SI2307051T1 - Notch-vezavna sredstva in antagonisti ter postopki njihove uporabe - Google Patents

Notch-vezavna sredstva in antagonisti ter postopki njihove uporabe

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Publication number
SI2307051T1
SI2307051T1 SI200931156T SI200931156T SI2307051T1 SI 2307051 T1 SI2307051 T1 SI 2307051T1 SI 200931156 T SI200931156 T SI 200931156T SI 200931156 T SI200931156 T SI 200931156T SI 2307051 T1 SI2307051 T1 SI 2307051T1
Authority
SI
Slovenia
Prior art keywords
antagonists
notch
methods
binding agents
binding
Prior art date
Application number
SI200931156T
Other languages
English (en)
Inventor
Austin L. Gurney
Timothy Charles Hoey
Van Der Horst Edward Thein Htun
Aaron Ken Sato
Yuan Ching Liu
Maureen Fitch Bruhns
John A. Lewicki
Original Assignee
Oncomed Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharmaceuticals, Inc. filed Critical Oncomed Pharmaceuticals, Inc.
Publication of SI2307051T1 publication Critical patent/SI2307051T1/sl

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
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    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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SI200931156T 2008-07-08 2009-07-08 Notch-vezavna sredstva in antagonisti ter postopki njihove uporabe SI2307051T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11269908P 2008-11-07 2008-11-07
US11270108P 2008-11-07 2008-11-07
EP09794821.0A EP2307051B1 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of use thereof
PCT/US2009/003994 WO2010005566A2 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of use thereof

Publications (1)

Publication Number Publication Date
SI2307051T1 true SI2307051T1 (sl) 2015-04-30

Family

ID=41507637

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200931146T SI2307459T1 (sl) 2008-07-08 2009-07-08 Notch 1 receptor vezavna sredstva in postopki njihove uporabe
SI200931156T SI2307051T1 (sl) 2008-07-08 2009-07-08 Notch-vezavna sredstva in antagonisti ter postopki njihove uporabe

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Application Number Title Priority Date Filing Date
SI200931146T SI2307459T1 (sl) 2008-07-08 2009-07-08 Notch 1 receptor vezavna sredstva in postopki njihove uporabe

Country Status (32)

Country Link
US (11) US8435513B2 (sl)
EP (4) EP2924051A1 (sl)
JP (2) JP5560271B2 (sl)
KR (2) KR101682490B1 (sl)
CN (3) CN102112490B (sl)
AU (2) AU2009269095B2 (sl)
BR (2) BRPI0914007A2 (sl)
CA (2) CA2729306C (sl)
CO (2) CO6390041A2 (sl)
CR (1) CR20110069A (sl)
CY (2) CY1116195T1 (sl)
DK (2) DK2307051T3 (sl)
DO (2) DOP2011000002A (sl)
EA (2) EA026109B1 (sl)
ES (2) ES2535614T3 (sl)
HK (2) HK1151218A1 (sl)
HR (2) HRP20150256T1 (sl)
IL (2) IL210222A (sl)
MA (2) MA32449B1 (sl)
ME (2) ME02069B (sl)
MX (2) MX2011000236A (sl)
MY (2) MY159815A (sl)
NZ (2) NZ590127A (sl)
PL (2) PL2307051T3 (sl)
PT (2) PT2307459E (sl)
RS (2) RS53924B1 (sl)
SG (2) SG192468A1 (sl)
SI (2) SI2307459T1 (sl)
SM (2) SMT201500047B (sl)
UA (1) UA101672C2 (sl)
WO (2) WO2010005567A2 (sl)
ZA (2) ZA201009280B (sl)

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US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US9540694B2 (en) * 2006-05-19 2017-01-10 The Johns Hopkins University HEYL as a therapeutic target and a diagnostic marker for neoplasia and uses therefor
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
WO2008076960A2 (en) 2006-12-18 2008-06-26 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
ES2535614T3 (es) 2008-07-08 2015-05-13 Oncomed Pharmaceuticals, Inc. Agentes de unión a Notch y antagonistas y métodos de uso de los mismos
AR073717A1 (es) * 2008-10-01 2010-11-24 Genentech Inc Anticuerpos anti-notch2 de murino y humano, y metodos de uso
WO2010146550A1 (en) 2009-06-18 2010-12-23 Pfizer Inc. Anti notch-1 antibodies
KR101782180B1 (ko) * 2009-09-30 2017-10-23 제넨테크, 인크. Ｎｏｔｃｈ3 길항제를 사용한 Ｎｏｔｃｈ1―길항제-내성 암(들)의 치료
JP5965318B2 (ja) 2009-10-16 2016-08-03 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｄｌｌ４アンタゴニストおよび降圧剤の治療的併用およびそれらによる治療の方法
EP2523682B1 (en) * 2010-01-13 2015-12-16 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
US9427429B2 (en) 2010-03-01 2016-08-30 Tau Therapeutics Llc Cancer diagnosis and imaging
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