ES2141086T3 - Anticuerpos contra los ligando-analogos y su uso en los dosificados ligando-receptores. - Google Patents
Anticuerpos contra los ligando-analogos y su uso en los dosificados ligando-receptores.Info
- Publication number
- ES2141086T3 ES2141086T3 ES91308408T ES91308408T ES2141086T3 ES 2141086 T3 ES2141086 T3 ES 2141086T3 ES 91308408 T ES91308408 T ES 91308408T ES 91308408 T ES91308408 T ES 91308408T ES 2141086 T3 ES2141086 T3 ES 2141086T3
- Authority
- ES
- Spain
- Prior art keywords
- ligand
- ligando
- antibodies
- ligand analogue
- dosages
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
- G01N33/541—Double or second antibody, i.e. precipitating antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/822—Identified hapten
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/824—Immunological separation techniques
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
MEDIOS PARA LA DETECCION DE CONJUGADOS DE ANALOGOS DE LIGANDOS LIBRES EN FLUIDOS DE PROCESOS DE ENSAYOS COMPETENTES RECEPTORES DE LIGANDOS. ANTICUERPOS DE ANALOGOS LIGANDOS QUE UNEN EL CONJUGADO DE ANALOGO LIGANDO CON UNA AFINIDAD SUSTANCIALMENTE MAYOR QUE SU AFINIDAD CON LIGANDOS OBJETIVO, SON SELECCIONADOS Y USADOS EN PROCESOS DE ENSAYOS COMPETENTES RECEPTORES DE LIGANDOS, PARA UNIR LA FRACCION LIBRE DEL CONJUGADO ANALOGO LIGANDO. ESTOS MEDIOS PERMITEN LA DETECCION DE LA FRACCION LIBRE DE CONJUGADOS ANALOGOS LIGANDOS AUN EN LA PRESENCIA DE CONCENTRACIONES SUSTANCIALMENTE MAYORES DE LIGANDO OBJETIVO LIBRE. PARA LOS PROPOSITOS DE ESTA INVENCION, LOS ANTICUERPOS DE ANALOGOS LIGANDOS, SON ANTICUERPOS QUE EXHIBEN POR LO MENOS UNA AFINIDAD 100 POR 100 MAYOR PARA EL CONJUGADO ANALOGO LIGANDO COMPARADO A SU AFINIDAD CON EL LIGANDO OBJETIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/583,046 US5143852A (en) | 1990-09-14 | 1990-09-14 | Antibodies to ligand analogues and their utility in ligand-receptor assays |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2141086T3 true ES2141086T3 (es) | 2000-03-16 |
Family
ID=24331471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91308408T Expired - Lifetime ES2141086T3 (es) | 1990-09-14 | 1991-09-13 | Anticuerpos contra los ligando-analogos y su uso en los dosificados ligando-receptores. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5143852A (es) |
EP (1) | EP0475783B1 (es) |
JP (1) | JPH05501922A (es) |
AT (1) | ATE187250T1 (es) |
AU (1) | AU8536191A (es) |
CA (1) | CA2071904C (es) |
DE (1) | DE69131811T2 (es) |
ES (1) | ES2141086T3 (es) |
IE (1) | IE913243A1 (es) |
PT (1) | PT98951B (es) |
WO (1) | WO1992005283A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451504A (en) * | 1991-07-29 | 1995-09-19 | Serex, Inc. | Method and device for detecting the presence of analyte in a sample |
US5233042A (en) * | 1991-12-16 | 1993-08-03 | Biosite Diagnostics, Inc. | Cocaine derivatives |
US5283344A (en) * | 1993-03-10 | 1994-02-01 | Abbott Laboratories | Coupling method using selective amination of maleimide |
US6653066B1 (en) | 1994-06-17 | 2003-11-25 | Trinity Biotech | Device and method for detecting polyvalent substances |
DE19504198A1 (de) * | 1995-02-09 | 1996-08-14 | Behringwerke Ag | Kompetitiver Immuntest unter Verwendung komplexierter Analytderivate |
US6627404B1 (en) * | 1995-04-18 | 2003-09-30 | Biosite, Inc. | Methods for improving the recovery of troponin I and T in membranes, filters and vessels |
US5795725A (en) * | 1995-04-18 | 1998-08-18 | Biosite Diagnostics Incorporated | Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays |
US6991907B1 (en) | 1995-04-18 | 2006-01-31 | Biosite, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
WO1997001755A2 (en) * | 1995-06-26 | 1997-01-16 | Perseptive Biosystems, Inc. | High speed, automated, continuous flow, multi-dimensional molecular selection and analysis |
US6156521A (en) * | 1997-12-19 | 2000-12-05 | Biosite Diagnostics, Inc. | Methods for the recovery and measurement of troponin complexes |
US5817770A (en) | 1997-03-21 | 1998-10-06 | Drug Abuse Sciences, Inc. | Cocaethylene immunogens and antibodies |
US6830731B1 (en) * | 1998-01-05 | 2004-12-14 | Biosite, Inc. | Immunoassay fluorometer |
US6392894B1 (en) | 1998-01-05 | 2002-05-21 | Biosite Incorporated | Media carrier for an assay device |
US7297554B2 (en) * | 1998-11-18 | 2007-11-20 | Microdiagnostics, Inc. | Immunoassay system |
EP1184666A3 (en) * | 2000-08-21 | 2002-04-10 | Roche Diagnostics GmbH | Auxiliary haptens and haptenylated agents in displacement immunoassays |
EP1395831A2 (en) * | 2001-04-19 | 2004-03-10 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Method for the relative determination of physicochemical properties |
CN101021526B (zh) | 2007-03-16 | 2012-01-25 | 艾博生物医药(杭州)有限公司 | 一种直观显示检测结果的装置和方法 |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
KR20220147717A (ko) | 2013-03-11 | 2022-11-03 | 메소 스케일 테크놀러지즈, 엘엘시 | 다중화 어세이를 수행하기 위한 개선된 방법 |
GB201403815D0 (en) * | 2014-03-04 | 2014-04-16 | Mologic Ltd | Assay |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US4203802A (en) * | 1971-05-14 | 1980-05-20 | Syva Company | Inhibitable enzyme amplification assay |
US3884898A (en) * | 1972-08-18 | 1975-05-20 | Syva Co | Normorphine derivatives bonded to proteins |
US3878187A (en) * | 1972-09-11 | 1975-04-15 | Syva Co | Polypeptide derivatives of amphetamine and analogs for immunoassays |
US4108972A (en) * | 1974-03-15 | 1978-08-22 | Dreyer William J | Immunological reagent employing radioactive and other tracers |
US4048298A (en) * | 1975-02-25 | 1977-09-13 | Rohm And Haas Company | Solid phase double-antibody radioimmunoassay procedure |
US4200690A (en) * | 1976-12-16 | 1980-04-29 | Millipore Corporation | Immunoassay with membrane immobilized antibody |
US4233402A (en) * | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
JPS5510590A (en) * | 1978-05-04 | 1980-01-25 | Wellcome Found | Enzyme immunity quantity analysis |
US4246339A (en) * | 1978-11-01 | 1981-01-20 | Millipore Corporation | Test device |
US4281065A (en) * | 1979-01-25 | 1981-07-28 | Syva Company | Phencyclidine conjugates to antigenic proteins and enzymes |
DE2923583A1 (de) * | 1979-06-11 | 1980-12-18 | Max Planck Gesellschaft | Verfahren zur immunologischen bestimmung von basalmembranmaterial und hierfuer geeignete neue basalmembranfragmente |
US4391904A (en) * | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4425438A (en) * | 1981-03-13 | 1984-01-10 | Bauman David S | Assay method and device |
US4446232A (en) * | 1981-10-13 | 1984-05-01 | Liotta Lance A | Enzyme immunoassay with two-zoned device having bound antigens |
US4506009A (en) * | 1982-03-30 | 1985-03-19 | University Of California | Heterogeneous immunoassay method |
GB8317124D0 (en) * | 1983-06-23 | 1983-07-27 | Ekins R P | Free ligand assay |
US4552839A (en) * | 1983-08-01 | 1985-11-12 | Syntex (U.S.A.) Inc. | Determination of analytes in particle-containing medium |
GB8331514D0 (en) * | 1983-11-25 | 1984-01-04 | Janssen Pharmaceutica Nv | Visualization method |
US4703017C1 (en) * | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
US4865997A (en) * | 1984-02-23 | 1989-09-12 | Becton Dickinson And Company | Assay for ligands by separating bound and free tracer from sample |
US4632901A (en) * | 1984-05-11 | 1986-12-30 | Hybritech Incorporated | Method and apparatus for immunoassays |
WO1986000668A1 (en) * | 1984-07-03 | 1986-01-30 | Baralaba Pty Ltd | Fuel injector |
US4745075A (en) * | 1984-09-06 | 1988-05-17 | Burroughs Wellcome Co. | Diagnostic test methods |
US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
CA1272127A (en) * | 1985-04-04 | 1990-07-31 | Hybritech Incorporated | Solid phase system for use in ligand-receptor assays |
WO1986006170A1 (en) | 1985-04-10 | 1986-10-23 | Immunicon Corporation | Direct homogeneous assay |
US4803170A (en) | 1985-05-09 | 1989-02-07 | Ultra Diagnostics Corporation | Competitive immunoassay method, device and test kit |
US4670381A (en) * | 1985-07-19 | 1987-06-02 | Eastman Kodak Company | Heterogeneous immunoassay utilizing horizontal separation in an analytical element |
US4806311A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having labeled reagent concentration zone |
DE3624464A1 (de) * | 1986-07-19 | 1988-01-28 | Boehringer Mannheim Gmbh | Verfahren zum nachweis eines analyten sowie hierfuer geeignetes mittel |
US4963468A (en) * | 1986-09-05 | 1990-10-16 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
US4959307A (en) * | 1986-09-05 | 1990-09-25 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
EP0271204A3 (en) * | 1986-11-07 | 1989-10-25 | Syntex (U.S.A.) Inc. | Immunochromatographic method and device |
US5028535A (en) * | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
-
1990
- 1990-09-14 US US07/583,046 patent/US5143852A/en not_active Expired - Lifetime
-
1991
- 1991-09-04 JP JP3515353A patent/JPH05501922A/ja active Pending
- 1991-09-04 AU AU85361/91A patent/AU8536191A/en not_active Abandoned
- 1991-09-04 WO PCT/US1991/006325 patent/WO1992005283A1/en active Application Filing
- 1991-09-04 CA CA002071904A patent/CA2071904C/en not_active Expired - Lifetime
- 1991-09-12 PT PT98951A patent/PT98951B/pt not_active IP Right Cessation
- 1991-09-13 DE DE69131811T patent/DE69131811T2/de not_active Expired - Fee Related
- 1991-09-13 AT AT91308408T patent/ATE187250T1/de not_active IP Right Cessation
- 1991-09-13 IE IE324391A patent/IE913243A1/en unknown
- 1991-09-13 ES ES91308408T patent/ES2141086T3/es not_active Expired - Lifetime
- 1991-09-13 EP EP91308408A patent/EP0475783B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0475783B1 (en) | 1999-12-01 |
ATE187250T1 (de) | 1999-12-15 |
EP0475783A1 (en) | 1992-03-18 |
CA2071904C (en) | 2003-02-18 |
IE913243A1 (en) | 1992-02-25 |
WO1992005283A1 (en) | 1992-04-02 |
CA2071904A1 (en) | 1992-03-15 |
PT98951A (pt) | 1994-01-31 |
DE69131811D1 (de) | 2000-01-05 |
PT98951B (pt) | 1999-02-26 |
US5143852A (en) | 1992-09-01 |
JPH05501922A (ja) | 1993-04-08 |
AU8536191A (en) | 1992-04-15 |
DE69131811T2 (de) | 2000-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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