NO933582L - Nye konjugater og analyser for simultan deteksjon av multiple ligander - Google Patents

Nye konjugater og analyser for simultan deteksjon av multiple ligander

Info

Publication number
NO933582L
NO933582L NO933582A NO933582A NO933582L NO 933582 L NO933582 L NO 933582L NO 933582 A NO933582 A NO 933582A NO 933582 A NO933582 A NO 933582A NO 933582 L NO933582 L NO 933582L
Authority
NO
Norway
Prior art keywords
binding
assays
simultaneous detection
binding domains
multiple ligands
Prior art date
Application number
NO933582A
Other languages
English (en)
Other versions
NO933582D0 (no
Inventor
Gunars Edwin Valkirs
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Publication of NO933582D0 publication Critical patent/NO933582D0/no
Publication of NO933582L publication Critical patent/NO933582L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

Nye konjugater og konkurrerende og ikke-konkurrerende analyser for samtidig påvisning av tilstedeværelsen eller mengden av minst to targetligander som kan konkurrere med et enkelt konjugat for binding til minst to forskjellige ligandreseptor- er. Oppfinnelsen lærer bindingsdomener koblet til et signal- utviklingselement til å danne et konjugat hvor hvert bindings- domene omfatter minst en ligandanalog eller ligandreseptor avhengig av analysedesign. Bindingsdomenene er konstruert slik at de kan fungere uavhengig i analyser for deres respek- tive targetligander. Hvert bindingsdomene kan binde sine respektive bindingspartnere i analysen uten å påvirke bind- ingsreaksjonene av andre bindingsdomener koblet til det samme signålutviklingselement, noe som gjør oppfinnelsen anvendbar i analysesystemer for samtidig påvisning av multiple target- ligander.
NO933582A 1991-04-12 1993-10-07 Nye konjugater og analyser for simultan deteksjon av multiple ligander NO933582L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68508491A 1991-04-12 1991-04-12
PCT/US1992/002839 WO1992018866A1 (en) 1991-04-10 1992-04-07 Novel conjugates and assays for simultaneous detection of multiple ligands

Publications (2)

Publication Number Publication Date
NO933582D0 NO933582D0 (no) 1993-10-07
NO933582L true NO933582L (no) 1993-12-10

Family

ID=24750715

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933582A NO933582L (no) 1991-04-12 1993-10-07 Nye konjugater og analyser for simultan deteksjon av multiple ligander

Country Status (11)

Country Link
US (1) US5851776A (no)
EP (1) EP0579767B1 (no)
JP (1) JP3290988B2 (no)
AT (1) ATE195808T1 (no)
AU (1) AU1911592A (no)
CA (1) CA2107899A1 (no)
DE (1) DE69231382T2 (no)
ES (1) ES2150915T3 (no)
FI (1) FI934438A (no)
NO (1) NO933582L (no)
WO (1) WO1992018866A1 (no)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470997A (en) * 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
EP0635019B1 (en) * 1992-04-06 1999-05-26 Biosite Diagnostics Inc. Opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
US6037455A (en) * 1992-11-09 2000-03-14 Biosite Diagnostics Incorporated Propoxyphene derivatives and protein and polypeptide propoxyphene derivative conjugates and labels
US5804452A (en) * 1995-04-27 1998-09-08 Quidel Corporation One step urine creatinine assays
US5965375A (en) 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
DE19859912C2 (de) * 1998-12-23 2001-06-21 Aventis Res & Tech Gmbh & Co Testsystem zur Erkennung verschiedener Marker, seine Herstellung sowie Verwendung
WO2001066568A2 (en) * 2000-03-09 2001-09-13 Heska Corporation Use of recombinant antigens to determine the immune status of an animal
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
US7981420B2 (en) 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7427490B2 (en) * 2001-08-20 2008-09-23 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
EP1666881B1 (en) * 2001-05-04 2010-02-17 Biosite Incorporated Diagnostic markers of acute coronary syndromes and methods of use thereof
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
CA2522709A1 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
JP2007518062A (ja) * 2003-09-29 2007-07-05 バイオサイト インコーポレイテッド 敗血症を診断する方法および診断するための組成物
US20050130243A1 (en) * 2003-12-15 2005-06-16 Zheng Yi F. Assay for entactogens
US6991911B2 (en) * 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US7022492B2 (en) * 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
US7115383B2 (en) * 2004-03-22 2006-10-03 Dade Behring Inc. Assays for amphetamine and methamphetamine
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents
WO2006031583A2 (en) * 2004-09-09 2006-03-23 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2006078813A2 (en) * 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
EP1715341B1 (de) * 2005-04-04 2008-02-27 Micronas Holding GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden
US20070087453A1 (en) * 2005-10-19 2007-04-19 Council Of Scientific And Industrial Research Immuno conjugate and process for preparation thereof
EP1929295A4 (en) * 2005-08-30 2010-03-17 Biosite Inc USE OF SOLUBLE FLT-1 AND ITS FRAGMENTS IN CARDIOVASCULAR CONDITIONS
US8906864B2 (en) 2005-09-30 2014-12-09 AbbVie Deutschland GmbH & Co. KG Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use
WO2007103568A2 (en) * 2006-03-09 2007-09-13 Biosite, Inc. Methods and compositions for the diagnosis of diseases of the aorta
EP1845377A1 (de) 2006-04-10 2007-10-17 Micronas GmbH Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von Liganden
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
ATE528411T1 (de) 2006-06-07 2011-10-15 Otago Innovation Ltd Diagnoseverfahren und -marker
CN101495868A (zh) * 2006-07-28 2009-07-29 博适公司 利用磁性颗粒进行受体结合试验的装置和方法
CN101611318B (zh) 2006-09-07 2015-03-04 奥塔哥创新有限公司 生物标记物
DE502006005987D1 (de) * 2006-10-20 2010-03-11 Micronas Holding Gmbh Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von Liganden
EP2095107B1 (en) * 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment
US8524462B2 (en) * 2006-11-14 2013-09-03 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7947465B2 (en) * 2007-08-20 2011-05-24 Bio-Rad Laboratories, Inc. Simultaneous assay for determining drugs
US20090053832A1 (en) * 2007-08-20 2009-02-26 Link William F Simultaneous assay for determining drugs
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
CN101977933A (zh) 2008-03-12 2011-02-16 奥塔哥创新有限公司 生物标记物
CN102037014A (zh) * 2008-03-12 2011-04-27 奥塔哥创新有限公司 生物标记物
KR20110073471A (ko) 2008-08-28 2011-06-29 아스튜트 메디컬 인코포레이티드 신손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물
EP2324354B1 (en) 2008-08-29 2014-07-16 Astute Medical, Inc. Methods for prognosis of acute renal failure
EP2347260A4 (en) 2008-10-21 2012-09-26 Astute Medical Inc METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
EP3246707B1 (en) 2008-10-21 2020-09-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104330574B (zh) 2008-11-10 2017-04-12 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
NZ592552A (en) 2008-11-22 2013-12-20 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20100204055A1 (en) * 2008-12-05 2010-08-12 Bonner-Ferraby Phoebe W Autoantibody detection systems and methods
NZ594771A (en) 2009-02-06 2013-06-28 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and failure
WO2011017654A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ594772A (en) 2009-02-06 2013-05-31 Astute Medical Inc Diagnosis and prognosis of renal injury and renal failure using vitamin k dependent protein c
WO2011006119A2 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP2462446B1 (en) 2009-08-07 2017-09-27 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104483488A (zh) 2009-08-28 2015-04-01 阿斯图特医药公司 肾损伤和肾衰竭的诊断及预后的方法及组合物
US20130045494A1 (en) 2009-09-18 2013-02-21 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ704383A (en) 2009-09-21 2016-09-30 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3153863B1 (en) 2009-11-07 2020-04-01 Astute Medical, Inc. Methods and uses for evaluation of acute renal failure/acute renal injury
JP2013510322A (ja) 2009-11-07 2013-03-21 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
ES2562832T3 (es) 2009-12-08 2016-03-08 Abbvie Deutschland Gmbh & Co Kg Anticuerpos monoclonales contra la proteína RGM para su uso en el tratamiento de la degeneración de la capa de fibra nerviosa de la retina
CN102725636B (zh) 2009-12-20 2015-04-01 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
BR112012019542A2 (pt) 2010-02-05 2018-03-27 Astute Medical Inc "método para avaliar o estado renal em um indivíduo, medição de um ou mais biomarcadores, e, kit"
US20130230871A1 (en) 2010-02-05 2013-09-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2789147A1 (en) 2010-02-05 2011-08-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EA201290711A1 (ru) 2010-02-26 2013-10-30 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
WO2011129382A1 (en) 2010-04-16 2011-10-20 Abbott Japan Co. Ltd. Methods and reagents for diagnosing rheumatoid arthritis
NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN103080743B (zh) 2010-06-23 2015-07-22 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
NZ703055A (en) 2010-06-23 2016-07-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9103840B2 (en) 2010-07-19 2015-08-11 Otago Innovation Limited Signal biomarkers
AU2011305197B2 (en) 2010-09-24 2015-06-11 Astute Medical, Inc. Methods and compositions for the evaluation of renal injury using hyaluronic acid
US10557856B2 (en) 2010-09-24 2020-02-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biomarkers of renal injury
CN103238068B (zh) 2010-10-07 2016-06-08 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
US8795975B2 (en) 2010-11-29 2014-08-05 Alere San Diego, Inc. Methods and compositions for diagnosis and risk prediction in heart failure
WO2012094658A2 (en) 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3761034A3 (en) 2011-01-26 2021-02-17 University of Pittsburgh - Of the Commonwealth System of Higher Education Urine biomarkers for prediction of recovery after acute kidney injury: proteomics
EP2668499A4 (en) 2011-01-29 2015-05-27 Astute Medical Inc METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
EA201490384A1 (ru) 2011-08-26 2014-08-29 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
WO2013078253A1 (en) 2011-11-22 2013-05-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2788759B1 (en) 2011-12-08 2019-02-20 Astute Medical, Inc. Methods and uses for diagnosis of renal injury and renal failure
CA2855570A1 (en) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
JP6342812B2 (ja) 2011-12-14 2018-06-13 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 鉄関連障害を診断および治療するための組成物および方法
CN107880124B (zh) 2012-01-27 2021-08-13 艾伯维德国有限责任两合公司 用于诊断和治疗与神经突变性相关的疾病的组合物和方法
CA2865563A1 (en) 2012-02-27 2013-09-06 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2015512892A (ja) 2012-03-13 2015-04-30 アッヴィ・インコーポレイテッド Ｖ１ｂアンタゴニスト療法について対象を選択または同定するための方法
WO2013141716A1 (en) 2012-03-20 2013-09-26 Christopher Joseph Pemberton Biomarkers
WO2013152047A1 (en) 2012-04-02 2013-10-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
US9733261B2 (en) 2012-04-24 2017-08-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
EP3572809A1 (en) 2012-07-23 2019-11-27 Astute Medical, Inc. Methods for diagnosis of sepsis
WO2014028339A1 (en) 2012-08-11 2014-02-20 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
ES2681955T3 (es) 2013-01-17 2018-09-17 Astute Medical, Inc. Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
EP3470416B1 (en) 2013-03-14 2022-04-27 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
EP3004873B1 (en) 2013-06-05 2024-01-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2914566A1 (en) 2013-06-07 2014-12-11 Duke University Inhibitors of complement factor h
BR112016002685A2 (pt) 2013-08-07 2018-01-30 Astute Medical Inc ensaios para timp2 que apresentam melhor desempenho em amostras biológicas
BR112016003454B1 (pt) 2013-08-23 2023-02-14 Reata Pharmaceuticals, Inc. Uso de composto de metil bardoxolona
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
EP3693738A1 (en) 2013-09-20 2020-08-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
CA3185700A1 (en) 2013-11-06 2015-05-14 Astute Medical, Inc. Assays for igfbp7 having improved performance in biological samples
US10300108B2 (en) 2013-12-03 2019-05-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2017506910A (ja) 2013-12-30 2017-03-16 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド 前立腺癌に関連したゲノム再編成及び該ゲノム再編成の使用方法
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3825417A3 (en) 2014-05-22 2021-09-15 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
WO2015179777A2 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
CA2949959A1 (en) 2014-05-22 2015-11-26 Northwestern University Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3968022A1 (en) 2014-10-20 2022-03-16 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3233106B1 (en) 2014-12-18 2023-02-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3281011B1 (en) 2015-04-09 2024-06-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN107735147A (zh) 2015-05-12 2018-02-23 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
JP2018518676A (ja) 2015-06-11 2018-07-12 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
EP3311164B1 (en) 2015-06-17 2022-04-20 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
US20190017117A1 (en) 2015-07-10 2019-01-17 West Virginia University Markers of stroke and stroke severity
US11209431B2 (en) 2015-10-06 2021-12-28 Bio-Rad Laboratories, Inc. Borrelia immunoassays and materials therefor
AU2017267728B2 (en) 2016-05-18 2021-11-04 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
US11243217B2 (en) 2016-06-06 2022-02-08 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
BR112019006710A2 (pt) 2016-10-03 2019-06-25 Abbott Lab métodos aprimorados para avaliação do estado da uch-l1 em amostras de pacientes
WO2018067730A1 (en) 2016-10-04 2018-04-12 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics
MX2019005401A (es) 2016-11-08 2019-08-05 Reata Pharmaceuticals Inc Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma.
CN114088950A (zh) 2017-01-12 2022-02-25 机敏医药股份有限公司 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物
JP2020511674A (ja) 2017-03-09 2020-04-16 クリラ バイオテック ベー．フェー． 細胞老化バイオマーカー
JP7346300B2 (ja) 2017-03-23 2023-09-19 アボット・ラボラトリーズ 早期バイオマーカーであるユビキチンカルボキシ末端ヒドロラーゼｌ１を使用する、ヒト対象における外傷性脳損傷の程度の診断及び決定の一助となるための方法
AU2018250688B2 (en) 2017-04-15 2024-07-04 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
AU2018256845B2 (en) 2017-04-28 2024-03-14 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
JP2020519904A (ja) 2017-05-07 2020-07-02 アスチュート メディカル，インコーポレイテッド 腎代替療法の管理におけるインスリン様増殖因子結合タンパク質７および組織メタロプロテアーゼ阻害物質２の使用
WO2018218169A1 (en) 2017-05-25 2018-11-29 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
BR112019025387A2 (pt) 2017-05-30 2020-07-07 Abbott Laboratories métodos para auxiliar no diagnóstico e avaliação de uma lesão traumática cerebral branda em um indivíduo humano com o uso de troponina cardíaca i e biomarcadores precoces
WO2019010131A1 (en) 2017-07-03 2019-01-10 Abbott Laboratories IMPROVED METHODS FOR MEASURING CARBOXY TERMINATION HYDROLASE LEVELS OF UBIQUITIN L1 IN BLOOD
CA3067055A1 (en) 2017-12-09 2019-06-13 Abbott Laboratories Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1
BR112019028254A2 (pt) 2017-12-09 2020-07-14 Abbott Laboratories métodos para ajudar no diagnóstico e avaliação de um paciente que sofreu uma lesão ortopédica e que sofreu ou pode ter sofrido uma lesão na cabeça, tal como uma lesão cerebral traumática (lct) leve, usando a proteína ácida fibrilar glial (gfap) e/ou a hidrolase carbóxi-terminal da ubiquitina l1 (uch-l1)
EP3732196A4 (en) 2017-12-28 2022-01-05 Astute Medical, Inc. ANTIBODIES AND DOSAGES FOR CCL14
WO2019133717A1 (en) 2017-12-29 2019-07-04 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
EP3788377A1 (en) 2018-05-04 2021-03-10 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2020051231A1 (en) 2018-09-04 2020-03-12 H. Lee Moffitt Cancer Center & Research Institute Inc. Use of delta-tocotrienol for treating cancer
CN118362716A (zh) 2018-12-28 2024-07-19 雅培制药有限公司 微粒上的单分子的直接检测
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
US11079395B2 (en) 2019-03-01 2021-08-03 Abbott Laboratories Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease
EP4136459A1 (en) 2020-04-13 2023-02-22 Abbott Laboratories Methods, complexes and kits for detecting or determining an amount of a ss-coronavirus antibody in a sample
EP4146226A1 (en) 2020-05-09 2023-03-15 Reata Pharmaceuticals Holdings, LLC Methods of treating covid-19 using bardoxolone methyl or analogs thereof
WO2021245025A1 (en) 2020-06-01 2021-12-09 Loop Diagnostics, S.L. Method and kit for the early detection of sepsis
EP4193151A1 (en) 2020-08-04 2023-06-14 Abbott Rapid Diagnostics International Unlimited Company Assays for detecting sars-cov-2
WO2022031804A1 (en) 2020-08-04 2022-02-10 Abbott Laboratories Improved methods and kits for detecting sars-cov-2 protein in a sample
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
WO2022119841A1 (en) 2020-12-01 2022-06-09 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
EP4259155A1 (en) 2020-12-11 2023-10-18 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy
WO2022147147A1 (en) 2020-12-30 2022-07-07 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
WO2022245920A1 (en) 2021-05-18 2022-11-24 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
JP2024521476A (ja) 2021-06-14 2024-05-31 アボット・ラボラトリーズ 音響エネルギー、電磁エネルギー、過圧波及び／又は爆風により引き起こされる脳損傷の診断法又は診断の一助となる方法
WO2023028186A1 (en) 2021-08-27 2023-03-02 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
CA3230038A1 (en) 2021-08-31 2023-03-09 Hongwei Zhang Methods and systems of diagnosing brain injury
CN118715440A (zh) 2021-08-31 2024-09-27 雅培实验室 诊断脑损伤的方法和系统
CA3232176A1 (en) 2021-09-30 2023-04-06 Beth MCQUISTON Methods and systems of diagnosing brain injury
WO2023114978A1 (en) 2021-12-17 2023-06-22 Abbott Laboratories Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
CN118591621A (zh) 2022-01-27 2024-09-03 赛诺菲巴斯德有限公司 修饰的Vero细胞及其用于病毒生产的方法
AU2023216317A1 (en) 2022-02-04 2024-09-05 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
WO2023212298A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Bispecific antibodies and methods of treating ocular disease
WO2023212293A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Complement factor h related 4-specific antibodies and uses thereof
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2024059708A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
WO2024163477A1 (en) 2023-01-31 2024-08-08 University Of Rochester Immune checkpoint blockade therapy for treating staphylococcus aureus infections
WO2024211475A1 (en) 2023-04-04 2024-10-10 Abbott Laboratories Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US4803170A (en) * 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5028535A (en) * 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay

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CA2107899A1 (en) 1992-10-11
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ATE195808T1 (de) 2000-09-15
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AU1911592A (en) 1992-11-17
DE69231382T2 (de) 2001-01-25

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