MX2019005401A - Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma. - Google Patents
Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma.Info
- Publication number
- MX2019005401A MX2019005401A MX2019005401A MX2019005401A MX2019005401A MX 2019005401 A MX2019005401 A MX 2019005401A MX 2019005401 A MX2019005401 A MX 2019005401A MX 2019005401 A MX2019005401 A MX 2019005401A MX 2019005401 A MX2019005401 A MX 2019005401A
- Authority
- MX
- Mexico
- Prior art keywords
- analogs
- alport syndrome
- methods
- bardoxolone methyl
- treating alport
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6943—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a pill, a tablet, a lozenge or a capsule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La presente invención proporciona métodos para tratar o prevenir el síndrome de Alport en pacientes que lo necesiten usando bardoxolona metilo o análogos de la misma, y/o mejorar la función renal de pacientes que han sido diagnosticados con el síndrome de Alport.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662419335P | 2016-11-08 | 2016-11-08 | |
US201762535663P | 2017-07-21 | 2017-07-21 | |
US201762580597P | 2017-11-02 | 2017-11-02 | |
PCT/US2017/060701 WO2018089539A1 (en) | 2016-11-08 | 2017-11-08 | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019005401A true MX2019005401A (es) | 2019-08-05 |
Family
ID=60409474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005401A MX2019005401A (es) | 2016-11-08 | 2017-11-08 | Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10953020B2 (es) |
EP (1) | EP3538104A1 (es) |
JP (1) | JP6633812B2 (es) |
KR (1) | KR102486434B1 (es) |
CN (1) | CN110198718B (es) |
AU (2) | AU2017356955B2 (es) |
BR (1) | BR112019009256A2 (es) |
CA (1) | CA3042123A1 (es) |
CL (1) | CL2019001258A1 (es) |
IL (1) | IL266427B2 (es) |
MA (1) | MA46749A (es) |
MX (1) | MX2019005401A (es) |
NZ (1) | NZ753546A (es) |
WO (1) | WO2018089539A1 (es) |
Families Citing this family (11)
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NZ588710A (en) | 2008-04-18 | 2012-12-21 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
US8993640B2 (en) | 2012-04-27 | 2015-03-31 | Reata Pharmaceuticals, Inc. | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法 |
US11584775B2 (en) | 2015-09-23 | 2023-02-21 | Reata Pharmaceuticals, Inc. | C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses |
WO2021104391A1 (zh) * | 2019-11-27 | 2021-06-03 | 鲁南制药集团股份有限公司 | 一种齐墩果烷苯丙烯酰胺衍生物及其制备方法和用途 |
WO2021202720A1 (en) * | 2020-04-01 | 2021-10-07 | Fronthera U.S. Pharmaceuticals Llc | Use of triterpenoid nrf2 inhibitors |
EP4146226A1 (en) * | 2020-05-09 | 2023-03-15 | Reata Pharmaceuticals Holdings, LLC | Methods of treating covid-19 using bardoxolone methyl or analogs thereof |
WO2022126129A1 (en) | 2020-12-11 | 2022-06-16 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids for use in therapy |
PE20231661A1 (es) * | 2021-01-18 | 2023-10-17 | Reata Pharmaceuticals Inc | Derivados de acido ursolico sinteticos y metodos de uso de los mismos |
CN117050134A (zh) * | 2022-05-05 | 2023-11-14 | 中国科学院上海有机化学研究所 | 酰胺化合物的合成及其用途 |
CN116509874A (zh) * | 2023-02-01 | 2023-08-01 | 潍坊医学院附属医院 | 甲基巴多索隆在制备改善病毒性心肌炎或病毒性心肌损伤的药物中的用途 |
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-
2017
- 2017-11-08 CN CN201780075149.8A patent/CN110198718B/zh active Active
- 2017-11-08 JP JP2019501698A patent/JP6633812B2/ja active Active
- 2017-11-08 MX MX2019005401A patent/MX2019005401A/es unknown
- 2017-11-08 BR BR112019009256A patent/BR112019009256A2/pt unknown
- 2017-11-08 US US16/315,821 patent/US10953020B2/en active Active
- 2017-11-08 CA CA3042123A patent/CA3042123A1/en active Pending
- 2017-11-08 EP EP17801274.6A patent/EP3538104A1/en active Pending
- 2017-11-08 WO PCT/US2017/060701 patent/WO2018089539A1/en unknown
- 2017-11-08 AU AU2017356955A patent/AU2017356955B2/en active Active
- 2017-11-08 KR KR1020197015352A patent/KR102486434B1/ko active IP Right Grant
- 2017-11-08 NZ NZ753546A patent/NZ753546A/en unknown
- 2017-11-08 MA MA046749A patent/MA46749A/fr unknown
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2021
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CL2019001258A1 (es) | 2019-07-05 |
AU2017356955A1 (en) | 2019-06-13 |
US10953020B2 (en) | 2021-03-23 |
US20210161914A1 (en) | 2021-06-03 |
BR112019009256A2 (pt) | 2019-07-16 |
US20190350941A1 (en) | 2019-11-21 |
KR102486434B1 (ko) | 2023-01-09 |
IL266427A (en) | 2019-06-30 |
US11446313B2 (en) | 2022-09-20 |
CA3042123A1 (en) | 2018-05-17 |
MA46749A (fr) | 2019-09-18 |
JP2019521150A (ja) | 2019-07-25 |
NZ753546A (en) | 2022-10-28 |
CN110198718A (zh) | 2019-09-03 |
AU2017356955B2 (en) | 2023-11-09 |
EP3538104A1 (en) | 2019-09-18 |
CN110198718B (zh) | 2023-01-10 |
AU2024200693A1 (en) | 2024-02-22 |
WO2018089539A1 (en) | 2018-05-17 |
KR20190101365A (ko) | 2019-08-30 |
IL266427B2 (en) | 2023-06-01 |
JP6633812B2 (ja) | 2020-01-22 |
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