DE69233724D1 - Bindungsdomänen des Serrate-Proteins - Google Patents

Bindungsdomänen des Serrate-Proteins

Info

Publication number
DE69233724D1
DE69233724D1 DE69233724T DE69233724T DE69233724D1 DE 69233724 D1 DE69233724 D1 DE 69233724D1 DE 69233724 T DE69233724 T DE 69233724T DE 69233724 T DE69233724 T DE 69233724T DE 69233724 D1 DE69233724 D1 DE 69233724D1
Authority
DE
Germany
Prior art keywords
binding domains
toporythmic protein
protein
fragment
serrate protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233724T
Other languages
English (en)
Other versions
DE69233724T2 (de
Inventor
Spyridon Artavanis-Tsakonas
New Heaven Fehon
New Heaven Rebay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Indiana University Foundation
Original Assignee
Yale University
Indiana University Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69233724(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yale University, Indiana University Foundation filed Critical Yale University
Application granted granted Critical
Publication of DE69233724D1 publication Critical patent/DE69233724D1/de
Publication of DE69233724T2 publication Critical patent/DE69233724T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69233724T 1991-05-03 1992-05-01 Bindungsdomänen des Serrate-Proteins Expired - Lifetime DE69233724T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US695189 1991-05-03
US79192391A 1991-11-14 1991-11-14
US791923 2004-03-03

Publications (2)

Publication Number Publication Date
DE69233724D1 true DE69233724D1 (de) 2008-03-27
DE69233724T2 DE69233724T2 (de) 2009-04-02

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69233791T Expired - Lifetime DE69233791D1 (de) 1991-05-03 1992-05-01 Verfahren zur Manipulation der Zelldifferenzierung
DE69233735T Expired - Lifetime DE69233735D1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Delta-proteins
DE69233724T Expired - Lifetime DE69233724T2 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Serrate-Proteins
DE69232832T Expired - Lifetime DE69232832T3 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69233791T Expired - Lifetime DE69233791D1 (de) 1991-05-03 1992-05-01 Verfahren zur Manipulation der Zelldifferenzierung
DE69233735T Expired - Lifetime DE69233735D1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des Delta-proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69232832T Expired - Lifetime DE69232832T3 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0930365B1 (de)
JP (7) JPH07503123A (de)
AT (4) ATE386116T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69233791D1 (de)
DK (4) DK0930366T3 (de)
ES (4) ES2348919T3 (de)
IE (2) IE85350B1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
AU723939B2 (en) * 1995-06-28 2000-09-07 Imperial Cancer Research Technology Ltd Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
EP0861894B1 (de) 1995-11-17 2006-03-08 Asahi Kasei Kabushiki Kaisha Polypeptid, das die differenzierung unterdrueckt
JP2000502246A (ja) * 1995-11-22 2000-02-29 エール ユニバーシティー 脊椎動物Ｄｅｌｔｅｘタンパク質、核酸および抗体ならびに関連方法および組成物
US6291210B1 (en) 1996-07-16 2001-09-18 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
DE69733695T2 (de) * 1996-11-07 2006-05-18 Lorantis Ltd. Notch-liganden zur verwendung in der immuntherapie
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
EP0972041B2 (de) 1997-04-04 2017-01-18 Millennium Pharmaceuticals, Inc. Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
CA2288218C (en) * 1997-05-14 2013-03-12 Asahi Kasei Kogyo Kabushiki Kaisha Novel differentiation-inhibitor
US6436650B1 (en) * 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
WO1999027096A1 (en) * 1997-11-22 1999-06-03 Hyseq, Inc. A NOVEL EGF MOTIF PROTEIN OBTAINED FROM A cDNA LIBRARY OF FETAL LIVER-SPLEEN
CA2329053A1 (en) * 1998-05-28 1999-12-02 Incyte Pharmaceuticals, Inc. Human socs proteins
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US20050089518A1 (en) * 2001-12-07 2005-04-28 Clarke Michael F. Prospective identification and characterization of breast cancer stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
WO2002018544A2 (en) * 2000-08-31 2002-03-07 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
AU2004256425A1 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20050232927A1 (en) * 2004-02-03 2005-10-20 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2628255C (en) * 2005-10-31 2016-04-19 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
DK2500360T3 (en) 2005-10-31 2015-10-26 Oncomed Pharm Inc Compositions and methods for the diagnosis and treatment of cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
EA018260B1 (ru) 2006-09-29 2013-06-28 Онкомед Фармасьютикалз, Инк. Антитела к дельта-подобному лиганду 4 человека и их применение
RU2448979C2 (ru) * 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
JP5386364B2 (ja) 2006-12-18 2014-01-15 ジェネンテック， インコーポレイテッド 抗Ｎｏｔｃｈ３アンタゴニスト抗体とＮｏｔｃｈ３関連疾患の予防及び治療におけるその使用
AU2008209482B2 (en) 2007-01-24 2014-05-01 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
EP2106439B1 (de) * 2007-01-24 2014-11-12 The Regents of the University of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von pankreaskrebs
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
EP2278642B1 (de) 2007-11-12 2013-01-16 GS Yuasa International Ltd. Herstellungsverfahren für ein aktives Material für eine Lithiumsekundärbatterie und eine Lithiumsekundärbatterie
ES2531541T3 (es) 2008-07-08 2015-03-17 Oncomed Pharmaceuticals, Inc. Agentes de unión del receptor Notch1 y procedimientos de uso de los mismos
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CN105079805A (zh) 2008-09-26 2015-11-25 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
DK2488204T3 (en) 2009-10-16 2016-06-06 Oncomed Pharm Inc Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
EP2552953B1 (de) 2010-04-01 2017-05-17 OncoMed Pharmaceuticals, Inc. Frizzled-bindende stoffe und ihre verwendungen
WO2011127470A1 (en) 2010-04-09 2011-10-13 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US20130095080A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Reserach Center Compositions and methods for providing hematopoietic function
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
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US9266959B2 (en) 2012-10-23 2016-02-23 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using frizzled-binding agents
US20140227252A1 (en) 2012-10-31 2014-08-14 Oncomed Pharmaceuticals , Inc. Methods and Monitoring of Treatment with a DLL4 Antagonist
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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
PT673390E (pt) * 1992-12-11 2001-01-31 Us Health Genes semelhantes a delta expressos em tumores neuroendocrinos

Also Published As

Publication number Publication date
JPH07503123A (ja) 1995-04-06
ES2303363T3 (es) 2008-08-01
EP0930365A2 (de) 1999-07-21
EP0930366A2 (de) 1999-07-21
DE69232832T2 (de) 2003-06-18
WO1992019734A1 (en) 1992-11-12
JP4604228B2 (ja) 2011-01-05
EP0930365B1 (de) 2008-02-13
DE69233791D1 (de) 2010-08-26
AU675203B2 (en) 1997-01-30
EP0933082A1 (de) 1999-08-04
DE69233724T2 (de) 2009-04-02
CA2102208A1 (en) 1992-11-12
ES2181674T5 (es) 2008-03-01
IE921367A1 (en) 1992-11-04
DK0933082T3 (da) 2010-10-25
IL101728A0 (en) 1992-12-30
JP2008005843A (ja) 2008-01-17
ES2310933T3 (es) 2009-01-16
ATE397661T1 (de) 2008-06-15
CA2102208C (en) 2003-04-29
JP2004065243A (ja) 2004-03-04
JP4430891B2 (ja) 2010-03-10
JP2011155979A (ja) 2011-08-18
ATE386116T1 (de) 2008-03-15
EP0576623B2 (de) 2007-10-03
JP2007330258A (ja) 2007-12-27
EP0576623B1 (de) 2002-10-23
IE20030774A1 (en) 2003-12-10
AU1919792A (en) 1992-12-21
ES2348919T3 (es) 2010-12-16
DK0576623T3 (da) 2003-02-24
JP4604227B2 (ja) 2011-01-05
DE69233735D1 (de) 2008-07-17
DK0930365T3 (da) 2008-06-02
EP0930366A3 (de) 1999-07-28
EP0930365A3 (de) 1999-07-28
ATE226633T1 (de) 2002-11-15
IE85350B1 (en) 2009-10-14
DE69232832T3 (de) 2008-02-28
EP0576623A1 (de) 1994-01-05
EP0576623A4 (de) 1995-01-18
JP2011135886A (ja) 2011-07-14
DE69232832D1 (de) 2002-11-28
DK0930366T3 (da) 2008-10-13
US5849869A (en) 1998-12-15
IL101728A (en) 2007-08-19
ATE473754T1 (de) 2010-07-15
ES2181674T3 (es) 2003-03-01
DK0576623T4 (da) 2008-01-02
JP2007330259A (ja) 2007-12-27
EP0930366B1 (de) 2008-06-04
EP0933082B1 (de) 2010-07-14

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