HRP20150443T1 - Djelotvorne tvari koje se vežu za notch i njihovi antagonisti te postupci njihove uporabe - Google Patents
Djelotvorne tvari koje se vežu za notch i njihovi antagonisti te postupci njihove uporabe Download PDFInfo
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- HRP20150443T1 HRP20150443T1 HRP20150443TT HRP20150443T HRP20150443T1 HR P20150443 T1 HRP20150443 T1 HR P20150443T1 HR P20150443T T HRP20150443T T HR P20150443TT HR P20150443 T HRP20150443 T HR P20150443T HR P20150443 T1 HRP20150443 T1 HR P20150443T1
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- 239000005557 antagonist Substances 0.000 title claims 2
- 102000005650 Notch Receptors Human genes 0.000 title 1
- 108010070047 Notch Receptors Proteins 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000013543 active substance Substances 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010007269 Carcinogenicity Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
- 101000577199 Homo sapiens Neurogenic locus notch homolog protein 2 Proteins 0.000 claims 1
- 101000577202 Homo sapiens Neurogenic locus notch homolog protein 3 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000007670 carcinogenicity Effects 0.000 claims 1
- 231100000260 carcinogenicity Toxicity 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 102000046883 human NOTCH2 Human genes 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
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Claims (19)
1. Izolirano protutijelo koje se specifično veže na humani Notch2 i Notch3, naznačeno time, da obuhvaća:
a) CDR1 jakog lanca koji sadrži SSSGMS (SEQ ID NO:5), CDR2 jakog lanca koji sadrži VIASSGSNTYYADSVKG (SEQ ID NO:6), i CDR3 jakog lanca koji sadrži SIFYTT (SEQ ID NO:51) ili SEQ ID NO:30; i
b) CDR1 slabog lanca koji sadrži RASQSVRSNYLA (SEQ ID NO:8), CDR2 slabog lanca koji sadrži GASSRAT (SEQ ID NO:9), i CDR3 slabog lanca koji sadrži QQYSNFPI (SEQ ID NO:10).
2. Protutijelo prema zahtjevu 1, naznačeno time, da CDR3 jakog lanca sadrži SIFYTT (SEQ ID NO:51).
3. Protutijelo prema zahtjevu 2, naznačeno time, da obuhvaća varijabilno područje jakog lanca od SEQ ID NO:50 i varijabilno područje slabog lanca od SEQ ID NO:13.
4. Protutijelo prema zahtjevu 1, naznačeno time, da CDR3 jakog lanca sadrži SIFYPT (SEQ ID NO:22), SSFFAS (SEQ ID NO:23), SSFYAS (SEQ ID NO:24), SSFFAT (SEQ ID NO:25), SIFYPS (SEQ ID NO:26), SSFFAN (SEQ ID NO:27), ili GIFFAI (SEQ ID NO:7).
5. Protutijelo prema zahtjevu 1, zahtjevu 2, ili zahtjevu 4, naznačeno time, da obuhvaća:
a) varijabilno područje jakog lanca, koje ima najmanje oko 90% identiteta sekvence od SEQ ID NO:50, SEQ ID NO:14, ili SEQ ID NO:20; i
b) varijabilno područje slabog lanca, koje ima najmanje oko 90% identiteta sekvence od SEQ ID NO:13 ili SEQ ID NO:19.
6. Protutijelo prema bilo kojem od zahtjeva 1 do 5, naznačeno time, da to protutijelo je rekombinantno protutijelo, monoklonalno protutijelo, kimerno protutijelo, humanizirano protutijelo, ljudsko protutijelo, fragment protutijela, bispecifično protutijelo, monospecifično protutijelo, IgG1-protutijelo ili IgG2-protutijelo.
7. Protutijelo, naznačeno time, da se kodira pomoću polinukleotida deponiranog u ATCC pod oznakom PTA-10170 ili pomoću polinukleotida deponiranog u ATCC pod oznakom PTA-9547.
8. Stanica, naznačena time, da ona obuhvaća ili proizvodi protutijelo određeno prema bilo kojem od zahtjeva 1 do 7.
9. Izolirani polinukleotid, naznačen time, da on obuhvaća polinukleotid koji kodira protutijelo prema bilo kojem od zahtjeva 1 do 7.
10. Protutijelo prema bilo kojem od zahtjeva 1 do 7, naznačeno time, da se upotrebljava u liječenju raka.
11. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 10, naznačeno time, da liječenje smanjuje kanceroznost tumora i/ili smanjuje frekvenciju matičnih stanica raka u tumoru.
12. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 10, naznačeno time, da rak je kolorektalni rak, rak dojke, rak gušterače, rak pluća ili melanom.
13. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 10, naznačeno time, da liječenje obuhvaća primjenu učinkovite količine protutijela na pojedincu, te nadalje obuhvaća primjenu terapeutski učinkovite količine druge djelotvorne tvari na pojedincu, pri čemu druga djelotvorna tvar je protutumorsko sredstvo i/ili anti-angiogensko sredstvo.
14. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 13, naznačeno time, da druga djelotvorna tvar je kemoterapeutsko sredstvo.
15. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 14, naznačeno time, da kemoterapeutsko sredstvo je paklitaksel, gemcitabin ili irinotekan.
16. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 13, naznačeno time, da druga djelotvorna tvar je antagonist faktora rasta vaskularne endotelijalne stanice (VEGF) ili je VEGF-receptor.
17. Protutijelo prema bilo kojem od zahtjeva 1 do 7, za uporabu prema zahtjevu 13, naznačeno time, da druga djelotvorna tvar je anti-DLL4-protutijelo.
18. Uporaba protutijela određenog prema bilo kojem od zahtjeva 1 do 7, naznačena time, da je za proizvodnju lijeka za liječenje raka.
19. Uporaba prema zahtjevu 18, naznačena time, da liječenje raka je liječenje određeno prema bilo kojem od zahtjeva 11 do 17.
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