JP2023526669A - 低pHスキンケア組成物及びその使用方法 - Google Patents
低pHスキンケア組成物及びその使用方法 Download PDFInfo
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Abstract
Description
組成物に関連して使用される「塗布する」又は「塗布」は、本発明の組成物を表皮などのヒトの皮膚表面上に塗布又は拡げることを意味する。
本明細書のスキンケア組成物は、皮膚の外観及び/又は機能を改善するためにヒト皮膚に局所塗布することを目的とする低pH組成物である。場合によっては、本発明の低pH組成物は、様々な皮膚状態の美容的(すなわち、非治療的)処置のために使用され得る。場合によっては、低pH組成物は、色素沈着過度のシミ、皮膚の色むら、及び/又は血色が悪い皮膚の外観を改善するのに特に好適であり得る。本明細書における低pH組成物は、有効量のビタミンB3化合物と、低pH環境に耐えることができるポリマー増粘剤と、塩/酸pH緩衝系(例えば、乳酸/乳酸ナトリウム及び/又はグリコール酸/グルコン酸ナトリウム)、及び任意選択的に、低分子量シリコーン油と、を含む。組成物は、任意選択的に、シリコーン乳化剤と、局所スキンケア組成物に一般的に見られる他の成分とを含んでもよい。理論に束縛されるものではないが、この成分の組み合わせは、良好な感触特性を有し、かつ皮膚に優しい有効なスキンケア組成物を提供すると考えられる。
本組成物は、例えば、米国特許第5,939,082号に記載されているように、様々な皮膚状態を調節するための、安全かつ有効な量のビタミンB3化合物を含む。本明細書における組成物は、組成物の重量又は体積に基づいて、0.1重量%~10重量%(例えば、0.5%~5%、又は1%~4%)のビタミンB3化合物を含有し得る。
Rが、CONH2(すなわち、ナイアシンアミド)、COOH(すなわち、ニコチン酸)、又はCH2OH(すなわち、ニコチニルアルコール)である化合物、それらの誘導体、及び上記のいずれかの塩を有する化合物を意味する。ビタミンB3化合物の例示的な誘導体としては、ニコチン酸の非血管拡張性エステル(例えば、トコフェリルニコチネート、ミリスチルニコチネート)、ニコチンアミドリボシド、ニコチニルアミノ酸、カルボン酸のニコチニルアルコールエステル、ニコチン酸N-オキシド、及びナイアシンアミドN-オキシドを含む、ニコチン酸エステルが挙げられる。場合によっては、ナイアシンアミドなどのビタミンB3化合物は、例えば、米国特許出願公開第2020/0009123号に記載されているように、比較的低いpHで改善された有効性を有し得る。
皮膚への局所塗布用の低pH組成物を提供する場合、皮膚への塗布後に組成物のpHを維持するのを助ける緩衝系を含むことが重要である。平均して、ヒトの皮膚のpHは、典型的には約5.0~6.0の範囲である。このpHを維持するために、ヒトの皮膚は、pHの変化に抵抗する天然の緩衝系を進化させてきた。したがって、低pH組成物が皮膚に塗布されると、皮膚の天然の緩衝系は、組成物のpHを調整して皮膚の自然なpHと一致させようとする。低pH組成物は、緩衝系の添加なしでは所望のスキンケア効果を提供することができない場合がある。
本明細書の低pH組成物は、低pHの電解環境に耐えることができるポリマー増粘剤を含む。すなわち、増粘剤は、酸塩緩衝系の存在下で、組成物を低pHで増粘又は安定化させる能力を失うことはない。いくつかの従来の中和された増粘剤は、より低いpHで、及び/又は酸塩緩衝液(例えば、乳酸ナトリウム)の存在下では、劣化する、及び/又は組成物を適切に増粘させる能力を失うことが知られている。例えば、一部の中和された増粘剤は低pH環境で劣化する。一方、セチルアルコール及びステアリルアルコールなどの脂肪族アルコール増粘剤は、一般に低pHで安定であるが、エッセンス、美容液などの形態である場合、組成物に望ましくない濁り又は不透明度を付与する傾向がある。いくつかのアニオン性ポリマー増粘剤は、低pH環境への好適な耐性を提供することができるが、酸と塩との組み合わせのために緩衝系を許容することができないことも判明している。したがって、場合によっては、本明細書に記載の低pH組成物は、中和された増粘剤、脂肪族アルコール増粘剤、及びアニオン性増粘剤を含まないか又は実質的に含まなくてもよい。増粘剤は、組成物の0.0001重量%~25重量%(例えば、0.001重量%~20重量%、0.01重量%~10重量%、0.5重量%~7重量%、又は1重量%若しくは5重量%)で存在してもよい。
場合によっては、低pH組成物が皮膚の標的部分に塗布される際に、アニオン性ポリマー増粘剤が望ましくない粘着感を与える可能性がある。低分子量のシリコーン流体を添加すると、この粘着感を軽減又は防止できることが判明している。シリコーン流体(シリコーン油と称される場合もある)の分子量は、シリコーン流体の粘度にも直接比例する、そのシリコーンポリマー鎖の長さに依存する。したがって、本低pH組成物での使用に好適な低分子量シリコーン流体は、25℃で100cSt以下(例えば、1cSt~90cSt、5cSt~50cSt、又は更には10cSt~30cSt)の動粘度を有する。動粘度は、シリコーン流体を分類する一般的な方法であり、材料の供給元から入手することができる。低分子量シリコーン流体の特に好適な例は、5cStのジメチコン流体である。本明細書で使用するところの「ジメチコン」とは、下式を有する化合物を意味する。
本明細書における低pH組成物は、皮膚科学的に許容可能な担体(「担体」と称される場合もある)を含んでよい。「皮膚科学的に許容される担体」なる語句は、担体がケラチン性組織への局所塗布に好適であり、良好な審美特性を有し、組成物中の活性物質と相溶性を有し、安全性又は毒性について不当な懸念をいっさい生じさせないことを意味する。一実施形態において、担体は、組成物の約50重量%~約99重量%、約60重量%~約98重量%、約70重量%~約98重量%、又は代替的に約80重量%~約95重量%の濃度で存在する。
本明細書の低pH組成物がエマルジョン(例えば、水中油型エマルジョン)の形態である場合、エマルジョンを安定化させる(すなわち、エマルジョンが相分離するのを防ぐ)ために乳化剤を含むことが望ましい場合がある。乳化剤は、組成物中に0.01%~10%(例えば、0.05%~5%、又は0.1%~2%)存在し得る。乳化剤は、非イオン性であってもよく、アニオン性であってもよく、又はカチオン性であってもよい。場合によっては、乳化剤は、シリコーン乳化剤であり得る。本明細書で使用するのに好適であり得る乳化剤のいくつかの非限定的な例は、米国特許第3,755,560号、同第4,421,769号、及びMcCutcheon’s Detergents and Emulsifiers,North American Edition、317-324頁(1986)に開示されている。
本組成物は、任意選択的に、化粧品組成物(例えば、着色剤、スキンケア活性物質、抗炎症剤、日焼け止め剤、乳化剤、緩衝液、レオロジー変性剤、これらの組み合わせなど)に一般的に使用される1つ以上の追加の成分を含んでもよく、ただし追加の成分が不所望に本組成物によって提供される皮膚健康上又は外観上の効果を変えるものではない。組成物中に組み入れられる場合、追加の成分は、過度の毒性、不適合性、不安定性、アレルギー反応などを示すことなく、ヒトの皮膚組織に接触させて用いるのに好適でなければならない。追加活性物質のいくつかの非限定的な例としては、ビタミン、ミネラル、ペプチド及びペプチド誘導体、糖アミン、日焼け止め剤、オイルコントロール剤、微粒子、フラボノイド化合物、育毛制御剤、抗酸化剤及び/又は抗酸化剤前駆体、防腐剤、プロテアーゼ阻害剤、チロシナーゼ阻害剤、抗炎症剤、保湿剤、角質除去剤、皮膚美白剤、サンレスタンニング剤、潤滑剤、抗ニキビ活性物質、抗セルライト活性物質、キレート剤、抗しわ活性物質、抗萎縮活性物質、フィトステロール及び/又は植物ホルモン、N-アシルアミノ酸化合物、抗菌剤、並びに抗真菌剤が挙げられる。本明細書での使用に好適であり得る追加の成分及び/又はスキンケア活性物質の他の非限定的な例が、米国特許出願公開第2002/0022040号、同第2003/0049212号、同第2004/0175347号、同第2006/0275237号、同第2007/0196344号、同第2008/0181956号、同第2008/0206373号、同第2010/00092408号、同第2008/0206373号、同第2010/0239510号、同第2010/0189669号、同第2010/0272667号、同第2011/0262025号、同第2011/0097286号、同第2012/0197016号、同第2012/0128683号、同第2012/0148515号、同第2012/0156146号、及び同第2013/0022557号、並びに米国特許第5,939,082号、同第5,872,112号、同第6,492,326号、同第6,696,049号、同第6,524,598号、同第5,972,359号、及び同第6,174,533号に記載されている。
本明細書における低pH化粧品組成物は、皮膚への局所塗布を目的として配合されている。本発明の低pH組成物の使用方法は、処置を必要とする人又は処置が所望される場合の皮膚の標的部分(例えば、皮膚の色むらを示す皮膚部分、血色が悪い皮膚、又は色素沈着過度のシミを有する皮膚)を特定する工程及び、有効量の低pH組成物を、処置期間にわたって皮膚の標的部分に塗布する工程を含む。組成物の有効量は、使用者が望む皮膚効果及び/又は処置領域の大きさに基づいて変化し得る。場合によっては、有効量は、0.1g~5g(例えば、0.2g~4g、0.3g~2g、又は更には0.5g~1g)の範囲であり得る。皮膚の標的部分は、額、口周囲、顎、眼窩周囲、鼻、及び/若しくは頬)などの顔の皮膚表面上、又は身体の別の部分(例えば、手、腕、脚部、背部、胸)にあってもよい。場合によっては、色素沈着過度のシミ又は皮膚の色むらなどの皮膚の老化の兆候を現在は示していないが、年齢とともにそのような特徴を一般に示す皮膚領域である皮膚の標的部分が選択されてもよい。これらの場合に、低pH組成物を使用して、このような望ましくない皮膚特徴の発生を防止することができる。
不透明度試験方法
この方法は、製品又は材料の不透明度を測定するために用いられる。結果は百分率として報告され、百分率が高い程、サンプルの不透明度がより大きい。不透明度を測定する前に、試験される試験組成物を、サンプル中に空気を導入しないように注意しながら、10,000rpmで1分間、S25N-25F分散ツール(又はその同等物)とともにUltra-turraxT25(ドイツ、IKA社製)又はその同等物を使用して粉砕する。2mmの光路を提供する好適な透過セル(例えば、Konica Minolta社製のCM-A130矩形セル又はその同等物)に十分な量の組成物を配置することによって、サンプルを調製する。この方法のために可視スペクトルにわたってCIE D65照明条件下で三刺激値CIEXYZをもたらすことができる好適な分光光度計(例えば、Konica Minolta社製のCM-3600A分光光度計又はその同等物)を使用して、サンプルの不透明度を測定する。2度視野及びD65光源を用いて1931 CIEにより定義された三刺激XYZ値をもたらすように分光光度計を設定する。不透明度を計算するために2組の三刺激値が必要であり、1つは、白色背景の前での製品の2mmサンプルセルの値であり、もう1つは、黒色背景の前での値である。許容可能な白色背景としては、不透明カード(Opacity Card Form 2A,Leneta Company,Inc(Mahwah,NJ,USA)、又は等価物など)の白色部分が挙げられ、許容可能な黒色背景は、不透明カード(Opacity Card Form 2A,Leneta Company,Inc(Mahwah,NJ,USA)、又は等価物など)の黒色部分である。不透明度は、黒色背景を使用するY三刺激値を白色背景を用いるY三刺激値で除した商に100%を乗じて計算することによって決定される。不透明度は、最も近い整数百分率で報告される。
この方法は、BROOKFIELDブランドの粘度計(モデルDV2T又は同等品など)及び好適なスピンドル(RV4又は同等品など)を製造元の指示に従って使用して、組成物又は材料の動粘度を測定する方法を提供する。当業者が製造元の推奨に従って適切なスピンドルを選択できることを理解されたい。粘度計を較正した後、スピンドルを十分な量(例えば、スピンドルをスピンドルシャフト上の浸漬マークまで浸漬するのに十分な量)の試験サンプルに浸漬する。スピンドル回転速度を5rpmに設定し、粘度計を起動する。表示された粘度の読み取り値が安定するまで待つ(約10~30秒)。読み取り値が安定したら、10秒間隔で5回の読み取りを行う。5回の読み取り値の平均として粘度を計算する。
表1は、本明細書に記載の低pH組成物の実施例、及びアスタリスクで特定される非本発明の組成物(実施例J及びR)の2つの比較例を示す。組成物を、スキンケア組成物を製造する従来の方法を使用して調製した。このような方法は、典型的には、加熱、冷却、真空の適用などを用いて又は用いずに、成分を1つ以上の工程で比較的均一な状態になるまで混合することを含む。典型的には、エマルジョンは、最初に水相の材料を脂肪相の材料とは別に混合し、その後、2つの相を適宜組み合わせて所望の連続層を得ることにより調製される。好ましくは、組成物は、安定性(物理的安定性、化学的安定性、光安定性)、及び/又は活性材料の送達を最適化するように調製される。この最適化には、pHの(すなわち5未満への)調節、活性剤と複合体を形成して、安定性又は送達に有害な影響を与え得る材料の排除(例えば混入鉄の排除)、複合体形成を防止する手法(例えば、適切な分散剤又は二重区画包装)の使用、適切な光安定性の手法(例えば、日焼け止め剤/日焼け防止剤の配合、不透明包装の使用)の使用などを挙げることができる。
2Ashland,Inc.社製CHRONOGEN YST
3Lucas Meyer Cosmetics社製PROGELINE
4Seppic社製SEPIMAX ZEN
5Shin-Etsu社製KF-6011
*比較例
この実施例は、乳酸/乳酸ナトリウム低pH緩衝系が、組成物のpHを正常なヒト皮膚の平均pH未満(すなわち、5.0未満)に維持する能力を実証する。被験者に、試験前に水で顔を洗浄するように求めた。次いで、好適な量(例えば、1g)の試験製品(表1の実施例F)を、被験者の顔に塗布した。皮膚の標的部分のpHを、製品が乾燥した後(塗布後約2~5分)、次いで塗布してから3時間後に測定した。pHは、フラットプローブを備えた好適なpH計を使用し、安定したpH値がpH計に表示されるまで被験者の皮膚にプローブを当てることによって測定することができる。pHプローブは、皮膚に当てる直前に脱イオン水で湿らせる必要がある。被験者の平均pHを以下の表2に示す。
この実施例は、本発明の低pH組成物が皮膚の外観を改善する能力を実証する。本実施例では、低pH組成物が提供する望ましい皮膚外観効果を示すために、テクスチャ面積率を選択した。テクスチャ面積率の算出方法は、皮膚のテクスチャがどのように知覚されるかに影響を及ぼす皮膚特徴(例えば、毛穴の大きさ、小じわ、及びしわ)を測定するための客観的な画像キャプチャ及び分析システムを使用する。テクスチャ面積率の改善は、皮膚の外観の改善に対応する。
第1の試験では、9人の被験者に、対照投与量を使用して、制御された温度、制御された湿度(CTCH)の室内で、表1(盲検)から組成物F、J、及びHを前腕に塗布するように求めた。次いで、被験者に、2分後及び6分後の粘着性を評価し、0は粘着性なし、5は高い粘着性の0から5までのスコアを付けるように求めた。3.0未満の粘着性が一般に望ましい。試験結果を表4Aにまとめる。スチューデントT検定を使用して、統計的有意性(閾値=0.05)を決定した。
この実施例は、本発明の低pH組成物の所望の不透明特性を実証する。15~75の不透明度が一般に望ましい。不透明度が15より低い場合、組成物は水によく似ているように見え、消費者はその有効性を疑問に思う場合がある。しかし、不透明度が75を超える場合、消費者は、組成物が濃厚である、粘着性である、及び/又は皮膚に浸透しないと想定する場合がある。本実施例では、組成物J、M、N、P、Q、R、S、及びTを試験した。更に、従来のスキンケア組成物(C1)の不透明度も試験した。従来の組成物は、Decknerらの米国特許第5,968,528号の実施例1である。試験の結果を表5にまとめる。表5に見られるように、油を全く含まない組成物(すなわち、組成物J及びR)は、十分な不透明度を提供せず、油及び増粘剤、スキンケア活性物質、及び/又は緩衝系の量のバランスをとるように調整されない組成物は、組成物C1によって実証されるように、不透明すぎる場合がある。
この実施例は、本発明の低pH組成物の低刺激性を実証する。低pH組成物を、臨床試験、インビトロ細胞ベースアッセイ及びインビボヒト試験で試験して、組成物の相対的な刺激性を調べた。
上記の実施例3に記載の臨床試験の一部として、被験者に、皮膚に塗布された試験製品に関連する刺激性のレベルを評価するアンケートに記入するように求めた。アンケートは、被験者に、試験製品が「皮膚を刺激しない」かどうかについて評価するように求めた。アンケートの回答の選択肢は、1)非常にそう思う、2)そう思う、3)ややそう思う、4)わからない、5)あまりそう思わない、6)そう思わない、及び7)全くそう思わない、の7つであった。この実施例で使用した試験組成物は、表1の組成物I及び実施例3のビヒクル対照であった。4週目及び8週目の試験結果を以下の表6にまとめる。「上位3」とは、「非常にそう思う」、「そう思う」、「ややそう思う」と回答した被験者の割合を指す。
この実施例のインビトロ部分は、試験組成物が市販のHEK293細胞において周知のTRPV1感覚受容体を活性化する能力を調べる。TRP受容体(例えば、TRPA1、TRPV1、及びTRPM8)は、中枢神経系への熱感覚(すなわち、高温及び低温)の伝達に関与することが知られている感覚受容体である。TRPV1はまた、かゆみ、灼熱感、疼痛、うずき、刺痛、及び炎症などの皮膚感覚刺激の誘発に関与すると考えられている。従来、ある材料又は組成物がTRPV1を活性化する能力を評価するため、特に、様々な消費者製品配合物の灼熱感、うずき、味覚感覚、及び/又は疼痛緩和効果を評価するために、特定のヒトTRPV1受容体発現細胞株が使用されてきた。この実施例では、HEK293細胞を、カルシウム結合色素であるFluo-4 AMで前処理し、FLIPR TETRAブランドの細胞スクリーニングシステム(Molecular Devices,LLCから入手可能)又は同等物を使用した高スループットの方法で、対照物質及び試験組成物で処理した。TRPV1イオンチャネルが活性化されると、カルシウムイオンが細胞に入り、Fluo-4色素に結合して蛍光シグナルを生成し、応答の定量化を可能にする。TRPV1活性化に関係しない非特異的なカルシウム動員の影響を低減するために、特定のTRPV1阻害剤/アンタゴニスト化合物の存在下及び非存在下で配合率応答を測定した。特定のアンタゴニストの存在下では、配合率によるTRPV1受容体活性化の陽性シグナルが消失又は減少し、それによって、配合率依存性のTRPV1活性化に起因するデータ収集の精度が向上した。
アッセイを開始するために、HEK293細胞を、10%のFBS、高グルコース、L-グルタミン、フェノールレッド、100ug/mlのG418、及びピルビン酸ナトリウムを含有するDMEM培地中で、33℃及び5%のCO2で4~5日間培養した(80~90%コンフルエント)(例えば、Sadofsky,L.R.,et al.Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1(TRPA1 and TRPV1)Co-Expressing Cells.Cells 2014,3,616-626を参照)。第2継代の細胞をPBSとともに組織培養容器から取り出し、分離した細胞を遠心分離器中で低速(800~1000rpm)で3分間遠心分離してペレットを形成した。PBS培地を除去し、細胞ペレットを4mLの増殖培地に再懸濁させた。25μLのPluronic F-127に溶解させた50μgのFluo-4 AMカルシウム色素を添加し、次いで、細胞を穏やかに振盪しながら室温で1時間インキュベートした。細胞を、45mLアッセイ緩衝液(1×HBSS、20mM HEPES)で3分間の低速遠心分離(800~1000rpm)により1回洗浄し、次いで、10mLのアッセイ緩衝液中に再懸濁させた。96ウェルの黒色平底プレートの各ウェルに100μLのアリコート(約15×104細胞)を分注した。プレートを室温で30分間静置し、次いで、細胞スクリーニングシステム(例えば、FLIPR TETRA又は等価物)を使用して、λex 488nm及びλem 514nmでベースライン蛍光を記録した。カプサイシン(350nM)を各プレートのアゴニスト対照として使用し、イオノマイシン(2uM)を陽性対照として使用した。
2Corbion社製PURAC HIPURE 90
3Corbion社製PURASAL S HQ-60
4Seppic社製SEPIMAX ZEN
5Shin-Etsu社製KF-6011P
2Corbion社製PURASAL S HQ-60
3Jungbunzlauer社製
4Seppic社製SEPIMAX ZEN
5Shin-Etsu社製KF-6011P
この実施例のインビボ部分は、異なる緩衝系を使用した比較例の低pH配合物と比較して、本組成物の低刺激性を示している。この試験は、25~54歳の女性被験者を使用した単一製品の盲検試験であった。被験者に、試験組成物約0.5g(すなわち、ポンプ1押し分)を1日2回(朝及び夜)、顔全体に塗布するように求めた。この試験の試験組成物は、上記の表7Aに示されている。1週間の使用後、試験組成物が皮膚を刺激するかどうかを被験者に尋ねた。インビボ試験の結果を以下の表8にまとめる。表8に見られるように、被験者の80%超が、組成物が皮膚を刺激しなかったと報告したが、比較例はこの基準を満たさなかった。データは、本発明の実施例が比較例よりも皮膚への刺激が少ないことを示唆している。
1.低pHスキンケア組成物であって、
a)約0.1%~10%のビタミンB3化合物と、
b)グルコン酸及びグルコン酸ナトリウムを含む、約0.1%~10%の低pH緩衝系と、
c)ポリアクリロイルジメチルタウリンナトリウム及びポリアクリレートクロスポリマー-6のうちの少なくとも一方を含む、約0.1%~5%のポリマー増粘剤と、を含み、
d)組成物のpHが、約2.0~約5.0、好ましくは約2.5~4.5、より好ましくは約3.5~4.3である、低pHスキンケア組成物。
2.約0.01%~約1%のシリコーン乳化剤を更に含む、段落Aに記載の組成物。
3.組成物が、不透明度試験に従って、約15~約75、好ましくは約35~約60の不透明度を有する、段落A又はBに記載の組成物。
4.約0.1%~約10%の粘着性を低下させる油を更に含む、段落1~3のいずれか1つに記載の組成物。
5.油が、25℃で100cSt以下、好ましくは10cSt以下の粘度を有するシリコーン油である、段落Dに記載の組成物。
6.セチルアルコール、ステアリルアルコール、ベヘニルアルコール、及びこれらの組み合わせからなる群から選択される安定な脂肪族アルコール増粘剤を更に含む、段落1~5のいずれか1つに記載の組成物。
7.組成物が、ビタミン、ミネラル、ペプチド、糖アミン、日焼け止め剤、オイルコントロール剤、フラボノイド化合物、抗酸化剤、プロテアーゼ阻害剤、チロシナーゼ阻害剤、抗炎症剤、保湿剤、角質除去剤、皮膚美白剤、抗ニキビ剤、抗しわ剤、フィトステロール、N-アシルアミノ酸化合物、抗菌剤、抗真菌剤、及びこれらの組み合わせからなる群から選択される、少なくとも1種の追加のスキンケア活性物質を含む、段落1~6のいずれか1つに記載の組成物。
8.ビタミンB3化合物が、ナイアシンアミドである、段落1~7のいずれか1つに記載の組成物。
9.組成物が、TRPV1アッセイに従って、約10%未満、好ましくは約5%未満のTRPV1活性化を示す、段落1~8のいずれか1つに記載の組成物。
10.組成物が、25℃で、約1cP~約30000cP、好ましくは約1000cP~約15000cPの粘度を有するエッセンスの形態である、段落1~9のいずれか1つに記載の組成物。
11.低pH緩衝系が、乳酸、ラクトビオン酸、及びマルトビオン酸から選択される追加の酸緩衝剤と、乳酸ナトリウム、グルコン酸乳酸カルシウム、乳酸カリウム、乳酸亜鉛、及びグルコン酸カリウムから選択される追加の塩緩衝剤と、を更に含む、段落1~10のいずれか1つに記載の組成物。
12.低pHスキンケア組成物であって、
a)約0.1%~10%のビタミンB3化合物と、
b)グルコン酸、ラクトビオン酸、及びマルトビオン酸から選択される酸緩衝剤、並びにグルコン酸ナトリウム、グルコン酸乳酸カルシウム、及びグルコン酸カリウムから選択される塩緩衝剤を含む、約0.1%~10%の低pH緩衝系と、
c)ポリアクリロイルジメチルタウリンナトリウム及びポリアクリレートクロスポリマー-6のうちの少なくとも一方を含む、約0.1%~5%のポリマー増粘剤と、を含み、
d)組成物のpHが、約2.0~約5.0、好ましくは約2.5~約4.5、より好ましくは約3.5~4.3である、低pHスキンケア組成物。
13.乳酸及び乳酸ナトリウムのうちの少なくとも一方を更に含む、段落Lに記載の組成物。
14.皮膚を美容的に処置する方法であって、
処置が望まれる皮膚の標的部分を特定することと、
処置期間の過程にわたって、皮膚の標的部分に、有効量の請求項1に記載の組成物を塗布することと、を含む、方法。
15.組成物が、TRPV1アッセイに従って、約10%未満、好ましくは5%未満のTRPV1活性化を示す、段落Nに記載の方法。
16.組成物が、処置期間中に皮膚の標的部分に顕著な皮膚刺激を引き起こさない、段落N又はOに記載の方法。
Claims (13)
- 低pHスキンケア組成物であって、
a.0.1%~10%のビタミンB3化合物と、
b.グルコン酸及びグルコン酸ナトリウムを含む、0.1%~10%の低pH緩衝系と、
c.ポリアクリロイルジメチルタウリンナトリウム及びポリアクリレートクロスポリマー-6のうちの少なくとも一方を含む、0.1%~5%のポリマー増粘剤と、
を含み、
d.前記組成物のpHが、2.0~5.0、好ましくは2.5~4.5、より好ましくは3.5~4.3である、
低pHスキンケア組成物。 - 0.01%~1%のシリコーン乳化剤を更に含む、請求項1に記載の組成物。
- 前記組成物が、不透明度試験に従って、15~75、好ましくは35~60の不透明度を有する、請求項1又は2に記載の組成物。
- 25℃で100cSt以下、好ましくは10cSt以下の粘度を有する0.1%~10%のシリコーン油を更に含む、請求項1~3のいずれか一項に記載の組成物。
- セチルアルコール、ステアリルアルコール、ベヘニルアルコール、及びこれらの組み合わせからなる群から選択される安定な脂肪族アルコール増粘剤を更に含む、請求項1~4のいずれか一項に記載の組成物。
- 前記組成物が、ビタミン、ミネラル、ペプチド、糖アミン、日焼け止め剤、オイルコントロール剤、フラボノイド化合物、抗酸化剤、プロテアーゼ阻害剤、チロシナーゼ阻害剤、抗炎症剤、保湿剤、角質除去剤、皮膚美白剤、抗ニキビ剤、抗しわ剤、フィトステロール、N-アシルアミノ酸化合物、抗菌剤、抗真菌剤、及びこれらの組み合わせからなる群から選択される、少なくとも1種の追加のスキンケア活性物質を含む、請求項1~5のいずれか一項に記載の組成物。
- 前記ビタミンB3化合物が、ナイアシンアミドである、請求項1~6のいずれか一項に記載の組成物。
- 前記組成物が、TRPV1アッセイに従って、10%未満、好ましくは5%未満のTRPV1活性化を示す、請求項1~7のいずれか一項に記載の組成物。
- 前記組成物が、25℃で、1cP~約30000cP、好ましくは約1000cP~約15000cPの粘度を有するエッセンスの形態である、請求項1~8のいずれか一項に記載の組成物。
- 前記低pH緩衝系が、乳酸、ラクトビオン酸、及びマルトビオン酸から選択される追加の酸緩衝剤と、乳酸ナトリウム、グルコン酸乳酸カルシウム、及びグルコン酸カリウムから選択される追加の塩緩衝剤とを更に含む、請求項1~9のいずれか一項に記載の組成物。
- 皮膚を美容的に処置する方法であって、
処置が望まれる皮膚の標的部分を特定することと、
処置期間の過程にわたって、前記皮膚の標的部分に、有効量の請求項1~10のいずれか一項に記載の組成物を塗布することと、
を含む、方法。 - 前記皮膚の標的部分が顔の皮膚であり、前記有効量が0.5g~2gであり、前記処置期間が少なくとも4週間であり、前記組成物が少なくとも1日1回塗布される、請求項11に記載の方法。
- 前記組成物が、前記処置期間中に前記皮膚の標的部分に顕著な皮膚刺激を引き起こさない、請求項11又は12に記載の方法。
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US20240148633A1 (en) | 2024-05-09 |
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US11911498B2 (en) | 2024-02-27 |
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