DOP2011000004A - Agentes y antagonistas fijadores de notch y metodos para el uso de los mismos - Google Patents
Agentes y antagonistas fijadores de notch y metodos para el uso de los mismosInfo
- Publication number
- DOP2011000004A DOP2011000004A DO2011000004A DO2011000004A DOP2011000004A DO P2011000004 A DOP2011000004 A DO P2011000004A DO 2011000004 A DO2011000004 A DO 2011000004A DO 2011000004 A DO2011000004 A DO 2011000004A DO P2011000004 A DOP2011000004 A DO P2011000004A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- methods
- antagonists
- notch
- present
- fixing agents
- Prior art date
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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- C—CHEMISTRY; METALLURGY
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- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
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- C—CHEMISTRY; METALLURGY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
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Abstract
El presente invento se relaciona con agentes fijadores de Notch y antagonistas de la proteína Notch y métodos para el uso de los agentes y/o antagonistas para el tratamiento de enfermedades como el cáncer. El presente invento suministra anticuerpos los cuales se fijan de manera específica a una región no fijadora de ligandos del dominio extracelular de uno o más receptores Notch humanos, como Notch2 y/o Notch3, e inhiben el crecimiento tumoral. El presente invento además suministra métodos para tratar el cáncer, los métodos comprenden la administración de una cantidad terapéuticamente efectiva de un anticuerpo el cual se fija de manera específica a una región no fijadora de ligandos del dominio extracelular de una proteína receptora Notch humana e inhibe el crecimiento tumoral.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7909508P | 2008-07-08 | 2008-07-08 | |
US11269908P | 2008-11-07 | 2008-11-07 | |
US11270108P | 2008-11-07 | 2008-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2011000004A true DOP2011000004A (es) | 2011-04-15 |
Family
ID=41507637
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2011000002A DOP2011000002A (es) | 2008-07-08 | 2011-01-05 | Agentes de fijación al receptor notch1 y metodos de uso de los mismos |
DO2011000004A DOP2011000004A (es) | 2008-07-08 | 2011-01-05 | Agentes y antagonistas fijadores de notch y metodos para el uso de los mismos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2011000002A DOP2011000002A (es) | 2008-07-08 | 2011-01-05 | Agentes de fijación al receptor notch1 y metodos de uso de los mismos |
Country Status (32)
Country | Link |
---|---|
US (11) | US8226943B2 (es) |
EP (4) | EP2307459B1 (es) |
JP (2) | JP5560271B2 (es) |
KR (2) | KR101682490B1 (es) |
CN (3) | CN104402998A (es) |
AU (2) | AU2009269095B2 (es) |
BR (2) | BRPI0914004A2 (es) |
CA (2) | CA2729306C (es) |
CO (2) | CO6390041A2 (es) |
CR (1) | CR20110069A (es) |
CY (2) | CY1116195T1 (es) |
DK (2) | DK2307051T3 (es) |
DO (2) | DOP2011000002A (es) |
EA (2) | EA201170157A1 (es) |
ES (2) | ES2535614T3 (es) |
HK (2) | HK1151296A1 (es) |
HR (2) | HRP20150256T1 (es) |
IL (2) | IL210222A (es) |
MA (2) | MA32448B1 (es) |
ME (2) | ME02148B (es) |
MX (2) | MX2011000233A (es) |
MY (2) | MY159815A (es) |
NZ (2) | NZ590131A (es) |
PL (2) | PL2307459T3 (es) |
PT (2) | PT2307459E (es) |
RS (2) | RS53750B1 (es) |
SG (2) | SG192468A1 (es) |
SI (2) | SI2307459T1 (es) |
SM (2) | SMT201500047B (es) |
UA (1) | UA101672C2 (es) |
WO (2) | WO2010005567A2 (es) |
ZA (2) | ZA201009280B (es) |
Families Citing this family (66)
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US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2007136856A2 (en) * | 2006-05-19 | 2007-11-29 | The Johns Hopkins University | Heyl as a therapeutic target and a diagnostic marker for neoplasia and uses therefor |
WO2007145840A2 (en) | 2006-06-13 | 2007-12-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
AR064388A1 (es) | 2006-12-18 | 2009-04-01 | Genentech Inc | Anticuerpos antagonistas anti- notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3 |
CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
MX2011000233A (es) | 2008-07-08 | 2011-05-19 | Oncomed Pharm Inc | Agentes de union del receptor notch1 y metodos para su uso. |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
CN102170909B (zh) * | 2008-10-01 | 2015-11-25 | 霍夫曼-拉罗奇有限公司 | 抗-notch2抗体和使用方法 |
PE20121494A1 (es) | 2009-06-18 | 2012-11-01 | Pfizer | Anticuerpos anti notch-1 |
RU2012117619A (ru) * | 2009-09-30 | 2013-11-10 | Дженентек, Инк. | ЛЕЧЕНИЕ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ, УСТОЙЧИВЫХ К ДЕЙСТВИЮ АНТАГОНИСТА Notch1, С ПОМОЩЬЮ АНТАГОНИСТА Notch3 |
ES2895226T3 (es) | 2009-10-16 | 2022-02-18 | Mereo Biopharma 5 Inc | Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos |
EP2523682B1 (en) * | 2010-01-13 | 2015-12-16 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
KR101821343B1 (ko) | 2010-03-01 | 2018-01-23 | 타우 쎄라퓨틱스 엘엘씨 | 암 진단 및 영상화 |
PE20130460A1 (es) * | 2010-05-03 | 2013-04-26 | Genentech Inc | Composiciones y metodos para el diagnostico y tratamiento de tumores |
KR101580726B1 (ko) | 2010-12-15 | 2015-12-29 | 와이어쓰 엘엘씨 | 항-노치1 항체 |
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