 (IL-8)
|
AU2003290330A1
(en)
|
2002-12-27 |
2004-07-22 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
AU2004215653B2
(en)
|
2003-02-28 |
2011-03-17 |
Lonza Biologics Plc. |
Antibody purification by protein A and ion exchange chromatography
|
KR20060026004A
(ko)
|
2003-02-28 |
2006-03-22 |
안티제닉스 아이엔씨 |
당단백질 및 항원성 분자의 올리고머화를 조장하는 렉틴의용도
|
US20040223970A1
(en)
*
|
2003-02-28 |
2004-11-11 |
Daniel Afar |
Antibodies against SLC15A2 and uses thereof
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
US20060257412A1
(en)
|
2003-03-04 |
2006-11-16 |
Bowdish Katherine S |
Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells
|
ES2347657T3
(es)
|
2003-03-24 |
2010-11-03 |
Zymogenetics, Inc. |
Anticuerpos dirigidos contra il-22ra y asociados de union y procedimiento de uso en inflamacion.
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
US9051373B2
(en)
|
2003-05-02 |
2015-06-09 |
Xencor, Inc. |
Optimized Fc variants
|
CA2526669A1
(en)
|
2003-06-02 |
2004-12-16 |
Wyeth |
Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders
|
JP2005004970A
(ja)
|
2003-06-09 |
2005-01-06 |
Hitachi Cable Ltd |
複合ケーブルおよびこれを用いた先行配線システム
|
WO2004113387A2
(en)
|
2003-06-24 |
2004-12-29 |
Merck Patent Gmbh |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
US7011924B2
(en)
*
|
2003-07-30 |
2006-03-14 |
Hynix Semiconductor Inc. |
Photoresist polymers and photoresist compositions comprising the same
|
WO2005023193A2
(en)
|
2003-09-04 |
2005-03-17 |
Interleukin Genetics, Inc. |
Methods of treating endometriosis
|
JP2007504245A
(ja)
*
|
2003-09-05 |
2007-03-01 |
ジェネンテック・インコーポレーテッド |
変更したエフェクター機能を有する抗体
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
US20080075712A1
(en)
*
|
2003-10-14 |
2008-03-27 |
Kunihiro Hattori |
Double Specific Antibodies Substituting For Functional Proteins
|
NZ546557A
(en)
|
2003-10-17 |
2010-01-29 |
Chugai Pharmaceutical Co Ltd |
Therapeutic agent for mesothelioma comprising interleukin-6
|
US20050164301A1
(en)
|
2003-10-24 |
2005-07-28 |
Avidia Research Institute |
LDL receptor class A and EGF domain monomers and multimers
|
CA2544146C
(en)
*
|
2003-11-05 |
2012-10-02 |
Ares Trading S.A. |
Process for the purification of il-18 binding protein
|
AU2004290070A1
(en)
*
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
US20050142133A1
(en)
|
2003-12-03 |
2005-06-30 |
Xencor, Inc. |
Optimized proteins that target the epidermal growth factor receptor
|
EP2221315A1
(en)
|
2003-12-04 |
2010-08-25 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
MXPA06005941A
(es)
*
|
2003-12-10 |
2006-08-23 |
Medarex Inc |
Anticuerpos ip-10 y sus usos.
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
NZ547593A
(en)
|
2003-12-31 |
2009-09-25 |
Schering Plough Ltd |
Neutralizing epitope-based growth enhancing vaccine
|
US20080089892A1
(en)
|
2004-01-12 |
2008-04-17 |
Eli Lilly And Co. |
Fc Region Variants
|
US20050169921A1
(en)
|
2004-02-03 |
2005-08-04 |
Leonard Bell |
Method of treating hemolytic disease
|
US20070116710A1
(en)
|
2004-02-03 |
2007-05-24 |
Leonard Bell |
Methods of treating hemolytic anemia
|
BRPI0506679A
(pt)
|
2004-02-11 |
2007-05-15 |
Warner Lambert Co |
métodos de tratar osteoartrite com antagonistas de il-6
|
US20070178095A1
(en)
|
2004-03-23 |
2007-08-02 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
US8398980B2
(en)
*
|
2004-03-24 |
2013-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleuken-6 receptor
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
WO2005092925A2
(en)
|
2004-03-24 |
2005-10-06 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
KR20070035482A
(ko)
|
2004-03-24 |
2007-03-30 |
추가이 세이야쿠 가부시키가이샤 |
인터로킨-6 안타고니스트를 활성성분으로 함유하는내이장해 치료제
|
US20050260711A1
(en)
|
2004-03-30 |
2005-11-24 |
Deepshikha Datta |
Modulating pH-sensitive binding using non-natural amino acids
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
WO2005115452A2
(en)
|
2004-04-16 |
2005-12-08 |
Macrogenics, Inc. |
Fcϝriib-specific antibodies and methods of use thereof
|
JP2008503217A
(ja)
*
|
2004-06-18 |
2008-02-07 |
アンブレツクス・インコーポレイテツド |
新規抗原結合ポリペプチド及びそれらの使用
|
US20060019342A1
(en)
*
|
2004-06-25 |
2006-01-26 |
Medimmune, Inc. |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
ES2372503T3
(es)
|
2004-07-06 |
2012-01-20 |
Bioren, Inc. |
Mutagénesis revisada para desarrollar polipéptidos alterados con propiedades potenciadas.
|
DE102004032634A1
(de)
|
2004-07-06 |
2006-02-16 |
Sms Demag Ag |
Verfahren und Einrichtung zum Messen und Regeln der Planheit und/oder der Bandspannungen eines Edelstahlbandes oder einer Edelstahlfolie beim Kaltwalzen in einem Vielwalzengerüst, insbesondere in einem 20-Walzen-Sendizimir-Walzwerk
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
SI2471813T1
(sl)
|
2004-07-15 |
2015-03-31 |
Xencor, Inc. |
Optimirane Fc variante
|
CA2574062A1
(en)
*
|
2004-07-20 |
2006-01-26 |
Symphogen A/S |
Anti-rhesus d recombinant polyclonal antibody and methods of manufacture
|
CN101001873B
(zh)
|
2004-08-04 |
2013-03-13 |
曼璀克生物科技有限责任公司 |
Fc区变体
|
AU2005277641A1
(en)
|
2004-08-16 |
2006-03-02 |
Medimmune, Llc |
Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity
|
WO2006031370A2
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
JP5553963B2
(ja)
*
|
2004-10-22 |
2014-07-23 |
アムジエン・インコーポレーテツド |
組換え抗体をリフォールディングする方法
|
CA2585043A1
(en)
|
2004-10-22 |
2007-01-04 |
Medimmune, Inc. |
High affinity antibodies against hmgb1 and methods of use thereof
|
CA2585891A1
(en)
|
2004-10-29 |
2006-05-11 |
Medimmune, Inc. |
Methods of preventing and treating rsv infections and related conditions
|
EP1810035A4
(en)
|
2004-11-10 |
2010-03-17 |
Macrogenics Inc |
EFFECTOR FUNCTION OBTAINED BY CREATION BY BIOLOGICAL GENE OF FC ANTIBODY REGIONS
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US20070135620A1
(en)
*
|
2004-11-12 |
2007-06-14 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
RU2412200C2
(ru)
|
2004-11-12 |
2011-02-20 |
Ксенкор, Инк. |
Fc-ВАРИАНТЫ С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ С FcRn
|
CA2587617C
(en)
|
2004-11-12 |
2011-02-01 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
US8329186B2
(en)
|
2004-12-20 |
2012-12-11 |
Isu Abxis Co., Ltd |
Treatment of inflammation using BST2 inhibitor
|
US20090061485A1
(en)
|
2004-12-22 |
2009-03-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
|
EP1831243B1
(en)
|
2004-12-23 |
2010-03-17 |
Novo Nordisk A/S |
Antibody binding affinity ligands
|
EP1833510A4
(en)
|
2004-12-27 |
2010-02-10 |
Progenics Pharmaceuticals Neva |
ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME
|
ES2557587T3
(es)
|
2004-12-28 |
2016-01-27 |
Innate Pharma |
Anticuerpos monoclonales contra NKG2A
|
AU2006204791A1
(en)
|
2005-01-12 |
2006-07-20 |
Xencor, Inc |
Antibodies and Fc fusion proteins with altered immunogenicity
|
GB0502358D0
(en)
|
2005-02-04 |
2005-03-16 |
Novartis Ag |
Organic compounds
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
EP1858924A1
(en)
|
2005-02-14 |
2007-11-28 |
ZymoGenetics, Inc. |
Methods of treating skin disorders using an il-31ra antagonist
|
AU2006227377B2
(en)
|
2005-03-18 |
2013-01-31 |
Medimmune, Llc |
Framework-shuffling of antibodies
|
JP5620626B2
(ja)
*
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
会合制御によるポリペプチド製造方法
|
AU2006230413B8
(en)
|
2005-03-31 |
2011-01-20 |
Xencor, Inc |
Fc variants with optimized properties
|
US9493569B2
(en)
|
2005-03-31 |
2016-11-15 |
Chugai Seiyaku Kabushiki Kaisha |
Structural isomers of sc(Fv)2
|
EP2824183B1
(en)
|
2005-04-08 |
2020-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing bispecific antibodies
|
EA017420B9
(ru)
*
|
2005-04-18 |
2013-03-29 |
Микромет Аг |
Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека
|
AU2006236417B2
(en)
|
2005-04-20 |
2011-02-03 |
Amgen Fremont Inc. |
High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies
|
TW200724548A
(en)
|
2005-04-25 |
2007-07-01 |
Pfizer |
Antibodies to myostatin
|
US8008443B2
(en)
|
2005-04-26 |
2011-08-30 |
Medimmune, Llc |
Modulation of antibody effector function by hinge domain engineering
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
UY29504A1
(es)
|
2005-04-29 |
2006-10-31 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
US8163881B2
(en)
|
2005-05-31 |
2012-04-24 |
The Board Of Regents Of The University Of Texas System |
Immunoglobulin molecules with improved characteristics
|
AU2006256041B2
(en)
*
|
2005-06-10 |
2012-03-29 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
CA2652434A1
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc. |
Optimized proteins that target ep-cam
|
ES2460517T3
(es)
|
2005-07-25 |
2014-05-13 |
Emergent Product Development Seattle, Llc |
Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20
|
SI2573114T1
(sl)
|
2005-08-10 |
2016-08-31 |
Macrogenics, Inc. |
Identifikacija in inženiring protiteles z variantnimi fc regijami in postopki za njih uporabo
|
EP2407486B1
(en)
|
2005-08-19 |
2017-11-22 |
Wyeth LLC |
Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders
|
AU2006299429B2
(en)
|
2005-10-03 |
2012-02-23 |
Xencor, Inc. |
Fc variants with optimized Fc receptor binding properties
|
CA2624976A1
(en)
|
2005-10-06 |
2007-04-19 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
US7973136B2
(en)
|
2005-10-06 |
2011-07-05 |
Xencor, Inc. |
Optimized anti-CD30 antibodies
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
AU2006300234B2
(en)
|
2005-10-14 |
2013-01-10 |
Chugai Seiyaku Kabushiki Kaisha |
Agents for suppressing damage to transplanted islets after islet transplantation
|
KR101239051B1
(ko)
|
2005-10-21 |
2013-03-04 |
추가이 세이야쿠 가부시키가이샤 |
심장질환 치료제
|
WO2007056441A2
(en)
*
|
2005-11-07 |
2007-05-18 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
AR057579A1
(es)
|
2005-11-23 |
2007-12-05 |
Merck & Co Inc |
Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
TW200803894A
(en)
|
2005-11-25 |
2008-01-16 |
Univ Keio |
Prostate cancer therapeutic agents
|
BRPI0619056A2
(pt)
|
2005-11-28 |
2011-09-20 |
Genmab As |
anticorpo monovalente, método para preparar e produzir um antcorpo monovalente, construção de ácido nucleico, célula hospedeira, imunoconjugado, uso de um anticorpo monovalente, e, composição farmacêutica
|
AU2006330807A1
(en)
|
2005-11-28 |
2007-07-05 |
Medimmune, Llc |
Antagonists of HMBG1 and/or rage and methods of use thereof
|
KR101152557B1
(ko)
|
2005-12-12 |
2012-09-07 |
에이씨 이뮨 에스.에이. |
치료 백신
|
EP1977763A4
(en)
*
|
2005-12-28 |
2010-06-02 |
Chugai Pharmaceutical Co Ltd |
STABILIZER PREPARATION CONTAINING ANTIBODIES
|
ES2517420T3
(es)
|
2005-12-29 |
2014-11-03 |
Janssen Biotech, Inc. |
Anticuerpos anti-IL-23 humanos, composiciones, procedimientos y usos
|
WO2007133816A2
(en)
*
|
2006-01-10 |
2007-11-22 |
Zymogenetics, Inc. |
Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists
|
CN104189907A
(zh)
|
2006-01-27 |
2014-12-10 |
学校法人庆应义塾 |
伴有脉络膜血管生成的疾病的治疗药
|
EP1988922A4
(en)
|
2006-02-03 |
2010-06-02 |
Medimmune Llc |
PROTEIN FORMULATIONS
|
US20070190056A1
(en)
|
2006-02-07 |
2007-08-16 |
Ravi Kambadur |
Muscle regeneration compositions and uses therefor
|
JP4179517B2
(ja)
|
2006-02-21 |
2008-11-12 |
プロテノバ株式会社 |
イムノグロブリン親和性リガンド
|
US8674073B2
(en)
|
2006-02-21 |
2014-03-18 |
Protenova Co., Ltd. |
Immunoglobulin affinity ligand
|
JP5722524B2
(ja)
|
2006-03-02 |
2015-05-20 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
補体活性を抑制することによる同種移植片の生存の延長
|
CA3148917A1
(en)
|
2006-03-08 |
2007-09-13 |
Archemix Llc |
Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders
|
KR20140057635A
(ko)
|
2006-03-15 |
2014-05-13 |
알렉시온 파마슈티칼스, 인코포레이티드 |
보체의 저해물질로 발작성 야간혈색뇨증 환자의 치료
|
JP5374359B2
(ja)
|
2006-03-17 |
2013-12-25 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
安定化されたポリペプチド化合物
|
WO2007108559A1
(ja)
|
2006-03-23 |
2007-09-27 |
Kirin Pharma Kabushiki Kaisha |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
EA200802061A1
(ru)
|
2006-03-28 |
2009-04-28 |
Байоджен Айдек Эмэй Инк. |
Антитело или его фрагмент, специфично связывающееся с рецептором 1 инсулиноподобного фактора роста (igf-r1) (варианты), композиция на его основе, полинуклеотид, кодирующий вариабельную область антитела (варианты), содержащие полинуклеотид композиция (варианты) и вектор, содержащая вектор клетка-хозяин (варианты), способ продуцирования антитела или его фрагмента (варианты) и способ лечения гиперпролиферативного заболевания у животного организма
|
EP4001409A1
(en)
|
2006-03-31 |
2022-05-25 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
US9670269B2
(en)
*
|
2006-03-31 |
2017-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of modifying antibodies for purification of bispecific antibodies
|
EP2004689A4
(en)
|
2006-04-05 |
2010-06-02 |
Abbott Biotech Ltd |
PURIFICATION OF ANTIBODIES
|
EP2025346B1
(en)
*
|
2006-04-07 |
2016-08-10 |
Osaka University |
Muscle regeneration promoter
|
TWI395754B
(zh)
|
2006-04-24 |
2013-05-11 |
Amgen Inc |
人類化之c-kit抗體
|
KR101416078B1
(ko)
|
2006-05-25 |
2014-07-07 |
글락소 그룹 리미티드 |
변형된 인간화 항인터루킨18 항체
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
MY159787A
(en)
|
2006-06-02 |
2017-01-31 |
Regeneron Pharma |
High affinity antibodies to human il-6 receptor
|
DK2047863T3
(da)
|
2006-06-08 |
2013-09-16 |
Chugai Pharmaceutical Co Ltd |
Middel til forebyggelse eller behandling af inflammatoriske sygdomme
|
ES2415655T3
(es)
*
|
2006-06-15 |
2013-07-26 |
The Board Of Trustees Of The University Of Arkansas |
Anticuerpos monoclonales que reconocen selectivamente Metanfetamina y compuestos similares a Metanfetamina
|
TW200817006A
(en)
|
2006-06-23 |
2008-04-16 |
Smithkline Beecham Corp |
IL-8 receptor antagonist
|
AR062223A1
(es)
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
ES2457072T3
(es)
|
2006-08-14 |
2014-04-24 |
Xencor, Inc. |
Anticuerpos optimizados que seleccionan como diana CD19
|
DE102006038844B4
(de)
|
2006-08-18 |
2018-03-22 |
Robert Bosch Gmbh |
Vorrichtung und Verfahren zur Ansteuerung von Personenschutzmittel
|
JP5058261B2
(ja)
|
2006-09-05 |
2012-10-24 |
イーライ リリー アンド カンパニー |
抗ミオスタチン抗体
|
US8323653B2
(en)
|
2006-09-08 |
2012-12-04 |
Medimmune, Llc |
Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
|
EP2064240A2
(en)
|
2006-09-18 |
2009-06-03 |
Xencor, Inc. |
Optimized antibodies that target hm1.24
|
JP2008104147A
(ja)
|
2006-09-19 |
2008-05-01 |
Ricoh Co Ltd |
撮像装置、撮像システム、画像データ処理方法およびプログラム
|
EP2695896B1
(en)
|
2006-10-06 |
2018-08-22 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Prevention of tissue ischemia, related methods and compositions
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
WO2008121160A2
(en)
|
2006-11-21 |
2008-10-09 |
Xencor, Inc. |
Optimized antibodies that target cd5
|
CN100455598C
(zh)
|
2006-11-29 |
2009-01-28 |
中国抗体制药有限公司 |
功能人源化抗人cd20抗体及其应用
|
WO2008091798A2
(en)
|
2007-01-22 |
2008-07-31 |
Xencor, Inc. |
Optimized ca9 antibodies and methods of using the same
|
MX2009007830A
(es)
|
2007-01-23 |
2009-10-07 |
Univ Shinshu |
Inhibidor de rechazo cronico.
|
AU2008207898B2
(en)
|
2007-01-23 |
2012-05-03 |
Xencor, Inc |
Optimized CD40 antibodies and methods of using the same
|
JPWO2008090960A1
(ja)
|
2007-01-24 |
2010-05-20 |
協和発酵キリン株式会社 |
ガングリオシドgm2に特異的に結合する遺伝子組換え抗体組成物
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
WO2008098115A2
(en)
|
2007-02-07 |
2008-08-14 |
Xencor, Inc. |
Optimized igf-1r antibodies and methods of using the same
|
DE602008004296D1
(de)
*
|
2007-02-14 |
2011-02-17 |
Vaccinex Inc |
Humanisierte anti-cd100-antikörper
|
HUE042172T2
(hu)
|
2007-02-23 |
2019-06-28 |
Merck Sharp & Dohme |
Genetikailag elõállított anti-il-23P19 antitestek
|
BRPI0809026A2
(pt)
|
2007-03-20 |
2014-09-23 |
Lilly Co Eli |
Anticorpos antiesclerotina
|
KR20100015773A
(ko)
|
2007-03-22 |
2010-02-12 |
노파르티스 아게 |
C5 항원 및 그의 용도
|
CL2008001071A1
(es)
|
2007-04-17 |
2009-05-22 |
Smithkline Beecham Corp |
Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
US20090252729A1
(en)
|
2007-05-14 |
2009-10-08 |
Farrington Graham K |
Single-chain Fc (scFc) regions, binding polypeptides comprising same, and methods related thereto
|
DK2176298T3
(en)
|
2007-05-30 |
2018-02-12 |
Xencor Inc |
Methods and compositions for inhibiting CD32B-expressing cells
|
EP2155790A1
(en)
|
2007-05-31 |
2010-02-24 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
CN101688200B
(zh)
|
2007-06-25 |
2012-08-08 |
艾斯巴技术,爱尔康生物医药研究装置有限责任公司 |
单链抗体的基于序列的改造和优化
|
CN103435696B
(zh)
|
2007-06-25 |
2016-10-12 |
艾斯巴技术-诺华有限责任公司 |
修饰抗体的方法和具有改善的功能性质的修饰抗体
|
EP2179282B1
(en)
|
2007-06-29 |
2016-06-01 |
Quest Diagnostics Investments Incorporated |
Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
|
WO2009014263A1
(ja)
|
2007-07-26 |
2009-01-29 |
Osaka University |
インターロイキン6受容体阻害剤を有効成分とする眼炎症疾患治療剤
|
WO2009026117A2
(en)
|
2007-08-16 |
2009-02-26 |
Glaxo Group Limited |
Novel compounds
|
JP2010538012A
(ja)
|
2007-08-28 |
2010-12-09 |
バイオジェン アイデック マサチューセッツ インコーポレイテッド |
Igf−1rの複数のエピトープに結合する組成物
|
CN101842117A
(zh)
|
2007-08-28 |
2010-09-22 |
比奥根艾迪克Ma公司 |
抗igf-1r抗体及其用途
|
EP2031064A1
(de)
*
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
DK2202245T3
(en)
|
2007-09-26 |
2016-11-21 |
Chugai Pharmaceutical Co Ltd |
A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
|
KR102467302B1
(ko)
*
|
2007-09-26 |
2022-11-14 |
추가이 세이야쿠 가부시키가이샤 |
항체 정상영역 개변체
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
BRPI0817250A2
(pt)
|
2007-09-26 |
2014-06-17 |
Chugai Pharmaceutical Co Ltd |
Anticorpo anti-receptor da il-6.
|
EP2584043A3
(en)
|
2007-09-28 |
2013-10-02 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-glypican 3 antibody having improved kinetics in plasma
|
CN101815532B
(zh)
|
2007-10-02 |
2012-08-15 |
中外制药株式会社 |
以白细胞介素6受体抑制剂为有效成分的移植物抗宿主病治疗剂
|
KR100888133B1
(ko)
|
2007-10-02 |
2009-03-13 |
에스케이에너지 주식회사 |
4종의 금속성분으로 구성된 다성분계 비스무스몰리브데이트 촉매 제조방법 및 상기촉매를 이용하여1,3-부타디엔을 제조하는 방법
|
AR068767A1
(es)
|
2007-10-12 |
2009-12-02 |
Novartis Ag |
Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
|
JP2011500756A
(ja)
|
2007-10-22 |
2011-01-06 |
メルク セローノ ソシエテ アノニム |
Fc融合タンパク質を精製する方法
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
AU2008321835B2
(en)
|
2007-11-15 |
2014-11-20 |
Chugai Seiyaku Kabushiki Kaisha |
Monoclonal antibody capable of binding to anexelekto, and use thereof
|
CA2708065C
(en)
|
2007-12-05 |
2015-02-24 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agent for pruritus
|
MY177564A
(en)
|
2007-12-05 |
2020-09-20 |
Chugai Pharmaceutical Co Ltd |
Anti-nr10 antibody and use thereof
|
US8414893B2
(en)
*
|
2007-12-21 |
2013-04-09 |
Amgen Inc. |
Anti-amyloid antibodies and uses thereof
|
CA3086659A1
(en)
|
2007-12-26 |
2009-07-09 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
CA2710439C
(en)
|
2008-01-18 |
2016-04-12 |
Stichting Sanquin Bloedvoorziening |
Methods for increasing the therapeutic efficacy of immunoglobulin g class 3 (igg3) antibodies
|
US20110183861A1
(en)
|
2008-01-29 |
2011-07-28 |
Ablynn N.V. |
Methods to stabilize proteins and polypeptides
|
EP3521311A1
(en)
|
2008-04-11 |
2019-08-07 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
AU2015227424A1
(en)
|
2008-04-11 |
2015-10-01 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
WO2009139822A1
(en)
*
|
2008-05-01 |
2009-11-19 |
Amgen Inc. |
Anti-hepcidin antibodies and methods of use
|
US9119818B2
(en)
|
2008-05-14 |
2015-09-01 |
Agriculture Victoria Services Pty Ltd |
Use of angiogenin or angiogenin agonists for treating diseases and disorders
|
US10717781B2
(en)
|
2008-06-05 |
2020-07-21 |
National Cancer Center |
Neuroinvasion inhibitor
|
MY159396A
(en)
|
2008-08-05 |
2016-12-30 |
Novartis Ag |
Compositions and methods for antibodies targeting complement protein c5
|
ES2499031T3
(es)
|
2008-09-17 |
2014-09-26 |
Xencor, Inc. |
Novedosas composiciones y métodos para el tratamiento de trastornos mediados por la IgE
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
JP5229888B2
(ja)
|
2008-09-30 |
2013-07-03 |
独立行政法人産業技術総合研究所 |
弱酸性域での易解離性を向上したプロテインa変異型タンパク質及び抗体捕捉剤
|
AR073829A1
(es)
|
2008-10-14 |
2010-12-01 |
Genentech Inc |
Variantes de inmunoglobulinas y sus usos.
|
NZ614351A
(en)
|
2008-11-10 |
2015-05-29 |
Alexion Pharma Inc |
Methods and compositions for treating complement-associated disorders
|
JP5807300B2
(ja)
|
2008-11-18 |
2015-11-10 |
株式会社シノテスト |
試料中のc反応性蛋白質の測定方法及び測定試薬
|
EP2361095B1
(en)
|
2008-11-25 |
2017-12-20 |
AlderBio Holdings LLC |
Antagonists of il-6 to raise albumin and/or lower crp
|
AR074777A1
(es)
|
2008-12-19 |
2011-02-09 |
Glaxo Group Ltd |
Proteinas de union a antigeno
|
JP5851842B2
(ja)
|
2009-01-12 |
2016-02-03 |
サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. |
改変した抗体組成物、それを作製および使用する方法
|
MX2011007833A
(es)
|
2009-01-23 |
2011-10-06 |
Biogen Idec Inc |
Polipeptidos fc estabilizados con funcion efectora reducida y metodos de uso.
|
US20100292443A1
(en)
*
|
2009-02-26 |
2010-11-18 |
Sabbadini Roger A |
Humanized platelet activating factor antibody design using anti-lipid antibody templates
|
US20120071634A1
(en)
*
|
2009-03-19 |
2012-03-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody Constant Region Variant
|
US9228017B2
(en)
*
|
2009-03-19 |
2016-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
JP4885308B2
(ja)
|
2009-03-19 |
2012-02-29 |
中外製薬株式会社 |
改良された抗体分子を含有する製剤
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
RU2011151069A
(ru)
|
2009-05-15 |
2013-06-20 |
Чугаи Сейяку Кабусики Кайся |
Анти-axl антитело
|
EP2435079A4
(en)
|
2009-05-26 |
2012-11-14 |
Univ Johns Hopkins |
NEW DESMINPHOSPHORYLATION ORTE FOR DIAGNOSIS AND INFLUENCING DISEASES
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
WO2010151526A1
(en)
|
2009-06-23 |
2010-12-29 |
Alexion Pharmaceuticals, Inc. |
Bispecific antibodies that bind to complement proteins
|
US8945511B2
(en)
|
2009-06-25 |
2015-02-03 |
Paul Weinberger |
Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
|
CN103833855A
(zh)
|
2009-06-26 |
2014-06-04 |
瑞泽恩制药公司 |
容易地分离的具有天然免疫球蛋白形式的双特异性抗体
|
GB0914691D0
(en)
|
2009-08-21 |
2009-09-30 |
Lonza Biologics Plc |
Immunoglobulin variants
|
PL3023438T3
(pl)
|
2009-09-03 |
2020-07-27 |
Merck Sharp & Dohme Corp. |
Przeciwciała anty-gitr
|
US10150808B2
(en)
*
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
RU2540020C2
(ru)
|
2009-10-06 |
2015-01-27 |
Медиммьюн Лтд |
Молекула, специфически связывающаяся с rsv
|
US8568726B2
(en)
|
2009-10-06 |
2013-10-29 |
Medimmune Limited |
RSV specific binding molecule
|
AU2010303415B2
(en)
|
2009-10-07 |
2015-02-19 |
Macrogenics, Inc. |
Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
|
CA2778673A1
(en)
|
2009-10-27 |
2011-05-05 |
Karen Margrete Miller |
Function modifying nav 1.7 antibodies
|
CN101875696B
(zh)
|
2009-11-11 |
2012-02-08 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其制备方法与应用
|
EP2327725A1
(en)
|
2009-11-26 |
2011-06-01 |
InflaRx GmbH |
Anti-C5a binding moieties with high blocking activity
|
AU329016S
(en)
|
2009-12-03 |
2009-12-22 |
Non Entity 49398 |
Induction system with integral air filter
|
CA2785414C
(en)
|
2009-12-25 |
2019-01-22 |
Tomoyuki Igawa |
Polypeptide modification method for purifying polypeptide multimers
|
US9624290B2
(en)
|
2010-01-28 |
2017-04-18 |
Ab Biosciences, Inc. |
Lowered affinity antibodies and methods of making the same
|
CA2789416A1
(en)
|
2010-02-09 |
2011-08-18 |
Glaxosmithkline Llc |
Novel uses
|
TW201127310A
(en)
*
|
2010-02-11 |
2011-08-16 |
jin-zhu Chen |
Step-less finetuning buckle
|
ES2586579T3
(es)
|
2010-02-19 |
2016-10-17 |
Xencor, Inc. |
Nuevas inmunoadhesinas de CTLA4-IG
|
US8999340B2
(en)
|
2010-03-01 |
2015-04-07 |
Alexion Pharmaceuticals, Inc. |
Methods for treating multiorgan, systemic degos' disease with a complement inhibitor
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
TW201206466A
(en)
|
2010-03-11 |
2012-02-16 |
Rinat Neuroscience Corp |
Antibodies with pH dependent antigen binding
|
JP2011184418A
(ja)
|
2010-03-11 |
2011-09-22 |
Tokyo Institute Of Technology |
親和性可変抗体
|
BR112012022917A2
(pt)
*
|
2010-03-11 |
2017-01-10 |
Pfizer |
anticorpos com ligação a antígeno dependente de ph
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
KR20130098161A
(ko)
|
2010-04-30 |
2013-09-04 |
알렉시온 파마슈티칼스, 인코포레이티드 |
인간에서 감소된 면역원성을 갖는 항체
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
US20130149302A1
(en)
|
2010-05-28 |
2013-06-13 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for pancreatic cancer
|
UY33421A
(es)
|
2010-06-03 |
2011-12-30 |
Glaxo Wellcome House |
Proteinas de union al antígeno humanizados
|
US8637641B2
(en)
|
2010-07-29 |
2014-01-28 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
CN105440134A
(zh)
|
2010-08-16 |
2016-03-30 |
安姆根公司 |
结合肌肉生长抑制素的抗体、组合物和方法
|
KR20130096731A
(ko)
|
2010-09-08 |
2013-08-30 |
할로자임, 아이엔씨 |
조건부 활성 치료적 단백질을 평가,확인 또는 진화시키는 방법
|
EP2640745B1
(en)
|
2010-09-10 |
2018-11-07 |
MedImmune Limited |
Bivalent and bispecific anti-il6/anti-il23 antibodies
|
RU2013126477A
(ru)
|
2010-11-08 |
2014-12-20 |
Дженентек, Инк. |
Вводимые подкожно антитела против рецептора il-6
|
CA2819356C
(en)
|
2010-11-30 |
2023-01-24 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
WO2012088247A2
(en)
|
2010-12-22 |
2012-06-28 |
Medimmune, Llc |
Anti-c5/c5a/c5adesr antibodies and fragments
|
EP2662385A4
(en)
|
2011-01-07 |
2015-11-11 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR IMPROVING THE PHYSICAL PROPERTIES OF ANTIBODIES
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
SG10201609665PA
(en)
|
2011-02-25 |
2017-01-27 |
Chugai Pharmaceutical Co Ltd |
FcɣRIIb-SPECIFIC Fc ANTIBODY
|
MX2013010011A
(es)
|
2011-03-01 |
2014-10-24 |
Amgen Inc |
Agentes de unión biespecífica.
|
CA2830254C
(en)
|
2011-03-16 |
2019-09-10 |
Amgen Inc. |
Fc variants
|
DK2698431T3
(da)
|
2011-03-30 |
2020-11-30 |
Chugai Pharmaceutical Co Ltd |
Opretholdelse af antigen-bindende molekyler i blodplasma og fremgangsmåde til modifikation af immunogenicitet
|
CA2833289A1
(en)
|
2011-04-19 |
2012-10-26 |
Amgen Inc. |
Method for treating osteoporosis
|
SG194701A1
(en)
|
2011-04-29 |
2013-12-30 |
Apexigen Inc |
Anti-cd40 antibodies and methods of use
|
ME03755B
(me)
|
2011-05-04 |
2021-04-20 |
Omeros Corp |
Kompozicije za inhibiciju masp-2 zavisne aktivacije komplementa
|
RS58765B1
(sr)
|
2011-05-21 |
2019-06-28 |
Macrogenics Inc |
Cd3-vezujući molekuli sposobni za vezivanje za humani i nehumani cd3
|
US9328170B2
(en)
|
2011-05-25 |
2016-05-03 |
Merck Sharp & Dohme Corp. |
Method for preparing Fc containing polypeptides having improved properties
|
EP2720708A4
(en)
|
2011-06-20 |
2015-10-14 |
Univ Saint Louis |
AIMING AT THE NEUROMUSCULAR END PLATE FOR TREATMENT PURPOSES
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
WO2013047748A1
(ja)
|
2011-09-30 |
2013-04-04 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
EP3778889A1
(en)
|
2011-09-30 |
2021-02-17 |
Chugai Seiyaku Kabushiki Kaisha |
Ion concentration-dependent binding molecule library
|
TW201817745A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
KR20140076593A
(ko)
|
2011-09-30 |
2014-06-20 |
추가이 세이야쿠 가부시키가이샤 |
항원의 소실을 촉진시키는 항원 결합 분자
|
CN110680920A
(zh)
|
2011-09-30 |
2020-01-14 |
中外制药株式会社 |
诱导针对靶抗原的免疫应答的抗原结合分子
|
EP2765192A4
(en)
|
2011-10-05 |
2015-04-15 |
Chugai Pharmaceutical Co Ltd |
ANTIGEN BINDING MOLECULE FOR PROMOTING THE PLASMA CLAIR OF AN ANTIGEN COMPRISING A SACCHARIDIC CHAIN TYPE RECEPTOR BINDING DOMAIN
|
CA2857159C
(en)
|
2011-11-30 |
2024-05-07 |
Chugai Seiyaku Kabushiki Kaisha |
Drug containing carrier into cell for forming immune complex
|
SG11201405137QA
(en)
|
2012-02-24 |
2014-12-30 |
Chugai Pharmaceutical Co Ltd |
ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB
|
EP3421488A3
(en)
|
2012-03-14 |
2019-04-17 |
Regeneron Pharmaceuticals, Inc. |
Multispecific antigen-binding molecules and uses thereof
|
RS57414B1
(sr)
|
2012-03-16 |
2018-09-28 |
Regeneron Pharma |
Antitela sa lakim lancem konstruisanim sa histidinom i genetički modifikovani glodari za generisanje istih
|
BR112014022855A2
(pt)
|
2012-03-16 |
2017-07-18 |
Regeneron Pharma |
animal não humano geneticamente modificado, mamífero geneticamente modificado, e, método para fabricar um animal não humano
|
US9453076B2
(en)
|
2012-03-29 |
2016-09-27 |
Novimmune S.A. |
Anti-TLR4 antibodies and uses thereof
|
TWI619729B
(zh)
|
2012-04-02 |
2018-04-01 |
再生元醫藥公司 |
抗-hla-b*27抗體及其用途
|
JP5988659B2
(ja)
|
2012-04-09 |
2016-09-07 |
シャープ株式会社 |
送風機
|
JP6211597B2
(ja)
|
2012-05-01 |
2017-10-11 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC |
新規抗体
|
US9255154B2
(en)
|
2012-05-08 |
2016-02-09 |
Alderbio Holdings, Llc |
Anti-PCSK9 antibodies and use thereof
|
EP3892638A1
(en)
|
2012-05-30 |
2021-10-13 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for eliminating aggregated antigens
|
AU2013268418B2
(en)
|
2012-05-30 |
2017-12-07 |
Chugai Seiyaku Kabushiki Kaisha |
Target-tissue-specific antigen-binding molecule
|
MX364738B
(es)
|
2012-06-15 |
2019-05-03 |
Pfizer |
Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos.
|
BR112015000167B1
(pt)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
|
KR20150041662A
(ko)
|
2012-08-13 |
2015-04-16 |
리제너론 파아마슈티컬스, 인크. |
Ph-의존적 결합 특성을 갖는 항-pcsk9 항체
|
US9133269B2
(en)
|
2012-08-24 |
2015-09-15 |
Anaptysbio, Inc. |
Humanized antibodies directed against complement protein C5
|
KR20230110836A
(ko)
|
2012-08-24 |
2023-07-25 |
추가이 세이야쿠 가부시키가이샤 |
FcγRIIb 특이적 Fc영역 개변체
|
US11236168B2
(en)
|
2012-08-24 |
2022-02-01 |
Chugai Seiyaku Kabushiki Kaisha |
Mouse FcγammaRII-specific Fc antibody
|
TWI595007B
(zh)
|
2012-09-10 |
2017-08-11 |
Neotope Biosciences Ltd |
抗mcam抗體及相關使用方法
|
CN104768969B
(zh)
|
2012-09-13 |
2021-04-16 |
百时美施贵宝公司 |
结合至肌生成抑制素的基于纤连蛋白的支架结构域蛋白
|
TW201418707A
(zh)
|
2012-09-21 |
2014-05-16 |
Alexion Pharma Inc |
補體組分c5拮抗劑之篩選分析
|
US20150284455A1
(en)
|
2012-11-06 |
2015-10-08 |
Scholar Rock, Inc. |
Compositions and methods for modulating cell signaling
|
CA2896076C
(en)
|
2012-12-21 |
2022-12-06 |
Aveo Pharmaceuticals, Inc. |
Anti-gdf15 antibodies
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
JP2016505633A
(ja)
|
2013-01-24 |
2016-02-25 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
TNFα抗原結合性タンパク質
|
BR112015018438A2
(pt)
|
2013-01-31 |
2017-07-18 |
Seoul Nat Univ R&Db Foundation |
anticorpo contra c5 e método para prevenir e tratar doenças relacionadas a complemento
|
US9481725B2
(en)
|
2013-03-14 |
2016-11-01 |
Alderbio Holdings, Llc |
Antibodies to HGF and compositions containing
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
SG11201507413XA
(en)
|
2013-03-15 |
2015-10-29 |
Amgen Inc |
Myostatin antagonism in human subjects
|
US20160031985A1
(en)
|
2013-03-15 |
2016-02-04 |
Katherine S. Bowdish |
Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
|
US9321686B2
(en)
|
2013-03-15 |
2016-04-26 |
Forta Corporation |
Reinforcement fiber coating compositions, methods of making and treating, and uses for improved adhesion to asphalt and portland cement concrete
|
EP2968985A2
(en)
|
2013-03-15 |
2016-01-20 |
Amgen, Inc. |
Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
|
EP2951203B1
(en)
|
2013-03-15 |
2019-05-22 |
Xencor, Inc. |
Heterodimeric proteins
|
EP3473272A1
(en)
|
2013-03-29 |
2019-04-24 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
|
EP2982689B1
(en)
|
2013-04-02 |
2020-08-26 |
Chugai Seiyaku Kabushiki Kaisha |
Fc region variant
|
CA2911514A1
(en)
|
2013-05-06 |
2014-11-13 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
CN105392800B
(zh)
|
2013-05-17 |
2020-07-31 |
国家科学研究中心 |
抗cxcl1、cxcl7和cxcl8抗体及其应用
|
WO2014190441A1
(en)
|
2013-05-31 |
2014-12-04 |
Zymeworks Inc. |
Heteromultimers with reduced or silenced effector function
|
EP4067383A1
(en)
|
2013-07-25 |
2022-10-05 |
Cytomx Therapeutics Inc. |
Multispecific antibodies, multispecific activatable antibodies and methods of using the same
|
CN105960414A
(zh)
|
2013-08-14 |
2016-09-21 |
诺华股份有限公司 |
治疗散发性包涵体肌炎的方法
|
EP3033093A1
(en)
|
2013-08-16 |
2016-06-22 |
Alexion Pharmaceuticals, Inc. |
Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant
|
EP3042912A4
(en)
|
2013-09-04 |
2017-05-03 |
Protenova Co., Ltd. |
Immunoglobulin-binding domain multimer
|
EP2853898B1
(en)
|
2013-09-27 |
2017-01-04 |
Medizinische Hochschule Hannover |
Analysis of myostatin in serum
|
EP3083696B1
(en)
|
2013-12-20 |
2018-02-14 |
F.Hoffmann-La Roche Ag |
Bispecific her2 antibodies and methods of use
|
JP2017510622A
(ja)
|
2014-01-27 |
2017-04-13 |
ノバルティス アーゲー |
筋萎縮を予測するバイオマーカー、方法および使用
|
RU2019119857A
(ru)
|
2014-02-20 |
2019-07-12 |
Аллерган, Инк. |
Антитела к компоненту комплемента c5
|
NZ631007A
(en)
|
2014-03-07 |
2015-10-30 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
US10183994B2
(en)
|
2014-06-30 |
2019-01-22 |
Merck Patent Gmbh |
Anti-TNFα antibodies with pH-dependent antigen binding for improved target clearence
|
CA3005158A1
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
WO2016073906A2
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Transforming growth factor-related immunoassays
|
TW201627007A
(zh)
|
2014-12-08 |
2016-08-01 |
諾華公司 |
用於治療肌力退化症之肌肉生長抑制素(myostatin)或活化素(activin)拮抗劑
|
NZ730607A
(en)
|
2014-12-19 |
2022-07-01 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
|
ES2899894T3
(es)
|
2014-12-19 |
2022-03-15 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos anti-C5 y métodos de uso
|
CN107428823B
(zh)
|
2015-01-22 |
2021-10-26 |
中外制药株式会社 |
两种以上抗-c5抗体的组合与使用方法
|
EA201791754A1
(ru)
|
2015-02-05 |
2019-01-31 |
Чугаи Сейяку Кабусики Кайся |
АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
|
BR112017014067B1
(pt)
|
2015-02-27 |
2021-01-12 |
Chugai Seiyaku Kabushiki Kaisha |
usos de um anticorpo receptor de il-6 para no tratamento de doenças relacionadas a il-6
|
JP6944375B2
(ja)
|
2015-03-31 |
2021-10-06 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
発作性夜間血色素尿症(pnh)患者の亜集団の同定および処置
|
MX2017013267A
(es)
|
2015-04-15 |
2018-08-15 |
Regeneron Pharma |
Metodos para aumentar la fuerza y funcionalidad con inhibidores del factor de diferenciacion y crecimiento 8 (gdf8).
|
EP3288586A1
(en)
|
2015-05-01 |
2018-03-07 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of kindney thansplant
|
WO2016209956A1
(en)
|
2015-06-26 |
2016-12-29 |
Alexion Pharmaceuticals, Inc. |
A method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
|
US10940126B2
(en)
|
2015-07-03 |
2021-03-09 |
Camilla Svensson |
Inhibition of IL-8 in the treatment of pain and/or bone loss
|
CN113896789A
(zh)
|
2015-09-15 |
2022-01-07 |
供石公司 |
抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其用途
|
EP3350202A1
(en)
|
2015-09-18 |
2018-07-25 |
Chugai Seiyaku Kabushiki Kaisha |
Il-8-binding antibodies and uses thereof
|
TW201718014A
(zh)
|
2015-10-12 |
2017-06-01 |
諾華公司 |
C5抑制劑於移植相關微血管病之用途
|
RU2742606C2
(ru)
|
2015-12-18 |
2021-02-09 |
Чугаи Сейяку Кабусики Кайся |
Антитела к с5 и способы их применения
|
SG10201707267RA
(en)
|
2015-12-18 |
2017-10-30 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
|
US10233252B2
(en)
|
2015-12-21 |
2019-03-19 |
Wisconsin Alumni Research Foundation |
pH-dependent antibodies targeting the transferrin receptor and methods of use thereof to deliver a therapeutic agent
|
JP7141336B2
(ja)
|
2015-12-25 |
2022-09-22 |
中外製薬株式会社 |
抗ミオスタチン抗体および使用方法
|
AU2017206069A1
(en)
|
2016-01-08 |
2018-07-19 |
Scholar Rock, Inc. |
Anti-pro/latent myostatin antibodies and methods of use thereof
|
US20190023775A1
(en)
|
2016-01-11 |
2019-01-24 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment
|
WO2017132259A1
(en)
|
2016-01-25 |
2017-08-03 |
Shire Human Genetic Therapies, Inc. |
Anti-c5 antibodies with enhanced ph switch
|
PT3368069T
(pt)
|
2016-06-13 |
2020-11-11 |
Scholar Rock Inc |
Uso de inibidores da miostatina e terapias de combinação
|
WO2017218515A1
(en)
|
2016-06-14 |
2017-12-21 |
Regeneron Pharmaceuticals, Inc. |
Anti-c5 antibodies and uses thereof
|
KR102306744B1
(ko)
|
2016-06-17 |
2021-09-28 |
추가이 세이야쿠 가부시키가이샤 |
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