DE69838062D1 - Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor - Google Patents

Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor

Info

Publication number
DE69838062D1
DE69838062D1 DE69838062T DE69838062T DE69838062D1 DE 69838062 D1 DE69838062 D1 DE 69838062D1 DE 69838062 T DE69838062 T DE 69838062T DE 69838062 T DE69838062 T DE 69838062T DE 69838062 D1 DE69838062 D1 DE 69838062D1
Authority
DE
Germany
Prior art keywords
growth factor
factor receptor
epidermal growth
human monoclonal
monoclonal antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69838062T
Other languages
English (en)
Other versions
DE69838062T2 (de
Inventor
Aya Jakobovits
Xiao-Dong Yang
Michael Gallo
Xiao-Chi Jia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Fremont Inc
Original Assignee
Amgen Fremont Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Fremont Inc filed Critical Amgen Fremont Inc
Publication of DE69838062D1 publication Critical patent/DE69838062D1/de
Application granted granted Critical
Publication of DE69838062T2 publication Critical patent/DE69838062T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
DE69838062T 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor Expired - Lifetime DE69838062T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US851362 1997-05-05
US08/851,362 US6235883B1 (en) 1997-05-05 1997-05-05 Human monoclonal antibodies to epidermal growth factor receptor
PCT/US1998/009160 WO1998050433A2 (en) 1997-05-05 1998-05-05 Human monoclonal antibodies to epidermal growth factor receptor

Publications (2)

Publication Number Publication Date
DE69838062D1 true DE69838062D1 (de) 2007-08-23
DE69838062T2 DE69838062T2 (de) 2008-01-31

Family

ID=25310591

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69838062T Expired - Lifetime DE69838062T2 (de) 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor
DE122008000009C Pending DE122008000009I1 (de) 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE122008000009C Pending DE122008000009I1 (de) 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor

Country Status (17)

Country Link
US (1) US6235883B1 (de)
EP (3) EP0979246B1 (de)
JP (9) JP3757986B2 (de)
KR (1) KR100558110B1 (de)
AT (1) ATE366747T1 (de)
AU (1) AU7287098A (de)
CA (1) CA2288962C (de)
CY (2) CY1107708T1 (de)
DE (2) DE69838062T2 (de)
DK (1) DK0979246T3 (de)
ES (1) ES2289779T3 (de)
FR (1) FR08C0006I2 (de)
HK (1) HK1027114A1 (de)
LU (1) LU91411I2 (de)
NL (1) NL300335I2 (de)
PT (1) PT979246E (de)
WO (1) WO1998050433A2 (de)

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