ATE397661T1 - Bindungsdomänen des delta-proteins - Google Patents

Bindungsdomänen des delta-proteins

Info

Publication number
ATE397661T1
ATE397661T1 AT99101563T AT99101563T ATE397661T1 AT E397661 T1 ATE397661 T1 AT E397661T1 AT 99101563 T AT99101563 T AT 99101563T AT 99101563 T AT99101563 T AT 99101563T AT E397661 T1 ATE397661 T1 AT E397661T1
Authority
AT
Austria
Prior art keywords
binding domain
toporythmic protein
delta protein
fragment
protein
Prior art date
Application number
AT99101563T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Scott Shepard
Original Assignee
Univ Yale
Indiana University Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE397661(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Indiana University Foundation filed Critical Univ Yale
Application granted granted Critical
Publication of ATE397661T1 publication Critical patent/ATE397661T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99101563T 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins ATE397661T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14

Publications (1)

Publication Number Publication Date
ATE397661T1 true ATE397661T1 (de) 2008-06-15

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0933082B1 (de)
JP (7) JPH07503123A (de)
AT (4) ATE386116T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69233791D1 (de)
DK (4) DK0930365T3 (de)
ES (4) ES2181674T5 (de)
IE (2) IE85350B1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
AU723939B2 (en) 1995-06-28 2000-09-07 Imperial Cancer Research Technology Ltd Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
WO1997019172A1 (fr) 1995-11-17 1997-05-29 Asahi Kasei Kogyo Kabushiki Kaisha Polypeptide suppresseur et de differenciation
JP2000502246A (ja) * 1995-11-22 2000-02-29 エール ユニバーシティー 脊椎動物Ｄｅｌｔｅｘタンパク質、核酸および抗体ならびに関連方法および組成物
AU720930B2 (en) 1996-07-16 2000-06-15 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
CN1524583A (zh) * 1996-11-07 2004-09-01 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
WO1998045434A1 (en) 1997-04-04 1998-10-15 Millennium Biotherapeutics, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
JP4171528B2 (ja) 1997-05-14 2008-10-22 旭化成株式会社 新規な分化抑制剤
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) * 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
CA2309897A1 (en) * 1997-11-22 1999-06-03 Hyseq, Inc. A novel egf motif protein obtained from a cdna library of fetal liver-spleen
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
WO2002018544A2 (en) * 2000-08-31 2002-03-07 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
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CA2469204A1 (en) * 2001-12-07 2003-06-19 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
EP2003196A3 (de) * 2003-06-09 2009-01-07 The Regents of the University of Michigan Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs
WO2005074633A2 (en) * 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
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JP5129149B2 (ja) * 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
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WO2009063838A1 (ja) 2007-11-12 2009-05-22 Gs Yuasa Corporation リチウム二次電池用活物質、リチウム二次電池及びその製造方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
EP2899211A1 (de) 2008-07-08 2015-07-29 OncoMed Pharmaceuticals, Inc. NOTCH1-Rezeptor-bindende Wirkstoffe und Verfahren zur Verwendung davon
JP5792621B2 (ja) 2008-09-26 2015-10-14 オンコメッド ファーマシューティカルズ インコーポレイテッド ｆｒｉｚｚｌｅｄ結合剤およびその使用
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TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
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US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
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WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
ES2151542T3 (es) * 1992-12-11 2001-01-01 Us Health Gen del tipo delta expresado en tumores neuroendocrinos.

Also Published As

Publication number Publication date
DK0930365T3 (da) 2008-06-02
EP0930365A3 (de) 1999-07-28
JP2011135886A (ja) 2011-07-14
JP2008005843A (ja) 2008-01-17
IL101728A0 (en) 1992-12-30
EP0576623B1 (de) 2002-10-23
AU675203B2 (en) 1997-01-30
EP0576623B2 (de) 2007-10-03
IE20030774A1 (en) 2003-12-10
ES2181674T5 (es) 2008-03-01
WO1992019734A1 (en) 1992-11-12
IE921367A1 (en) 1992-11-04
DE69233791D1 (de) 2010-08-26
DE69233724D1 (de) 2008-03-27
DK0576623T4 (da) 2008-01-02
ES2303363T3 (es) 2008-08-01
ES2181674T3 (es) 2003-03-01
DE69232832T2 (de) 2003-06-18
EP0933082B1 (de) 2010-07-14
ATE386116T1 (de) 2008-03-15
EP0930366A2 (de) 1999-07-21
JP4430891B2 (ja) 2010-03-10
AU1919792A (en) 1992-12-21
EP0576623A4 (de) 1995-01-18
DE69233724T2 (de) 2009-04-02
JP2007330258A (ja) 2007-12-27
CA2102208C (en) 2003-04-29
DK0576623T3 (da) 2003-02-24
JP2011155979A (ja) 2011-08-18
US5849869A (en) 1998-12-15
ES2310933T3 (es) 2009-01-16
DE69233735D1 (de) 2008-07-17
EP0930365A2 (de) 1999-07-21
EP0576623A1 (de) 1994-01-05
ES2348919T3 (es) 2010-12-16
IE85350B1 (en) 2009-10-14
JPH07503123A (ja) 1995-04-06
ATE226633T1 (de) 2002-11-15
JP2007330259A (ja) 2007-12-27
EP0930366B1 (de) 2008-06-04
EP0933082A1 (de) 1999-08-04
IL101728A (en) 2007-08-19
DK0930366T3 (da) 2008-10-13
ATE473754T1 (de) 2010-07-15
DE69232832D1 (de) 2002-11-28
CA2102208A1 (en) 1992-11-12
JP4604227B2 (ja) 2011-01-05
JP2004065243A (ja) 2004-03-04
DK0933082T3 (da) 2010-10-25
DE69232832T3 (de) 2008-02-28
JP4604228B2 (ja) 2011-01-05
EP0930366A3 (de) 1999-07-28
EP0930365B1 (de) 2008-02-13

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