ATE397661T1 - Bindungsdomänen des delta-proteins - Google Patents
Bindungsdomänen des delta-proteinsInfo
- Publication number
- ATE397661T1 ATE397661T1 AT99101563T AT99101563T ATE397661T1 AT E397661 T1 ATE397661 T1 AT E397661T1 AT 99101563 T AT99101563 T AT 99101563T AT 99101563 T AT99101563 T AT 99101563T AT E397661 T1 ATE397661 T1 AT E397661T1
- Authority
- AT
- Austria
- Prior art keywords
- binding domain
- toporythmic protein
- delta protein
- fragment
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69518991A | 1991-05-03 | 1991-05-03 | |
US79192391A | 1991-11-14 | 1991-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE397661T1 true ATE397661T1 (de) | 2008-06-15 |
Family
ID=27105529
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99101562T ATE386116T1 (de) | 1991-05-03 | 1992-05-01 | Bindungsdomänen des serrate-proteins |
AT99101563T ATE397661T1 (de) | 1991-05-03 | 1992-05-01 | Bindungsdomänen des delta-proteins |
AT92911557T ATE226633T1 (de) | 1991-05-03 | 1992-05-01 | Bindungsdomänen in notch- und delta-proteinen |
AT99101561T ATE473754T1 (de) | 1991-05-03 | 1992-05-01 | Verfahren zur manipulation der zelldifferenzierung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99101562T ATE386116T1 (de) | 1991-05-03 | 1992-05-01 | Bindungsdomänen des serrate-proteins |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92911557T ATE226633T1 (de) | 1991-05-03 | 1992-05-01 | Bindungsdomänen in notch- und delta-proteinen |
AT99101561T ATE473754T1 (de) | 1991-05-03 | 1992-05-01 | Verfahren zur manipulation der zelldifferenzierung |
Country Status (12)
Country | Link |
---|---|
US (1) | US5849869A (de) |
EP (4) | EP0933082B1 (de) |
JP (7) | JPH07503123A (de) |
AT (4) | ATE386116T1 (de) |
AU (1) | AU675203B2 (de) |
CA (1) | CA2102208C (de) |
DE (4) | DE69233791D1 (de) |
DK (4) | DK0930365T3 (de) |
ES (4) | ES2181674T5 (de) |
IE (2) | IE85350B1 (de) |
IL (1) | IL101728A (de) |
WO (1) | WO1992019734A1 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
US6004924A (en) | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US5750652A (en) * | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
AU723939B2 (en) | 1995-06-28 | 2000-09-07 | Imperial Cancer Research Technology Ltd | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
WO1997019172A1 (fr) | 1995-11-17 | 1997-05-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Polypeptide suppresseur et de differenciation |
JP2000502246A (ja) * | 1995-11-22 | 2000-02-29 | エール ユニバーシティー | 脊椎動物Deltexタンパク質、核酸および抗体ならびに関連方法および組成物 |
AU720930B2 (en) | 1996-07-16 | 2000-06-15 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitor |
US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
CN1524583A (zh) * | 1996-11-07 | 2004-09-01 | 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用 | |
US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
WO1998045434A1 (en) | 1997-04-04 | 1998-10-15 | Millennium Biotherapeutics, Inc. | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
JP4171528B2 (ja) | 1997-05-14 | 2008-10-22 | 旭化成株式会社 | 新規な分化抑制剤 |
US6692919B1 (en) | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
US6436650B1 (en) * | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
US6392019B1 (en) | 1997-11-22 | 2002-05-21 | John Ford | Antibodies specific for EGF motif proteins |
US6808890B2 (en) | 1999-07-28 | 2004-10-26 | Nuvelo, Inc. | Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein |
CA2309897A1 (en) * | 1997-11-22 | 1999-06-03 | Hyseq, Inc. | A novel egf motif protein obtained from a cdna library of fetal liver-spleen |
WO1999061614A2 (en) * | 1998-05-28 | 1999-12-02 | Incyte Pharmaceuticals, Inc. | Human socs proteins |
US8084258B2 (en) | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
US6448197B1 (en) * | 2000-07-13 | 2002-09-10 | Exxonmobil Chemical Patents Inc. | Method for making a metal containing small pore molecular sieve catalyst |
US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
WO2002018544A2 (en) * | 2000-08-31 | 2002-03-07 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
US7399633B2 (en) * | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
GB0118155D0 (en) | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
CA2469204A1 (en) * | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
EP2003196A3 (de) * | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs |
WO2005074633A2 (en) * | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
WO2006135886A2 (en) * | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
CA2612021A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
JP5129149B2 (ja) * | 2005-10-31 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を処置および診断するための組成物および方法 |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
PL2500360T3 (pl) | 2005-10-31 | 2016-01-29 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworu |
ES2413087T3 (es) | 2006-06-13 | 2013-07-15 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para el diagnóstico y tratamiento del cáncer |
EA018260B1 (ru) | 2006-09-29 | 2013-06-28 | Онкомед Фармасьютикалз, Инк. | Антитела к дельта-подобному лиганду 4 человека и их применение |
RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
US7935791B2 (en) | 2006-12-18 | 2011-05-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
EP2125887A4 (de) | 2007-01-24 | 2010-11-10 | Oncomed Pharm Inc | Zusammensetzungen und verfahren zur behandlung und diagnostizierung von krebs |
EP2106439B1 (de) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Zusammensetzungen und verfahren zur behandlung und diagnostizierung von pankreaskrebs |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
US8068607B2 (en) | 2007-07-31 | 2011-11-29 | Ricoh Company, Limited | Information processing apparatus and information processing method |
WO2009063838A1 (ja) | 2007-11-12 | 2009-05-22 | Gs Yuasa Corporation | リチウム二次電池用活物質、リチウム二次電池及びその製造方法 |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
EP2899211A1 (de) | 2008-07-08 | 2015-07-29 | OncoMed Pharmaceuticals, Inc. | NOTCH1-Rezeptor-bindende Wirkstoffe und Verfahren zur Verwendung davon |
JP5792621B2 (ja) | 2008-09-26 | 2015-10-14 | オンコメッド ファーマシューティカルズ インコーポレイテッド | frizzled結合剤およびその使用 |
US8883145B2 (en) | 2009-10-16 | 2014-11-11 | Oncomed Pharmaceuticals, Inc. | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
MX347515B (es) | 2010-04-01 | 2017-04-28 | Oncomed Pharmaceuticals Inc * | Agentes que se unen al receptor encrespado y usos de los mismos. |
WO2011127472A1 (en) | 2010-04-09 | 2011-10-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
JP6165627B2 (ja) | 2010-04-09 | 2017-07-19 | フレッド ハッチンソン キャンサー リサーチ センター | Hlaの適合なしに造血機能を提供するための組成物および方法 |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
US8858941B2 (en) | 2011-09-23 | 2014-10-14 | Oncomed Pharmaceuticals, Inc. | VEGF/DLL4 binding agents and uses thereof |
US9834755B2 (en) | 2011-12-08 | 2017-12-05 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
CN104768579A (zh) | 2012-10-23 | 2015-07-08 | 昂科梅德制药有限公司 | 使用Wnt途径结合剂来治疗神经内分泌肿瘤的方法 |
EP2914961A4 (de) | 2012-10-31 | 2016-04-20 | Oncomed Pharm Inc | Verfahren und überwachung der behandlung mit einem dll4-antagonisten |
CA2897499A1 (en) | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
MX2016005689A (es) | 2013-10-31 | 2016-08-08 | Hutchinson Fred Cancer Res | Celulas no t efectoras y madre/progenitoras hematopoyeticas modificadas y usos de estas. |
JP6641299B2 (ja) | 2014-06-04 | 2020-02-05 | フレッド ハッチンソン キャンサー リサーチ センター | Notch 1および/またはNotch 2アゴニストを用いた幹細胞の増殖および生着 |
WO2016070051A2 (en) | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
WO2016176651A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
EP3288570A4 (de) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modifizierte stammzellen und verwendungen davon |
CN109071644B (zh) | 2015-09-23 | 2023-09-19 | 昂考梅德药品有限公司 | 治疗癌症的方法和组合物 |
BR112018011327A2 (pt) | 2015-12-04 | 2018-12-04 | Hutchinson Fred Cancer Res | usos de populações expandidas de células-tronco/progenitoras hematopoiéticas |
US20220098613A1 (en) | 2018-09-12 | 2022-03-31 | Fred Hutchinson Cancer Research Center | Reducing cd33 expression to selectively protect therapeutic cells |
WO2023150393A2 (en) | 2022-02-07 | 2023-08-10 | Ensoma, Inc. | Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3884853A (en) * | 1973-11-14 | 1975-05-20 | Staley Mfg Co A E | Alkali-curable cationic/anionic starch for paper coating binders |
US5115096A (en) * | 1988-04-15 | 1992-05-19 | Oncogen | Amphiregulin: a bifunctional growth modulating glycoprotein |
US5098833A (en) * | 1989-02-23 | 1992-03-24 | Genentech, Inc. | DNA sequence encoding a functional domain of a lymphocyte homing receptor |
US5368712A (en) * | 1989-11-02 | 1994-11-29 | Synporin Technologies, Inc. | Biologically mimetic synthetic ion channel transducers |
WO1992010518A1 (en) * | 1990-12-07 | 1992-06-25 | Yale University | Purified slit protein and sequence elements thereof |
IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
WO1993012141A1 (en) * | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
ES2151542T3 (es) * | 1992-12-11 | 2001-01-01 | Us Health | Gen del tipo delta expresado en tumores neuroendocrinos. |
-
1992
- 1992-04-29 IL IL101728A patent/IL101728A/en not_active IP Right Cessation
- 1992-05-01 DK DK99101562T patent/DK0930365T3/da active
- 1992-05-01 AT AT99101562T patent/ATE386116T1/de active
- 1992-05-01 DE DE69233791T patent/DE69233791D1/de not_active Expired - Lifetime
- 1992-05-01 DE DE69233724T patent/DE69233724T2/de not_active Expired - Lifetime
- 1992-05-01 ES ES92911557T patent/ES2181674T5/es not_active Expired - Lifetime
- 1992-05-01 DE DE69233735T patent/DE69233735D1/de not_active Expired - Lifetime
- 1992-05-01 DK DK99101563T patent/DK0930366T3/da active
- 1992-05-01 ES ES99101561T patent/ES2348919T3/es not_active Expired - Lifetime
- 1992-05-01 AT AT99101563T patent/ATE397661T1/de active
- 1992-05-01 ES ES99101563T patent/ES2310933T3/es not_active Expired - Lifetime
- 1992-05-01 EP EP99101561A patent/EP0933082B1/de not_active Expired - Lifetime
- 1992-05-01 DE DE69232832T patent/DE69232832T3/de not_active Expired - Lifetime
- 1992-05-01 JP JP4510668A patent/JPH07503123A/ja not_active Withdrawn
- 1992-05-01 DK DK92911557T patent/DK0576623T4/da active
- 1992-05-01 DK DK99101561.1T patent/DK0933082T3/da active
- 1992-05-01 AU AU19197/92A patent/AU675203B2/en not_active Expired
- 1992-05-01 AT AT92911557T patent/ATE226633T1/de active
- 1992-05-01 EP EP99101562A patent/EP0930365B1/de not_active Expired - Lifetime
- 1992-05-01 EP EP92911557A patent/EP0576623B2/de not_active Expired - Lifetime
- 1992-05-01 WO PCT/US1992/003651 patent/WO1992019734A1/en active Search and Examination
- 1992-05-01 AT AT99101561T patent/ATE473754T1/de active
- 1992-05-01 EP EP99101563A patent/EP0930366B1/de not_active Expired - Lifetime
- 1992-05-01 ES ES99101562T patent/ES2303363T3/es not_active Expired - Lifetime
- 1992-05-01 CA CA002102208A patent/CA2102208C/en not_active Expired - Lifetime
- 1992-07-01 IE IE20030774A patent/IE85350B1/en active IP Right Revival
- 1992-07-01 IE IE136792A patent/IE921367A1/en not_active IP Right Cessation
-
1994
- 1994-11-28 US US08/346,126 patent/US5849869A/en not_active Expired - Lifetime
-
2003
- 2003-05-26 JP JP2003148322A patent/JP4430891B2/ja not_active Expired - Lifetime
-
2007
- 2007-07-11 JP JP2007182688A patent/JP4604228B2/ja not_active Expired - Lifetime
- 2007-07-11 JP JP2007182684A patent/JP4604227B2/ja not_active Expired - Lifetime
- 2007-07-11 JP JP2007182683A patent/JP2008005843A/ja not_active Withdrawn
-
2011
- 2011-02-04 JP JP2011023396A patent/JP2011135886A/ja not_active Withdrawn
- 2011-03-07 JP JP2011049708A patent/JP2011155979A/ja not_active Withdrawn
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