ATE386116T1 - Bindungsdomänen des serrate-proteins - Google Patents

Bindungsdomänen des serrate-proteins

Info

Publication number
ATE386116T1
ATE386116T1 AT99101562T AT99101562T ATE386116T1 AT E386116 T1 ATE386116 T1 AT E386116T1 AT 99101562 T AT99101562 T AT 99101562T AT 99101562 T AT99101562 T AT 99101562T AT E386116 T1 ATE386116 T1 AT E386116T1
Authority
AT
Austria
Prior art keywords
binding domain
toporythmic protein
protein
fragment
serrate protein
Prior art date
Application number
AT99101562T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Richard Fehon
Ilaria Rebay
Original Assignee
Univ Yale
Indiana University Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE386116(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Indiana University Foundation filed Critical Univ Yale
Application granted granted Critical
Publication of ATE386116T1 publication Critical patent/ATE386116T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99101562T 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins ATE386116T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14

Publications (1)

Publication Number Publication Date
ATE386116T1 true ATE386116T1 (de) 2008-03-15

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0576623B2 (de)
JP (7) JPH07503123A (de)
AT (4) ATE397661T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69232832T3 (de)
DK (4) DK0933082T3 (de)
ES (4) ES2303363T3 (de)
IE (2) IE85350B1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

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US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
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US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
ATE442373T1 (de) 1995-06-28 2009-09-15 Imp Cancer Res Tech Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
EP0861894B1 (de) 1995-11-17 2006-03-08 Asahi Kasei Kabushiki Kaisha Polypeptid, das die differenzierung unterdrueckt
AU728798B2 (en) * 1995-11-22 2001-01-18 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
JP3922726B2 (ja) * 1996-07-16 2007-05-30 旭化成株式会社 分化抑制剤
CN1524583A (zh) * 1996-11-07 2004-09-01 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
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US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
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US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001288628A1 (en) * 2000-08-31 2002-03-13 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
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US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
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PL2307459T3 (pl) 2008-07-08 2015-05-29 Oncomed Pharm Inc Czynniki wiążące receptor Notch1 i sposoby ich stosowania
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
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HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
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WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
WO1994013701A2 (en) * 1992-12-11 1994-06-23 The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Healthand Human Services Delta-like gene expressed in neuroendocrine tumors

Also Published As

Publication number Publication date
ES2310933T3 (es) 2009-01-16
CA2102208C (en) 2003-04-29
WO1992019734A1 (en) 1992-11-12
ATE226633T1 (de) 2002-11-15
EP0933082B1 (de) 2010-07-14
DE69233724T2 (de) 2009-04-02
IE20030774A1 (en) 2003-12-10
JP4604228B2 (ja) 2011-01-05
DE69232832T2 (de) 2003-06-18
EP0930366B1 (de) 2008-06-04
IL101728A0 (en) 1992-12-30
DE69232832D1 (de) 2002-11-28
DE69233735D1 (de) 2008-07-17
JP2007330258A (ja) 2007-12-27
DE69232832T3 (de) 2008-02-28
EP0576623A4 (de) 1995-01-18
EP0930365A3 (de) 1999-07-28
IE921367A1 (en) 1992-11-04
EP0933082A1 (de) 1999-08-04
ATE473754T1 (de) 2010-07-15
ES2181674T5 (es) 2008-03-01
DK0933082T3 (da) 2010-10-25
AU1919792A (en) 1992-12-21
DK0576623T3 (da) 2003-02-24
JP2004065243A (ja) 2004-03-04
US5849869A (en) 1998-12-15
AU675203B2 (en) 1997-01-30
ES2303363T3 (es) 2008-08-01
JP2008005843A (ja) 2008-01-17
EP0930366A3 (de) 1999-07-28
DE69233724D1 (de) 2008-03-27
JPH07503123A (ja) 1995-04-06
DK0930365T3 (da) 2008-06-02
EP0576623A1 (de) 1994-01-05
JP2011135886A (ja) 2011-07-14
ES2348919T3 (es) 2010-12-16
DK0930366T3 (da) 2008-10-13
JP2007330259A (ja) 2007-12-27
DE69233791D1 (de) 2010-08-26
JP2011155979A (ja) 2011-08-18
ATE397661T1 (de) 2008-06-15
EP0576623B2 (de) 2007-10-03
JP4430891B2 (ja) 2010-03-10
IE85350B1 (en) 2009-10-14
EP0576623B1 (de) 2002-10-23
JP4604227B2 (ja) 2011-01-05
EP0930366A2 (de) 1999-07-21
EP0930365B1 (de) 2008-02-13
IL101728A (en) 2007-08-19
CA2102208A1 (en) 1992-11-12
DK0576623T4 (da) 2008-01-02
ES2181674T3 (es) 2003-03-01
EP0930365A2 (de) 1999-07-21

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