WO2017093788A1

WO2017093788A1 - An anti fissure herbal composition for targeting fissure and method of synthesizing the same

Info

Publication number: WO2017093788A1
Application number: PCT/IB2015/059306
Authority: WO
Inventors: Asghar MORADI
Original assignee: Moradi Asghar
Priority date: 2015-12-03
Filing date: 2015-12-03
Publication date: 2017-06-08

Abstract

The embodiments herein disclose method and composition for the treatment of external fissures, internal fissures, constipation and tissue crack around anus. The herbal spray for external anal fissure comprises 32000mg of Matricaria recutita extract, l000mg of Crocus sativus extract, 7000mg of Aloe vera extract and 10000mg of Althaea officinalis flower extract. The herbal spray for internal anal fissure comprises 40000mg of Matricaria recutita flower extract, 25000mg Allium porrum shoot extract, 25000mg Apium graveolens stalk extract, 15000mg Fumaria officinalis shoot extract and 5000mg honey. The topical anti constipation oil mixture comprises 30000mg Sesamum indicum and 20000mg castor oil. The anus anti-crack ointment comprises 15000mg sesame oil, 8500mg olive oil and 1500mg spermaceti. The external spray treats clots and bleeding. The internal herbal mixture stops bleeding, heals internal swelling, eases defecation and recovers rectum. The topical oil and anti-crack ointment softens the skin and helps the recovery of cracks inside the anus.

Description

AN ANTI FISSURE HERBAL COMPOSITION FOR TARGETTING FISSURE AND A METHOD OF SYNTHESIZING THE SAME

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the priority of US Provisional Patent Application with serial number No. 62/154861, filed on April 30, 2015, with the tile, "Anti Fissure", and the content of which is incorporated herein by reference in its entirety.

BACKGROUND

Technical field

[0002] The embodiments herein generally relates to the herbal composition. The embodiments herein particularly relate to a composition for targeting fissures. The embodiment herein more particularly relate to a herbal composition and method of synthesizing the herbal composition for targeting fissures.

Description of the Related Art

[0003] An anal fissure or rectal fissure is a break or tear in the skin of the anal canal. Anal fissures may be noticed by bright red color and bleeding on toilet paper. Sometimes the bleeding can occur in the toilet while defecation. In acute cases, the fissures cause pain after defecation. In chronic fissures, the intensity of pain is less. Anal fissures usually extend from the anal opening and are usually located posteriorly in the midline. The anal fissures are of relatively unsupported nature and poorly perfuse with the anal wall in that location. Fissure depth may be superficial or sometimes extends down to the underlying sphincter muscle.

[0004] Anal fissures are a spilt along the lower part of the anal canal, which is the small area of bowel connecting the rectum with the anus. The anal fissures are a common condition. It is estimated that anal fissures affect approximately 11% of the population in both men and women equally. The anal fissures generally occur in people aged between 20 and 40 years old.

[0005] Anal fissures are either acute or chronic. Acute fissures occur with a sudden onset and heal within 2 weeks. The chronic fissures generally fail to heal within 8 weeks.

[0006] Anal fissures are classified according to location. Most of the anal fissures are located at the back (known as posterior fissures). Although the fissures can also be located at the front (anterior fissure). Anal fissures are also located in more than one location. The location provides more information related to the cause of the anal fissures. For example, fissure generally located at the side of anal canal are likely to be due to Crohn's diseases.

[0007] Most anal fissures are caused by a stretching of the anal mucosa beyond its capability. Superficial or shallow anal fissures appear like a paper cut and are hard to detect upon visual inspection. The superficial or shallow anal fissures will generally self heal within a couple of weeks. However some anal fissures become chronic, deep and do not get healed. The most common cause of non-healing is spasming of the internal anal sphincter muscle which results in an impaired blood supply to the anal mucosa. The result is a non healing ulcer, which gets infected by fecal bacteria. In adults, the anal fissures occur because of constipation. In a condition like constipation, the anal fissures occur due to the passing of large, hard stools or by a prolonged diarrhea. In older adults, fissures may be caused by decreased blood flow to the area. Laterally formed fissures are caused due to tuberculosis, occult abscesses, leukemic infiltrates, carcinoma, acquired immune deficiency syndrome (AIDS) or inflammatory bowel diseases. Some sexually transmitted infections can promote the breakdown of tissue resulting in a fissure.

[0008] The other common causes of anal fissures include: child birth trauma in women, sexual activities, Crohn's disease, ulcerative colitis and poor toileting in young children. In case of infants, a frequent diaper change can prevent anal fissure. As constipation can cause anal fissures, the infants must be administered enough fluids (i.e. breast milk, proper ratios when mixing formulas).

[0009] Many remedies are known for the targeting these symptoms. Most of the remedies in the art have varying degrees of success, and few remedies have been successful in substantially reducing or completely eliminating fissures without any side effects. Both surgical and non-surgical methods are used for the treatment of anal fissures.

[0010] Medications or formulas are applied locally to relax the sphincter muscle, thereby allowing the healing to take place. Many medications in the form of ointments have been developed. For example: nitroglycerine ointment, calcium channel blockers, nifedipine ointment and topical diltiazem. In general topical nitroglycerine ointment, topical nifedipine 0.3% with lidocaine 1.5% ointment and diltiazem 2% are reported to be effective for anal fissures. A common side effect or drawback of ointments is headache. The headache is caused by systematic absorption of the drug/ointment by the patient's body.

[0011] A combined surgical and pharmacological treatment is given by colorectal surgeons. One such method is the direct injection of botulinum toxin into the anal sphincter muscle to relax it. It is reported in many cases that the patients subjected to Botox injections, eventually had to choose another cure, as the injections proved less potent. This makes the patients spending thousands of dollars for a partial cure. Lateral sphincterotomy is a standard procedure for curing this affliction. A combination of medical therapies may offer less percentage of cure rate.

[0012] Patients with anal fissures are subjected to surgical procedures, if they have taken medical therapy for at least one to three months and have no positive outcome. The surgical methods are not the first option in the treatment of anal fissures. The main side effect of surgery is the development of anal incontinence. Anal incontinence includes inability to control gas, mild fecal soiling or loss of solid stool. During the immediate surgical recovery period, the degree of incontinence reported in patients is upto 45%. The incontinence is rarely permanent and is usually mild. The complications and risk are high in the surgical procedures.

[0013] Surgical treatment under general anaesthesia is either anal stretch or lateral sphicteroctomy where the internal anal sphincter muscle is incised. Both operations aim to decrease sphincter spasming and thereby restore normal blood supply to the anal mucosa. Surgical operations involve administration of general anaesthetic and can be painful postoperatively. Anal stretch is also associated with anal incontinence in a small proportion of cases and thus sphincterotomy is the operation of choice.

[0014] Lateral internal sphincterotomy (LIS) is the surgical procedure of choice for anal fissures due to its simplicity and its high success rate (approx. 95%). In LIS procedure, the internal anal sphincter is partially divided in order to reduce spasming. The LIS procedure improves the blood supply and helps in the anal fissure healing. The weakening of the sphincter reduces the potential for anal fissure recurrence. The LIS procedure is generally performed as one day surgery after the patient is given general anesthesia. The pain from LIS is mild and often less than the pain of the fissure itself. Patients often return to normal actively with a week. [0015] Lateral internal sphincterotomy have a number of potential side effects including problems with incision site healing and incontinence to flatus and feaces. Surveys of surgical results suggest incontinence rates of up to 36%. Though lateral internal sphincterotomy (LIS) is considered safe on short term basis, there are concerns about its long term safety. Studies and analysis reveal a long term continence disturbance in two years after the LIS procedure. The incidence of long term continence distribution is 14%. Hence caution and care has to be taken in patient selection before undergoing LIS.

[0016] A number of surgical techniques are used if conservative management and simple procedures fail. All surgical treatments are associated with some degree of complications including bleeding, infection, anal structures and urinary retention, due to the close proximity of the rectum to the nerves that supply the bladder. Also, a small risk of fecal incontinence occurs, particularly of liquid, and the risk rates are within 0% - 28%. There are undesirable side effects of these known treatments.

[0017] There are case reports which reveal that the patient are not healed even after surgery due to the presence of elements such as camazolene. Camazolene is anti-flaming agent. Linoleic acid which is disinfectant agent is known to heal severe injuries. The other treatments in the market are application of creams comprising macromolecules. The macromolecules are less absorbable by body tissues.

[0018] Anal dilation or stretching of the anal canal has fallen out of favor in recent years, primarily due to the unacceptability high incidence of fecal incontinence. In addition, a body stretching process increases the rate of flatus incontinence.

[0019] Conservative treatment typically consists of foods rich in dietary fiber, intake of oral fluids to maintain hydration, non-steroidal anti-inflammatory drugs, sitz baths, and rest. Increased fiber intake has been shown to improve the outcomes. The increased fiber intake is achieved by dietary alterations or the consumption of fiber supplements. Evidence for complete eradication and benefits from the conservative treatment is lacking.

[0020] These undesirable side effects of these treatments prevent patients from obtaining adequate relief.

[0021] Hence, there is a need for a treatment for fissures that substantially or completely eliminates fissures. Also there is a need for a simple herbal composition which eliminates fissures without any undesirable side effects associated with the treatment. Further there is a need for a simple method to synthesize the herbal composition for treating fissures.

[0022] The above mentioned shortcomings, disadvantages and problems are addressed herein and which will be understood by reading and studying the following specification.

OBJECTIVES OF THE EMBODIMENTS

[0023] The primary objective of the embodiment herein is to provide anti- fissures herbal compositions for the treatment of external anal fissures, internal anal fissures, constipation and tissue crack around anus.

[0024] Another object of the embodiment herein is to provide a simple method for the synthesis of anti-fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus.

[0025] Yet another object of the embodiment herein is to provide a low cost anti- fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus.

[0026] Yet another object of the embodiment herein is to provide anti-fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus without any side effects.

[0027] Yet another object of the embodiment herein is to provide anti-fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus at an economical cost or at cheaper cost, when compared to the existing therapies.

[0028] Yet another object of the embodiment herein is to synthesize a herbal spray for the treatment of external fissures.

[0029] Yet another object of the embodiment herein is to synthesize a herbal spray mixture for the treatment of internal fissures.

[0030] Yet another object of the embodiment herein is to synthesize a herbal oil for the treatment of constipation.

[0031] Yet another object of the embodiment herein is to synthesize a herbal anti- crack ointment for the treatment of tissue crack around anus.

[0032] Yet another object of the embodiment herein is to provide an anti-constipation oil which regulates constipation through peristalsis of intestine and anal cavity, tranquilizes pain and makes the stool to pass without any difficulty.

[0033] Yet another object of the embodiment herein is to provide anti-fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus to eliminate the causes of fissures.

[0034] Yet another object of the embodiment herein is to provide anti-fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus to inhibit pressure on anus and rectum to eliminate pain and bleeding. [0035] Yet another object of the embodiment herein is to provide anti-fissure herbal compositions that is suitable for patients of all age groups and administered easily for the treatment of external fissures, internal fissures, constipation and tissue crack around anus.

[0036] Yet another object of the embodiment herein is to provide anti-fissure herbal compositions that is used or administered in homes, clinics and medical centers for the treatment of external fissures, internal fissures, constipation and tissue crack around anus.

[0037] These objects and the other advantages of the embodiments herein will become readily apparent from the following detailed description taken in conjunction with the accompanying drawings.

SUMMARY

[0038] The various embodiments herein provide an anti-fissure herbal composition for the treatment of external fissures, internal fissures, constipation and tissue crack around anus. The embodiments herein also provide a simple method for the synthesis of anti-fissure herbal compositions for the treatment of external fissures, internal fissures, constipation and tissue crack around anus.

[0039] According to one embodiment herein, there are four herbal compositions or herbal medicines for the treatment of external fissures, internal fissures, constipation and tissue crack around anus. They are listed as follows. First is a herbal spray for external fissures, which is administered as an external spray twice a day to resolve the clots and to stop bleeding. The second one is a herbal mixture or spray for internal fissures. The herbal mixture is injected in 2 ml into the anus to stop a bleeding that is caused by constipation, to heal an internal swelling, to ease out the act of defecation and to recover the injuries inside the rectum. A third composition is a topical oil for constipation. The topical oil is injected in 2-3ml into the anus frequently to soften the skin and to help the recovery of cracks inside the anus. By soothing rectum, the oil relieves the pressure on the rectum and anus. The fourth composition is an anti-crack ointment. The anti-crack ointment is applied twice daily on the affected areas of the anus. The anti-crack ointment heals the skin tissues cracked around anus.

[0040] According to one embodiment herein, a method of synthesizing a plurality of herbal compositions for targeting fissures is provided. The method comprises the following steps. A herbal spray composition for external fissures is synthesized. The herbal spray composition is sprayed or applied on the external fissures. A herbal mixture for internal fissures is synthesized. The herbal mixture is injected or applied on the internal fissures. An anti-constipation topical oil synthesized. The anti-constipation topical oil is injected for a constipation relief. An anti-crack ointment for anal tissue cracks is synthesized. The anti- crack ointment is applied on the anal tissue cracks.

[0041] According to one embodiment herein, the herbal spray composition for external fissures is a mixture comprising the extracts of Matricaria recutita flower, Aloe vera, Althaea officinalis flower, Crocus sativus stigma extract, linseed enamel and thickened grape juice. According to one embodiment herein, the herbal mixture for internal fissures is a mixture comprising the extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk and Fumaria officinalis shoot. According to one embodiment herein, the anti-constipation topical oil is a mixture comprising Sesamum indicum oil and the Ricinus communis oil. According to one embodiment herein, the anti-crack ointment for anal tissue cracks comprises Olea europaea fruit oil, Sesamum indicum oil and spermaceti. [0042] According to one embodiment herein, the method for synthesizing the herbal spray composition for external fissures comprises the following steps. The Matricaria recutita flowers, Aloe vera flowers, Crocus sativus stigma and Althaea officinalis flowers are cleaned to remove contaminants. The Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers are milled separately to obtain Matricaria recutita flower powder, Aloe vera flower powder and Althaea officinalis flower powder. The Crocus sativus stigma is grinded separately and the stigma extract is extracted. The Matricaria recutita flower powder is mixed in a preset quantity with a preset quantity of hydrochloric solvent separately. The Matricaria recutita flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Matricaria recutita flower powder solution is obtained. The Aloe vera flower powder is mixed in a preset ratio with a preset ratio of hydrochloric solvent separately. The Aloe vera flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Aloe vera flower powder solution is obtained. The Althaea officinalis flower powder is mixed in a preset ratio with a preset ratio of hydrochloric solvent separately. The Althaea officinalis flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The, Althaea officinalis flower powder solution obtained.

[0043] The extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower are obtained after incubating the Matricaria recutita flower powder solution, Aloe vera flower powder solution and Althaea officinalis flower powder solution in a steam distillation apparatus for four days. The extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower and Crocus sativus stigma extract are mixed to obtain a herbal extract mixture. The herbal extract mixture is blended in a blender to obtain a homogeneous mixture. The linseed enamel and thickened grape juice are added to the herbal extract mixture while blending. A mixture comprising extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower, Crocus sativus stigma extract, linseed enamel and thickened grape juice, is obtained. The mixture is filtered.

[0044] The mixture is pasteurized. The herbal extract mixture is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the herbal spray composition for external fissures, Matricaria recutita flower extract is mixed in a preset quantity with a preset quantity of an Aloe vera flower extract, a preset quantity of an Althaea officinalis flower extract and with a preset quantity of Crocus sativus stigma extract. The preset quantity of Matricaria recutita flower extract mixed is 4.6 ml. The preset quantity of Aloe vera flower extract mixed is 4.1 ml. The preset quantity of Althaea officinalis flower extract mixed is 2.0 ml. The preset quantity of Crocus sativus extract mixed is 2.0 ml.

[0045] According to one embodiment herein, the herbal spray composition for external fissures is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0046] According to one embodiment herein, the herbal spray composition for external fissures is an anti-inflammatory agent. The herbal spray composition for external fissures is an anti-crack agent. The herbal spray composition for external fissures relieves myalgia. The herbal spray composition for external fissures removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external fissures prevents chronic wounds. The herbal extract mixture for external fissures comprises small molecules. The small molecules of the herbal extract spray are absorbed and penetrated into the skin/tissue layers. The herbal spray composition for external fissures applied or administered twice a day on the area of the wound or fissures. The herbal composition for external fissures or spray is sprayed/ administered at a quantity of 2ml on the anus twice a day. Preferably the external fissures treatment spray is sprayed/ administered once in the morning and once at night. The colour of the herbal spray composition for external fissures is cream color. The density of the herbal composition for external fissures is 0.99 g/cm³. The pH of the herbal composition for external fissures is 2.89. The average volume of the herbal composition for external fissures is 110 ml. The herbal composition for external fissures is opaque. The viscosity of the herbal composition for external fissures is 9.98 m²/s. The amount of the active constituent in the herbal composition for external fissures is 0.013% w/w. The amount of flavonoids in the herbal spray composition for external fissures is 0.013% w/w.

[0047] According to one embodiment herein, a method for synthesizing the herbal mixture/spray composition for internal fissures is provided. The method comprises the following steps. The Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot are cleaned to remove the contaminants. The Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis shoot powder are obtained after milling the Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot separately. The Matricaria recutita flower powder is mixed in a preset ratio with a preset ratio of a solvent. The Matricaria recutita flower powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. A solution of Matricaria recutita flower powder is obtained. [0048] The Allium porrum shoot powder is mixed in a preset ratio with a preset ratio of a solvent. The, Allium porrum shoot powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Allium porrum shoot powder is obtained. The Apium graveolens stalk powder is mixed in a preset ratio with a preset ratio of a solvent. The Apium graveolens stalk powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solutions of Apium graveolens stalk powder is obtained. The Fumaria officinalis stalk powder is mixed in a preset ratio with a preset ratio of a solvent. The Fumaria officinalis stalk powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solutions of Fumaria officinalis stalk powder is obtained. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis stalk powder are mixed separately for 4 hours. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis stalk powder are filtered after 4 hours. A filtrate is obtained. The filtrate comprises of herbal extracts of Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis stalk. The herbal extracts of Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis stalk are mixed to get a mixture. Honey is added to the mixture to obtain a herbal extract mixture. The herbal extract mixture is blended in a mixer to attain consistency /homogenous mixture. The herbal extract mixture is filtered and pasteurized. The herbal extract mixture is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the herbal mixture/spray composition for internal fissures, a Matricaria recutita flower extract is mixed with a Allium porrum shoot extract, a Apium graveolens stalk extract, Fumaria officinalis shoot extract and honey. The preset quantity Matricaria recutita flower extract mixed is 3.25 ml. The preset quantity of Allium porrum shoot extract mixed is 3.15 ml. The preset quantity of Apium graveolens stalk extract mixed is 2.25 ml. The preset quantity of Fumaria officinalis shoot extract mixed is 0.9 ml and a preset quantity of honey mixed is 0.45 ml.

[0049] According to one embodiment herein, the herbal mixture/spray composition for internal fissures is a laxative agent. The herbal spray composition for internal fissures is a tranquilizer agent. The herbal spray composition for internal fissures is an anti-bleeding agent. The herbal spray composition for internal fissures is an intestinal antiseptic. The herbal spray composition for internal fissures is an internal wound tranquilizer. The herbal spray composition for internal fissures removes internal swelling. The herbal extract mixture for internal fissures comprises small molecules. The small molecules of the herbal extract spray get absorbed and penetrated into the skin/tissue layers. The herbal extract mixture for internal fissures makes defecation easy without difficulty. The herbal extract mixture for internal fissures regulates the intestinal peristalsis and heals wounds. The herbal mixture/spray composition for internal fissures is applied or administered twice a day on the area of the wound or fissures. The herbal composition for internal fissures or spray is administered/injected in anus in a quantity of 2ml on the anus twice a day. Preferably the internal fissures treatment spray is sprayed/ administered once in the morning and once at night. The colour of the herbal composition mixture/spray for internal fissures is cream color. The density of the herbal composition for internal fissures is 0.99 g/cm³. The pH of the herbal composition for internal fissures is 2.89. The average volume of the herbal composition for internal fissures is 110 ml. The herbal composition for internal fissures is opaque. The viscosity of the herbal composition for internal fissures is 9.98 m²/s. The amount of the active constituent in the herbal composition for internal fissures is 0.013% w/w. The amount of flavonoids in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0050] According to one embodiment herein, the method for synthesizing the anti- constipation topical oil for constipation is provided. The method comprises the following steps. The sesame seeds and castor seeds are cleaned to remove the contaminants. The sesame seeds are crushed for extracting the sesame seed shells and seed kernels. A dough from the sesame seed kernel is synthesized. The pressure is applied to the sesame seed kernel dough at a low temperature. Oil is extracted from the sesame seed kernel dough by using a cold pressing technique. The concentration of extracted oil from sesame seed kernel dough is 38-50% v/v. Castor seed shells are removed to obtain the castor seeds. Hydraulic pressure is applied on the castor oil seeds in a low temperature for extracting the castor oil. The castor oil is refined. The concentration of the refined castor oil is 33% v/v. The sesame seed oil and the castor oil are mixed to obtain an oil mixture. The oil mixture is blended to attain uniform consistency.

[0051] The oil mixture is filtered. The oil mixture is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the anti- constipation topical oil for constipation, Sesamum indicum oil is mixed with the Ricinus communis oil. The Sesamum indicum oil is mixed in a preset quantity of 60% v/v. The Ricinus communis oil is mixed in a preset quantity of 40% v/v. The anti-constipation topical oil for constipation is administered in a quantity of 2 ml. The anti-constipation topical oil is injected into anus by a syringe. Preferably the anti-constipation topical oil is administered in the morning and at midnight. [0052] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0053] According to one embodiment herein, the colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti-constipation topical oil is 0.89 g/cm³. The pH of the anti-constipation topical oil is 4.46. The average weight of the anti- constipation topical oil is 25 ml. The viscosity of the anti-constipation topical oil is 2690 m²/s. The amount of acidity of anti-constipation topical oil is 2.24.

[0054] According to one embodiment herein, the anti-constipation topical oil is a laxative agent. The anti-constipation topical oil is a healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth, easy and comfortablw without any pain. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[0055] According to one embodiment herein, the method for synthesizing the anti- crack ointment for cracked tissues in and around anus comprises the following steps. The sesame seeds and olive fruits are cleaned to remove the contaminants. The sesame seeds are crushed for extracting the sesame seed shells and for obtaining the seed kernels. A dough from the sesame seed kernel is synthesized. Pressure is applied to the sesame seed kernel dough at a low temperature. Oil is extracted from the sesame seed kernel dough by cold pressing. The concentration of extracted oil from sesame seed kernel dough is 38-50% v/v. The olive fruits are crushed at a low temperature. A dough is synthesized from the crushed olive fruits. A hydraulic pressure is applied on the dough of the olive fruits in a low temperature for extracting olive oil. The sesame seed oil and the olive oil are mixed to obtain an oil mixture. Spermaceti is heated for melting at a temperature of 70°C. The oil mixture is added to the molten spermaceti with a constant stirring. The oil mixture and spermaceti mixture are constantly stirred till spermaceti is cooled. The oil mixture is blended with spermaceti to attain a uniform consistency. The anti-crack ointment is obtained. The anti- crack ointment is sampled. The anti-crack ointment is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the anti-crack ointment for cracked tissues in and around anus, Sesamum indicum oil and Olea europaea oil are mixed with the spermaceti. The Sesamum indicum oil is mixed in a preset quantity of 60% v/v. The Olea europaea oil is mixed in a preset quantity of 34% v/v. The spermaceti is mixed in a preset quantity of 6%v/v. The anti-crack ointment for cracked tissues is applied in and around anus twice in a day. Preferably the anti-crack ointment for cracked tissues is administered in and around anus in the morning and at night.

[0056] According to one embodiment herein, the colour of the anti-crack ointment for cracked tissues found in and around anus is cream. The density of the anti-crack ointment for cracked tissues found in and around anus is 0.89 g/cm³. The pH of the anti-crack ointment for cracked tissues found in and around anus is 4.46. The average weight of the anti-crack ointment for cracked tissues found in and around anus is 25 gram. The viscosity of the anti- crack ointment for cracked tissues found in and around anus is 2690 mVs.

[0057] According to one embodiment herein, the integrated herbal composition for targeting fissures with plurality or combination of herbal compositions comprises a herbal spray composition for external fissures, a herbal mixture composition for internal fissures, an anti-constipation topical oil and an anti-crack ointment for cracked tissues found in and around anus. [0058] According to one embodiment herein, the composition of herbal spray composition for external fissures comprises a Matricaria recutita extract, an Aloe vera extract, an Althaea officinalis and a Crocus sativus extract. The Matricaria recutita extract is present in a preset quantity of 4.6 ml. The Aloe vera extract is present in a preset quantity of 4.1 ml. The Crocus sativus extract is present in a preset quantity of 2.0 ml. The Althaea officinalis extract is present in a preset quantity of 2.0 ml.

[0059] According to one embodiment herein, the herbal spray composition for external fissures is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0060] According to one embodiment herein, the herbal spray composition for external fissures is an anti-inflammatory agent. The herbal spray composition for external fissures is an anti-crack agent. The herbal spray composition for external fissures relieves myalgia. The herbal spray composition for external fissures removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external fissures prevents chronic wounds. The herbal extract mixture for external fissures comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrated into the skin/tissue layers.

[0061] According to one embodiment herein, the colour of the herbal composition for external fissures is cream. The density of the herbal composition for external fissures is 0.99 g/cm³. The pH of the herbal composition for external fissures is 2.89. The average volume of the herbal composition for external fissures is 110 ml. The herbal composition for external fissures is opaque. The viscosity of the herbal composition for external fissures is 9.98 m²/s. The amount of the active constituent in the herbal composition for external fissures is 0.013% w/w. The amount of flavonoids in the herbal composition for external fissures is 0.013% w/w.

[0062] According to one embodiment herein, the composition of herbal mixture/spray composition for internal fissures comprises a Matricaria recutita flower extract, a Allium porrum shoot extract, a Apium graveolens stalk extract, Fumaria officinalis shoot extract and honey. The, Matricaria recutita flower extract is present in a preset quantity of 3.25 ml. The Allium porrum shoot extract is present in a preset quantity of 3.15 ml. The Apium graveolens stalk extract is present in a preset quantity of 2.25 ml. The Fumaria officinalis shoot extract is present in a preset quantity of 0.9 ml. The honey is present in a preset quantity of 0.45 ml.

[0063] According to one embodiment herein, the herbal mixture/spray composition for internal fissures is a laxative agent. The herbal mixture/spray composition for internal fissures is a tranquilizer agent. The herbal mixture/spray composition for internal fissures is an anti-bleeding agent. The herbal mixture/spray composition for internal fissures is an intestinal antiseptic. The herbal mixture/spray composition for internal fissures is an internal wound tranquilizer. The herbal mixture/spray composition for internal fissures removes internal swelling. The herbal extract mixture/spray for internal fissures comprises small molecules. The small molecules of the herbal extract spray get absorbed and penetrated into the skin/tissue layers. The herbal extract mixture/spray for internal fissures makes defecation easy without any difficulty. The herbal extract mixture for internal fissures regulates intestinal peristalsis and heals wounds. [0064] According to one embodiment herein, the colour of the herbal mixture/spray composition for internal fissures is cream. The density of the herbal composition for internal fissures is 0.99 g/cm³. The pH of the herbal composition for internal fissures is 2.89. The average volume of the herbal composition for internal fissures is 110 ml. The herbal composition for internal fissures is opaque. The viscosity of the herbal composition for internal fissures is 9.98 m²/s. The amount of the active constituent in the herbal composition for internal fissures is 0.013% w/w. The amount of flavonoids in the herbal mixture/spray composition for internal fissures is 0.013% w/w.

[0065] According to one embodiment herein, the anti-constipation topical oil for constipation comprises a Sesamum indicum oil, and a Ricinus communis oil. The Sesamum indicum oil is present in a preset quantity of 60% v/v. The Ricinus communis oil is present in a preset quantity of 40% v/v.

[0066] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus. The colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti- constipation topical oil is 0.89 g/cm³. The pH of the anti-constipation topical oil is 4.46. The average weight of the anti-constipation topical oil is 25 ml. The viscosity of the anti- constipation topical oil is 2690 m²/s. The amount of acidity of anti-constipation topical oil is 2.24. The anti-constipation topical oil is a laxative agent. The anti-constipation topical oil is a healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth and easy without any difficulty. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[0067] According to one embodiment herein, the anti-crack ointment for cracked tissue found in and around anus comprises an Olea europaea oil, a Sesamum indicum oil and spermaceti. The Olea europaea oil is present in a preset quantity of 34% v/v. The Sesamum indicum oil is present in a preset quantity of 60% v/v. The spermaceti is present in a preset quantity of 6% v/v. The spermaceti is an excipient.

[0068] According to one embodiment herein, the colour of the anti-crack ointment for cracked tissue found in and around anus is cream. The density of the anti-crack ointment for cracked tissue found in and around anus is 0.88 g/cm³. The pH of the anti-crack ointment for cracked tissue found in and around anus is 4.46. The average weight of the anti-crack ointment for cracked tissue found in and around anus is 25 gram. The viscosity of the anti- crack ointment for cracked tissue found in and around anus is 2690 m²/s. The anti-crack ointment for cracked tissue found in and around anus is a laxative agent. The anti-crack ointment for cracked tissue found in and around anus is a healing agent. The anti-crack ointment for cracked tissue found in and around anus is tranquilizer. The anti-crack ointment for cracked tissue found in and around anus makes defecation smooth and easy without any pain. The anti-crack ointment for cracked tissue found in and around anus stops application of pressure on anus and damaged tissues. The anti-crack ointment for cracked tissue found in and around anus relieves pain and stops bleeding in damaged tissues. The anti-crack ointment for cracked tissue found in and around anus heals the damaged and torn tissues.

[0069] These and other aspects of the embodiments herein will be better appreciated and understood when considered in conjunction with the following description and the accompanying drawings. It should be understood, however, that the following descriptions, while indicating preferred embodiments and numerous specific details thereof, are given by way of illustration and not of limitation. Many changes and modifications may be made within the scope of the embodiments herein without departing from the spirit thereof, and the embodiments herein include all such modifications.

BRIEF DESCRIPTION OF THE DRAWINGS

[0070] The other objects, features and advantages will occur to those skilled in the art from the following description of the preferred embodiment and the accompanying drawings in which:

[0071] FIG.l illustrates a flow chart indicating a method for synthesizing a herbal spray for external fissures, according to one embodiment herein.

[0072] FIG.2 illustrates an anti-microbial analysis report of herbal spray for external fissures, according to one embodiment herein.

[0073] FIG.3 illustrates a flow chart indicating a method for synthesizing a herbal composition for internal fissures, according to one embodiment herein.

[0074] FIG.4 illustrates a flow chart indicating a method for synthesizing anti- constipation topical oil, according to one embodiment herein.

[0075] FIG.5 illustrates an anti-microbial analysis report of anti-constipation topical oil, according to one embodiment herein.

[0076] FIG.6 illustrates an physico-chemical analysis report of anti-constipation topical oil, according to one embodiment herein.

[0077] FIG.7 illustrates a flow chart indicating a method for synthesizing anti-crack ointment, according to one embodiment herein.

[0078] FIG.8 illustrates a report indicating the result of thin layer chromatography of the olive leaf extract, according to one embodiment herein.

[0079] FIG.9 illustrates an physico-chemical analysis report of anti-crack ointment, according to one embodiment herein.

[0080] Although the specific features of the embodiments herein are shown in some drawings and not in others. This is done for convenience only as each feature may be combined with any or all of the other features in accordance with the embodiments herein.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0081] In the following detailed description, a reference is made to the accompanying drawings that form a part hereof, and in which the specific embodiments that may be practiced is shown by way of illustration. The embodiments are described in sufficient detail to enable those skilled in the art to practice the embodiments and it is to be understood that the logical, mechanical and other changes may be made without departing from the scope of the embodiments. The following detailed description is therefore not to be taken in a limiting sense.

[0082] According to one embodiment herein, there are four herbal compositions or herbal medicines for the treatment of external fissures, internal fissures, constipation and tissue crack around anus. They are listed as follows. First is a herbal spray for external fissures, which is administered as an external spray twice a day to resolve the clots and to stop bleeding. The second one is a herbal mixture or spray for internal fissures. The herbal mixture is injected in 2 ml into the anus to stop a bleeding that is caused by constipation, to heal an internal swelling, to ease out the act of defecation and to recover the injuries inside the rectum. A third composition is a topical oil for constipation. The topical oil is injected in 2-3ml into the anus frequently to soften the skin and to help the recovery of cracks inside the anus. By soothing rectum, the oil relieves the pressure on the rectum and anus. The fourth composition is an anti-crack ointment. The anti-crack ointment is applied twice daily on the affected areas of the anus. The anti-crack ointment heals the skin tissues cracked around anus.

[0083] According to one embodiment herein, a method of synthesizing a plurality of herbal compositions for targeting fissures is provided. The method comprises the following steps. A herbal spray composition for external fissures is synthesized. The herbal spray composition is sprayed or applied on the external fissures. A herbal mixture for internal fissures is synthesized. The herbal mixture is injected or applied on the internal fissures. An anti-constipation topical oil synthesized. The anti-constipation topical oil is injected for a constipation relief. An anti-crack ointment for anal tissue cracks is synthesized. The anti- crack ointment is applied on the anal tissue cracks.

[0084] According to one embodiment herein, the herbal spray composition for external fissures is a mixture comprising the extracts of Matricaria recutita flower, Aloe vera, Althaea officinalis flower, Crocus sativus stigma extract, linseed enamel and thickened grape juice. According to one embodiment herein, the herbal mixture for internal fissures is a mixture comprising the extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk and Fumaria officinalis shoot. According to one embodiment herein, the anti-constipation topical oil is a mixture comprising Sesamum indicum oil and the Ricinus communis oil. According to one embodiment herein, the anti-crack ointment for anal tissue cracks comprises Olea europaea fruit oil, Sesamum indicum oil and spermaceti.

[0085] According to one embodiment herein, the method for synthesizing the herbal spray composition for external fissures comprises the following steps. The Matricaria recutita flowers, Aloe vera flowers, Crocus sativus stigma and Althaea officinalis flowers are cleaned to remove contaminants. The Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers are milled separately to obtain Matricaria recutita flower powder, Aloe vera flower powder and Althaea officinalis flower powder. The Crocus sativus stigma is grinded separately and the stigma extract is extracted. The Matricaria recutita flower powder is mixed in a preset quantity with a preset quantity of hydrochloric solvent separately. The Matricaria recutita flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Matricaria recutita flower powder solution is obtained. The Aloe vera flower powder is mixed in a preset ratio with a preset ratio of hydrochloric solvent separately. The Aloe vera flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Aloe vera flower powder solution is obtained. The Althaea officinalis flower powder is mixed in a preset ratio with a preset ratio of hydrochloric solvent separately. The Althaea officinalis flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The, Althaea officinalis flower powder solution obtained.

[0086] The extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower are obtained after incubating the Matricaria recutita flower powder solution, Aloe vera flower powder solution and Althaea officinalis flower powder solution in a steam distillation apparatus for four days. The extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower and Crocus sativus stigma extract are mixed to obtain a herbal extract mixture. The herbal extract mixture is blended in a blender to obtain a homogeneous mixture. The linseed enamel and thickened grape juice are added to the herbal extract mixture while blending. A mixture comprising extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower, Crocus sativus stigma extract, linseed enamel and thickened grape juice, is obtained. The mixture is filtered.

[0087] The mixture is pasteurized. The herbal extract mixture is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the herbal spray composition for external fissures, Matricaria recutita flower extract is mixed in a preset quantity with a preset quantity of an Aloe vera flower extract, a preset quantity of an Althaea officinalis flower extract and with a preset quantity of Crocus sativus stigma extract. The preset quantity of Matricaria recutita flower extract mixed is 4.6 ml. The preset quantity of Aloe vera flower extract mixed is 4.1 ml. The preset quantity of Althaea officinalis flower extract mixed is 2.0 ml. The preset quantity of Crocus sativus extract mixed is 2.0 ml.

[0088] According to one embodiment herein, the herbal spray composition for external fissures is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0089] According to one embodiment herein, the herbal spray composition for external fissures is an anti-inflammatory agent. The herbal spray composition for external fissures is an anti-crack agent. The herbal spray composition for external fissures relieves myalgia. The herbal spray composition for external fissures removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external fissures prevents chronic wounds. The herbal extract mixture for external fissures comprises small molecules. The small molecules of the herbal extract spray are absorbed and penetrated into the skin/tissue layers. The herbal spray composition for external fissures applied or administered twice a day on the area of the wound or fissures. The herbal composition for external fissures or spray is sprayed/ administered at a quantity of 2ml on the anus twice a day. Preferably the external fissures treatment spray is sprayed/ administered once in the morning and once at night. The colour of the herbal spray composition for external fissures is cream color. The density of the herbal composition for external fissures is 0.99 g/cm³. The pH of the herbal composition for external fissures is 2.89. The average volume of the herbal composition for external fissures is 110 ml. The herbal composition for external fissures is opaque. The viscosity of the herbal composition for external fissures is 9.98 m²/s. The amount of the active constituent in the herbal composition for external fissures is 0.013% w/w. The amount of flavonoids in the herbal spray composition for external fissures is 0.013% w/w.

[0090] According to one embodiment herein, a method for synthesizing the herbal mixture/spray composition for internal fissures is provided. The method comprises the following steps. The Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot are cleaned to remove the contaminants. The Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis shoot powder are obtained after milling the Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot separately. The Matricaria recutita flower powder is mixed in a preset ratio with a preset ratio of a solvent. The Matricaria recutita flower powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. A solution of Matricaria recutita flower powder is obtained.

[0091] The Allium porrum shoot powder is mixed in a preset ratio with a preset ratio of a solvent. The, Allium porrum shoot powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Allium porrum shoot powder is obtained. The Apium graveolens stalk powder is mixed in a preset ratio with a preset ratio of a solvent. The Apium graveolens stalk powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solutions of Apium graveolens stalk powder is obtained. The Fumaria officinalis stalk powder is mixed in a preset ratio with a preset ratio of a solvent. The Fumaria officinalis stalk powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solutions of Fumaria officinalis stalk powder is obtained. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis stalk powder are mixed separately for 4 hours. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis stalk powder are filtered after 4 hours. A filtrate is obtained. The filtrate comprises of herbal extracts of Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis stalk. The herbal extracts of Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis stalk are mixed to get a mixture. Honey is added to the mixture to obtain a herbal extract mixture. The herbal extract mixture is blended in a mixer to attain consistency /homogenous mixture. The herbal extract mixture is filtered and pasteurized. The herbal extract mixture is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the herbal mixture/spray composition for internal fissures, a Matricaria recutita flower extract is mixed with a Allium porrum shoot extract, a Apium graveolens stalk extract, Fumaria officinalis shoot extract and honey. The preset quantity Matricaria recutita flower extract mixed is 3.25 ml. The preset quantity of Allium porrum shoot extract mixed is 3.15 ml. The preset quantity of Apium graveolens stalk extract mixed is 2.25 ml. The preset quantity of Fumaria officinalis shoot extract mixed is 0.9 ml and a preset quantity of honey mixed is 0.45 ml.

[0092] According to one embodiment herein, the herbal mixture/spray composition for internal fissures is a laxative agent. The herbal spray composition for internal fissures is a tranquilizer agent. The herbal spray composition for internal fissures is an anti-bleeding agent. The herbal spray composition for internal fissures is an intestinal antiseptic. The herbal spray composition for internal fissures is an internal wound tranquilizer. The herbal spray composition for internal fissures removes internal swelling. The herbal extract mixture for internal fissures comprises small molecules. The small molecules of the herbal extract spray get absorbed and penetrated into the skin/tissue layers. The herbal extract mixture for internal fissures makes defecation easy without difficulty. The herbal extract mixture for internal fissures regulates the intestinal peristalsis and heals wounds. The herbal mixture/spray composition for internal fissures is applied or administered twice a day on the area of the wound or fissures. The herbal composition for internal fissures or spray is administered/injected in anus in a quantity of 2ml on the anus twice a day. Preferably the internal fissures treatment spray is sprayed/ administered once in the morning and once at night. The colour of the herbal composition mixture/spray for internal fissures is cream color. The density of the herbal composition for internal fissures is 0.99 g/cm³. The pH of the herbal composition for internal fissures is 2.89. The average volume of the herbal composition for internal fissures is 110 ml. The herbal composition for internal fissures is opaque. The viscosity of the herbal composition for internal fissures is 9.98 m²/s. The amount of the active constituent in the herbal composition for internal fissures is 0.013% w/w. The amount of flavonoids in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0093] According to one embodiment herein, the method for synthesizing the anti- constipation topical oil for constipation is provided. The method comprises the following steps. The sesame seeds and castor seeds are cleaned to remove the contaminants. The sesame seeds are crushed for extracting the sesame seed shells and seed kernels. A dough from the sesame seed kernel is synthesized. The pressure is applied to the sesame seed kernel dough at a low temperature. Oil is extracted from the sesame seed kernel dough by using a cold pressing technique. The concentration of extracted oil from sesame seed kernel dough is 38-50% v/v. Castor seed shells are removed to obtain the castor seeds. Hydraulic pressure is applied on the castor oil seeds in a low temperature for extracting the castor oil. The castor oil is refined. The concentration of the refined castor oil is 33% v/v. The sesame seed oil and the castor oil are mixed to obtain an oil mixture. The oil mixture is blended to attain uniform consistency.

[0094] The oil mixture is filtered. The oil mixture is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the anti- constipation topical oil for constipation, Sesamum indicum oil is mixed with the Ricinus communis oil. The Sesamum indicum oil is mixed in a preset quantity of 60% v/v. The Ricinus communis oil is mixed in a preset quantity of 40% v/v. The anti-constipation topical oil for constipation is administered in a quantity of 2 ml. The anti-constipation topical oil is injected into anus by a syringe. Preferably the anti-constipation topical oil is administered in the morning and at midnight.

[0095] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0096] According to one embodiment herein, the colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti-constipation topical oil is 0.89 g/cm³. The pH of the anti-constipation topical oil is 4.46. The average weight of the anti- constipation topical oil is 25 ml. The viscosity of the anti-constipation topical oil is 2690 m²/s. The amount of acidity of anti-constipation topical oil is 2.24.

[0097] According to one embodiment herein, the anti-constipation topical oil is a laxative agent. The anti-constipation topical oil is a healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth, easy and comfortablw without any pain. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[0098] According to one embodiment herein, the method for synthesizing the anti- crack ointment for cracked tissues in and around anus comprises the following steps. The sesame seeds and olive fruits are cleaned to remove the contaminants. The sesame seeds are crushed for extracting the sesame seed shells and for obtaining the seed kernels. A dough from the sesame seed kernel is synthesized. Pressure is applied to the sesame seed kernel dough at a low temperature. Oil is extracted from the sesame seed kernel dough by cold pressing. The concentration of extracted oil from sesame seed kernel dough is 38-50% v/v. The olive fruits are crushed at a low temperature. A dough is synthesized from the crushed olive fruits. A hydraulic pressure is applied on the dough of the olive fruits in a low temperature for extracting olive oil. The sesame seed oil and the olive oil are mixed to obtain an oil mixture. Spermaceti is heated for melting at a temperature of 70°C. The oil mixture is added to the molten spermaceti with a constant stirring. The oil mixture and spermaceti mixture are constantly stirred till spermaceti is cooled. The oil mixture is blended with spermaceti to attain a uniform consistency. The anti-crack ointment is obtained. The anti- crack ointment is sampled. The anti-crack ointment is stored in the containers. The containers are polyethylene terephthalate (PET) containers. For the synthesis of the anti-crack ointment for cracked tissues in and around anus, Sesamum indicum oil and Olea europaea oil are mixed with the spermaceti. The Sesamum indicum oil is mixed in a preset quantity of 60% v/v. The Olea europaea oil is mixed in a preset quantity of 34% v/v. The spermaceti is mixed in a preset quantity of 6%v/v. The anti-crack ointment for cracked tissues is applied in and around anus twice in a day. Preferably the anti-crack ointment for cracked tissues is administered in and around anus in the morning and at night.

[0099] According to one embodiment herein, the colour of the anti-crack ointment for cracked tissues found in and around anus is cream. The density of the anti-crack ointment for cracked tissues found in and around anus is 0.89 g/cm³. The pH of the anti-crack ointment for cracked tissues found in and around anus is 4.46. The average weight of the anti-crack ointment for cracked tissues found in and around anus is 25 gram. The viscosity of the anti- crack ointment for cracked tissues found in and around anus is 2690 m²/s.

[00100] According to one embodiment herein, the integrated herbal composition for targeting fissures with plurality or combination of herbal compositions comprises a herbal spray composition for external fissures, a herbal mixture composition for internal fissures, an anti-constipation topical oil and an anti-crack ointment for cracked tissues found in and around anus.

[00101] According to one embodiment herein, the composition of herbal spray composition for external fissures comprises a Matricaria recutita extract, an Aloe vera extract, an Althaea officinalis and a Crocus sativus extract. The Matricaria recutita extract is present in a preset quantity of 4.6 ml. The Aloe vera extract is present in a preset quantity of 4.1 ml. The Crocus sativus extract is present in a preset quantity of 2.0 ml. The Althaea officinalis extract is present in a preset quantity of 2.0 ml.

[00102] According to one embodiment herein, the herbal spray composition for external fissures is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[00103] According to one embodiment herein, the herbal spray composition for external fissures is an anti-inflammatory agent. The herbal spray composition for external fissures is an anti-crack agent. The herbal spray composition for external fissures relieves myalgia. The herbal spray composition for external fissures removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external fissures prevents chronic wounds. The herbal extract mixture for external fissures comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrated into the skin/tissue layers.

[00104] According to one embodiment herein, the colour of the herbal composition for external fissures is cream. The density of the herbal composition for external fissures is 0.99 g/cm3. The pH of the herbal composition for external fissures is 2.89. The average volume of the herbal composition for external fissures is 110 ml. The herbal composition for external fissures is opaque. The viscosity of the herbal composition for external fissures is 9.98 m2/s. The amount of the active constituent in the herbal composition for external fissures is 0.013% w/w. The amount of flavonoids in the herbal composition for external fissures is 0.013% w/w.

[00105] According to one embodiment herein, the composition of herbal mixture/spray composition for internal fissures comprises a Matricaria recutita flower extract, a Allium porrum shoot extract, a Apium graveolens stalk extract, Fumaria officinalis shoot extract and honey. The Matricaria recutita flower extract is present in a preset quantity of 3.25 ml. The Allium porrum shoot extract is present in a preset quantity of 3.15 ml. The Apium graveolens stalk extract is present in a preset quantity of 2.25 ml. The Fumaria officinalis shoot extract is present in a preset quantity of 0.9 ml. The honey is present in a preset quantity of 0.45 ml.

[00106] According to one embodiment herein, the herbal mixture/spray composition for internal fissures is a laxative agent. The herbal mixture/spray composition for internal fissures is a tranquilizer agent. The herbal mixture/spray composition for internal fissures is an anti-bleeding agent. The herbal mixture/spray composition for internal fissures is an intestinal antiseptic. The herbal mixture/spray composition for internal fissures is an internal wound tranquilizer. The herbal mixture/spray composition for internal fissures removes internal swelling. The herbal extract mixture/spray for internal fissures comprises small molecules. The small molecules of the herbal extract spray get absorbed and penetrated into the skin/tissue layers. The herbal extract mixture/spray for internal fissures makes defecation easy without any difficulty. The herbal extract mixture for internal fissures regulates intestinal peristalsis and heals wounds.

[00107] According to one embodiment herein, the colour of the herbal mixture/spray composition for internal fissures is cream. The density of the herbal composition for internal fissures is 0.99 g/cm3. The pH of the herbal composition for internal fissures is 2.89. The average volume of the herbal composition for internal fissures is 110 ml. The herbal composition for internal fissures is opaque. The viscosity of the herbal composition for internal fissures is 9.98 m2/s. The amount of the active constituent in the herbal composition for internal fissures is 0.013% w/w. The amount of flavonoids in the herbal mixture/spray composition for internal fissures is 0.013% w/w.

[00108] According to one embodiment herein, the anti-constipation topical oil for constipation comprises a Sesamum indicum oil, and a Ricinus communis oil. The Sesamum indicum oil is present in a preset quantity of 60% v/v. The Ricinus communis oil is present in a preset quantity of 40% v/v.

[00109] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus. The colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti- constipation topical oil is 0.89 g/cm3. The pH of the anti-constipation topical oil is 4.46. The average weight of the anti-constipation topical oil is 25 ml. The viscosity of the anti- constipation topical oil is 2690 m2/s. The amount of acidity of anti-constipation topical oil is 2.24. The anti-constipation topical oil is a laxative agent. The anti-constipation topical oil is a healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth and easy without any difficulty. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[00110] According to one embodiment herein, the anti-crack ointment for cracked tissue found in and around anus comprises an Olea europaea oil, a Sesamum indicum oil and spermaceti. The Olea europaea oil is present in a preset quantity of 34% v/v. The Sesamum indicum oil is present in a preset quantity of 60% v/v. The spermaceti is present in a preset quantity of 6% v/v. The spermaceti is an excipient.

[00111] According to one embodiment herein, the colour of the anti-crack ointment for cracked tissue found in and around anus is cream. The density of the anti-crack ointment for cracked tissue found in and around anus is 0.88 g/cm3. The pH of the anti-crack ointment for cracked tissue found in and around anus is 4.46. The average weight of the anti-crack ointment for cracked tissue found in and around anus is 25 gram. The viscosity of the anti- crack ointment for cracked tissue found in and around anus is 2690 m2/s. The anti-crack ointment for cracked tissue found in and around anus is a laxative agent. The anti-crack ointment for cracked tissue found in and around anus is a healing agent. The anti-crack ointment for cracked tissue found in and around anus is tranquilizer. The anti-crack ointment for cracked tissue found in and around anus makes defecation smooth and easy without any pain. The anti-crack ointment for cracked tissue found in and around anus stops application of pressure on anus and damaged tissues. The anti-crack ointment for cracked tissue found in and around anus relieves pain and stops bleeding in damaged tissues. The anti-crack ointment for cracked tissue found in and around anus heals the damaged and torn tissues. [00112] According to one embodiment herein, there are four herbal compositions or herbal medicines for the treatment of external fissures, internal fissures, constipation and tissue crack around anus. They are listed as follows. First is a herbal spray for external fissures, which is administered as an external spray twice a day to resolve the clots and to stop bleeding. The second one is a herbal mixture or spray for internal fissures. The herbal mixture is injected in 2 ml into the anus to stop a bleeding that is caused by constipation, to heal an internal swelling, to ease out the act of defecation and to recover the injuries inside the rectum. A third composition is a topical oil for constipation. The topical oil is injected in 2-3ml into the anus frequently to soften the skin and to help the recovery of cracks inside the anus. By soothing rectum, the oil relieves the pressure on the rectum and anus. The fourth composition is an anti-crack ointment. The anti-crack ointment is applied twice daily on the affected areas of the anus. The anti-crack ointment heals the skin tissues cracked around anus.

[00113] According to one embodiment herein, the spray for external fissure treatment comprises of herbal extracts from Matricaria recutita (Chamoline) flower, Crocus sativus (Saffron) stigma, Aloe vera (Aloe vera) flower and Althaea officinalis (Marsh mallow) flower. The herbal extracts from Matricaria recutita flower, Aloe vera (Aloe vera) flower and Althaea officinalis (Marsh mallow) flower are extracted through steam distillation or percolation extraction method.

[00114] The Matricaria recutita (Chamoline) flower, Aloe vera (Aloe vera) flower and Althaea officinalis (Marsh mallow) flower are washed. After washing the Matricaria recutita (Chamoline) flowers, Aloe vera (Aloe vera) flowers and Althaea officinalis (Marsh mallow) flowers are grinded or mashed. The mashed Matricaria recutita (Chamoline) flowers, Aloe vera (Aloe vera) flowers and Althaea officinalis (Marsh mallow) flowers are subjected to steam distillation or percolation extraction separately. Similarly the Crocus sativus (Saffron) stigma extract is obtained. A herbal extract mixture is prepared by mixing the Matricaria recutita (Chamoline) flowers extract, Aloe vera (Aloe vera) flowers extract and Althaea officinalis (Marsh mallow) flowers extract in a predetermined amount. The repository is filled with the herbal extract mixture. The herbal extract mixture is stored in the containers. The herbal extract mixture is administered as spray for external fissures. To formulate or synthesize 50000mg of this herbal mixture for external anal fissure, 32000 mg of Matricaria recutita (Chamoline) flower extract, 1000 mg of Crocus sativus (Saffron) stigma extract, 7000 mg of Aloe vera (Aloe vera) flower extract and 10000 mg of Althaea officinalis (Marsh mallow) flower extract are mixed.

[00115] According to one embodiment herein, because of the components, this anti- fissure spray relieves myalgia, removes external inflammations through lymphatic vessels recovery to prevent and heal the chronic wounds by softening skin, the composition is also used an anti-inflammation and anti-crack spray. The anti-fissure spray is administered twice a day on the area of the wound in such a way that the area becomes completely wet. Because of the presence of small molecules in this spray, the medicine penetrates into the skin layers quickly. The camazolene in the Matricaria recutita and the other vitamins that exist in the plants recover the wounds, cracks and the swellings of anus. This spray is used at home, clinics, medical centers, and private centers easily and there is no limitation regarding the use of sprays with respect to the age of patients. The spray does not have any side effects. The availability of the plant resources in Iran are abundant. Hence the spray for external fissures is manufactured at a very economic cost. [00116] According to one embodiment herein, the herbal composition for the treatment of internal fissure comprises the extracts from Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk, Fumaria officinalis (fumitory) shoot and honey. The herbal extracts from the aforementioned plants are mixed with honey. For the synthesis of herbal treatment composition for internal fissure, the extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk, Fumaria officinalis (fumitory) shoot extract are obtained through steam distillation.

[00117] The Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk, Fumaria officinalis (fumitory) shoot are cleaned to remove the contaminants and impurities. The Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk, Fumaria officinalis (fumitory) shoot are mashed or grinded and subjected to steam distillation. The repositories are filled with the individual herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk, Fumaria officinalis (fumitory) shoot.

[00118] Honey is added to the herbal extracts to synthesize herbal composition for the treatment of the internal fissure. The herbal mixture is subjected to a mixer till the consistency of the herbal mixture become constant or a homogenous mixture is obtained. For the synthesis of HOOOmg of internal fissure herbal treatment composition, 40000mg of Matricaria recutita (Chamoline) flower extract, 25000mg of Allium porrum (Leek) shoot extract, 25000mg of Apium graveolens (Celery) stalk extract, 15000mg of Fumaria officinalis (fumitory) shoot extract and 5000mg of honey are mixed. This herbal combination makes the mixture laxative and tranquilizer, anti bleeding agent, intestinal antiseptic agent and anti inflammation agent. The herbal combination tranquilizes internal wounds and removes itching. This herbal mixture makes defecation easy, without difficulty and this result in a quick recovery of the patients.

[00119] The herbal composition for the treatment of internal fissure is injected in a quantity of 2 ml in the anus for every 12 hours. Because of the presence of small molecules in this herbal mixture for internal fissures, the molecules penetrate in to the skin layers quickly. The camazolene in the Matricaria recutita and the other vitamins that exist in the plants help to recover from the wounds, cracks and swellings of anus, stop bleeding and make defecation easy by regulating the intestinal peristalsis. The herbal mixture for internal fissures is used at home, clinics, medical centers and private centers easily. The mixture is applied effectively for patients of all age groups without any limitation. The herbal mixture for internal fissures does not have any side effects. The availability of the plant resources in Iran are abundant. Hence the spray for internal fissures is manufactured at a very economic cost.

[00120] According to one embodiment herein, the anti-constipation oil comprises of mixture of Sesamum indicum (Sesame) oil and Ricinus communis (Castor oil plant) oil. To make 50000mg of this topical anti-constipation oil mixture, 30000mg of Sesamum indicum (60%v/v) and 20000mg of castor oil 40% v/v oil are mixed.

[00121] According to one embodiment herein, the sesame seeds are cleaned for the synthesis of anti-constipation oil mixture. After cleaning, the sesame seeds are crushed for extracting the shells. The seed kernals are obtained after removing the seed shells. The seed kernels are turned into dough. The seed kernel dough is put under pressure in a low temperature condition. This process is called cold pressing and about 38-50% of oil is extracted from the sesame seeds. For extracting the castor oil, the castor seed shells are removed. The castor seeds obtained after removing shells are kept under hydraulic pressure in a low temperature condition. After refining, 33% of castor oil obtained.

[00122] The sesame seed oil and the castor oil are mixed to obtain an oil mixture. The oil mixture is blended in a mixer till the extracted molecules become completely consistent/homogenous. The repository is filled with the oil mixture. The herbal extract mixture is stored in the containers. The oil mixture is a laxative agent, a healing agent, and tranquilizer. The oil mixture eases stool passing/defecation without any difficulty or pain and stops pressure on the anus and rectum to eliminate pain and bleeding.

[00123] According to one embodiment herein, the anus anti-crack composition or anti-tissue crack composition comprises mixture of Sesamum indicum (Sesame) oil, Olea europaea (Olive oil plant) oil and spermaceti. To synthesize 50000mg of this topical anti constipation oil mixture, 30000mg of Sesamum indicum (60%v/v) and 20000mg of castor oil (40% v/v) oil are mixed.

[00124] To synthesize 25000mg of anus anti-crack ointment, 15000mg of sesame oil with 60% v/v, 8500mg of olive oil with 34%v/v and 1500mg of spermaceti with 6%v/v are mixed.

[00125] The sesame seeds are cleaned and then crushed for removing the shells. The seed kernels are made into dough. The dough of the sesame seed kernel is subjected to pressure in a low temperature condition. This process is called cold pressing and about 38- 50% oil is extracted from the sesame seed kernel dough. For extracting olive oil, the olive fruits are milled to obtain a dough. The core of the olive fruits are not crushed. Then olive fruit dough is put in a bag which is made of plant fibers and squeezed to extract the olive oil. [00126] The yellow color of spermaceti is removed by sun or by using chemical substances like potassium dichromate or sulphuric acid. The spermaceti after cleaning is added to the mixture of sesame oil and olive oil. The spermaceti acts as a base of the anti- crack ointment. EXPERIMENT- 1 Herbal Composition For External Fissures;

[00127] According to one embodiment herein, Table 1 below illustrates the components used for the synthesis of herbal composition for external fissures:

[00128] FIG. 1 illustrates a flow chart indicating a method for synthesizing herbal spray for external fissures, according to one embodiment herein. The Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers are cleaned to remove the contaminants (101). Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers are milled separately and Crocus sativus stigma are grinded separately (102). One part of the Matricaria recutita flower powder, Aloe vera flower powder and Althaea officinalis flower powder are mixed separately with three part of hydrochloric solvent (30% v/v) to obtain separate mixtures (103). One part of the Crocus sativus stigma powder is mixed separately with three part of hydrochloric solvent (30% v/v) to obtain separate mixture (104). The Matricaria recutita flower powder mixture, Aloe vera flower powder mixture, Althaea officinalis flower powder mixture and Crocus sativus stigma powder mixture are incubated separately in the steam distillation apparatus or percolating for four days (105). The extracts of Matricaria recutita flower powder, Aloe vera flower powder, Althaea officinalis flower powder mixture are obtained and are mixed to get a mixture (106). The Crocus sativus stigma extract is added to the mixture of extracts of Matricaria recutita flower powder, Aloe vera lower powder, Althaea officinalis flower powder extracts to obtain herbal extract mixture (107). The herbal extract mixture is blended in a mixer to attain consistency. Linseed enamel and thickened grape juice are added while blending the herbal extract mixture(108). The herbal extract mixture is filtered and pasteurized to avoid bacterial and fungal infection (109). The herbal extract mixture is stored in 50 ml polyethylene terephthalate (PET) containers (110).

[00129] FIG.2 illustrates an anti-microbial analysis report of herbal spray for external fissures, according to one embodiment herein. The results illustrates that the herbal spray for external fissures is negative for Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[00130] According to one embodiment herein, the Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers are cleaned to remove contaminants. Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers are milled separately and Crocus sativus stigma are grinded separately. One part of the Matricaria recutita flower powder, Aloe vera flower powder and Althaea officinalis flower powder are mixed separately with three part of hydrochloric solvent (30% v/v) to obtain separate mixtures. One part of the Crocus sativus stigma powder is mixed separately with three part of hydrochloric solvent (30% v/v) to obtain separate mixture. The Matricaria recutita flower powder mixture, Aloe vera flower powder mixture, Althaea officinalis flower powder mixture and Crocus sativus stigma powder mixture are incubated separately in the steam distillation apparatus or percolated for four days. The extracts of Matricaria recutita flower powder, Aloe vera flower powder, Althaea officinalis flower powder mixture are obtained and are mixed to get a mixture. The Crocus sativus stigma extract is added to the mixture of extracts of Matricaria recutita flower powder, Aloe vera lower powder, Althaea officinalis flower powder extracts to obtain a herbal extract mixture. The herbal extract mixture is blended in a mixer to attain consistency. Linseed enamel and thickened grape juice are added while blending. The herbal extract mixture is filtered and pasteurized to avoid bacterial and fungal infection. The herbal extract mixture is stored in 50 ml polyethylene terephthalate (PET) containers.

[00131] Table 2 below illustrates the active constituents of the herbal composition for external fissures:

[00132] According to one embodiment herein, for the formulation or synthesizing 50000mg of this herbal mixture for external anal fissure, 32000 mg of Matricaria recutita (Chamoline) flower extract, 1000 mg of Crocus sativus (Saffron) stigma extract, 7000 mg of Aloe vera (Aloe vera) flower extract and 10000 mg of Althaea officinalis (Marsh mallow) flower extract are mixed.

[00133] According to one embodiment herein, this anti-fissure anal spray relieves myalgia, removes external inflammations through lymphatic vessels recovery, prevents and heals the chronic wounds by softening skin because of the presence of components. The spray also acts as an anti-inflammation and anti-crack spray. The anti-fissure spray is administered twice a day on the area of the wound in such a way that the area becomes completely wet. Because of the presence of small molecules in this spray, the medicine penetrates into the skin layers quickly. The camazolene in the Matricaria recutita and the other vitamins that are exist in the plants help to heal the wounds, cracks and the swellings of anus. This spray is used at home, clinics, medical centers, and private centers easily and is applied smoothly on the patients of all age groups without any limitation. The spray does not have any side effects. The availability of the plant resources in Iran are abundant. Hence the spray for external fissures is manufactured at a very economic cost.

[00134] According to one embodiment herein, the herbal composition or spray for external fissures is sprayed/ administered at a quantity of 2ml on the anus twice a day. Preferably the external fissure treatment spray is sprayed/ administered once in the morning and once at night.

[00135] According to one embodiment herein, the Crocus sativus stigma's are crushed with drops of distilled water for performing the thin layer chromatographic (TLC) analysis of the Crocus sativus stigma's extract. After 3 minutes, 1 ml methanol is added to obtain a mixture. The mixture is incubated in dark room/area for 20 minutes. After incubation, the mixture is filtered to obtain a filtrate. 10 μΐ of the filtrate is used for the thin Layer Chromatography (TLC).

[00136] After the analysis of the Crocus sativus extract the organic substances are found to be present in a quantity of 0.56% w/w. The total quantity of ash present is 7.5% w/w. The insoluble ash is present in hydrochloric acid in a quantity of 0.83% w/w. The quantity of humidity is 4.8%w/w. Crocus sativus is used as an aromatic substance and as a flavor. Fresh Crocus sativus is used as sedative and antispasmodic.

[00137] According to one embodiment herein, the Aloe vera contains glycoproteins which prevents pain and inflammation and accelerate the healing process. Further Aloe vera also contains polysaccharide which stimulates skins growth and repairing/rejenuvation. The gel from Aloe vera is used for healing internal and external wounds. Aloe vera accelerates a healing process of many skin wounds such as sores, scalds and chilblain. The thin layer chromatographic (TLC) analysis of Aloe vera illustrates that the Aloe vera plant comprises hydroxyanthracene derivatives of alanine A and alanine B (25-40%) of the whole constituents, vitamin A, C and E, vitamin B12, folic acid and choline, alkaline phosphatise, amylase, carboxypeptidase, catalase, cellulose, lipase and peroxidise. The Aloe vera plant comprises calcium, chromium, copper, selenium, magnesium, manganese, potassium, sodium, zinc, monosaccharide (glucose and fructose) and polysaccharide (glucomannan/polymannose).

[00138] According to one embodiment herein, the Althaea officinalis (marsh mallow) is a perennial species which is used as a medicinal plant. The fruit of Althaea officinalis is medicinal plant. The fruits, flower and root are used for medical purpose. The analysis of Althaea officinalis illustrates that Althaea officinalis comprises of mucilage, starch, fat, anthocyanin, altheine, dioxybenzoic acid and cyaniding.

[00139] According to one embodiment herein, the Matricaria recutita flower is bitter. The flower comprises a group of lipophilic substances which are anti-inflammatory. The major constituents of Matricaria recutita flower extracts are matricine, bisabolol and its oxides which result in Matricaris inflammatory activities. This activity is attributed to antioxidants effects. The analysis of the Matricaria recutita extract illustrates that the extract comprises of impurities are 25%, sulphated ash 13%, total ash 9% and soluble ash in acid 7.5%. [00140] Table 3 below illustrates the physicochemical properties of the herbal composition for external fissures:

Row Physical & Iranian Acceptable Examination

chemical sample range reference

examinations

1. Color cream cream internal

2. Smell special special internal

3. Density(g/cc) 0.99 (0.8-1.2) internal

4. Ph 2.89 (2-5) internal

5. Average volume 110 ml (104-116)ml USP34

6. Transparency opaque opaque USP34

7. Viscosity(cp) 9.98 (7-20) USP34

8. Active 0.013% (0.0104- BP2012

constituent 0.0156)%

9. identification match The sample's Rf Iran

is the same as pharmacopoeia standard Rf [00141] According to one embodiment herein, the standardization of the final product or the herbal spray composition for external fissures is necessary according to European pharmacopoeia is necessary. The amount of product is determined according to the amount f an active constituent. The method of determining the active constituent according to BP2012 is as follows: 10 ml of the sample herbal composition for external fissures is poured in the 100 ml round bottom flask. 1 ml of 0.5% hexa methyl tetra amine (The 0.5% of hexa methyl tetra amine is synthesized by dissolving 0.5 gram of hexa methyl tetra amine in water and pouring/transferring the same into 100 ml volumetric flask). 20 ml of acetone and 7 ml of 25% hydrochloric acid are added to the sample herbal composition for external fissures. The round bottom flask is incubated in a water bath for 30 minutes. After 30 minutes of incubation, the contents of the volumetric flask are filtered with cotton into another 100 ml volumetric flask. The filtrate is collected in 100 ml volumetric flask and boiled with 20 ml acetone twice. The contents of the volumetric flask is cooled and filtered to obtain a solution mixture which is added to filtered solvent. The volume of the solution mixture is made up to 100 ml with acetone. 20 ml of the solvent is taken and transferred in a decanter and 20ml distilled water is added. Extraction is done once with 15 ml ethyl acetate and three times with 10 ml ethyl acetate. The solvent is embrocated with 50ml distilled water two times and then volume it in a 50ml volumetric flask with ethyl acetate.

[00142] 10ml of the sample is poured into two 25ml volumetric flask. 1ml of aluminum chloride is add to one flask (aluminium chloride is obtained by dissolving 2g aluminum chloride in methanol acetic acid 5% and the volume is made up in 100ml volumetric flask). The volume of the volumetric flasks are made up with 5%methanol acetic acid. The contents of volumetric flask are incubated for 20minutes to have a complete color complex. The absorption of sample in 425nm wavelength is read and the total flavonoids is calculated from the below formula.

A * 1.25

sample flanoids percent »~ —

V=the volume of used sample

A=the absorption of tested sample

The amount of active constituent of sample:

V=10ml

A=0.106

Sample flavonoids percent= 0.106 * 1.25/10 = 0.013%

[00143] According to one embodiment herein, the flavonoids content in the herbal composition for external fissures or spray is 0.013% w/w. The herbal composition for external fissures is kept in cool, dry place. The herbal composition for external fissures is kept away from sun light and under 30°C. EXPERIMENT-2 Herbal Composition For Internal Fissures;

[00144] According to one embodiment herein, Table 4 below illustrates the components used for the synthesis of herbal composition for internal fissures:

Rows Common Scientific name Sources Used parts name

1- Chamomile Matricaria Plant cultivation in flower recutita Khuzestan

2- leek Allium porrum Plant cultivation in shoot

Khuzestan

3- celery Apium graveolens Plant cultivation in stalk

Khuzestan

4- fumitory Fumaria Plant cultivation in shoot officinalis Khuzestan [00145] According to one embodiment herein, the herbal composition for treatment of internal fissures comprises extracts from Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot. The herbal extracts from the aforementioned plants are mixed with honey.

[00146] FIG.3 illustrates a flow chart indicating a method for synthesizing herbal composition for internal fissures, according to one embodiment herein. The Matricaria recutita flowers, Allium porrum shoots, Apium graveolens stalks and Fumaria officinalis shoot are cleaned to remove the contaminants (301). The, Matricaria recutita flowers, Allium porrum shoots, Apium graveolens stalks and Fumaria officinalis shoot are milled separately in a mash mixer to obtain powder (302). One part of the powder of Matricaria recutita flowers, Allium porrum shoots, Apium graveolens stalks and Fumaria officinalis shoot are mixed separately with three part of water as solvent to get separate solutions (303). One part of the powder solutions of Matricaria recutita flowers, Allium porrum shoots, Apium graveolens stalks and Fumaria officinalis shoot are heated separately with three part of water for 4 hours (304). The solutions are filtered after 4 hours to obtain a filtrate comprising herbal extracts of Matricaria recutita flowers, Allium porrum shoots, Apium graveolens stalks and Fumaria officinalis shoot (305). The herbal extracts of Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk are mixed to get a mixture (306). Honey is added to the mixture to obtain herbal extract mixture (307). The herbal extract mixture is blended in a mixer to attain consistency (308). The herbal extract mixture is filtered and pasteurized (309). The herbal extract mixture in is stored 110 ml PET containers (310).

[00147] According to one embodiment herein, Matricaria recutita flowers, Allium porrum shoots, Apium graveolens stalks and Fumaria officinalis shoot are cleaned to remove all the contaminants. The Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk and Fumaria officinalis shoot are milled in a Mash mixer to obtain a grinded powder. The herbal extracts from Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk and Fumaria officinalis shoot are extracted through steam distillation or percolation. One part of Matricaria recutita (Chamoline) flower powder, Allium porrum (Leek) shoot powder, Apium graveolens (Celery) stalk and Fumaria officinalis shoot powder are mixed separately with 4 parts of water as a solvent. The plant powders and water are heated and cooked for 4 hours. The filtration is done after 4 hours to obtain filtrate comprising herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk and Fumaria officinalis shoot. In order to control bacterial and fungal infections, the herbal extract is pasteurized. The herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk and Fumaria officinalis shoot are mixed till the consistency is achieved. Honey is added to the herbal extract mixture and is mixed in a mixer till a uniform consistency is achieved. Then the herbal extract mixture is filtered and pasteurized to control bacterial and fungal infections. After confirmation, the sampling is done and packed in 110 ml polyethylene terephthalate (PET) containers.

[00148] Table 5 below illustrates the active constituents of the herbal composition for internal fissures:

Main Constituen Form of Percent of Amount of Role of consti ts' names constituents constituents constituents used constituents in tuents used in (w/v or w/w) in 10 ml formulation

formulation formulation

1_ Matricaria Liquid 32.5% 3.25 ml active

extract

2_ Allium Liquid 31.5% active porrum 3.15 ml

extract

3_ Apium Liquid 22.5% 2.25 ml active

graveolens

extract

4_ Fumitory Liquid 9% 0.9 ml Active

extract

1- honey liquid 4.5% 0.45 ml excipient

[00149] For the synthesis of l lOOOmg of herbal composition for the treatment of internal fissure, 40000mg of Matricaria recutita (Chamoline) flower extract, 25000mg of Allium porrum (Leek) shoot extract, 25000mg of Apium graveolens (Celery) stalk extract, 15000mg of Fumaria officinalis (fumitory) shoot extract and 5000mg of honey are mixed. This herbal combination makes the mixture laxative and tranquilizer, anti bleeding agent, intestinal antiseptic agent and anti inflammation agent. The herbal combination tranquilizes internal wounds and removes itching. This herbal mixture makes defecation easy, without difficulty and this result in a quick recovery of patients.

[00150] The herbal composition for the treatment internal fissure is injected in a quantity of 2 ml in the anus for every 12 hours. Because of the presence of small molecules in this herbal mixture for internal fissures, the molecules penetrate into the skin layers quickly. The camazolene in the Matricaria recutita and the other vitamins that exist in the plants help to heal the wounds, cracks and swellings of anus, stop bleeding and make defecation easy by regulating the intestinal peristalsis. The herbal mixture for internal fissures is used at home, clinics, medical centers and private centers easily. The herbal mixture is applied on the patients of all ages without any limitation. The herbal mixture for internal fissures does not have any side effects. The availability of the plant resources in Iran are abundant. Hence the spray for internal fissures is manufactured at a very economic cost. [00151] According to one embodiment herein, the herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk and Fumaria officinalis shoot are subjected for the thin layer chromatographic (TLC) analysis. The 11 gram powder of each one of the Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot, Apium graveolens (Celery) stalk and Fumaria officinalis shoot are taken in separate test tubes. 2.5 ml of a mixture comprising 0.25 g dimethyl amino benz aldehyde, 5 ml of 85% phosphoric acid, 45 ml of 30% acetic acid and 45 ml of distilled water are added to the test tubes comprising 11 g powder of the each plant. The test tubes are heated for 5 minutes on a water bath. After cooling the test tubes at room temperature, 5 ml of petroleum ether is added to each test tube and shaken for 1-2 minutes. A blue green color is developed. 10 μΐ of the content from each test tube is used for the TLC (thin Layer Chromatography) .

[00152] The analysis of the Matricaria recutita (Chamoline) flower extract has revealed that the impurities are present in a quantity of upto 25% and the sulfated ash is present in a quantity upto 13%, while total ash is present in a quantity of 9% and soluble ash in acid is present in a quantity of 7.5%. The flowers of Matricaris recutita comprises a group of lipophilic substances which are anti-inflammatory. The major constituents of Matricaris recutita extract are matricine, bisabolol and its oxides which result in matricasia inflammatory activities. This activity is attributed to anti-oxidants effects.

[00153] The analysis of the Allium porrum (Leek) shoot extract has revealed that that the Allium porrum has an essence which consists of sulfide compounds. The leaves have enzymes such as maltase, isomaltase, invertase, and emulsin. There are plurality of carbohydrates in the roots, specifically arabinose and galactose. Following are the percentage of the different components present Allium porrum shoot extract: Organic substance is present in a quantity of 0.92%. The total ash content is present in a quantity of 6.73%. the insoluble ash in hydrochloric acid is present in a quantity of 1.04%. The soluble extract in water is present in a quantity of 6.73 % and humidity is 4.23.

[00154] The analysis of the Apium graveolens (Celery) stalk extract has revealed the following results. The impurities are present upto 1%. The total ash is present upto 10%. The insoluble ash in hydrochloric acid is present upto 2% and the soluble extract present in water is 12%. The ripe fruit of Apium graveolens are used for medical purpose. The fruits are dark brown, oblong shaped with white vertical ridges and they are strongly aromatic.

[00155] The analysis of the Fumaria officinalis shoot extract has indicated that the shoot comprises alkaloids, flavonoids, potassium chloride and phenol and the pharmacologic effects of Fumaria officinalis shoot extract are due to the aforementioned organic compounds. The phenol compounds remove skin pruritus and eczema. The shoot is diuretic because of the presence of potassium chloride. The medical part of the plant is its shoot. The plant has digitate leaves which are green ad small purple flowers. The shoot is green, bitter and without any smell. The analysis reveals that the total ash is present in a quantity of 16%, and the insoluble ash is present in hydrochloric acid in a quanity of 3% while the soluble extract in water is present in a quantity of 12 %.

[00156] According to one embodiment herein, the analysis of the herbal composition for internal fissures comprises organic substances at a rate of 1.1%, total ash at a rate of 7.89%, insoluble ash in hydrochloric acid at a rate of 1.112%, soluble extract in water at a quantity of 5.3% and humidity at 4.8%. [00157] Table 6 below illustrates the physicochemical properties of the herbal composition for internal fissures:

[00158] According to one embodiment herein, the high percentage of the organic molecules in the celery seeds/stalk extract make them antispasmodic. The presence of n- butylphthalide and methylphthalide make the celery seeds/stalk extract sedative. The apiol in the celery seeds/stalk extract makes it diuretic and some of the coumarins in the plant are sedative. The fruits (seeds) of celery are dark-brown, oblong shaped with white vertical ridges, and they are strongly aromatic. The seeds of celery have impurities in a quantity of 1% w/w, total ash in a quantity of 10% w/w, insoluble ash in hydrochloric acid in a quantity of 2% w/w and soluble extract in water in a quantity of 12% w/w.

[00159] Matricaria recutita (Chamoline) flower comprises a group of lipophilic substances which are anti-inflammatory. The major constituents of Matricaria recutita (Chamoline) flower extract are matricine, bisabolol and its oxides which act against inflammation. This inflammatory activity is attributed to antioxidants' effects, similar to leukotrienes synthesis. The Matricaria recutita (Chamoline) flower extract comprises impurities in a quantity of 25% w/w, sulfated ash in a quantity of 13%, total ash in a quantity of 9% w/w and soluble ash in acid in a quantity of 7.5% w/w.

[00160] For the analysis of the flavonoids content in the herbal composition for internal fissures, 10 ml of the sample herbal composition is poured in the 100 ml round bottom flask. 20ml acetone and 7ml hydrochloric acid 25%v/v are added to 1 ml hexa methyl tetra amine 0.5% v/v in the flak to obtain a mixture. The hexa methyl tetra amine is obtained by dissolving 0.5 g hexa methyl tetra amine in water and pouring it in 100ml volumetric flask. The mixture is incubated in a water bath for 30 minutes. Then the mixture is filtered by cotton in a 100ml volumetric flask to obtain a filtrate. A cotton plug is inserted in the round bottom flask and the filtrate is boiled with 20ml acetone twice. After cooling the filtrate, it is added to a solvent.

[00161] The volume of the sample is made up to 100ml with acetone to obtain a mixture. 20ml of the mixture is taken and put it in a decanter. 20ml of distilled water is added to it. Extraction is done once with 15ml ethyl acetate and three times with 10ml ethyl acetate. The solvent is embrocated with 50ml distilled water two times and then volume is adjusted to 50ml in a volumetric flask with ethyl acetate.

[00162] 10ml of the sample is poured in two 25ml volumetric flask. In one flask, lml aluminum chloride is added (aluminium chloride is obtained by dissolving 2g aluminum chloride in methanol acetic acid 5% and the volume is made up in 100ml volumetric flask). The volume of the volumetric flasks are made up with 5% methanol acetic acid. The volumetric flask is incubated for 20minutes to have a complete color complex. The sample absorption in 425nm wavelength Reading and calculated the total flavonoids from the below formula.

A * 1.25

sample flanoids percent »~ —

V=the volume of used sample

A=the absorption of tested sample

The amount of sample active constituent:

V=10ml

A=0.106

iSample flavonoids percent ~- "·^:·""· -~-"--^~-"=o.013%

[00163] According to one embodiment herein, the flavonoids content in the herbal composition for internal fissures or spray is 0.013% w/w.

EXPERIMENT-3 Topical Oil for Constipation;

[00164] According to one embodiment herein, Table 7 below illustrates the components used for the synthesis of topical oil for constipation:

[00165] According to one embodiment herein, the sesame seeds are cleaned for the synthesis of anti-constipation oil mixture. After cleaning, the sesame seeds are crushed for extracting the shells. The seed kernals are obtained after removing the seed shells. The seed kernels are turned into dough. The seed kernel dough is put under pressure in a low temperature condition. This process is called cold pressing and about 38-50% of oil is extracted from the sesame seeds. The castor seed shells are removed for extracting the castor oil. The seeds obtained after removing shells are kept under hydraulic pressure in low temperature condition. After refining, 33% castor oil obtained.

[00166] The sesame seed oil and the castor oil are mixed. The oil mixture is blended in a mixer till the extract molecules become completely consistence and the extract mixture is obtained. The repository is filled with the oil mixture. The herbal extract mixture is stored in the containers. 50 ml Polyethylene terephthalate containers are filled with the oil mixture. The oil mixture is laxative, healing agent, tranquilizer and it makes stool passing without difficulty and stops pressure on the anus and rectum so there is no pain and bleeding.

[00167] According to one embodiment herein, the oil mixture for constipation is preferably administered in a quantity of 2 ml in the anus by a syringe twice a day. Preferably the oil is administered in the morning and at midnight.

[00168] FIG.4 illustrates a flow chart indicating a method for synthesizing anti- constipation topical oil, according to one embodiment herein. The sesame seeds and castor seeds are cleaned to remove the contaminants (401). The sesame seeds are crushed for extracting the seed shells and the seed kernel is obtained (402). A dough is made from the seed kernel and the kernel dough is put under pressure at a low temperature (403). 38-50% of oil is extracted from the sesame kernel dough by cold pressing (404). The castor oil seed shells are removed and the castor oil seeds are obtained (405). The hydraulic pressure is applied on castor oil seeds in a low temperature to extract castor oil (406). The extracted castor oil is refined to obtain 33% refined castor oil (407). The sesame seed oil and castor oil are mixed to obtain an oil mixture (408). The oil mixture is blended in a mixer to attain consistency (409). The oil mixture is filtered (410). The oil mixture is stored in 50 ml PET containers (411).

[00169] According to one embodiment herein, the anti-constipation topical oil comprises a mixture of Sesamum indicum (Sesame) oil and Ricinus communis (Castor oil plant) oil. for synthesizing 50000mg of this topical anti-constipation oil mixture, 30000mg of Sesamum indicum (60%v/v) and 20000mg of castor oil (40% v/v) oil are mixed. The oil is kept/stored in a cool and dry place, under 30°C and away from sun light.

[00170] Table 8 below illustrates the active constituents of the topical oil for constipation:

EXPERIMENT-3.1 Different Qualitative and Quantitative Analysis of Castor Oil;

[00171] During the preliminary identification of castor oil, the castor oil changes into an ointment like substance at a temperature of 60°C. 2.00 ml petroleum ether is added to 5ml castor oil to acquire a clear mixture that becomes opaque by adding more petroleum ether to it. Moreover 5g of this substance is mixed to 5ml HNO₃ and shaken with 5ml resorcinol to have a color change from red to purple blue. 3g of this substance is heated with l .Og potassium hydroxide to acquire a smell similar to octyl alcohol's smell. For obtaining the sebacic acid crystals, 30 ml water is added to the oil with potassium hydroxide mixture. A large amount of magnesium oxide is added to the mixture. The mixture is refined and acidized with hydrochloric acid. The sebacic acid crystals are settled. Only a little of this oil dissolves in hexane and it makes a clear liquid with the same amount of ethanol.

[00172] For the acidity analysis of the castor oil, 5g of the oil is added to 25g of a mixture that includes (same amount of) ethanol (96%), and ether which is neutralized by KOH and 0.5ml of phenolphthalein as an identifier. When the substance becomes completely neutralized, the titration is done with KOH. During titration, the flask is shaken continuously till a pink color is obtained at least for 15 seconds. Acidity is calculated through 5.610v/w, where v stands for the volume of potassium hydroxide needed according to Ml and W stands for the weight of tested substance according to g. When the oil is old, the acidity is higher and the higher acidity at the beginning of oil preparation is the sign of inappropriate extraction, spoiled seed and bad preservation. The acidity of the oil is 2.0

[00173] According to one embodiment herein, light absorption property is 1.0 and wavelength of the castor oil in the 1% solution W/V in ethanol (96%) is 268-270nm. According to one embodiment herein, optical rotation property of castor oil is + 3.5° to + 6.0°. According to one embodiment herein, primary oxidation value or peroxide value of castor oil up to 5.0. According to one embodiment herein, refractive index of castor oil is 1.477 to 1.481. According to one embodiment herein, relative density of the castor oil is 0.952 to 0.965. According to one embodiment herein, the sesame seeds are small and about 2-4 mm wide, ovate and slightly flattened. The weight of sesame seeds is within 20 and 40 mg. The sesame seeds are yellow colored, sweet and oily. The sesame oil is extracted by putting sesame seeds under pressure.

EXPERIMENT-3.2 Different Qualitative and Quantitative Analysis of Sesame Oil;

[00174] For the sesame oil identification, the existence of sesamol and sesamolin in non-triglyceride part of sesame oil is identified easily through Baudouin test and Villavecchia test. This test is used to identify sesame oil. 10ml sesame oil is mixed with 4.5ml acetic anhydride, 0.5ml of formaldehyde, and 0.35% solvent in acetic anhydride for 1 minute. The mixture obtained is refined through a filter paper saturated by acetic anhydride. 0.2 ml of sulfuric acid is added to the mixture. If the color is blue green, the presence of sesame oil is confirmed.

[00175] According to one embodiment herein, the acidity refers to the amount of organic acids in fats and the acidity is less than 0.6 for sesame oil.

[00176] According to one embodiment herein, the saponification value represents the number of milligrams of potassium hydroxide required to saponify lg of fat under conditions specified. The saponification value of sesame oil is 188-195.

[00177] According to one embodiment herein, the iodine value refers to the amount of unsaturated fatty acids. The iodine value for sesame oil is 104-116.

[00178] According to one embodiment herein, the peroxide value refers to the amount of peroxide oxygen per 1 kilogram of fat or oil, which is a good method for evaluating the degree of oil corruption. The peroxide value for sesame oil is 1-3.

[00179] According to one embodiment herein, physical characteristics of sesame oil is pale yellow in color, liquid in normal room temperature and almost without smell and with mild flavor. The sesame oil changes into solid in -4°C and has a weight 0.921-0.924 at 15°C. The refractive index of sesame oil is 1.473-1.476.

[00180] According to one embodiment herein, thin layer chromatography (TCL) is used for the purity examination of sesame oil. In the TLC analysis, the stationary phase is silica gel G F 254 and the mobile phase is acetic acid 99%. [00181] According to one embodiment herein, the quality analysis of sesame seeds discloses that the total ash is present is in a quantity of 5.5%w/w, sulfated ash is present in a quantity of 3.6% w/w and soluble ash in water is present in a quantity of 0.86% w/w.

[00182] According to one embodiment herein, the sesame oil is used as laxative, skin healer and softener. Sesame oil decreases blood sugar. Sesame oil is used as a solvent and an oil base for pharmaceutical industry, for healthcare and cosmetics industry.40-60 gram of sesame oil is used as laxative.

[00183] Table 9 below illustrates the physicochemical properties of the topical oil for constipation:

[00184] FIG.5 illustrates an anti-microbial analysis report of anti-constipation topical oil, according to one embodiment herein. The results illustrates that the anti- constipation topical oil is negative for Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[00185] FIG.6 illustrates a physico-chemical analysis report of anti-constipation topical oil, according to one embodiment herein. The physic-chemical analysis indicates that the anti-constipation topical oil has a density of 0.90 g/cm³. The pH of the anti-constipation topical oil is 5.68. The color of the anti-constipation topical oil is slight yellow.

[00186] According to one embodiment herein, 5g of the oil mixture is taken for the acidity determination of the topical oil for constipation. 25g of a mixture includes (same amount of) ethanol (96%), and ether which is neutralized by potassium hydroxide and 0.5ml of phenolphthalein as an identifier) is added. When the mixture becomes completely neutralized, titration is done against potassium hydroxide. The flask is shaken continuously till the pink color is consistent at least for 15 seconds.

Acidity is calculated through 5.61 , where V=the volume of used potassium hydroxide, W= weight of substance in g, Acidity= - .b I ;;·; =2.24, V= 2 ml, and W=5g

EXPERIMENT-4 Anti-Crack Ointment for Anal Cracks:

[00187] According to one embodiment herein, Table 10 below illustrates the components used for the synthesis of topical oil for constipation:

Rows Common Scientific name Sources Used parts name

1- olive Olea europaea Plant cultivation in Fruit

Roodbar

2- sesame Sesamum indicum Plant cultivation seed [00188] According to one embodiment herein, the anus anti-crack composition or anti-tissue crack composition comprises mixture of Sesamum indicum (Sesame) oil, Olea europaea (Olive oil plant) oil and spermaceti. To make 50000mg of this topical anti constipation oil mixture, 30000mg of Sesamum indicum (60%v/v) and 20000mg of castor oil (40% v/v) oil is mixed.

[00189] To synthesize 25000mg of anus anti-crack ointment: 15000mg of sesame oil (60% v/v), 8500mg of olive oil (34% v/v) and 1500mg of spermaceti (6%v/v) are mixed.

[00190] The sesame seeds are cleaned and then crushed for removing the shells. The seed kernels are made into dough. The dough of the sesame seed kernel is subjected to pressure in low temperature condition. This process is called cold pressing and about 38-50% oil is extracted from the sesame seed kernel dough. For extracting olive oil, the olive fruits are milled to obtain a dough. The core of the olive fruits is not crushed. Then olive fruit dough is put in the bag which is made of plant fibers and squeezed to extract the olive oil.

[00191] The yellow color of spermaceti is removed by sun or by using chemical substances like potassium dichromate or sulphuric acid. The spermaceti after cleaning is added to the mixture of sesame oil and olive oil. The spermaceti acts as a base of the anti- crack ointment.

[00192] FIG.7 illustrates a flow chart indicating a method for synthesizing anti- crack ointment, according to one embodiment herein. The sesame seeds and olive fruits are cleaned to remove contaminants (701). The sesame seeds are crushed for extracting the seed shells and the seed kernel is obtained (702). A dough is made from the seed kernel and the kernel dough is put under pressure at a low temperature (703). 38-50% of oil is extracted from the sesame kernel dough by cold pressing (704). The olive fruits are crushed and grinded to obtain a dough from the crushed olive fruits (705). A dough is made from the crushed olive fruit and the dough is put under pressure at a low temperature (706). The olive oil is extracted from the olive fruit dough by cold pressing (707). The sesame seed oil and olive oil are mixed to obtain an oil mixture (708). The spermaceti is heated and melted in a container at a temperature of 70°C (709). Oil mixture is added to a molten spermaceti while constantly stirring/mixing till the spermaceti is cooled and a uniform consistency is attained. The anti-crack ointment for anal tissue crack is obtained (710). The anti-crack ointment is sampled and the oil mixture is stored in 25 ml PET containers (711).

[00193] According to one embodiment herein, to synthesize 25000mg of anti-crack ointment, 15000mg of sesame oil (60%v/v), 8500mg of olive oil (34%v/v) and 1500mg of spermaceti (6%v/v) are mixed together. The yellow color of spermaceti is removed by sun light or by using chemical substances like potassium dichromate or sulphuric acid.

[00194] Table 11 below illustrates the active constituents of the anti-crack ointment for anal tissue crack:

[00195] According to one embodiment herein, the anti-crack ointment is applied twice a day on the anus and around anus where skin tissues are cracked. Preferably the anti- crack ointment is applied once in the morning and once at night. [00196] According to one embodiment herein, the part which is in olive tree is its leaves. The leaves are arranged opposite each other, they are oblong, measuring 8cm, dark tipped, leathery which have petiole. The leaves are green-gray on the top, silver and fluffy on the back.

[00197] Olive leaf comprises sugar, bitter substances such as resin, wax, chlorophyll, tannins, gallic acid, and mannite. Olive leaf contains a bitter substance named oleuropein (C25H₃2O1₃). Besides the olive leaf contains fatty acid and flavonoids (flavonoids: 7beta-D- glucosile , 7 beta-D gliconil coteolin, 4beta-D glocosile loteolin and 7 beta- D glocosile apigenin). The leaf contains substances such as nitrogen, phosphorus, calcium, and magnesium. It also contains sugar alcohols (e.g. mannitol), tannins, saponines, and coumarins.

[00198] Purity test of the Olive leaf contents is done through thin layer chromatography (TCL). The stationary phase is silica gel g-f-254. The mobile phase is ethyl acetate, glacial acetic acid, formic acid and water (100: 11 : 11 :26). The reagents are natural product.

[00199] Dried leaf of Olea europaea mainly comprises a minimum 5.0 per cent of oleuropein (C25H₃2O1₃ Mr. (540. q dried drug). The leaf is simple, thick and coriaceous, lanceolate to obovate, 30 mm to 50 mm long and 10 mm to 15 mm wide, with a mucronate apex and tapering at the base to a short petiolei. The margins are entire and reflexed abaxially. The upper surface is greyish-green, smooth and shiny. The lower surface is paler and pubescent, particularly along the midrib and main lateral veins.

[00200] The powder of the olive leaf is yellowish-green. Examination under a microscope using chlorohydrate solution illustrates that the powder shows the following diagnostic characters: fragments of the epidermis in surface view with small, thick- walled polygonal cells and, in the lower epidermis only, small anomocytic stomala (2.8.3). The fragments of the lamina in sectional view shows a thick cuticle. A palisade is composed of 3 layers of cells and a small-celled spongy parenchymat numerous sclereids, very thick-walled and mostly fibre-like with blunt or, occasionally, forked ends, isolated or associated with the parenchyma of the mesophyll; abundant, very large peltate trichomes, with a central unicellular stalk from which radiate some 10 to 30 thin- walled cells which become free from the adjoining cells at the margin of the shield, given an uneven, jagged appearance.

[00201] The leaf chemical composition is analyzed by thin layer chromatography (TLC). The test solution is made from 1.0 gram of the powdered olive leaf. 10 ml of methanol is added and boiled under a reflex condenser for 15 minutes. After 15 minutes, the solution is cooled and filtered. The reference solution is made by dissolving 10 mg of oleuropein and 1 mg of rutin in 1 ml of methanol. The TLC silica gel plate is prepared by standard protocol. Further the mobile phase comprises water, methanol, methylene chloride (1.5: 15: 85 V/V/V). 10 μΐ of the sample are applied on the TLC silica gel plate. After application of the test sample and the reference sample, the TLC silica gel plate is placed in the mobile phase. The TLC silica gel plate is placed in the mobile phase until the mobile phase travels over a path of 10 cm. The TLC silica gel plate is removed from mobile phase after the mobile phase travels over a path of 10 cm. The TLC silica gel plate is air dried. After TLC silica gel plate is air dried, the TLC silica gel plate is sprayed with vanillin reagent and subjected to heat at 100-105°C for 5 minutes. The TLC silica gel plate is examined in daylight. [00202] The foreign matter is present in a quantity of 2%. The loss of drying is a maximum of 10%, when l .OOOg of the powdered drug is dried in an oven at 100-105°C for 2 hours. The total ash content is maximum 9%.

[00203] FIG.8 illustrates the result of thin layer chromatography of the olive leaf extract, according to one embodiment herein. The TLC confirms the presence of oleuropein.

[00204] FIG.9 illustrates a physico-chemical analysis report of anti-crack ointment, according to one embodiment herein. The physico-chemical analysis of anti-crack ointment illustrates that the density of the anti-crack ointment is 0.88 g/cm³. The color of the anti- crack ointment is cream.

[00205] For performing the TLC test, the olive leaf extract is prepared by the following method. A preset amount of Olive leaf sample is decanted through chloroform. Chloroformic phase is collected through each step. The chloroformic phase is condensed in vacuum by άΪ8ίϊ11θΓ.20μ1 of chloroformic extract and 20μ1 olive oil are cultivated on the plates separately. After cultivating and spreading the solvent, the plates are dried by hood and the situation of stains is analyzed under UV lamps (365 wavelengths). The same spectrum is the sign of olive oil existence. The quality evaluation illustrates that total ash content is upto 3.5%, insoluble ash in acid is present upto 1% and humidity is present upto 4.42%.

[00206] According to one embodiment herein, the liquid chromatography assay is performed. The test solution is prepared by placing 1.0 gram of the powdered drug and 50 ml of methanol is added. The solution mixture is heated in a water bath at 60 °C for 30 minutes with shaking. The solution mixture is allowed to cool and filtered into a 100 ml volumetric flask. The flask is rinsed with methanol and the solution mixture is diluted to 100 ml with methanol. Further, 2 ml of the solution is diluted to 20 ml with water. The reference solution is prepared by dissolving 5 mg of oleuropein in 5 ml of methanol. 1 ml of the oleuropein- methanol solution is diluted to 25 ml with water. The column is prepared to have the has following specifications: size 0.15m, ø value = 3.9 mm. The stationary phase is octadecylsilyl silica gel. The column is kept at a temperature of 25°C. The mobile phase comprises two compositions A and B. The mobile phase A comprises of dilute 1.0 ml of glacial acetic acid diluted to 100 ml with water. The mobile phase B comprises of methanol.

[00207] The flow rate is maintained at 1 ml/min. The analysis is done by Sphectrophotometer at 254 nm. The volume of injection is 20 μΐ. The retention time of oleuropein is 9 minute. The percentage content of oleuropein is calculated from the expression:

Where Ai= area of the peak due to oleuropein in the chromatogram obtained with the test solution

A₂= area of the peak due to oleuropein in the chromatogram obtained with the reference solution

ml= mass of the drug to be examined, in grams

m2 = mass of the oleuropein in the reference solution, in grams

p= percentage content of oleuropein [00208] Table 12 below illustrates the physicochemical properties of the anti-crack ointment for anal tissue crack:

[00209] For the standardization of the final product or the anti-crack ointment for anal tissue damage according to Europe pharmacopoeia, the following steps are followed. 1 gram of the sample is taken in the volumetric flask. 50 ml of ethanol is added to the flask. The flask is incubated in a water bath for 30 minutes at 60°C. After 30 minutes, the flask contents are filtered in a 100 ml volumetric flask. The volume of the filtered sample is made upto 100 ml with 100 ml with methanol. 20 ml of the mixture is taken and 20 ml distilled water is added to it.

[00210] It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the appended claims. [00211] Although the embodiments herein are described with various specific embodiments, it will be obvious for a person skilled in the art to practice the invention with modifications. However, all such modifications are deemed to be within the scope of the claims.

[00212] It is also to be understood that the following claims are intended to cover all of the generic and specific features of the embodiments described herein and all the statements of the scope of the embodiments which as a matter of language might be said to fall there between.

Claims

CLAIMS What is claimed is:

1. A method of synthesizing a plurality of herbal compositions for targeting fissures, the method comprises the steps of:

synthesizing a herbal spray composition for external fissures, and wherein the herbal spray composition is sprayed or applied on the external fissures;

synthesizing a herbal mixture for internal fissures, and wherein the herbal mixture is injected or applied on the internal fissures;

synthesizing an anti-constipation topical oil, and wherein the anti-constipation topical oil is injected for a constipation relief; and

synthesizing an anti-crack ointment for anal tissue cracks, and wherein the anti- crack ointment is applied on the anal tissue cracks; and

wherein the herbal spray composition for external fissures is a mixture comprising extracts of Matricaria recutita flower, Aloe vera, Althaea officinalis flower, Crocus sativus stigma extract, linseed enamel and thickened grape juice, and wherein the herbal mixture for internal fissures is a mixture comprising extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk and Fumaria officinalis shoot, and wherein the anti-constipation topical oil is a mixture comprising Sesamum indicum oil and the Ricinus communis oil, and wherein the anti-crack ointment for anal tissue cracks comprising Olea europaea fruit oil, Sesamum indicumoil and spermaceti.

2. The method according to claim 1, wherein the method for synthesizing the herbal spray composition for external fissures comprises the steps of:

cleaning Matricaria recutita flowers, Aloe vera flowers, Crocus sativus stigma and Althaea officinalis flowers to remove contaminants;

milling the Matricaria recutita flowers, Aloe vera flowers and Althaea officinalis flowers separately to obtain Matricaria recutita flower powder, Aloe vera flower powder and Althaea officinalis flower powder;

grinding Crocus sativus stigma separately and extracting the stigma extract;

mixing the Matricaria recutita flower powder in a preset quantity with a preset quantity of hydrochloric solvent separately, and wherein the Matricaria recutita flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3, and wherein the quantity of the hydrochloric solvent is 30%v/v;

obtaining Matricaria recutita flower powder solution;

mixing the Aloe vera flower powder in a preset ratio with a preset ratio of hydrochloric solvent separately, and wherein the Aloe vera flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3, and wherein the quantity of the hydrochloric solvent is 30%v/v;

obtaining Aloe vera flower powder solution;

mixing the Althaea officinalis flower powder in a preset ratio with a preset ratio of hydrochloric solvent separately, and wherein the Althaea officinalis flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3, and wherein the quantity of the hydrochloric solvent is 30%v/v;

obtaining Althaea officinalis flower powder solution; obtaining the extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower after incubating the Matricaria recutita flower powder solution, Aloe vera flower powder solution and Althaea officinalis flower powder solution in a steam distillation apparatus for four days;

mixing the extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower and Crocus sativus stigma extract to obtain a herbal extract mixture;

blending the herbal extract mixture in a blender to obtain a homogeneous mixture; adding linseed enamel and thickened grape juice to the herbal extract mixture while blending, and wherein a mixture is obtained comprising extracts of Matricaria recutita flower, Aloe vera flower and Althaea officinalis flower, Crocus sativus stigma extract, linseed enamel and thickened grape juice;

filtering the mixture;

pasteurizing the mixture; and

storing the herbal extract mixture in containers, and wherein the containers are a polyethylene terephthalate (PET) containers, and wherein for the synthesis of the herbal spray composition for external fissures Matricaria recutita flower extract is mixed in a preset quantity with an Aloe vera flower extract in a preset quantity, an Althaea officinalis flower extract in a preset quanity and with a Crocus sativus stigma extract in a preset quanity, and wherein the Matricaria recutita flower extract is mixed in a preset quantity of 4.6 ml, and wherein the Aloe vera flower extract is mixed in a preset quantity of 4.1 ml, and wherein the Althaea officinalis flower extract is mixed in a preset quantity of 2.0 ml, and wherein the Crocus sativus extract is mixed in a preset quantity of 2.0 ml.

3. The method according to claim 1, wherein the herbal spray composition for external fissures is negative for the growth of plurality of bacterial species, and wherein the bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus, and wherein the herbal spray composition for external fissuresis an anti-inflammatory agent, and wherein the herbal spray composition for external fissures is an anti-crack agent, and wherein the herbal spray composition for external fissures relieves myalgia, and wherein the herbal spray composition for external fissures removes external inflammations through lymphatic vessels recovery, and wherein the herbal spray composition for external fissures prevents chronic wounds, and wherein the herbal extract mixture for external fissures comprises of small molecules, and wherein the small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers, and wherein the herbal spray composition for external fissures applied or administered twice a day on the area of the wound or fissures, and wherein the herbal composition for external fissures or spray is sprayed/ administered at a quantity of 2ml on the anus twice a day, preferably the external fissures treatment spray is sprayed/ administered once in the morning and once at night, and wherein the colour of the herbal spray composition for external fissures is cream, and wherein the density of the herbal composition for external fissures is 0.99g/cm³, and wherein the pH of the herbal composition for external fissures is 2.89, and wherein the average volume of the herbal composition for external fissures is 110 ml, and wherein the herbal composition for external fissures is opaque, and wherein viscosity of the herbal composition for external fissures is 9.98 m²/s, and wherein the amount of the active constituent in the herbal composition for external fissures is 0.013% w/w, and wherein the amount of flavonoids in the herbal spray composition for external fissures is 0.013% w/w.

4. The method according to claim 1, wherein a method for synthesizing the herbal mixture/spray composition for internal fissures comprises the steps of:

cleaning the Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot to remove contaminants;

obtaining the Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis shoot powder after milling the Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis shoot separately;

mixing Matricaria recutita flower powder in a preset ratio with a preset ratio of a solvent, and wherein the Matricaria recutita flower powder and the solvent are mixed in a ratio of 1 :3, and wherein the solvent is water, and wherein the solution of Matricaria recutita flower powder is obtained;

mixing Allium porrum shoot powder in a preset ratio with a preset ratio of a solvent, and wherein the Allium porrum shoot powder and the solvent are mixed in a ratio of 1 :3, and wherein the solvent is water, and wherein the solution of Allium porrum shoot powder is obtained; mixing Apium graveolens stalk powder in a preset ratio with a preset ratio of a solvent, and wherein the Apium graveolens stalk powder and the solvent are mixed in a ratio of 1 :3, and wherein the solvent is water, and wherein the solutions of Apium graveolens stalk powder is obtained;

mixing Fumaria officinalis stalk powder in a preset ratio with a preset ratio of a solvent, and wherein the Fumaria officinalis stalk powder and the solvent are mixed in a ratio of 1 :3, and wherein the solvent is water, and wherein the solutions of Fumaria officinalis stalk powder is obtained;

heating the solutions of Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis stalk powder separately for 4 hours;

filtering the solutions of Matricaria recutita flower powder, Allium porrum shoot powder, Apium graveolens stalk powder and Fumaria officinalis stalk powder after 4 hours;

obtaining a filtrate, and wherein the filtrate comprises of herbal extracts of Matricaria recutita flower, Allium porrum shoot, Apium graveolens stalk and Fumaria officinalis stalk;

mixing the herbal extracts of Matricaria recutita flower, Allium porrum shoot,

Apium graveolens stalk and Fumaria officinalis stalk to get a mixture;

adding honey to the mixture to obtain herbal extract mixture;

blending the herbal extract mixture in a mixer to attain consistency;

filtering and pasteurizing the herbal extract mixture;

storing the herbal extract mixture in containers; and wherein the containers are polyethylene terephthalate (PET) containers, and wherein for the synthesis of the herbal mixture/spray composition for internal fissures a Matricaria recutita flower extract is mixed with a Allium porrum shoot extract, a Apium graveolens stalk extract, Fumaria officinalis shoot extract and honey, and wherein Matricaria recutita flower extract is mixed in a preset quantity of 3.25 ml, and wherein Allium porrum shoot extract is mixed in a preset quantity of 3.15 ml, and wherein Apium graveolens stalk extract is mixed in a preset quantity of 2.25 ml, and wherein the Fumaria officinalis shoot extract is mixed in a preset quantity of 0.9 ml and wherein the honey is mixed in a preset quantity of 0.45 ml.

5. The method according to claim 1, wherein the herbal mixture/spray composition for internal fissures is a laxative agent, and wherein the herbal spray composition for internal fissuresis a tranquilizer agent, and wherein the herbal spray composition for internal fissuresis an anti-bleeding agent, and wherein the herbal spray composition for internal fissuresis an intestinal antiseptic, and wherein the herbal spray composition for internal fissuresis an internal wound tranquilizer, and wherein the herbal spray composition for internal fissuresremoves internal swelling, and wherein the herbal extract mixture for internal fissurescomprises of small molecules, and wherein the small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers, and wherein the herbal extract mixture for internal fissuresmakes defecation easy without difficulty, and wherein the herbal extract mixture for internal fissuresregulates intestinal peristalsis and heals wounds, and wherein the herbal mixture/spray composition for internal fissures is applied or administered twice a day on the area of the wound or fissures, and wherein the herbal composition for internal fissuresor spray is administered/injected in anus in a quantity of 2ml on the anus twice a day, preferably the internal fissurestreatment spray is sprayed/ administered once in the morning and once at night, and wherein the colour of the herbal composition mixture/spray for internal fissuresis cream, and wherein the density of the herbal composition for internal fissuresis 0.99 g/cm³, and wherein the pH of the herbal composition for internal fissuresis 2.89, and wherein the average volume of the herbal composition for internal fissuresis 110 ml, and wherein the herbal composition for internal fissuresis opaque, and wherein viscosity of the herbal composition for internal fissuresis 9.98 m²/s, and wherein the amount of the active constituent in the herbal composition for internal fissuresis 0.013% w/w, and wherein the amount of flavonoids in the herbal composition for internal haemorrhoids is 0.013% w/w.

6. The method according to claim 1, wherein a method for synthesizing the anti- constipation topical oil for constipation comprises the steps of:

cleaning sesame seeds and castor seeds to remove contaminants;

crushing the sesame seeds for extracting sesame seed shells and obtaining seed kernels;

synthesizing a dough from the sesame seed kernel;

applying pressure to the sesame seed kernel dough at a low temperature; extracting oil from the sesame seed kernel dough by cold pressing, and wherein the concentration of extracted oil from sesame seed kernel dough is 38-50% v/v; removing castor seed shells to obtain the castor seeds;

applying a hydraulic pressure on castor oil seeds in a low temperature for extracting castor oil;

refining the castor oil, and wherein the concentration of refined castor oil is 33% v/v;

mixing the sesame seed oil and the castor oil to obtain an oil mixture;

blending the oil mixture to attain uniform consistency;

filtering the oil mixture;

storing the oil mixture in containers, and wherein the containers are polyethylene terephthalate (PET) containers; and

wherein for the synthesis of the anti-constipation topical oil for constipation Sesamum indicum oil is mixed with the Ricinus communis oil, and wherein the Sesamum indicum oil is mixed in a preset quantity of 60% v/v, and wherein Ricinus communis oil is mixed in a preset quantity of 40% v/v, and wherein the anti-constipation topical oil for constipation is administered in a quantity of 2 ml, and wherein the anti-constipation topical oil is injected into anus by a syringe, and wherein preferably the anti-constipation topical oil is administered in the morning and at midnight, wherein the anti-constipation topical oil is negative for the growth of plurality of bacterial species, and wherein the bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

The method according to claim 1, wherein the colour of the herbal composition for anti-constipation topical oil is cream, and wherein the density of the anti- constipation topical oil is 0.89 g/cm³, and wherein the pH of the anti-constipation topical oil is 4.46, and wherein the average weight of the anti-constipation topical oil is 25 ml, and wherein viscosity of the anti-constipation topical oil is 2690 m²/s, and wherein the amount of acidity of anti-constipation topical oil is 2.24.

The method according to claim 1, wherein the anti-constipation topical oil is a laxative agent, and wherein the anti-constipation topical oil is a healing agent, and wherein the anti-constipation topical oil is tranquilizer, and wherein the anti- constipation topical oil makes defecation smooth, and wherein the anti- constipation topical oil stops pressure on anus and rectum, and wherein the anti- constipation topical oil relieves pain and stops bleeding.

The method according to claim 1, wherein a method for synthesizing the anti- crack ointment for cracked tissues in and around anus comprises the steps of: cleaning sesame seeds and olive fruits to remove contaminants;

synthesizing a dough from the sesame seed kernel;

applying pressure to the sesame seed kernel dough at a low temperature;

extracting oil from the sesame seed kernel dough by cold pressing, and wherein the concentration of extracted oil from sesame seed kernel dough is 38-50% v/v; crushing the olive fruits at a low temperature;

synthesizing a dough from the crushed olive fruits;

applying a hydraulic pressure on the dough of the olive fruits in a low temperature for extracting olive oil;

mixing the sesame seed oil and the olive oil to obtain an oil mixture;

heating spermaceti for melting at a temperature of 70°C;

adding the oil mixture to the molten spermaceti with constant stirring, and wherein the oil mixture and spermaceti mixture is constantly stirred till spermaceti cools;

blending the oil mixture with spermaceti to attain uniform consistency;

obtaining the anti-crack ointment;

sampling the anti-crack ointment;

storing the anti-crack ointment in containers, and wherein the containers are polyethylene terephthalate (PET) containers; and

wherein for the synthesis of the anti-crack ointment for cracked tissues in and around anus Sesamum indicum oil and Olea europaea oil are mixed with the spermaceti, and wherein the Sesamum indicum oil is mixed in a preset quantity of 60% v/v, and wherein Olea europaea oil is mixed in a preset quantity of 34% v/v, and wherein the spermaceti is mixed in a preset quantity of 6%v/v, and wherein the anti-crack ointment for cracked tissues in and around anusis appliedtwice in a day, and wherein preferably the anti-crack ointment for cracked tissues in and around anus is administered in the morning and at night.

10. The method according to claim 1, wherein the colour of the anti-crack ointment for cracked tissues in and around anus is cream, and wherein the density of the anti-crack ointment for cracked tissues in and around anus is 0.89 g/cm³, and wherein the pH of the anti-crack ointment for cracked tissues in and around anus is 4.46, and wherein the average weight of the anti-crack ointment for cracked tissues in and around anus is 25 gram, and wherein viscosity of the anti-crack ointment for cracked tissues in and around anus is 2690 mVs.

11. An integrated herbal composition for targeting fissures with plurality or combination of herbal compositions, the integrated composition comprises of: a herbal spray composition for external fissures;

a herbal mixture composition for internal fissures; and

an anti-constipation topical oil; and

anti-crack ointment for cracked tissues in and around anus.

12. The composition according to claim 11, wherein in the composition of herbal spray composition for external fissures comprises a Matricaria recutita extract, an Aloe vera extract, an Althaea officinalis and a Crocus sativus extract, and wherein the Matricaria recutita extract is present in a preset quantity of 4.6 ml, and wherein the Aloe vera extract is present in a preset quantity of 4.1 ml, and wherein the Crocus sativus extract is present in a preset quantity of 2.0 ml, and wherein the Althaea officinalis extract is present in a preset quantity of 2.0 ml, and wherein the herbal spray composition for external fissures is negative for the growth of plurality of bacterial species, and wherein the bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

13. The composition according to claim 11, wherein the herbal spray composition for external fissures is an anti- inflammatory agent, and wherein the herbal spray composition for external fissures is an anti-crack agent, and wherein the herbal spray composition for external fissures relieves myalgia, and wherein the herbal spray composition for external fissures removes external inflammations through lymphatic vessels recovery, and wherein the herbal spray composition for external fissures prevents chronic wounds, and wherein the herbal extract mixture for external fissures comprises of small molecules, and wherein the small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers.

14. The composition according to claim 11, wherein the colour of the herbal composition for external fissures is cream, and wherein the density of the herbal composition for external fissures is 0.99 g/cm³, and wherein the pH of the herbal composition for external fissuresis 2.89, and wherein the average volume of the herbal composition for external fissures is 110 ml, and wherein the herbal composition for external fissures is opaque, and wherein viscosity of the herbal composition for external fissures is 9.98 m²/s, and wherein the amount of the active constituent in the herbal composition for external fissures is 0.013% w/w, and wherein the amount of flavonoids in i/zeherbal composition for external fissures is 0.013% w/w.

15. The composition according to claim 11, wherein the composition of herbal mixture/spray composition for internal fissures comprises a Matricaria recutita flower extract, a Allium porrum shoot extract, a Apium graveolens stalk extract, Fumaria officinalis shoot extract and honey, and wherein Matricaria recutita flower extract is present in a preset quantity of 3.25 ml, and wherein Allium porrum shoot extract is present in a preset quantity of 3.15 ml, and wherein Apium graveolens stalk extract is present in a preset quantity of 2.25 ml, and wherein Fumaria officinalis shoot extract is present in a preset quantity of 0.9 ml, and wherein the honey is present in a preset quantity of 0.45 ml.

16. The composition according to claim 11, wherein the herbal mixture/spray composition for internal fissures is a laxative agent, and wherein the herbal mixture/spray composition for internal fissures is a tranquilizer agent, and wherein the herbal mixture/spray composition for internal fissures is an anti- bleeding agent, and wherein the herbal mixture/spray composition for internal fissures is an intestinal antiseptic, and wherein the herbal mixture/spray composition for internal fissures is an internal wound tranquilizer, and wherein the herbal mixture/spray composition for internal fissuresremoves internal swelling, and wherein the herbal extract mixture/spray for internal fissures comprises of small molecules, and wherein the small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers, and wherein the herbal extract mixture/spray for internal fissures makes defecation easy without difficulty, and wherein the herbal extract mixture for internal fissures regulates intestinal peristalsis and heals wounds.

17. The composition according to claim 11, wherein the colour of the herbal mixture/spray composition for internalfissures is cream, and wherein the density of the herbal composition for internal fissures is 0.99 g/cm³, and wherein the pH of the herbal composition for internal fissures is 2.89, and wherein the average volume of the herbal composition for internal fissures is 110 ml, and wherein the herbal composition for internal fissures is opaque, and wherein viscosity of the herbal composition for internal fissures is 9.98 m²/s, and wherein the amount of the active constituent in the herbal composition for internal fissures is 0.013% w/w, and wherein the amount of flavonoids in i/zeherbal mixture/spray composition for internal fissures is 0.013% w/w.

18. The composition according to claim 11, wherein the anti- constipation topical oil for constipation comprises a Sesamum indicum oil, a Ricinus communis oil, and wherein the Sesamum indicum oil is present in a preset quantity of 60% v/v, and wherein Ricinus communis oil is present in a preset quantity of 40% v/v, and wherein the anti-constipation topical oil is negative for the growth of plurality of bacterial species, and wherein the bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus, and wherein the colour of the herbal composition for anti- constipation topical oil is cream, and wherein the density of the anti-constipation topical oil is 0.89 g/cm³, and wherein the pH of the anti-constipation topical oil is 4.46, and wherein the average weight of the anti-constipation topical oil is 25 ml, and wherein viscosity of the anti-constipation topical oil is 2690 m²/s, and wherein the amount of acidity of anti-constipation topical oil is 2.24, and wherein the anti-constipation topical oil is a laxative agent, and wherein the anti-constipation topical oil is a healing agent, and wherein the anti-constipation topical oil is tranquilizer, and wherein the anti-constipation topical oil makes defecation smooth, and wherein the anti- constipation topical oil stops pressure on anus and rectum, and wherein the anti- constipation topical oil relieves pain and stops bleeding.

19. The composition according to claim 11, wherein the anti-crack ointment for cracked tissue in and around anus comprises an Olea europaea oil, a Sesamum indicum oil and spermaceti, and wherein the Olea europaea oil is present in a present quantity of 34% v/v, and wherein Sesamum indicum oil is present in a present in a preset quantity of 60% v/v, and wherein the spermaceti is preset in a preset quantity of 6% v/v, and wherein the spermaceti is an excipient.

20. The composition according to claim 11, wherein the colour of the anti-crack ointment for cracked tissue in and around anus is cream, and wherein the density of the anti-crack ointment for cracked tissue in and around anus is 0.88 g/cm³, and wherein the pH of the anti-crack ointment for cracked tissue in and around anus is 4.46, and wherein the average weight of the anti-crack ointment for cracked tissue in and around anus is 25 gram, and wherein viscosity of the anti-crack ointment for cracked tissue in and around anus is 2690 m²/s, and wherein the anti-crack ointment for cracked tissue in and around anus is a laxative agent, and wherein the anti-crack ointment for cracked tissue in and around anus is a healing agent, and wherein the anti-crack ointment for cracked tissue in and around anus is tranquilizer, and wherein the anti-crack ointment for cracked tissue in and around anus makes defecation smooth, and wherein the anti-crack ointment for cracked tissue in and around anus stops pressure on anus and damaged tissues, and wherein the anti-crack ointment for cracked tissue in and around anus relieves pain and stops bleeding in damaged tissues, and wherein the anti-crack ointment for cracked tissue in and around anus heals the damaged and torn tissues.