DE69231382T2 - Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden - Google Patents

Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden

Info

Publication number
DE69231382T2
DE69231382T2 DE69231382T DE69231382T DE69231382T2 DE 69231382 T2 DE69231382 T2 DE 69231382T2 DE 69231382 T DE69231382 T DE 69231382T DE 69231382 T DE69231382 T DE 69231382T DE 69231382 T2 DE69231382 T2 DE 69231382T2
Authority
DE
Germany
Prior art keywords
binding
test procedures
simultaneous determination
multiple ligands
binding domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231382T
Other languages
English (en)
Other versions
DE69231382D1 (de
Inventor
Edwin Valkirs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere San Diego Inc
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Application granted granted Critical
Publication of DE69231382D1 publication Critical patent/DE69231382D1/de
Publication of DE69231382T2 publication Critical patent/DE69231382T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
DE69231382T 1991-04-12 1992-04-07 Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden Expired - Fee Related DE69231382T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68508491A 1991-04-12 1991-04-12
PCT/US1992/002839 WO1992018866A1 (en) 1991-04-10 1992-04-07 Novel conjugates and assays for simultaneous detection of multiple ligands

Publications (2)

Publication Number Publication Date
DE69231382D1 DE69231382D1 (de) 2000-09-28
DE69231382T2 true DE69231382T2 (de) 2001-01-25

Family

ID=24750715

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231382T Expired - Fee Related DE69231382T2 (de) 1991-04-12 1992-04-07 Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden

Country Status (11)

Country Link
US (1) US5851776A (de)
EP (1) EP0579767B1 (de)
JP (1) JP3290988B2 (de)
AT (1) ATE195808T1 (de)
AU (1) AU1911592A (de)
CA (1) CA2107899A1 (de)
DE (1) DE69231382T2 (de)
ES (1) ES2150915T3 (de)
FI (1) FI934438A (de)
NO (1) NO933582L (de)
WO (1) WO1992018866A1 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470997A (en) * 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
AU3941893A (en) * 1992-04-06 1993-11-08 Biosite Diagnostics Incorporated Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
US6037455A (en) * 1992-11-09 2000-03-14 Biosite Diagnostics Incorporated Propoxyphene derivatives and protein and polypeptide propoxyphene derivative conjugates and labels
US5804452A (en) * 1995-04-27 1998-09-08 Quidel Corporation One step urine creatinine assays
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
DE19859912C2 (de) * 1998-12-23 2001-06-21 Aventis Res & Tech Gmbh & Co Testsystem zur Erkennung verschiedener Marker, seine Herstellung sowie Verwendung
CA2399202A1 (en) * 2000-03-09 2001-09-13 Heska Corporation Use of recombinant antigens to determine the immune status of an animal
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
JP4986370B2 (ja) 2000-12-22 2012-07-25 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ Rgmおよびそのモジュレーターの用途
US7632647B2 (en) * 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
EP2261669A1 (de) 2001-05-04 2010-12-15 Alere San Diego, Inc. Diagnostischer Marker akuter Koronarsyndrome und Verfahren zu deren Verwendung
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
JP2005522669A (ja) * 2001-08-20 2005-07-28 バイオサイト インコーポレイテッド 卒中および脳損傷の診断マーカーおよびその使用方法
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
EP1616181B1 (de) 2003-04-17 2009-08-12 Vermillion, Inc. Mit natriuretischen peptiden verwandte polypeptide und verfahren zu ihrer identifizierung und verwendung
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
CA2537668A1 (en) * 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
US6991911B2 (en) * 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US7022492B2 (en) * 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
US20050130243A1 (en) * 2003-12-15 2005-06-16 Zheng Yi F. Assay for entactogens
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents
US7115383B2 (en) * 2004-03-22 2006-10-03 Dade Behring Inc. Assays for amphetamine and methamphetamine
CA2579370A1 (en) * 2004-09-09 2006-03-23 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7879979B2 (en) * 2005-01-21 2011-02-01 Alere International Arginine analogs, and methods for their synthesis and use
US7939342B2 (en) * 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
EP1715341B1 (de) * 2005-04-04 2008-02-27 Micronas Holding GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden
US20070087453A1 (en) * 2005-10-19 2007-04-19 Council Of Scientific And Industrial Research Immuno conjugate and process for preparation thereof
WO2007028070A2 (en) * 2005-08-30 2007-03-08 Biosite, Inc. Use of soluble flt-1 and its fragments in cardiovascular conditions
JP2009510002A (ja) 2005-09-30 2009-03-12 アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 反発誘導分子(rgm)タンパク質ファミリーのタンパク質の結合ドメイン、及びその機能的断片、及びそれらの使用
EP2005168A4 (de) * 2006-03-09 2009-05-20 Biosite Inc Verfahren und zusammensetzung zur diagnose von krankheiten der aorta
EP1845377A1 (de) 2006-04-10 2007-10-17 Micronas GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von Liganden
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
WO2007142540A1 (en) 2006-06-07 2007-12-13 Otago Innovation Limited Diagnostic methods and markers
WO2008094198A2 (en) * 2006-07-28 2008-08-07 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
CN101611318B (zh) 2006-09-07 2015-03-04 奥塔哥创新有限公司 生物标记物
DE502006005987D1 (de) * 2006-10-20 2010-03-11 Micronas Holding Gmbh Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von Liganden
WO2008061149A2 (en) * 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for diagnosis and prognosis of renal artery stenosis
WO2008060607A2 (en) * 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7947465B2 (en) * 2007-08-20 2011-05-24 Bio-Rad Laboratories, Inc. Simultaneous assay for determining drugs
US20090053832A1 (en) * 2007-08-20 2009-02-26 Link William F Simultaneous assay for determining drugs
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
WO2009113879A1 (en) 2008-03-12 2009-09-17 Christopher Joseph Pemberton Biomarkers
JP2011516038A (ja) 2008-03-12 2011-05-26 オタゴ イノベーション リミテッド バイオマーカー
BRPI0917711A2 (pt) 2008-08-28 2017-06-20 Astute Medical Inc método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal
WO2010025434A1 (en) 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2740923A1 (en) 2008-10-21 2010-04-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3974836A1 (de) 2008-10-21 2022-03-30 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
BRPI0922021A2 (pt) 2008-11-10 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal
NZ604873A (en) 2008-11-22 2014-05-30 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20100204055A1 (en) * 2008-12-05 2010-08-12 Bonner-Ferraby Phoebe W Autoantibody detection systems and methods
JP5981144B2 (ja) 2009-02-06 2016-08-31 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断
NZ594771A (en) 2009-02-06 2013-06-28 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and failure
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP2462446B1 (de) 2009-08-07 2017-09-27 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
EP2462440B1 (de) 2009-08-07 2017-05-17 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
JP5775874B2 (ja) 2009-08-28 2015-09-09 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
JP2013513086A (ja) 2009-09-18 2013-04-18 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
NZ599105A (en) 2009-09-21 2014-08-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EA201290192A1 (ru) 2009-11-07 2013-02-28 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
MX2012005210A (es) 2009-11-07 2012-08-03 Astute Medical Inc Metodos y composiciones para diagnostico y pronostico de lesion renal y falla renal.
EP2510001B1 (de) 2009-12-08 2015-12-02 AbbVie Deutschland GmbH & Co KG Monoklonale antikörper gegen das rgm-a-protein zur behandlung von degenerationen der retinalen nervenfaserschicht
CA2784889C (en) 2009-12-20 2018-06-19 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102884205B (zh) 2010-02-05 2016-05-04 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
WO2011097540A1 (en) 2010-02-05 2011-08-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ700695A (en) 2010-02-05 2016-05-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9029093B2 (en) 2010-02-26 2015-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011129382A1 (en) 2010-04-16 2011-10-20 Abbott Japan Co. Ltd. Methods and reagents for diagnosing rheumatoid arthritis
EP2899545B1 (de) 2010-06-23 2018-08-22 Astute Medical, Inc. Verfahren zur diagnose und prognose von nierenläsion und niereninsuffizienz
EP2585825B1 (de) 2010-06-23 2018-01-10 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2629850T3 (es) 2010-07-19 2017-08-16 Otago Innovation Limited Biomarcadores de señal
CN106248921A (zh) 2010-09-24 2016-12-21 阿斯图特医药公司 利用透明质酸评价肾损伤的方法和组合物
US10557856B2 (en) 2010-09-24 2020-02-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biomarkers of renal injury
JP2013539861A (ja) 2010-10-07 2013-10-28 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
CN103370619B (zh) 2010-11-29 2016-01-20 美艾利尔圣地亚哥有限公司 诊断或风险预测心力衰竭的方法和试剂
WO2012094658A2 (en) 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2668497B1 (de) 2011-01-26 2020-03-25 University of Pittsburgh - Of the Commonwealth System of Higher Education Urinbiomarker zur vorhersage der erholung nach einer akuten nierenverletzung: proteomik
WO2012103450A2 (en) 2011-01-29 2012-08-02 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3489690A1 (de) 2011-08-26 2019-05-29 Astute Medical, Inc. Methoden und zusammensetzungen für die evaluierung des nierenstatus
IN2014MN00949A (de) 2011-11-22 2015-04-24 Astute Medical Inc
ES2734494T3 (es) 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
AU2012352168C1 (en) 2011-12-14 2018-01-25 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
US9636398B2 (en) 2011-12-14 2017-05-02 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
PL2807192T3 (pl) 2012-01-27 2019-02-28 Abbvie Deutschland Kompozycja oraz sposób diagnostyki i leczenia chorób związanych ze zwyrodnieniem neurytów
CA2865563A1 (en) 2012-02-27 2013-09-06 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2825891A1 (de) 2012-03-13 2015-01-21 AbbVie Inc. Verfahren zur auswahl oder identifikation einer person für eine v1b-antagonisten-therapie
CN104470942B (zh) 2012-03-20 2018-12-14 奥塔哥创新有限公司 生物标志物
US20150293131A1 (en) 2012-04-02 2015-10-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
WO2013163345A1 (en) 2012-04-24 2013-10-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
US20150177260A1 (en) 2012-07-23 2015-06-25 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
EP2882767B1 (de) 2012-08-11 2023-07-12 Astute Medical, Inc. Bewertung von nierenläsionen mithilfe von hyaluronsäure
CA3158996A1 (en) 2013-01-17 2014-07-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9694069B2 (en) 2013-03-14 2017-07-04 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
WO2014197729A1 (en) 2013-06-05 2014-12-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2014197885A2 (en) 2013-06-07 2014-12-11 Duke University Inhibitors of complement factor h
MX2016001573A (es) 2013-08-07 2016-09-07 Astute Medical Inc Ensayos para timp2 con mejor rendimiento en muestras biológicas.
MX2016002375A (es) 2013-08-23 2016-12-20 Reata Pharmaceuticals Inc Métodos de tratamiento y prevencion de la disfunción endotelial utilizando metil bardoxololona o sus análogos.
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015179773A1 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
US10794917B2 (en) 2013-09-20 2020-10-06 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
CA2929547C (en) 2013-11-06 2023-02-28 Astute Medical, Inc. Assays for igfbp7 having improved performance in biological samples
WO2015084939A1 (en) 2013-12-03 2015-06-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2934878A1 (en) 2013-12-30 2015-07-09 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Genomic rearrangements associated with prostate cancer and methods of using the same
EP3825418A3 (de) 2014-05-22 2021-09-15 The Scripps Research Institute Molekulare signaturen zur unterscheidung von lebertransplantatabstossungen oder -verletzungen
WO2015179777A2 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
BR112017008218A2 (pt) 2014-10-20 2018-01-09 Astute Medical Inc métodos e composições para diagnóstico e prognóstico de lesão renal e insuficiência renal
ES2943579T3 (es) 2014-12-18 2023-06-14 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3294416A4 (de) 2015-05-12 2018-11-21 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
US11506672B2 (en) 2015-06-11 2022-11-22 Astute Medical, Inc. Follistatin-related protein 3 for diagnosis and prognosis of renal injury and renal failure
WO2016205740A1 (en) 2015-06-17 2016-12-22 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
CA2992139A1 (en) 2015-07-10 2017-01-19 West Virginia University Markers of stroke and stroke severity
US11209431B2 (en) 2015-10-06 2021-12-28 Bio-Rad Laboratories, Inc. Borrelia immunoassays and materials therefor
AU2017267728B2 (en) 2016-05-18 2021-11-04 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
CN109844526A (zh) 2016-06-06 2019-06-04 机敏医药股份有限公司 使用胰岛素样生长因子结合蛋白7和金属蛋白酶2的组织抑制剂管理急性肾损伤
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
JP2019535015A (ja) 2016-10-03 2019-12-05 アボット・ラボラトリーズAbbott Laboratories 患者サンプルにおけるgfap状況を評価する改善された方法
EP3522893A4 (de) 2016-10-04 2020-08-26 University Of Maryland, Baltimore Verfahren zur behandlung von sepsis unter verwendung von therapeutika auf der basis von anti-sepsis-lipid a (asla)
KR102486434B1 (ko) 2016-11-08 2023-01-09 리아타 파마슈티컬즈 홀딩스, 엘엘씨 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법
JP2020504157A (ja) 2017-01-12 2020-02-06 アスチュート メディカル,インコーポレイテッド C−cモチーフケモカインリガンド14の測定に基づく腎損傷および腎不全の評価および処置のための方法および組成物
US20200041492A1 (en) 2017-03-09 2020-02-06 Rijksuniversiteit Groningen Biomarkers for cellular senescence
WO2018175942A1 (en) 2017-03-23 2018-09-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
US10877048B2 (en) 2017-04-15 2020-12-29 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
JP7080899B2 (ja) 2017-04-28 2022-06-06 アボット・ラボラトリーズ 同じヒト対象に由来する少なくとも2つの試料に対して早期バイオマーカーを使用する、外傷性脳損傷の超急性の診断及び決定の一助となるための方法
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
WO2018208684A1 (en) 2017-05-07 2018-11-15 Astute Medical, Inc. Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy
BR112019024701A2 (pt) 2017-05-25 2020-06-09 Abbott Lab métodos para auxiliar na determinação se um exame de imagem deve ser realizado em um indivíduo humano que sofreu ou pode ter sofrido uma lesão na cabeça com o uso de biomarcadores precoces
CA3059601A1 (en) 2017-05-30 2018-12-06 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers
US11169159B2 (en) 2017-07-03 2021-11-09 Abbott Laboratories Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
JP7379165B2 (ja) 2017-12-09 2023-11-14 アボット・ラボラトリーズ Gfapとuch-l1との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法
WO2019113525A2 (en) 2017-12-09 2019-06-13 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
US11891439B2 (en) 2017-12-28 2024-02-06 Astute Medical, Inc. Antibodies and assays for CCL14
WO2019133717A1 (en) 2017-12-29 2019-07-04 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
US20210239700A1 (en) 2018-05-04 2021-08-05 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
EP4043015A1 (de) 2018-09-04 2022-08-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Delta-tocotrienol zur behandlung von krebs
CN113454455A (zh) 2018-12-28 2021-09-28 雅培制药有限公司 微粒上的单分子的直接检测
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
WO2020180695A1 (en) 2019-03-01 2020-09-10 Abbott Laboratories Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease
EP4136459A1 (de) 2020-04-13 2023-02-22 Abbott Laboratories Verfahren, komplexe und kits zum nachweis oder zur bestimmung einer menge eines ss-coronavirus-antikörpers in einer probe
AU2021273460A1 (en) 2020-05-09 2022-12-08 Reata Pharmaceuticals Holdings, LLC Methods of treating covid-19 using bardoxolone methyl or analogs thereof
MX2022015287A (es) 2020-06-01 2023-02-22 Loop Diagnostics S L Metodo y kit para la deteccion temprana de septicemia.
WO2022031804A1 (en) 2020-08-04 2022-02-10 Abbott Laboratories Improved methods and kits for detecting sars-cov-2 protein in a sample
JP2023536737A (ja) 2020-08-04 2023-08-29 アボット・ラピッド・ダイアグノスティクス・インターナショナル・アンリミテッド・カンパニー Sars-cov-2を検出するためのアッセイ
CA3198161A1 (en) 2020-12-01 2022-06-09 Beth MCQUISTON Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
WO2022126129A1 (en) 2020-12-11 2022-06-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids for use in therapy
EP4271998A1 (de) 2020-12-30 2023-11-08 Abbott Laboratories Verfahren zur bestimmung des sars-cov-2-antigens und anti-sars-cov-2-antikörpers in einer probe
AU2022279156A1 (en) 2021-05-18 2023-11-02 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
AU2022293389A1 (en) 2021-06-14 2024-01-04 Abbott Laboratories Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
WO2023028186A1 (en) 2021-08-27 2023-03-02 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
WO2023034777A1 (en) 2021-08-31 2023-03-09 Abbott Laboratories Methods and systems of diagnosing brain injury
WO2023056268A1 (en) 2021-09-30 2023-04-06 Abbott Laboratories Methods and systems of diagnosing brain injury
WO2023114978A1 (en) 2021-12-17 2023-06-22 Abbott Laboratories Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
WO2023129942A1 (en) 2021-12-28 2023-07-06 Abbott Laboratories Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023150652A1 (en) 2022-02-04 2023-08-10 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
WO2023212293A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Complement factor h related 4-specific antibodies and uses thereof
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof
WO2023212298A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Bispecific antibodies and methods of treating ocular disease
WO2024059708A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US4803170A (en) * 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5028535A (en) * 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay

Also Published As

Publication number Publication date
NO933582L (no) 1993-12-10
WO1992018866A1 (en) 1992-10-29
FI934438A0 (fi) 1993-10-08
EP0579767A1 (de) 1994-01-26
US5851776A (en) 1998-12-22
NO933582D0 (no) 1993-10-07
EP0579767B1 (de) 2000-08-23
DE69231382D1 (de) 2000-09-28
AU1911592A (en) 1992-11-17
ATE195808T1 (de) 2000-09-15
JPH06507021A (ja) 1994-08-04
ES2150915T3 (es) 2000-12-16
EP0579767A4 (de) 1995-05-17
FI934438A (fi) 1993-11-04
CA2107899A1 (en) 1992-10-11
JP3290988B2 (ja) 2002-06-10

Similar Documents

Publication Publication Date Title
DE69231382D1 (de) Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden
CA2064915A1 (en) Tumour necrosis factor binding ligands
KR970074793A (ko) 올리고머화된 수용체를 사용한 결정 방법
DE69421582T2 (de) Verfahren für nicht-kompetitive Bindungsassays
CA2007532A1 (en) Threshold ligand-receptor assay
CA2112130A1 (en) Screening Assay for the Detection of DNA-Binding Molecules
ATE221997T1 (de) Immunoassays zum nachweis von antiphospholipid- antikörpern
ES2067604T3 (es) Anticuerpos frente a proteina que se une a tnf i y a sus fragmentos f(ab).
DE68921650T2 (de) Immunoassays.
SE7702464L (sv) Reagens till anvendning vid immunkemiska bestemningsmetoder
DE69022286D1 (de) Reagenzien, Verfahren und Testsätze zum Nachweis von Amphetaminen durch einen Fluoreszenz-Polarisations-Immunoassay.
DE68926779D1 (de) Zusammensetzung und Methoden zur Bestimmung der Anwesenheit von Amphetaminen in einer Probe, die in Verdacht steht, Amphetamine und/oder Metamphetamine zu enthalten
ES2141086T3 (es) Anticuerpos contra los ligando-analogos y su uso en los dosificados ligando-receptores.
RU2004122925A (ru) Система внутренней калибровки проточных тест-систем
KR900002075A (ko) 특이적으로 결합가능한 물질의 정량 방법 및 시약
ATE343597T1 (de) Diagnostisches assay für typ-2-heparin induzierte thrombocytopenie
DE69018968D1 (de) BLUTGERINNUNGSFAKTOR BETA XIIa MONOKLONALE ANTIKÖRPER UND IMMUNANALYSE.
DE69431526D1 (de) Ligand fähig zur bindung an der adenosinedeaminase-bindungsstelle von cd26
KR930702680A (ko) 증폭된 불균질 화학발광 면역 검정법
ES2115750T3 (es) Ensayo de captura de proteinas de union.
DE68919294T2 (de) Bestätigender Nachweis für Chlamydia trachomatis.
CA2021658A1 (en) Multiplex immunoassay system
ATE27494T1 (de) Diagnostisches testsystem.
ATE290211T1 (de) Modulare anordnung zur reagenzlosen affinitätsseparation und detektion von analyten
ATE302949T1 (de) Knorpelresorptionsassays

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee