CY1112365T1 - Εξανθρωπισμος του μυοειδους αντισωματος - Google Patents

Εξανθρωπισμος του μυοειδους αντισωματος

Info

Publication number
CY1112365T1
CY1112365T1 CY20121100047T CY121100047T CY1112365T1 CY 1112365 T1 CY1112365 T1 CY 1112365T1 CY 20121100047 T CY20121100047 T CY 20121100047T CY 121100047 T CY121100047 T CY 121100047T CY 1112365 T1 CY1112365 T1 CY 1112365T1
Authority
CY
Cyprus
Prior art keywords
antibody
enlargement
complementarity determining
determining region
grafted onto
Prior art date
Application number
CY20121100047T
Other languages
English (en)
Inventor
Carlos F Barbas Iii
Christoph Rader
Original Assignee
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25532007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1112365(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Scripps Research Institute filed Critical The Scripps Research Institute
Publication of CY1112365T1 publication Critical patent/CY1112365T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Παρέχεται εξανθρωπισμένο μυοειδές αντίσωμα. Οι ακολουθίες αμινοξέων μιας περιοχής καθορισμού συμπληρωματικότητας ελαφριών αλυσίδων από ένα αντίσωμα ποντικού, μοσχεύονται επάνω σε μια ανθρώπινη ελαφριά αλυσίδα, και μιας περιοχή καθορισμού συμπληρωματικότητας βαριών αλυσίδων από ένα αντίσωμα ποντικού, μοσχεύονται επάνω σε μια ανθρώπινη βαριά αλυσίδα αντισωμάτων για παραγωγή βιβλιοθηκών, από τις οποίες επιλέγεται ένα εξανθρωπισμένο μυοειδές αντίσωμα που έχει την επιθυμητή εξειδίκευση.
CY20121100047T 1997-12-05 2012-01-17 Εξανθρωπισμος του μυοειδους αντισωματος CY1112365T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98601697A 1997-12-05 1997-12-05
EP98960758A EP1034298B1 (en) 1997-12-05 1998-12-04 Humanization of murine antibody

Publications (1)

Publication Number Publication Date
CY1112365T1 true CY1112365T1 (el) 2015-12-09

Family

ID=25532007

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100047T CY1112365T1 (el) 1997-12-05 2012-01-17 Εξανθρωπισμος του μυοειδους αντισωματος

Country Status (13)

Country Link
US (1) US7087409B2 (el)
EP (1) EP1034298B1 (el)
JP (1) JP4460155B2 (el)
AT (1) ATE531812T1 (el)
AU (1) AU760562B2 (el)
BR (1) BR9813365A (el)
CA (1) CA2312208C (el)
CY (1) CY1112365T1 (el)
DK (1) DK1034298T3 (el)
ES (1) ES2375931T3 (el)
IL (2) IL136544A0 (el)
PT (1) PT1034298E (el)
WO (1) WO1999029888A1 (el)

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