YU45501A - Humana monoklonalna antitela za ctla-4 - Google Patents

Humana monoklonalna antitela za ctla-4

Info

Publication number
YU45501A
YU45501A YU45501A YU45501A YU45501A YU 45501 A YU45501 A YU 45501A YU 45501 A YU45501 A YU 45501A YU 45501 A YU45501 A YU 45501A YU 45501 A YU45501 A YU 45501A
Authority
YU
Yugoslavia
Prior art keywords
antibodies
ctla
human monoclonal
monoclonal antibodies
light chain
Prior art date
Application number
YU45501A
Other languages
English (en)
Inventor
Douglas Charles Hanson
Mark Joseph Neveu
Elleen Elliot Muller
Jeffrey Herbert Hanke
Steven Christopher Gilman
C. Geoffrey Davis
Jose Ramon Corvalan
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU45501A publication Critical patent/YU45501A/sh
Publication of RS51309B publication Critical patent/RS51309B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

U saglasnosti sa ovim pronalaskom, obezbedjena su potpuna humana monoklonalna antitela protiv humanog citotoksičnog T-limfocitnog antigena 4 (CTLA-4). Nukleotidne sekvence koje kodiraju i amino kiselinske sekvence koje obuhvataju teških i lakih lanaca imunoglobulin molekule, naročito susedne teških i lakih lanaca sekvence koje se protežu preko komplementarnih odredjujućih regiona (CDRs), specifično od unutar FR1 i/ili CDR1 do CDR3 i/ili unutar FR4 su ovime obezbedjeni. Dalje su obezbedjena antitela koja imaju slične osobine vezivanja i antitela (ili drugi antagonisti) koji imaju slične funkcionalnosti kao antitela opisana ovde.[In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T- lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. Also provided is a cell culture system for assaying T cell stimulation.
YUP-455/01A 1998-12-23 1999-12-23 Humana monoklonalna antitela za ctla-4 RS51309B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11364798P 1998-12-23 1998-12-23

Publications (2)

Publication Number Publication Date
YU45501A true YU45501A (sh) 2005-07-19
RS51309B RS51309B (sr) 2010-12-31

Family

ID=22350712

Country Status (41)

Country Link
EP (3) EP2112166B1 (sh)
JP (2) JP3793693B2 (sh)
KR (3) KR100849443B1 (sh)
CN (1) CN1328571B (sh)
AP (1) AP1590A (sh)
AT (1) ATE458008T1 (sh)
AU (1) AU772676B2 (sh)
BG (1) BG65899B1 (sh)
BR (2) BR9916853A (sh)
CA (1) CA2356215C (sh)
CR (2) CR6425A (sh)
CU (1) CU23292B7 (sh)
CY (1) CY1121451T1 (sh)
CZ (2) CZ303703B6 (sh)
DE (1) DE69942037D1 (sh)
DK (2) DK1141028T3 (sh)
EA (1) EA006972B1 (sh)
EE (1) EE05483B1 (sh)
ES (2) ES2706547T3 (sh)
GE (1) GEP20053594B (sh)
HK (1) HK1041274B (sh)
HR (2) HRP20010551B1 (sh)
HU (2) HU1300750D0 (sh)
ID (1) ID29991A (sh)
IL (2) IL143797A0 (sh)
IS (2) IS2798B (sh)
LT (1) LT2112166T (sh)
MX (1) MXPA01006422A (sh)
NO (2) NO332618B1 (sh)
NZ (1) NZ512553A (sh)
OA (1) OA11917A (sh)
PL (2) PL214003B1 (sh)
PT (2) PT1141028E (sh)
RS (1) RS51309B (sh)
SG (2) SG156547A1 (sh)
SI (2) SI1141028T1 (sh)
SK (2) SK288057B6 (sh)
TR (2) TR200200735T2 (sh)
UA (1) UA76936C2 (sh)
WO (1) WO2000037504A2 (sh)
ZA (1) ZA200105742B (sh)

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