DK2708558T3 - Antigenbindende molekyle, som er i stand til gentagne at binde to eller flere antigenmolekyler - Google Patents
Antigenbindende molekyle, som er i stand til gentagne at binde to eller flere antigenmolekyler Download PDFInfo
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- DK2708558T3 DK2708558T3 DK13195713.6T DK13195713T DK2708558T3 DK 2708558 T3 DK2708558 T3 DK 2708558T3 DK 13195713 T DK13195713 T DK 13195713T DK 2708558 T3 DK2708558 T3 DK 2708558T3
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- antigen
- binding
- antibody
- binding molecule
- antibodies
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Claims (2)
1. Fremgangsmåde til screening for et antistof fra et antistofbibliotek til anvendelse i en farmaceutisk sammensætning, som omfattende følgende trin: (a) bestemmelse af den antigenbindende aktivitet for et antistof fra biblioteket ved pH 6,7 til pH 10,0; (b) bestemmelse af den antigenbindende aktivitet for antistoffet ved pH 4,0 til pH 6,5; og (c) udvælgelse af et antistof fra bibliotektet, hvis antigenbindende aktivitet ved pH 6,7 til 10,0 er større end den antigenbindende aktivitet ved pH 4,0 til pH 6,5; hvor antigenet er et membranantigen eller et opløseligt antigen.
2. Screeningsfremgangsmåde ifølge krav 1, som omfatter trinnet med at vælge et antistof, hvis antigenbindende aktivitet ved pH 6,7 til pH 10,0 er dobbelt så høj eller højere end den antigenbindende aktivitet ved pH 4,0 til pH 6,5. d
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EP09729337.7A EP2275443B1 (en) | 2008-04-11 | 2009-04-10 | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
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DK13195713.6T DK2708558T3 (da) | 2008-04-11 | 2009-04-10 | Antigenbindende molekyle, som er i stand til gentagne at binde to eller flere antigenmolekyler |
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