AR073829A1 - Variantes de inmunoglobulinas y sus usos. - Google Patents

Variantes de inmunoglobulinas y sus usos.

Info

Publication number
AR073829A1
AR073829A1 ARP090103925A ARP090103925A AR073829A1 AR 073829 A1 AR073829 A1 AR 073829A1 AR P090103925 A ARP090103925 A AR P090103925A AR P090103925 A ARP090103925 A AR P090103925A AR 073829 A1 AR073829 A1 AR 073829A1
Authority
AR
Argentina
Prior art keywords
amino acid
substitution
residue
acid residue
variant igg
Prior art date
Application number
ARP090103925A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41571534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073829(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR073829A1 publication Critical patent/AR073829A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Reivindicacion 1: Una IgG variante que comprende una region Fc de la lgG humana que comprende dos o más sustituciones de aminoácidos respecto de una region Fc de la IgG humana de tipo silvestre en dos o más de residuos de aminoácidos 251, 252, 307, 308, 378, 428, 430, 434, y 436, numerados de acuerdo con el índice de EU como en Kabat, en donde la IgG variante tiene una vida media incrementada comparada con la vida media de una lgG que tiene la region Fc de la IgG humana de tipo silvestre, y en donde al menos dos de las sustituciones de aminoácidos están en los residuos de aminoácidos 251, 252, 307, 308, 378, 428, 430, 434, o 436, y una sustitucion de aminoácido en el residuo do aminoácido 251 es una sustitucion por ácido aspártico o ácido glutámico, una sustitucion de aminoácido en el residuo de aminoácido 252 es una sustitucion por tirosina, una sustitucion de aminoácido en el residuo de aminoácido 307 es una sustitucion por glutamina, una sustitucion de aminoácido en el residuo de aminoácido 308 es una sustitucion por prolina, una sustitucion de aminoácido en el residuo de aminoácido 378 es una sustitucion por valina, una sustitucion de aminoácido en el residuo de aminoácido 428 es una sustitucion por leucina, una sustitucion de aminoácido en el residuo de aminoácido 430 es una sustitucion por alanina o lisina, una sustitucion de aminoácido en el residuo de aminoácido 434 es una sustitucion por alanina, serina o tirosina, y una sustitucion de aminoácido en el residuo de aminoácido 436 es una sustitucion por isoleucina. Reivindicacion 14: Una composicion farmacéutica que comprenden la IgG variante de acuerdo con la reivindicacion 1 o 3 y un portador farmacéuticamente aceptable. Reivindicacion 20: Uso de una IgG variante de acuerdo con la reivindicacion 1 o 3, para la produccion de un medicamento para modular la permeabilidad vascular en un sujeto. Reivindicacion 21: Uso de una IgG variante de acuerdo con la reivindicacion 1 o 3, para la produccion de un medicamento para inhibir o evitar el crecimiento de células cancerosas en un sujeto.
ARP090103925A 2008-10-14 2009-10-13 Variantes de inmunoglobulinas y sus usos. AR073829A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10508608P 2008-10-14 2008-10-14
US15213109P 2009-02-12 2009-02-12
US17176809P 2009-04-22 2009-04-22
US22051409P 2009-06-25 2009-06-25

Publications (1)

Publication Number Publication Date
AR073829A1 true AR073829A1 (es) 2010-12-01

Family

ID=41571534

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103925A AR073829A1 (es) 2008-10-14 2009-10-13 Variantes de inmunoglobulinas y sus usos.

Country Status (22)

Country Link
US (3) US20100098730A1 (es)
EP (2) EP3524620A1 (es)
JP (2) JP5913980B2 (es)
KR (3) KR20190025057A (es)
CN (3) CN102245208B (es)
AR (1) AR073829A1 (es)
AU (1) AU2009303526B2 (es)
BR (1) BRPI0914091B1 (es)
CA (1) CA2739429C (es)
CL (1) CL2015000148A1 (es)
ES (1) ES2828721T3 (es)
HK (2) HK1209130A1 (es)
IL (2) IL212048B (es)
MX (1) MX2011004001A (es)
PE (2) PE20150682A1 (es)
PH (1) PH12016500081B1 (es)
PL (1) PL2352521T3 (es)
RU (1) RU2536937C2 (es)
SG (2) SG195558A1 (es)
TW (2) TWI572357B (es)
WO (1) WO2010045193A1 (es)
ZA (1) ZA201102413B (es)

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KR20110070914A (ko) 2011-06-24
HK1163550A1 (zh) 2012-09-14
JP2016026144A (ja) 2016-02-12
RU2011119447A (ru) 2012-11-27
US20210002359A1 (en) 2021-01-07
TW201023884A (en) 2010-07-01
TWI572357B (zh) 2017-03-01
IL212048B (en) 2020-02-27
KR101834999B1 (ko) 2018-03-06
MX2011004001A (es) 2011-05-19
PE20110707A1 (es) 2011-10-11
BRPI0914091B1 (pt) 2022-05-10
TW201542228A (zh) 2015-11-16
PH12016500081B1 (en) 2017-01-16
BRPI0914091A2 (pt) 2016-09-27
US20100098730A1 (en) 2010-04-22
HK1209130A1 (en) 2016-03-24
EP2352521B1 (en) 2020-09-16
CN104447990A (zh) 2015-03-25
CN110317272A (zh) 2019-10-11
ES2828721T3 (es) 2021-05-27
WO2010045193A1 (en) 2010-04-22
TWI572359B (zh) 2017-03-01
JP6122072B2 (ja) 2017-04-26
PL2352521T3 (pl) 2021-03-08
CA2739429A1 (en) 2010-04-22
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CN102245208A (zh) 2011-11-16
RU2536937C2 (ru) 2014-12-27

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