EA200100698A1 - Моноклональные антитела человека к ctla-4 - Google Patents

Моноклональные антитела человека к ctla-4

Info

Publication number
EA200100698A1
EA200100698A1 EA200100698A EA200100698A EA200100698A1 EA 200100698 A1 EA200100698 A1 EA 200100698A1 EA 200100698 A EA200100698 A EA 200100698A EA 200100698 A EA200100698 A EA 200100698A EA 200100698 A1 EA200100698 A1 EA 200100698A1
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EA
Eurasian Patent Office
Prior art keywords
antibodies
ctla
human monoclonal
monoclonal antibodies
heavy
Prior art date
Application number
EA200100698A
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English (en)
Other versions
EA006972B1 (ru
Inventor
Дуглас Чарльз Хансон
Марк Джозеф Невью
Ейлин Эллиотт Мюллер
Джеффри Герберт Ханк
Стивен Кристофер Гилман
К. Джеффри Дэвис
Хосе Рамон Корвалан
Original Assignee
Пфайзер Инк.
Абдженикс, Инк.
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Application filed by Пфайзер Инк., Абдженикс, Инк. filed Critical Пфайзер Инк.
Publication of EA200100698A1 publication Critical patent/EA200100698A1/ru
Publication of EA006972B1 publication Critical patent/EA006972B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

В соответствии с настоящим изобретением предлагаются полностью человеческие моноклональные антитела против антигена 4 цитотоксических T-лимфоцитов человека (CTLA-4). Предлагаются последовательности нуклеотидов, кодирующие аминокислотные последовательности, включающие молекулы тяжелых и легких цепей иммуноглобулинов, в частности прилегающие последовательности тяжелых и легких цепей, охватывающие районы, определяющие комплементарность (CDRs), особенно от FR1 и/или CDR1 до CDR3 включительно и/или в пределах FR4. Дополнительно предлагаются антитела, имеющие сходные связывающие свойства, и антитела (или другие антагонисты), имеющие функциональные свойства, сходные с раскрытыми здесь антителами.Отчет о международном поиске был опубликован 2000.09.14.
EA200100698A 1998-12-23 1999-12-23 Моноклональное антитело человека к ctla-4 и способы его применения EA006972B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11364798P 1998-12-23 1998-12-23
PCT/US1999/030895 WO2000037504A2 (en) 1998-12-23 1999-12-23 Human monoclonal antibodies to ctla-4

Publications (2)

Publication Number Publication Date
EA200100698A1 true EA200100698A1 (ru) 2001-12-24
EA006972B1 EA006972B1 (ru) 2006-06-30

Family

ID=22350712

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100698A EA006972B1 (ru) 1998-12-23 1999-12-23 Моноклональное антитело человека к ctla-4 и способы его применения

Country Status (41)

Country Link
EP (3) EP1141028B1 (ru)
JP (2) JP3793693B2 (ru)
KR (3) KR100617337B1 (ru)
CN (1) CN1328571B (ru)
AP (1) AP1590A (ru)
AT (1) ATE458008T1 (ru)
AU (1) AU772676B2 (ru)
BG (1) BG65899B1 (ru)
BR (2) BRPI9916853B8 (ru)
CA (1) CA2356215C (ru)
CR (2) CR6425A (ru)
CU (1) CU23292B7 (ru)
CY (1) CY1121451T1 (ru)
CZ (2) CZ302706B6 (ru)
DE (1) DE69942037D1 (ru)
DK (2) DK2112166T3 (ru)
EA (1) EA006972B1 (ru)
EE (1) EE05483B1 (ru)
ES (2) ES2706547T3 (ru)
GE (1) GEP20053594B (ru)
HK (1) HK1041274B (ru)
HR (2) HRP20010551B1 (ru)
HU (2) HU1300750D0 (ru)
ID (1) ID29991A (ru)
IL (2) IL143797A0 (ru)
IS (2) IS2798B (ru)
LT (1) LT2112166T (ru)
MX (1) MXPA01006422A (ru)
NO (2) NO332618B1 (ru)
NZ (1) NZ512553A (ru)
OA (1) OA11917A (ru)
PL (2) PL210435B1 (ru)
PT (2) PT1141028E (ru)
RS (1) RS51309B (ru)
SG (2) SG156547A1 (ru)
SI (2) SI1141028T1 (ru)
SK (2) SK288274B6 (ru)
TR (2) TR200200735T2 (ru)
UA (1) UA76936C2 (ru)
WO (1) WO2000037504A2 (ru)
ZA (1) ZA200105742B (ru)

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