ES2074562T3 - Anticuerpo monoclonal contra proteina c. - Google Patents
Anticuerpo monoclonal contra proteina c.Info
- Publication number
- ES2074562T3 ES2074562T3 ES90902092T ES90902092T ES2074562T3 ES 2074562 T3 ES2074562 T3 ES 2074562T3 ES 90902092 T ES90902092 T ES 90902092T ES 90902092 T ES90902092 T ES 90902092T ES 2074562 T3 ES2074562 T3 ES 2074562T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- antibody
- activation
- isolation
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
ANTICUERPO MONOCLONAL DEPENDIENTE DE CA2+ QUE SE UNE ESPECIFICAMENTE A UNA SECUENCIA ESPECIFICA DE DOCE PEPTIDOS (E D Q V D P R L I D G K) EN LA REGION DE ACTIVACION DE LA PROTEINA C. EL ANTICUERPO NO SE UNE A LA PROTEINA C ACTIVADA Y PUEDE USARSE PARA INHIBIR LA ACTIVACION DE LA PROTEINA C MEDIANTE TROMBINA-TROMBOMODULINA. EL ANTICUERPO PUEDE AISLARSE DEL CULTIVO DE CELULAS O FLUIDO DE ASCITIS EN GRANDES CANTIDADES POR CROMATOGRAFIA DE AFINIDAD CON CONDICIONES FAVORABLES USANDO EL PEPTIDO UNIDO A UN SUSTRATO INMOVILIZADO. EL ANTICUERPO TIENE CIERTO NUMERO DE USOS ESPECIFICOS EN EL AISLAMIENTO Y CARACTERIZACION DE LA PROTEINA C Y COMO MODELO DE DISEÑO DE ANTICUERPOS DEPENDIENTES DE CA2+ PARA EL AISLAMIENTO DE OTRAS PROTEINAS, COMO DIAGNOSIS Y COMO TERAPIA PARA PREVENIR LA ACTIVACION DE LA PROTEINA C. LA PROTEINA C PUEDE PRODUCIRSE NATURALMENTE O MEDIANTE LA EXPRESION DEL GEN RECOMBINANTE. ENTRE LAS VENTAJAS DEL ANTICUERPO EN LA PURIFICIACION DE LA PROTEINA C SE INCLUYEN LA ESPECIFICIDAD PARA LA PROTEINA C Y LA PROTEINA C NO ACTIVADA, Y LA ESPECIFICIDAD DE LA UNION UNICA DE CA2+-PEPTIDO QUE PERMITE QUE EL LUGAR DE UNION QUEDE PROTEGIDO CUANDO SE INMOVILICE EN EL SOPORTE CROMATOGRAFICO. "IN VIVO" SE HA DEMOSTRADO QUE EL ANTICUERPO INHIBE EL CRECIMIENTO DE TUMORES. EL ANTICUERPO PUEDE UTILIZARSE TAMBIEN PARA ACTIVAR LA COAGULACION EN PACIENTES CON ALTOS NIVELES DE INHIBIDORES DE FACTOR VIII.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29244788A | 1988-12-30 | 1988-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2074562T3 true ES2074562T3 (es) | 1995-09-16 |
Family
ID=23124711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90902092T Expired - Lifetime ES2074562T3 (es) | 1988-12-30 | 1989-12-28 | Anticuerpo monoclonal contra proteina c. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0407544B1 (es) |
JP (1) | JP2559537B2 (es) |
KR (1) | KR940002033B1 (es) |
AT (1) | ATE122057T1 (es) |
AU (2) | AU641634B2 (es) |
CA (1) | CA2006684C (es) |
DE (1) | DE68922491T2 (es) |
DK (1) | DK171826B1 (es) |
ES (1) | ES2074562T3 (es) |
FI (1) | FI101476B1 (es) |
WO (1) | WO1990007524A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5298599A (en) * | 1988-12-30 | 1994-03-29 | Oklahoma Medical Research Foundation | Expression and purification of recombinant soluble tissue factor |
AT402262B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Arzneimittel enthaltend aktiviertes protein c |
WO1994002172A1 (en) * | 1992-07-24 | 1994-02-03 | Oklahoma Medical Research Foundation | Blockade of protein c activation reduces microvascular surgical blood loss |
JP3735112B2 (ja) * | 1992-08-27 | 2006-01-18 | ステイヒテイング・セントラール・ラボラトリウム・バン・デ・ブレドトランスフシーデイーンスト・バン・ヘト・ネーデルランドセ・ロデ・クルイス | 凝血性蛋白質に特異的な抗体、未変性蛋白質を単離するためのそれらの利用、その蛋白質の蛋白質分解性開裂産物を含まない凝血性組成物 |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
US5532136A (en) * | 1993-06-22 | 1996-07-02 | Bionebraska, Inc. | Monoclonal antibody assay and kit for detecting metal cations in body fluids |
US5840858A (en) * | 1993-07-09 | 1998-11-24 | T Cell Sciences, Inc. | Protein purification using immobilized metal affinity chromatography for complement receptor proteins |
HRP940645A2 (en) * | 1993-10-06 | 1996-12-31 | Immuno Ag | Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained |
WO1995034652A1 (en) * | 1994-06-10 | 1995-12-21 | Oklahoma Medical Research Foundation | Calcium binding recombinant antibody against protein c |
TW200407335A (en) * | 2002-07-22 | 2004-05-16 | Chugai Pharmaceutical Co Ltd | Non-neutralizing antibody to inhibit the inactivation of activated protein C |
KR20220162801A (ko) | 2008-04-11 | 2022-12-08 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
EP2647706B1 (en) * | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
EP2679681B2 (en) | 2011-02-25 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIB-specific FC antibody |
WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
US20160229922A1 (en) * | 2013-09-20 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hemorrhagic diseases by anti-protein-c antibody |
KR102515796B1 (ko) | 2014-12-19 | 2023-03-30 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 그의 사용 방법 |
KR20180054923A (ko) | 2014-12-19 | 2018-05-24 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
US11053308B2 (en) | 2016-08-05 | 2021-07-06 | Chugai Seiyaku Kabushiki Kaisha | Method for treating IL-8-related diseases |
WO2018139623A1 (en) | 2017-01-30 | 2018-08-02 | Chugai Seiyaku Kabushiki Kaisha | Anti-sclerostin antibodies and methods of use |
-
1989
- 1989-12-27 CA CA002006684A patent/CA2006684C/en not_active Expired - Lifetime
- 1989-12-28 KR KR1019900701945A patent/KR940002033B1/ko not_active IP Right Cessation
- 1989-12-28 DE DE68922491T patent/DE68922491T2/de not_active Expired - Lifetime
- 1989-12-28 AU AU49683/90A patent/AU641634B2/en not_active Expired
- 1989-12-28 WO PCT/US1989/005851 patent/WO1990007524A1/en active IP Right Grant
- 1989-12-28 ES ES90902092T patent/ES2074562T3/es not_active Expired - Lifetime
- 1989-12-28 AT AT90902092T patent/ATE122057T1/de not_active IP Right Cessation
- 1989-12-28 JP JP2502801A patent/JP2559537B2/ja not_active Expired - Lifetime
- 1989-12-28 EP EP90902092A patent/EP0407544B1/en not_active Expired - Lifetime
-
1990
- 1990-08-29 FI FI904262A patent/FI101476B1/fi active IP Right Grant
- 1990-08-30 DK DK209090A patent/DK171826B1/da not_active IP Right Cessation
-
1993
- 1993-07-28 AU AU44228/93A patent/AU669540B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU669540B2 (en) | 1996-06-13 |
DK209090A (da) | 1990-08-30 |
FI904262A0 (fi) | 1990-08-29 |
WO1990007524A1 (en) | 1990-07-12 |
EP0407544A1 (en) | 1991-01-16 |
FI101476B (fi) | 1998-06-30 |
KR910700266A (ko) | 1991-03-14 |
AU4968390A (en) | 1990-08-01 |
DK171826B1 (da) | 1997-06-23 |
DE68922491D1 (de) | 1995-06-08 |
DE68922491T2 (de) | 1995-11-09 |
JPH03504332A (ja) | 1991-09-26 |
AU4422893A (en) | 1994-01-27 |
ATE122057T1 (de) | 1995-05-15 |
EP0407544B1 (en) | 1995-05-03 |
JP2559537B2 (ja) | 1996-12-04 |
AU641634B2 (en) | 1993-09-30 |
FI101476B1 (fi) | 1998-06-30 |
CA2006684A1 (en) | 1990-06-30 |
DK209090D0 (da) | 1990-08-30 |
KR940002033B1 (ko) | 1994-03-14 |
CA2006684C (en) | 1996-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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