BR112023024169A2 - Métodos para avaliar lesão cerebral em um indivíduo pediátrico - Google Patents

Métodos para avaliar lesão cerebral em um indivíduo pediátrico

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Publication number
BR112023024169A2
BR112023024169A2 BR112023024169A BR112023024169A BR112023024169A2 BR 112023024169 A2 BR112023024169 A2 BR 112023024169A2 BR 112023024169 A BR112023024169 A BR 112023024169A BR 112023024169 A BR112023024169 A BR 112023024169A BR 112023024169 A2 BR112023024169 A2 BR 112023024169A2
Authority
BR
Brazil
Prior art keywords
methods
brain injury
gfap
uch
pediatric
Prior art date
Application number
BR112023024169A
Other languages
English (en)
Inventor
Beth Mcquiston
Hongwei Zhang
Jaime Marino
Raj Chandran
Saul Datwyler
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR112023024169A2 publication Critical patent/BR112023024169A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Abstract

métodos para avaliar lesão cerebral em um indivíduo pediátrico. são revelados no presente documento métodos e kits para uso nesses métodos, que auxiliam no diagnóstico e avaliação de um indivíduo pediátrico para lesão cerebral traumática (tbi), utilizando ubiquitina hidrolase carboxi-terminal l1 (uch-l1), proteína glial fibrilar ácida ( gfap) ou uma combinação dos mesmos. também são revelados no presente documento métodos e kits para uso nos ditos métodos, que auxiliam na determinação se um indivíduo pediátrico se beneficiaria e, portanto, receberia um procedimento de imageamento, como ressonância magnética ou tomografia computadorizada (ct) da cabeça com base nos níveis de gfap, uch-l1 ou gfap e uch-l1.
BR112023024169A 2021-05-18 2022-05-18 Métodos para avaliar lesão cerebral em um indivíduo pediátrico BR112023024169A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163189757P 2021-05-18 2021-05-18
US202163192370P 2021-05-24 2021-05-24
PCT/US2022/029798 WO2022245920A1 (en) 2021-05-18 2022-05-18 Methods of evaluating brain injury in a pediatric subject

Publications (1)

Publication Number Publication Date
BR112023024169A2 true BR112023024169A2 (pt) 2024-02-06

Family

ID=81975040

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023024169A BR112023024169A2 (pt) 2021-05-18 2022-05-18 Métodos para avaliar lesão cerebral em um indivíduo pediátrico

Country Status (6)

Country Link
US (1) US20220381796A1 (pt)
EP (1) EP4341699A1 (pt)
AU (1) AU2022279156A1 (pt)
BR (1) BR112023024169A2 (pt)
CA (1) CA3216320A1 (pt)
WO (1) WO2022245920A1 (pt)

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Also Published As

Publication number Publication date
WO2022245920A1 (en) 2022-11-24
US20220381796A1 (en) 2022-12-01
AU2022279156A1 (en) 2023-11-02
CA3216320A1 (en) 2022-11-24
EP4341699A1 (en) 2024-03-27
AU2022279156A9 (en) 2023-11-16
WO2022245920A9 (en) 2023-01-19

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