US5795725A - Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays - Google Patents

Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays Download PDF

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Publication number
US5795725A
US5795725A US08/423,582 US42358295A US5795725A US 5795725 A US5795725 A US 5795725A US 42358295 A US42358295 A US 42358295A US 5795725 A US5795725 A US 5795725A
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United States
Prior art keywords
troponin
antibody
isoform
cardiac
complexes
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Expired - Lifetime
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US08/423,582
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Kenneth F. Buechler
Paul H. McPherson
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Biosite Inc
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Alere San Diego Inc
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Priority to US08/423,582 priority Critical patent/US5795725A/en
Assigned to BIOSITE DIAGNOSTICS, INCORPORATED reassignment BIOSITE DIAGNOSTICS, INCORPORATED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BUECHLER, KENNETH F., MCPHERSON, PAUL H.
Priority claimed from US08/633,248 external-priority patent/US6174686B1/en
Priority claimed from US08/769,077 external-priority patent/US6627404B1/en
Publication of US5795725A publication Critical patent/US5795725A/en
Application granted granted Critical
Priority claimed from US09/687,051 external-priority patent/US6991907B1/en
Assigned to BIOSITE INCORPORATED reassignment BIOSITE INCORPORATED CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: BUECHLER, KENNETH F., MCPHERSON, PAUL H.
Assigned to BIOSITE, INC. reassignment BIOSITE, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: BIOSITE DIAGNOSTICS, INC.
Assigned to BIOSITE, INC. reassignment BIOSITE, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: BIOSITE DIAGNOSTICS, INC.
Assigned to BIOSITE INCORPORATED reassignment BIOSITE INCORPORATED CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: BUECHLER, KENNETH F., MCPHERSON, PAUL H.
Assigned to GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT reassignment GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT SECURITY AGREEMENT Assignors: BIOSITE INCORPORATED
Assigned to GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT reassignment GENERAL ELECTRIC CAPITAL CORPORATION, AS AGENT SECURITY AGREEMENT Assignors: BIOSITE INCORPORATED
Assigned to GENERAL ELECTRIC CAPITAL CORPORATION reassignment GENERAL ELECTRIC CAPITAL CORPORATION SECURITY AGREEMENT Assignors: ADVANTAGE DIAGNOSTICS CORPORATION, ALERE MEDICAL INCORPORATED, ALERE SAN DIEGO, INC., ALERE SCARBOROUGH, INC., AMEDITECH INC., APPLIED BIOTECH, INC., BINAX, INC., BIOSITE INCORPORATED, CHOLESTECH CORPORATION, GENECARE MEDICAL GENETICS CENTER, INC., HEMOSENSE, INC., INSTANT TECHNOLOGIES, INC., INVERNESS MEDICAL - BIOSTAR INC., ISCHEMIA TECHNOLOGIES, INC., MARTIA HEALTHCARE, INC., MATRITECH, INC., ZYCARE INC.
Assigned to ZYCARE, INC., ISCHEMIA TECHNOLOGIES, INC., BIOSITE INCORPORATED, MATRITECH, INC., MATRIA HEALTHCARE, INC., AMEDITECH INC., ALERE SAN DIEGO, INC., GENECARE MEDICAL GENETICS CENTER, INC., INVERNESS MEDICAL - BIOSTAR INC., ADVANTAGE DIAGNOSTICS CORPORATION, ALERE SCARBOROUGH, INC., APPLIED BIOTECH, INC., CHOLESTECH CORPORATION, BINAX, INC., HEMOSENSE, INC., INSTANT TECHNOLOGIES, INC., ALERE MEDICAL, INC. reassignment ZYCARE, INC. NOTICE OF RELEASE OF SECURITY INTEREST IN PATENTS RECORDED AT REEL 026557 FRAME 0287 Assignors: GENERAL ELECTRIC CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT AND COLLATERAL AGENT
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Assigned to GENERAL ELECTRIC CAPITAL CORPORATION, AS COLLATERAL AGENT reassignment GENERAL ELECTRIC CAPITAL CORPORATION, AS COLLATERAL AGENT INTELLECTUAL PROPERTY SECURITY AGREEMENT Assignors: ALERE CONNECT, LLC, ALERE SAN DIEGO, INC. (FKA BIOSITE INC. OR FKA CHOLESTECH CORP. OR FKA HEMOSENSE INC. OR FKA INVERNESS MEDICAL-BIOSTAR INC. OR FKA ISCHEMIA TECHNOLOGIES, INC. OR FKA TWISTDX, INC.), ALERE SCARBOROUGH, INC. (FKA MATRITECH, INC. FKA ADVANTAGE DIAGNOSTICS CORP. OR FKA BINAX, INC. OR FKA MILANO ACQUISITION CORP.), ESCREEN, INC., INNOVACON, INC. (FKA APPLIED BIOTECH, INC. OR FKA AMEDITECH INC.), IONIAN TECHNOLOGIES, LLC (FKA IONIAN TECHNOLOGIES, INC.), QUALITY ASSURED SERVICES INC. (FKA ZYCARE INC.), STANDING STONE, LLC
Assigned to HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS SUCCESSOR ADMINISTRATIVE AGENT reassignment HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS SUCCESSOR ADMINISTRATIVE AGENT ASSIGNMENT OF IP SECURITY AGREEMENT, PREVIOUSLY RECORDED AT REEL 036994, FRAME 0192 Assignors: GENERAL ELECTRIC CAPITAL CORPORATION, AS RETIRING ADMINISTRATIVE AGENT
Assigned to ALERE SAN DIEGO, INC. (FKA BIOSITE INC. OR FKA CHOLESTECH CORP. OR FKA HEMOSENSE INC. OR FKA INVERNESS MEDICAL-BIOSTAR INC. OR FKA ISCHEMIA TECHNOLOGIES, INC. OR FKA TWISTDX, INC.), INNOVACON, INC. (FKA APPLIED BIOTECH, INC. OR FKA AMEDITECH INC.), IONIAN TECHNOLOGIES, LLC (FKA IONIAN TECHNOLOGIES, INC.), ALERE SCARBOROUGH, INC. (FKA MATRITECH, INC. FKA ADVANTAGE DIAGNOSTICS CORP. OR FKA BINAX, INC. OR FKA MILANO ACQUISITION CORP.), QUALITY ASSURED SERVICES INC. (FKA ZYCARE INC.), ESCREEN, INC., ALERE CONNECT, LLC, STANDING STONE, LLC reassignment ALERE SAN DIEGO, INC. (FKA BIOSITE INC. OR FKA CHOLESTECH CORP. OR FKA HEMOSENSE INC. OR FKA INVERNESS MEDICAL-BIOSTAR INC. OR FKA ISCHEMIA TECHNOLOGIES, INC. OR FKA TWISTDX, INC.) RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY RECORDED AT REEL 036994, FRAME 0192 AND REEL 037115, FRAME 0498 Assignors: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS COLLATERAL AGENT
Application status is Expired - Lifetime legal-status Critical

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