DK0576623T4 - Bindingsdomæner i Notch-proteiner - Google Patents

Bindingsdomæner i Notch-proteiner

Info

Publication number
DK0576623T4
DK0576623T4 DK92911557T DK92911557T DK0576623T4 DK 0576623 T4 DK0576623 T4 DK 0576623T4 DK 92911557 T DK92911557 T DK 92911557T DK 92911557 T DK92911557 T DK 92911557T DK 0576623 T4 DK0576623 T4 DK 0576623T4
Authority
DK
Denmark
Prior art keywords
binding domains
toporythmic protein
notch proteins
fragment
cell
Prior art date
Application number
DK92911557T
Other languages
English (en)
Other versions
DK0576623T3 (da
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
Scott Brockewell Shepard
Original Assignee
Univ Yale
Advanced Res & Tech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0576623(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Advanced Res & Tech Inst filed Critical Univ Yale
Application granted granted Critical
Publication of DK0576623T3 publication Critical patent/DK0576623T3/da
Publication of DK0576623T4 publication Critical patent/DK0576623T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK92911557T 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner DK0576623T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (2)

Publication Number Publication Date
DK0576623T3 DK0576623T3 (da) 2003-02-24
DK0576623T4 true DK0576623T4 (da) 2008-01-02

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering
DK92911557T DK0576623T4 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Notch-proteiner
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK99101562T DK0930365T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Serrate-protein
DK99101561.1T DK0933082T3 (da) 1991-05-03 1992-05-01 Fremgangsmåde til manipulation af celledifferentiering

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99101563T DK0930366T3 (da) 1991-05-03 1992-05-01 Bindingsdomæner i Delta-proteiner

Country Status (12)

Country Link
US (1) US5849869A (da)
EP (4) EP0930366B1 (da)
JP (7) JPH07503123A (da)
AT (4) ATE386116T1 (da)
AU (1) AU675203B2 (da)
CA (1) CA2102208C (da)
DE (4) DE69233791D1 (da)
DK (4) DK0930365T3 (da)
ES (4) ES2181674T5 (da)
IE (2) IE921367A1 (da)
IL (1) IL101728A (da)
WO (1) WO1992019734A1 (da)

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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
EP0861261B9 (en) 1995-06-28 2010-02-24 Imperial Cancer Research Technology Limited Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
JP2000502246A (ja) * 1995-11-22 2000-02-29 エール ユニバーシティー 脊椎動物Ｄｅｌｔｅｘタンパク質、核酸および抗体ならびに関連方法および組成物
CA2260365C (en) 1996-07-16 2004-08-10 Asahi Kasei Kogyo Kabushiki Kaisha Differentiation-suppressive polypeptide
CZ295997B6 (cs) * 1996-11-07 2005-12-14 Lorantis Limited Farmaceutický prostředek s obsahem ligandu Notch a způsob tvorby T-buněk
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
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US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
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US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
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US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
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CN107530419B (zh) 2014-10-31 2021-05-18 昂考梅德药品有限公司 治疗疾病的组合疗法
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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
DE69329037T2 (de) * 1992-12-11 2001-03-22 Us Gov Nat Inst Health Delta ähnliches gen welches in neuroendokrinen tumoren exprimiert wird

Also Published As

Publication number Publication date
DE69233791D1 (de) 2010-08-26
JP2007330258A (ja) 2007-12-27
AU675203B2 (en) 1997-01-30
ATE386116T1 (de) 2008-03-15
EP0930365A2 (en) 1999-07-21
WO1992019734A1 (en) 1992-11-12
EP0576623A4 (en) 1995-01-18
JP2008005843A (ja) 2008-01-17
JP4430891B2 (ja) 2010-03-10
JP2004065243A (ja) 2004-03-04
JP4604228B2 (ja) 2011-01-05
JP2011155979A (ja) 2011-08-18
ATE226633T1 (de) 2002-11-15
EP0576623A1 (en) 1994-01-05
DK0930365T3 (da) 2008-06-02
JP4604227B2 (ja) 2011-01-05
DE69232832D1 (de) 2002-11-28
IL101728A0 (en) 1992-12-30
ES2181674T3 (es) 2003-03-01
EP0933082A1 (en) 1999-08-04
ATE473754T1 (de) 2010-07-15
EP0576623B1 (en) 2002-10-23
IE921367A1 (en) 1992-11-04
EP0930365B1 (en) 2008-02-13
ES2310933T3 (es) 2009-01-16
DK0930366T3 (da) 2008-10-13
US5849869A (en) 1998-12-15
ES2303363T3 (es) 2008-08-01
JP2007330259A (ja) 2007-12-27
DK0933082T3 (da) 2010-10-25
EP0930366A2 (en) 1999-07-21
AU1919792A (en) 1992-12-21
EP0933082B1 (en) 2010-07-14
ATE397661T1 (de) 2008-06-15
EP0930365A3 (en) 1999-07-28
DE69233724T2 (de) 2009-04-02
CA2102208A1 (en) 1992-11-12
ES2348919T3 (es) 2010-12-16
EP0576623B2 (en) 2007-10-03
EP0930366A3 (en) 1999-07-28
JP2011135886A (ja) 2011-07-14
DE69233735D1 (de) 2008-07-17
DE69232832T2 (de) 2003-06-18
DK0576623T3 (da) 2003-02-24
IE20030774A1 (en) 2003-12-10
IL101728A (en) 2007-08-19
CA2102208C (en) 2003-04-29
ES2181674T5 (es) 2008-03-01
IE85350B1 (en) 2009-10-14
DE69232832T3 (de) 2008-02-28
EP0930366B1 (en) 2008-06-04
DE69233724D1 (de) 2008-03-27
JPH07503123A (ja) 1995-04-06

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