ATE226633T1 - Bindungsdomänen in notch- und delta-proteinen - Google Patents

Bindungsdomänen in notch- und delta-proteinen

Info

Publication number
ATE226633T1
ATE226633T1 AT92911557T AT92911557T ATE226633T1 AT E226633 T1 ATE226633 T1 AT E226633T1 AT 92911557 T AT92911557 T AT 92911557T AT 92911557 T AT92911557 T AT 92911557T AT E226633 T1 ATE226633 T1 AT E226633T1
Authority
AT
Austria
Prior art keywords
notch
binding domain
toporythmic protein
delta proteins
fragment
Prior art date
Application number
AT92911557T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
St Prospect
Scott Brockwell Shepard
Original Assignee
Univ Yale
Advanced Res & Tech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE226633(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Advanced Res & Tech Inst filed Critical Univ Yale
Application granted granted Critical
Publication of ATE226633T1 publication Critical patent/ATE226633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT92911557T 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen ATE226633T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (1)

Publication Number Publication Date
ATE226633T1 true ATE226633T1 (de) 2002-11-15

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0576623B2 (de)
JP (7) JPH07503123A (de)
AT (4) ATE226633T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69233724T2 (de)
DK (4) DK0933082T3 (de)
ES (4) ES2348919T3 (de)
IE (2) IE921367A1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
DE69638023D1 (de) 1995-06-28 2009-10-22 Univ Yale Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
AU728798B2 (en) * 1995-11-22 2001-01-18 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
AU720930B2 (en) 1996-07-16 2000-06-15 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
ATE299184T1 (de) * 1996-11-07 2005-07-15 Lorantis Ltd Notch-liganden zur verwendung in der immuntherapie
DE69836131T3 (de) 1997-04-04 2017-06-14 Millennium Pharmaceuticals, Inc. Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
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US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
EP1032666A1 (de) * 1997-11-22 2000-09-06 Hyseq, Inc. Protein mit egf-motif aus foetaler leber-milz cdna genbank
AU4202699A (en) * 1998-05-28 1999-12-13 Incyte Pharmaceuticals, Inc. Human socs proteins
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
CA2469204A1 (en) * 2001-12-07 2003-06-19 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
CA2528669A1 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
JP2007526455A (ja) * 2004-02-03 2007-09-13 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
WO2006135886A2 (en) * 2005-06-13 2006-12-21 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1907858A4 (de) * 2005-06-13 2009-04-08 Univ Michigan Zusammensetzungen und verfahren zur behandlung und diagnose von krebs
JP5129149B2 (ja) * 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1961065A4 (de) 2005-10-31 2009-11-11 Oncomed Pharm Inc Zusammensetzungen und verfahren zur diagnostizierung und behandlung von krebs
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
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RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
WO2008076960A2 (en) 2006-12-18 2008-06-26 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
EP2125887A4 (de) 2007-01-24 2010-11-10 Oncomed Pharm Inc Zusammensetzungen und verfahren zur behandlung und diagnostizierung von krebs
EP2106439B1 (de) * 2007-01-24 2014-11-12 The Regents of the University of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von pankreaskrebs
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
KR101323126B1 (ko) 2007-11-12 2013-10-30 가부시키가이샤 지에스 유아사 리튬 이차전지의 제조방법
SI2307051T1 (sl) 2008-07-08 2015-04-30 Oncomed Pharmaceuticals, Inc. Notch-vezavna sredstva in antagonisti ter postopki njihove uporabe
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
NZ592338A (en) 2008-09-26 2012-11-30 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
WO2011047383A1 (en) 2009-10-16 2011-04-21 Oncomed Pharmaceuticals, Inc. Therapeutic combination and methods of treatment with a dll4 antagonist and an anti-hypertensive agent
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
EP3097916B1 (de) 2010-04-09 2021-07-07 Fred Hutchinson Cancer Research Center Zusammensetzungen und verfahren zur bereitstellung einer hämatopoietischen funktion
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
ES2707580T3 (es) 2011-09-23 2019-04-04 Oncomed Pharm Inc Agentes de unión a VEGF/DLL4 y usos de los mismos
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WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
EP2914961A4 (de) 2012-10-31 2016-04-20 Oncomed Pharm Inc Verfahren und überwachung der behandlung mit einem dll4-antagonisten
EP2943566A1 (de) 2013-01-08 2015-11-18 Fred Hutchinson Cancer Research Center Zusammensetzungen und verfahren zur expansion von embryonalen hämatopoetischen stammzellen
CA2899353A1 (en) 2013-02-04 2014-08-07 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
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BR112016028537A2 (pt) 2014-06-04 2017-08-22 Hutchinson Fred Cancer Res expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2
ES2808153T3 (es) 2014-10-31 2021-02-25 Mereo Biopharma 5 Inc Terapia de combinación para tratamiento de enfermedad
JP6985934B2 (ja) 2015-04-29 2021-12-22 フレッド ハッチンソン キャンサー リサーチ センター 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用
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WO2023150393A2 (en) 2022-02-07 2023-08-10 Ensoma, Inc. Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids

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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
JPH08509358A (ja) * 1992-12-11 1996-10-08 アメリカ合衆国 神経内分泌腫瘍で発現されるδ様遺伝子

Also Published As

Publication number Publication date
WO1992019734A1 (en) 1992-11-12
EP0576623B2 (de) 2007-10-03
IL101728A (en) 2007-08-19
EP0933082B1 (de) 2010-07-14
DE69233724T2 (de) 2009-04-02
EP0930365B1 (de) 2008-02-13
CA2102208C (en) 2003-04-29
EP0930366B1 (de) 2008-06-04
DE69233735D1 (de) 2008-07-17
JP2007330258A (ja) 2007-12-27
JP2011155979A (ja) 2011-08-18
DE69233724D1 (de) 2008-03-27
JP2011135886A (ja) 2011-07-14
EP0576623B1 (de) 2002-10-23
AU675203B2 (en) 1997-01-30
DK0930365T3 (da) 2008-06-02
ATE397661T1 (de) 2008-06-15
JP2007330259A (ja) 2007-12-27
ES2181674T3 (es) 2003-03-01
EP0930365A3 (de) 1999-07-28
DE69232832D1 (de) 2002-11-28
JPH07503123A (ja) 1995-04-06
DE69233791D1 (de) 2010-08-26
ES2303363T3 (es) 2008-08-01
EP0576623A4 (de) 1995-01-18
EP0930366A3 (de) 1999-07-28
IE921367A1 (en) 1992-11-04
JP2004065243A (ja) 2004-03-04
IL101728A0 (en) 1992-12-30
ES2181674T5 (es) 2008-03-01
DE69232832T2 (de) 2003-06-18
DK0576623T3 (da) 2003-02-24
JP4604228B2 (ja) 2011-01-05
EP0933082A1 (de) 1999-08-04
EP0930366A2 (de) 1999-07-21
ATE473754T1 (de) 2010-07-15
EP0576623A1 (de) 1994-01-05
CA2102208A1 (en) 1992-11-12
DE69232832T3 (de) 2008-02-28
DK0933082T3 (da) 2010-10-25
AU1919792A (en) 1992-12-21
DK0930366T3 (da) 2008-10-13
ES2348919T3 (es) 2010-12-16
IE20030774A1 (en) 2003-12-10
IE85350B1 (en) 2009-10-14
ES2310933T3 (es) 2009-01-16
ATE386116T1 (de) 2008-03-15
EP0930365A2 (de) 1999-07-21
JP2008005843A (ja) 2008-01-17
US5849869A (en) 1998-12-15
JP4604227B2 (ja) 2011-01-05
JP4430891B2 (ja) 2010-03-10
DK0576623T4 (da) 2008-01-02

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